dbPTM

GAK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GAK_HUMAN
UniProt AC	O14976
Protein Name	Cyclin-G-associated kinase
Gene Name	GAK
Organism	Homo sapiens (Human).
Sequence Length	1311
Subcellular Localization	Cytoplasm, perinuclear region . Golgi apparatus, trans-Golgi network . Cell junction, focal adhesion . Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
Protein Description	Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1..
Protein Sequence	MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEIAAARNVNPKSPITELLEQNGGYGSATLSRGPPPPVGPAGSGYSGGLALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVAEEPITPHSKPILVRAVVMTPVPLFSKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSREAPPWENSSMRGLNPKILFSSREEQQDILSKFGKPELPRQPGSTAQYDAGAGSPEAEPTDSDSPPSSSADASRFLHTLDWQEEKEAETGAENASSKESESALMEDRDESEVSDEGGSPISSEGQEPRADPEPPGLAAGLVQQDLVFEVETPAVLPEPVPQEDGVDLLGLHSEVGAGPAVPPQACKAPSSNTDLLSCLLGPPEAASQGPPEDLLSEDPLLLASPAPPLSVQSTPRGGPPAAADPFGPLLPSSGNNSQPCSNPDLFGEFLNSDSVTVPPSFPSAHSAPPPSCSADFLHLGDLPGEPSKMTASSSNPDLLGGWAAWTETAASAVAPTPATEGPLFSPGGQPAPCGSQASWTKSQNPDPFADLGDLSSGLQGSPAGFPPGGFIPKTATTPKGSSSWQTSRPPAQGASWPPQAKPPPKACTQPRPNYASNFSVIGAREERGVRAPSFAQKPKVSENDFEDLLSNQGFSSRSDKKGPKTIAEMRKQDLAKDTDPLKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVGMADLVAPEQVKKHYRRAVLAVHPDKAAGQPYEQHAKMIFMELNDAWSEFENQGSRPLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSLLQSALD ------CCHHHHHHH	49.44	19369195
2	Phosphorylation	------MSLLQSALD ------CCHHHHHHH	49.44	28464451
6	Phosphorylation	--MSLLQSALDFLAG --CCHHHHHHHHHHC	30.67	28348404
16	Phosphorylation	DFLAGPGSLGGASGR HHHHCCCCCCCCCCC	27.29	24043423
21	Phosphorylation	PGSLGGASGRDQSDF CCCCCCCCCCCCCCC	37.32	30108239
26	Phosphorylation	GASGRDQSDFVGQTV CCCCCCCCCCCCCEE	36.99	27499020
73	Phosphorylation	YALKRLLSNEEEKNR HHHHHHHCCHHHHHH	46.95	25159151
78	Ubiquitination	LLSNEEEKNRAIIQE HHCCHHHHHHHHHHH	55.82	-
90	Acetylation	IQEVCFMKKLSGHPN HHHHHHHHHHCCCCC	30.25	25953088
90	Ubiquitination	IQEVCFMKKLSGHPN HHHHHHHHHHCCCCC	30.25	-
91	Ubiquitination	QEVCFMKKLSGHPNI HHHHHHHHHCCCCCH	35.78	-
112	Phosphorylation	ASIGKEESDTGQAEF HHCCCCCCCCCCHHH	41.38	21082442
114	Phosphorylation	IGKEESDTGQAEFLL CCCCCCCCCCHHHHH	40.24	21082442
127	Ubiquitination	LLLTELCKGQLVEFL HHHHHHHHHHHHHHH	63.42	-
135	Ubiquitination	GQLVEFLKKMESRGP HHHHHHHHHHHHCCC	56.23	-
153	Phosphorylation	DTVLKIFYQTCRAVQ HHHHHHHHHHHHHHH	13.34	-
166	Ubiquitination	VQHMHRQKPPIIHRD HHHHHHCCCCEECCC	53.36	-
175	Ubiquitination	PIIHRDLKVENLLLS CEECCCCCHHHEEEC	52.36	21906983
182	Phosphorylation	KVENLLLSNQGTIKL CHHHEEECCCCEEEE	27.38	22210691
186	Phosphorylation	LLLSNQGTIKLCDFG EEECCCCEEEECCCC	12.74	27067055
201	Phosphorylation	SATTISHYPDYSWSA CCCEECCCCCCCHHH	7.33	22210691
