CLCB_HUMAN - dbPTM
CLCB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLCB_HUMAN
UniProt AC P09497
Protein Name Clathrin light chain B
Gene Name CLTB
Organism Homo sapiens (Human).
Sequence Length 229
Subcellular Localization Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side. Membrane, coated pit
Peripheral membrane protein
Cytoplasmic side. Cytoplasmic face of coated pits and vesicles.
Protein Description Clathrin is the major protein of the polyhedral coat of coated pits and vesicles..
Protein Sequence MADDFGFFSSSESGAPEAAEEDPAAAFLAQQESEIAGIENDEGFGAPAGSHAAPAQPGPTSGAGSEDMGTTVNGDVFQEANGPADGYAAIAQADRLTQEPESIRKWREEQRKRLQELDAASKVTEQEWREKAKKDLEEWNQRQSEQVEKNKINNRIADKAFYQQPDADIIGYVASEEAFVKESKEETPGTEWEKVAQLCDFNPKSSKQCKDVSRLRSVLMSLKQTPLSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationDFGFFSSSESGAPEA
CCCCCCCCCCCCCHH		34.283128543
13PhosphorylationGFFSSSESGAPEAAE
CCCCCCCCCCCHHHH		42.053128543
87PhosphorylationANGPADGYAAIAQAD
CCCCCCHHHHHHHHH		8.0722817900
97PhosphorylationIAQADRLTQEPESIR
HHHHHHHHCCHHHHH		31.6020068231
102PhosphorylationRLTQEPESIRKWREE
HHHCCHHHHHHHHHH		38.1120068231
122UbiquitinationQELDAASKVTEQEWR
HHHHHHHHHCHHHHH		48.74-
133MalonylationQEWREKAKKDLEEWN
HHHHHHHHHHHHHHH		58.8726320211
134UbiquitinationEWREKAKKDLEEWNQ
HHHHHHHHHHHHHHH		72.85-
157 (in isoform 2)Phosphorylation-14.7128348404
175PhosphorylationDIIGYVASEEAFVKE
CHHEEECCHHHHHHC		26.4021815630
181AcetylationASEEAFVKESKEETP
CCHHHHHHCCCCCCC		50.2226051181
184UbiquitinationEAFVKESKEETPGTE
HHHHHCCCCCCCCCC		61.74-
187PhosphorylationVKESKEETPGTEWEK
HHCCCCCCCCCCHHH		28.2721815630
190PhosphorylationSKEETPGTEWEKVAQ
CCCCCCCCCHHHHHH		38.84-
194MethylationTPGTEWEKVAQLCDF
CCCCCHHHHHHHCCC		43.90-
194UbiquitinationTPGTEWEKVAQLCDF
CCCCCHHHHHHHCCC		43.90-
199GlutathionylationWEKVAQLCDFNPKSS
HHHHHHHCCCCCCCC		3.5922555962
204AcetylationQLCDFNPKSSKQCKD
HHCCCCCCCCHHHCC		69.3525953088
204MethylationQLCDFNPKSSKQCKD
HHCCCCCCCCHHHCC		69.35-
204UbiquitinationQLCDFNPKSSKQCKD
HHCCCCCCCCHHHCC		69.35-
204MalonylationQLCDFNPKSSKQCKD
HHCCCCCCCCHHHCC		69.3526320211
205PhosphorylationLCDFNPKSSKQCKDV
HCCCCCCCCHHHCCH		43.9822704991
207UbiquitinationDFNPKSSKQCKDVSR
CCCCCCCHHHCCHHH		67.80-
207MethylationDFNPKSSKQCKDVSR
CCCCCCCHHHCCHHH		67.80-
213PhosphorylationSKQCKDVSRLRSVLM
CHHHCCHHHHHHHHH		35.4123898821
217PhosphorylationKDVSRLRSVLMSLKQ
CCHHHHHHHHHHHHC		24.9729970186
221PhosphorylationRLRSVLMSLKQTPLS
HHHHHHHHHHCCCCC		28.4029970186
223UbiquitinationRSVLMSLKQTPLSR-
HHHHHHHHCCCCCC-		44.83-
223AcetylationRSVLMSLKQTPLSR-
HHHHHHHHCCCCCC-		44.8325953088
223MalonylationRSVLMSLKQTPLSR-
HHHHHHHHCCCCCC-		44.8326320211
225PhosphorylationVLMSLKQTPLSR---
HHHHHHCCCCCC---		25.3026270265
228PhosphorylationSLKQTPLSR------
HHHCCCCCC------		36.8326270265
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
205SPhosphorylationKinaseGRK2P25098
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLCB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLCB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLH2_HUMANCLTCL1physical
26344197
CH10_HUMANHSPE1physical
26344197
HAP28_HUMANPDAP1physical
26344197
AP2A1_HUMANAP2A1physical
26496610
AP2A2_HUMANAP2A2physical
26496610
AP2B1_HUMANAP2B1physical
26496610
AP2M1_HUMANAP2M1physical
26496610
AP2S1_HUMANAP2S1physical
26496610
CLCA_HUMANCLTAphysical
26496610
CLH1_HUMANCLTCphysical
26496610
DAB2_HUMANDAB2physical
26496610
EPS15_HUMANEPS15physical
26496610
GAK_HUMANGAKphysical
26496610
MYO6_HUMANMYO6physical
26496610
P3C2A_HUMANPIK3C2Aphysical
26496610
SEC13_HUMANSEC13physical
26496610
CLH2_HUMANCLTCL1physical
26496610
PICAL_HUMANPICALMphysical
26496610
NUMB_HUMANNUMBphysical
26496610
HIP1R_HUMANHIP1Rphysical
26496610
EPN4_HUMANCLINT1physical
26496610
SC16A_HUMANSEC16Aphysical
26496610
AAK1_HUMANAAK1physical
26496610
TNR6A_HUMANTNRC6Aphysical
26496610
GTSE1_HUMANGTSE1physical
26496610
BMP2K_HUMANBMP2Kphysical
26496610
DEN1A_HUMANDENND1Aphysical
26496610
TPC_HUMANSLC25A19physical
26496610
WNK1_HUMANWNK1physical
26496610
STON2_HUMANSTON2physical
26496610
FCHO2_HUMANFCHO2physical
26496610
FA83B_HUMANFAM83Bphysical
26496610
CLH1_HUMANCLTCphysical
21411634
VP33A_HUMANVPS33Aphysical
21411634
VP33B_HUMANVPS33Bphysical
21411634
VPS41_HUMANVPS41physical
21411634
AP3D1_HUMANAP3D1physical
21411634
DP13A_HUMANAPPL1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLCB_HUMAN

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Related Literatures of Post-Translational Modification

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