dbPTM

KDIS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KDIS_HUMAN
UniProt AC	Q9ULH0
Protein Name	Kinase D-interacting substrate of 220 kDa
Gene Name	KIDINS220
Organism	Homo sapiens (Human).
Sequence Length	1771
Subcellular Localization	Membrane Multi-pass membrane protein . Late endosome. Localized at late endosome before or after nerve growth factor (NGF) stimulation.
Protein Description	Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway..
Protein Sequence	MSVLISQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGARHLSPTETDGDMLGYDLYSSALADILSEPTMQPPICVGLYAQWGSGKSFLLKKLEDEMKTFAGQQIEPLFQFSWLIVFLTLLLCGGLGLLFAFTVHPNLGIAVSLSFLALLYIFFIVIYFGGRREGESWNWAWVLSTRLARHIGYLELLLKLMFVNPPELPEQTTKALPVRFLFTDYNRLSSVGGETSLAEMIATLSDACEREFGFLATRLFRVFKTEDTQGKKKWKKTCCLPSFVIFLFIIGCIISGITLLAIFRVDPKHLTVNAVLISIASVVGLAFVLNCRTWWQVLDSLLNSQRKRLHNAASKLHKLKSEGFMKVLKCEVELMARMAKTIDSFTQNQTRLVVIIDGLDACEQDKVLQMLDTVRVLFSKGPFIAIFASDPHIIIKAINQNLNSVLRDSNINGHDYMRNIVHLPVFLNSRGLSNARKFLVTSATNGDVPCSDTTGIQEDADRRVSQNSLGEMTKLGSKTALNRRDTYRRRQMQRTITRQMSFDLTKLLVTEDWFSDISPQTMRRLLNIVSVTGRLLRANQISFNWDRLASWINLTEQWPYRTSWLILYLEETEGIPDQMTLKTIYERISKNIPTTKDVEPLLEIDGDIRNFEVFLSSRTPVLVARDVKVFLPCTVNLDPKLREIIADVRAAREQISIGGLAYPPLPLHEGPPRAPSGYSQPPSVCSSTSFNGPFAGGVVSPQPHSSYYSGMTGPQHPFYNRPFFAPYLYTPRYYPGGSQHLISRPSVKTSLPRDQNNGLEVIKEDAAEGLSSPTDSSRGSGPAPGPVVLLNSLNVDAVCEKLKQIEGLDQSMLPQYCTTIKKANINGRVLAQCNIDELKKEMNMNFGDWHLFRSTVLEMRNAESHVVPEDPRFLSESSSGPAPHGEPARRASHNELPHTELSSQTPYTLNFSFEELNTLGLDEGAPRHSNLSWQSQTRRTPSLSSLNSQDSSIEISKLTDKVQAEYRDAYREYIAQMSQLEGGPGSTTISGRSSPHSTYYMGQSSSGGSIHSNLEQEKGKDSEPKPDDGRKSFLMKRGDVIDYSSSGVSTNDASPLDPITEEDEKSDQSGSKLLPGKKSSERSSLFQTDLKLKGSGLRYQKLPSDEDESGTEESDNTPLLKDDKDRKAEGKVERVPKSPEHSAEPIRTFIKAKEYLSDALLDKKDSSDSGVRSSESSPNHSLHNEVADDSQLEKANLIELEDDSHSGKRGIPHSLSGLQDPIIARMSICSEDKKSPSECSLIASSPEENWPACQKAYNLNRTPSTVTLNNNSAPANRANQNFDEMEGIRETSQVILRPSSSPNPTTIQNENLKSMTHKRSQRSSYTRLSKDPPELHAAASSESTGFGEERESIL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVLISQSV ------CCEEECHHH	36.61	28464451
6	Phosphorylation	--MSVLISQSVINYV --CCEEECHHHHHHH	16.55	26503514
12	Phosphorylation	ISQSVINYVEEENIP ECHHHHHHHHHHCCH	9.71	25884760
22	Ubiquitination	EENIPALKALLEKCK HHCCHHHHHHHHHCC	38.81	-
27	Ubiquitination	ALKALLEKCKDVDER HHHHHHHHCCCCCCC	46.70	33845483
59	Ubiquitination	EIVKELIKNGANCNL HHHHHHHHCCCCCCH	63.05	29967540
169	Phosphorylation	KVNCSDKYGTTPLVW EEECCCCCCCCHHHH	25.37	22817900
203	Phosphorylation	VDQEGANSMTALIVA CCCCCHHHCEEEEEE	19.58	-
215	Phosphorylation	IVAVKGGYTQSVKEI EEEECCCCHHHHHHH	15.41	25884760
216	Phosphorylation	VAVKGGYTQSVKEIL EEECCCCHHHHHHHH	20.04	-
244	Phosphorylation	NTALMIASKEGHTEI CEEEEEEECCCCHHH	21.95	-
249	Ubiquitination	IASKEGHTEIVQDLL EEECCCCHHHHHHHH	37.96	32015554
249 (in isoform 2)	Ubiquitination	-	37.96	21890473
291	Ubiquitination	IVRALLQKYADIDIR HHHHHHHHHCCCEEC	42.23	22817900
291 (in isoform 1)	Ubiquitination	-	42.23	21890473