204	Phosphorylation	TISHYPDYSWSAQRR EECCCCCCCHHHHHH	13.92	22817900
205	Phosphorylation	ISHYPDYSWSAQRRA ECCCCCCCHHHHHHH	23.18	22210691
207	Phosphorylation	HYPDYSWSAQRRALV CCCCCCHHHHHHHHH	14.48	21082442
235	Phosphorylation	TPEIIDLYSNFPIGE CHHHHHHHCCCCCCC	9.60	21945579
276	Phosphorylation	LRIVNGKYSIPPHDT EEEECCCEECCCCCC	17.15	-
277	Phosphorylation	RIVNGKYSIPPHDTQ EEECCCEECCCCCCH	31.91	-
285	Phosphorylation	IPPHDTQYTVFHSLI CCCCCCHHHHHHHHH	13.63	-
290	Phosphorylation	TQYTVFHSLIRAMLQ CHHHHHHHHHHHHHC	17.64	-
325	Ubiquitination	AARNVNPKSPITELL HHCCCCCCCHHHHHH	64.76	21906983
326	Phosphorylation	ARNVNPKSPITELLE HCCCCCCCHHHHHHH	23.85	28450419
329	Phosphorylation	VNPKSPITELLEQNG CCCCCHHHHHHHHCC	24.78	28450419
338	Phosphorylation	LLEQNGGYGSATLSR HHHHCCCCCCCCCCC	14.87	-
340	Phosphorylation	EQNGGYGSATLSRGP HHCCCCCCCCCCCCC	15.03	27251275
342	Phosphorylation	NGGYGSATLSRGPPP CCCCCCCCCCCCCCC	27.28	27251275
344	Phosphorylation	GYGSATLSRGPPPPV CCCCCCCCCCCCCCC	30.73	27251275
356	Phosphorylation	PPVGPAGSGYSGGLA CCCCCCCCCCCCCEE	36.34	28348404
359	Phosphorylation	GPAGSGYSGGLALAE CCCCCCCCCCEEEEE	29.88	24719451
367	Phosphorylation	GGLALAEYDQPYGGF CCEEEEEECCCCCCH	17.80	27642862
371	Phosphorylation	LAEYDQPYGGFLDIL EEEECCCCCCHHHHH	25.01	22817900
387	Phosphorylation	GGTERLFTNLKDTSS CCHHHHHCCCCCCCH	44.21	29978859
390	Ubiquitination	ERLFTNLKDTSSKVI HHHHCCCCCCCHHHH	62.11	-
392	Phosphorylation	LFTNLKDTSSKVIQS HHCCCCCCCHHHHHH	33.06	28857561
393	Phosphorylation	FTNLKDTSSKVIQSV HCCCCCCCHHHHHHH	37.99	29978859
394	Phosphorylation	TNLKDTSSKVIQSVA CCCCCCCHHHHHHHH	32.79	29978859
395	Acetylation	NLKDTSSKVIQSVAN CCCCCCHHHHHHHHH	43.03	7962549
395	Ubiquitination	NLKDTSSKVIQSVAN CCCCCCHHHHHHHHH	43.03	-
399	Phosphorylation	TSSKVIQSVANYAKG CCHHHHHHHHHHHCC	16.45	29978859
403	Phosphorylation	VIQSVANYAKGDLDI HHHHHHHHHCCCCCH	10.43	28152594
405	Ubiquitination	QSVANYAKGDLDISY HHHHHHHCCCCCHHH	42.47	-
412	Phosphorylation	KGDLDISYITSRIAV CCCCCHHHHHCEEEE	14.46	-
421	Phosphorylation	TSRIAVMSFPAEGVE HCEEEEEECCHHHHH	22.83	-
432	Ubiquitination	EGVESALKNNIEDVR HHHHHHHHCCHHHEH	47.90	21906983
439	Methylation	KNNIEDVRLFLDSKH HCCHHHEHHHHCCCC	31.85	-
445	Ubiquitination	VRLFLDSKHPGHYAV EHHHHCCCCCCCEEE	54.18	-
453	Phosphorylation	HPGHYAVYNLSPRTY CCCCEEEEECCCCCC	11.38	29214152
456	Phosphorylation	HYAVYNLSPRTYRPS CEEEEECCCCCCCCC	14.54	17192257
540	Phosphorylation	EAAVYMFSMKRCPPG HHHHHHHHHCCCCCC	13.58	24719451
555	Phosphorylation	IWPSHKRYIEYMCDM CCHHHHHHHHHHHHH	11.69	27050516
572	Phosphorylation	EEPITPHSKPILVRA CCCCCCCCCCEEEEE	41.13	27050516
583	Phosphorylation	LVRAVVMTPVPLFSK EEEEEEECCCCCCCC	14.99	-
589	Phosphorylation	MTPVPLFSKQRSGCR ECCCCCCCCCCCCCC	35.25	24719451
590	Ubiquitination	TPVPLFSKQRSGCRP CCCCCCCCCCCCCCC	42.25	-
593	Phosphorylation	PLFSKQRSGCRPFCE CCCCCCCCCCCCCEE	39.49	28348404
602	Phosphorylation	CRPFCEVYVGDERVA CCCCEEEEECCEEEE	4.04	29759185
610	Phosphorylation	VGDERVASTSQEYDK ECCEEEECCCCHHHH	26.24	29759185
612	Phosphorylation	DERVASTSQEYDKMR CEEEECCCCHHHHHC	20.65	29759185
615	Phosphorylation	VASTSQEYDKMRDFK EECCCCHHHHHCCEE	17.15	22817900
617	Ubiquitination	STSQEYDKMRDFKIE CCCCHHHHHCCEECC	34.63	-
682	Ubiquitination	PRNATTVKFAKYDLD CCCCCEEEEEEECCC	37.20	-
685	Acetylation	ATTVKFAKYDLDACD CCEEEEEEECCCCCC	42.29	25953088
685	Ubiquitination	ATTVKFAKYDLDACD CCEEEEEEECCCCCC	42.29	-
733	Malonylation	SMRGLNPKILFSSRE CCCCCCHHHCCCCHH	51.47	32601280
748	Ubiquitination	EQQDILSKFGKPELP HHHHHHHHHCCCCCC	55.48	-
751	Ubiquitination	DILSKFGKPELPRQP HHHHHHCCCCCCCCC	38.15	-
760	Phosphorylation	ELPRQPGSTAQYDAG CCCCCCCCCCCCCCC	27.53	28450419
761	Phosphorylation	LPRQPGSTAQYDAGA CCCCCCCCCCCCCCC	24.56	28450419
764	Phosphorylation	QPGSTAQYDAGAGSP CCCCCCCCCCCCCCC	12.80	28450419
770	Phosphorylation	QYDAGAGSPEAEPTD CCCCCCCCCCCCCCC	21.02	21712546
776	Phosphorylation	GSPEAEPTDSDSPPS CCCCCCCCCCCCCCC	39.37	30278072
778	Phosphorylation	PEAEPTDSDSPPSSS CCCCCCCCCCCCCCH	42.33	30278072
780	Phosphorylation	AEPTDSDSPPSSSAD CCCCCCCCCCCCHHH	42.54	30278072
783	Phosphorylation	TDSDSPPSSSADASR CCCCCCCCCHHHHHH	40.07	30278072
784	Phosphorylation	DSDSPPSSSADASRF CCCCCCCCHHHHHHH	35.01	30278072
785	Phosphorylation	SDSPPSSSADASRFL CCCCCCCHHHHHHHH	34.21	30278072
789	Phosphorylation	PSSSADASRFLHTLD CCCHHHHHHHHHHCC	24.90	24043423
794	Phosphorylation	DASRFLHTLDWQEEK HHHHHHHHCCHHHHH	28.67	23917254
801	Ubiquitination	TLDWQEEKEAETGAE HCCHHHHHHHHHCCC	62.56	-
805	Phosphorylation	QEEKEAETGAENASS HHHHHHHHCCCCCCC	49.06	18691976
811	Phosphorylation	ETGAENASSKESESA HHCCCCCCCHHHHHH	54.23	18691976
812	Phosphorylation	TGAENASSKESESAL HCCCCCCCHHHHHHH	37.72	18691976
815	Phosphorylation	ENASSKESESALMED CCCCCHHHHHHHHCC	40.36	23927012
817	Phosphorylation	ASSKESESALMEDRD CCCHHHHHHHHCCCC	35.66	28355574
826	Phosphorylation	LMEDRDESEVSDEGG HHCCCCCCCCCCCCC	47.81	29255136
829	Phosphorylation	DRDESEVSDEGGSPI CCCCCCCCCCCCCCC	26.37	29255136
834	Phosphorylation	EVSDEGGSPISSEGQ CCCCCCCCCCCCCCC	29.89	21712546
837	Phosphorylation	DEGGSPISSEGQEPR CCCCCCCCCCCCCCC	26.22	21082442
838	Phosphorylation	EGGSPISSEGQEPRA CCCCCCCCCCCCCCC	46.60	21082442
905	Phosphorylation	PQACKAPSSNTDLLS HHHCCCCCCCCCHHH	40.87	28348404
906	Phosphorylation	QACKAPSSNTDLLSC HHCCCCCCCCCHHHH	42.56	28348404
908	Phosphorylation	CKAPSSNTDLLSCLL CCCCCCCCCHHHHHH	29.94	27251275
939	O-linked_Glycosylation	EDPLLLASPAPPLSV CCCCEECCCCCCCCC	22.89	OGP
939	Phosphorylation	EDPLLLASPAPPLSV CCCCEECCCCCCCCC	22.89	29496963
945	Phosphorylation	ASPAPPLSVQSTPRG CCCCCCCCCCCCCCC	24.72	26074081
1027	Phosphorylation	EPSKMTASSSNPDLL CCCCCCCCCCCCCCC	25.73	28348404
1028	Phosphorylation	PSKMTASSSNPDLLG CCCCCCCCCCCCCCC	31.50	26074081
1029	Phosphorylation	SKMTASSSNPDLLGG CCCCCCCCCCCCCCH	50.30	26074081
1041	Phosphorylation	LGGWAAWTETAASAV CCHHHHCCHHHHHHC	20.80	28348404
1043	Phosphorylation	GWAAWTETAASAVAP HHHHCCHHHHHHCCC	21.83	28348404
1046	Phosphorylation	AWTETAASAVAPTPA HCCHHHHHHCCCCCC	22.32	28348404
1051	Phosphorylation	AASAVAPTPATEGPL HHHHCCCCCCCCCCC	18.80	28348404
1054	Phosphorylation	AVAPTPATEGPLFSP HCCCCCCCCCCCCCC	42.55	28348404
1060	Phosphorylation	ATEGPLFSPGGQPAP CCCCCCCCCCCCCCC	30.25	28348404
1070	Phosphorylation	GQPAPCGSQASWTKS CCCCCCCCCCCCCCC	29.32	27251275
1073	Phosphorylation	APCGSQASWTKSQNP CCCCCCCCCCCCCCC	27.86	27251275
1090	Phosphorylation	FADLGDLSSGLQGSP CCCHHHHCCCCCCCC	27.40	27251275
1091	Phosphorylation	ADLGDLSSGLQGSPA CCHHHHCCCCCCCCC	51.31	27251275
1096	Phosphorylation	LSSGLQGSPAGFPPG HCCCCCCCCCCCCCC	9.90	17192257
1116	Phosphorylation	TATTPKGSSSWQTSR CCCCCCCCCCCCCCC	27.59	20068231
1118	Phosphorylation	TTPKGSSSWQTSRPP CCCCCCCCCCCCCCC	25.54	-
1123	Methylation	SSSWQTSRPPAQGAS CCCCCCCCCCCCCCC	44.61	-
1130	O-linked_Glycosylation	RPPAQGASWPPQAKP CCCCCCCCCCCCCCC	47.11	23301498
1130	Phosphorylation	RPPAQGASWPPQAKP CCCCCCCCCCCCCCC	47.11	-
1143	Phosphorylation	KPPPKACTQPRPNYA CCCCCCCCCCCCCCC	46.60	21945579
1149	Phosphorylation	CTQPRPNYASNFSVI CCCCCCCCCCCCEEE	17.68	21945579
1151	Phosphorylation	QPRPNYASNFSVIGA CCCCCCCCCCEEEEC	28.22	21945579
1154	Phosphorylation	PNYASNFSVIGAREE CCCCCCCEEEECCHH	19.64	21945579
1168	Phosphorylation	ERGVRAPSFAQKPKV HCCCCCCCHHCCCCC	32.03	28857561
1172	Acetylation	RAPSFAQKPKVSEND CCCCHHCCCCCCCCH	43.29	25953088
1172	Ubiquitination	RAPSFAQKPKVSEND CCCCHHCCCCCCCCH	43.29	-
1176	Phosphorylation	FAQKPKVSENDFEDL HHCCCCCCCCHHHHH	36.49	26657352
1185	Phosphorylation	NDFEDLLSNQGFSSR CHHHHHHHCCCCCCC	34.11	20873877
1192	Methylation	SNQGFSSRSDKKGPK HCCCCCCCCCCCCCH	47.91	-
1213	Phosphorylation	KQDLAKDTDPLKLKL HHHHHCCCCHHHHHH	38.52	-
1217	Ubiquitination	AKDTDPLKLKLLDWI HCCCCHHHHHHHHHH	49.30	-
1219	Ubiquitination	DTDPLKLKLLDWIEG CCCHHHHHHHHHHCC	45.47	-
1265	Ubiquitination	VAPEQVKKHYRRAVL CCHHHHHHHHHHHEE	47.19	-
1278	Ubiquitination	VLAVHPDKAAGQPYE EEECCCCCCCCCCHH	44.58	-
1284	Nitration	DKAAGQPYEQHAKMI CCCCCCCHHHHHHHH	21.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
412	Y	Phosphorylation	Kinase	SRC	P12931	PSP
1149	Y	Phosphorylation	Kinase	SRC	P12931	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GAK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GAK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USO1_HUMAN	USO1	physical	16189514
CDK5_HUMAN	CDK5	physical	9013862
CCNG1_HUMAN	CCNG1	physical	9013862
A4_HUMAN	APP	physical	21832049
PPM1B_HUMAN	PPM1B	physical	26344197
AP2A1_HUMAN	AP2A1	physical	26496610
AP2A2_HUMAN	AP2A2	physical	26496610
AP2B1_HUMAN	AP2B1	physical	26496610
CALL3_HUMAN	CALML3	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
AP2M1_HUMAN	AP2M1	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLCB_HUMAN	CLTB	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
CBPM_HUMAN	CPM	physical	26496610
DAB2_HUMAN	DAB2	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
EPS15_HUMAN	EPS15	physical	26496610
GOGB1_HUMAN	GOLGB1	physical	26496610
HIP1_HUMAN	HIP1	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
P3C2A_HUMAN	PIK3C2A	physical	26496610
PSA5_HUMAN	PSMA5	physical	26496610
SEC13_HUMAN	SEC13	physical	26496610
SP1_HUMAN	SP1	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
CLH2_HUMAN	CLTCL1	physical	26496610
PICAL_HUMAN	PICALM	physical	26496610
NUMB_HUMAN	NUMB	physical	26496610
TNK1_HUMAN	TNK1	physical	26496610
HIP1R_HUMAN	HIP1R	physical	26496610
XPR1_HUMAN	XPR1	physical	26496610
SC24C_HUMAN	SEC24C	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
FEM1B_HUMAN	FEM1B	physical	26496610
ACK1_HUMAN	TNK2	physical	26496610
RBM14_HUMAN	RBM14	physical	26496610
KIF3A_HUMAN	KIF3A	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
AAK1_HUMAN	AAK1	physical	26496610
EDRF1_HUMAN	EDRF1	physical	26496610
SERA_HUMAN	PHGDH	physical	26496610
CHM4A_HUMAN	CHMP4A	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
GTSE1_HUMAN	GTSE1	physical	26496610
PLXA3_HUMAN	PLXNA3	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
KDIS_HUMAN	KIDINS220	physical	26496610
STALP_HUMAN	STAMBPL1	physical	26496610
DEN1A_HUMAN	DENND1A	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
ZN106_HUMAN	ZNF106	physical	26496610
INF2_HUMAN	INF2	physical	26496610
WNK1_HUMAN	WNK1	physical	26496610
CPSF7_HUMAN	CPSF7	physical	26496610
PUS7L_HUMAN	PUS7L	physical	26496610
PAR10_HUMAN	PARP10	physical	26496610
STON2_HUMAN	STON2	physical	26496610
MISP_HUMAN	MISP	physical	26496610
ACTT1_HUMAN	ACTRT1	physical	26496610
FA83B_HUMAN	FAM83B	physical	26496610
FA83H_HUMAN	FAM83H	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GAK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-829, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-326; TYR-615;THR-776; SER-778; SER-780; THR-805; SER-815; SER-817; SER-826;SER-829; SER-834; SER-837; SER-838; SER-939; SER-1070; SER-1073;SER-1176 AND SER-1185, AND MASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826; SER-829 ANDSER-834, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-456; SER-770;SER-780; SER-826; SER-829; SER-834 AND SER-1096, AND MASSSPECTROMETRY.	18691976 [Abstract]