291 (in isoform 4)	Ubiquitination	-	42.23	21890473
292	Ubiquitination	VRALLQKYADIDIRG HHHHHHHHCCCEECC	9.13	32015554
292 (in isoform 3)	Ubiquitination	-	9.13	21890473
303	Ubiquitination	DIRGQDNKTALYWAV EECCCCCHHHHEHHH	43.39	29967540
307	Phosphorylation	QDNKTALYWAVEKGN CCCHHHHEHHHHCCC	6.72	25884760
325	Ubiquitination	VRDILQCNPDTEICT EEHHHHCCCCCCEEC	25.23	33845483
337	Phosphorylation	ICTKDGETPLIKATK EECCCCCCCCEECCC	28.99	24719451
341	Ubiquitination	DGETPLIKATKMRNI CCCCCCEECCCCCCC	58.65	29967540
362	Phosphorylation	LDKGAKVSAVDKKGD HHCCCCEEEECCCCC	23.13	29396449
367	Ubiquitination	KVSAVDKKGDTPLHI CEEEECCCCCCCEEE	58.52	33845483
368	Ubiquitination	VSAVDKKGDTPLHIA EEEECCCCCCCEEEE	50.17	33845483
370	Phosphorylation	AVDKKGDTPLHIAIR EECCCCCCCEEEEEE	36.10	29396449
374	Ubiquitination	KGDTPLHIAIRGRSR CCCCCEEEEEECCCH	4.49	32142685
382	Acetylation	AIRGRSRKLAELLLR EEECCCHHHHHHHHH	53.98	25953088
398	Phosphorylation	PKDGRLLYRPNKAGE CCCCCEEECCCCCCC	28.72	-
406	Phosphorylation	RPNKAGETPYNIDCS CCCCCCCCCCCCCCC	30.10	-
416	Ubiquitination	NIDCSHQKSILTQIF CCCCCCHHHHHHHHH	33.76	21963094
417	Ubiquitination	IDCSHQKSILTQIFG CCCCCHHHHHHHHHC	19.09	32142685
465	Phosphorylation	PPICVGLYAQWGSGK CCEEEEEEEECCCCH	7.27	25884760
549 (in isoform 2)	Ubiquitination	-	60.59	-
591	Ubiquitination	ELPEQTTKALPVRFL CCCHHCCCCCCEEEE	51.84	23503661
599	Ubiquitination	ALPVRFLFTDYNRLS CCCEEEEEECHHHHH	4.49	32142685
641	Ubiquitination	TRLFRVFKTEDTQGK HHHHHHHCCCCCCCC	48.42	32142685
642	Ubiquitination	RLFRVFKTEDTQGKK HHHHHHCCCCCCCCC	27.85	32142685
695	Ubiquitination	TVNAVLISIASVVGL CHHHHHHHHHHHHHH	14.13	32142685
695 (in isoform 2)	Ubiquitination	-	14.13	-
731	Phosphorylation	KRLHNAASKLHKLKS HHHHHHHHHHHHHHH	33.08	23403867
732	Ubiquitination	RLHNAASKLHKLKSE HHHHHHHHHHHHHHC	50.30	23503661
735	Ubiquitination	NAASKLHKLKSEGFM HHHHHHHHHHHCCHH	68.96	23503661
737	Ubiquitination	ASKLHKLKSEGFMKV HHHHHHHHHCCHHHH	51.79	32142685
738	Ubiquitination	SKLHKLKSEGFMKVL HHHHHHHHCCHHHHH	54.08	32142685
743	Acetylation	LKSEGFMKVLKCEVE HHHCCHHHHHHHHHH	42.00	7296999
743	Ubiquitination	LKSEGFMKVLKCEVE HHHCCHHHHHHHHHH	42.00	23503661
746	Acetylation	EGFMKVLKCEVELMA CCHHHHHHHHHHHHH	31.19	7297011
746	Ubiquitination	EGFMKVLKCEVELMA CCHHHHHHHHHHHHH	31.19	-
796	Phosphorylation	DTVRVLFSKGPFIAI HHHHHHHCCCCEEEE	32.32	24719451
833	Phosphorylation	SNINGHDYMRNIVHL CCCCCCHHHHHHCCH	7.72	25884760
843	Phosphorylation	NIVHLPVFLNSRGLS HHCCHHHHHCCCCCC	5.16	32142685
849	Ubiquitination	VFLNSRGLSNARKFL HHHCCCCCCCCCCEE	3.29	33845483
849 (in isoform 2)	Ubiquitination	-	3.29	21890473
853	Ubiquitination	SRGLSNARKFLVTSA CCCCCCCCCEEEECC	34.21	32142685
853 (in isoform 2)	Ubiquitination	-	34.21	-
854	Ubiquitination	RGLSNARKFLVTSAT CCCCCCCCEEEECCC	40.41	29967540
876	Phosphorylation	DTTGIQEDADRRVSQ CCCCCCHHHHHHHHH	37.08	32142685
882	Phosphorylation	EDADRRVSQNSLGEM HHHHHHHHHCCHHHH	23.10	30266825
885	Phosphorylation	DRRVSQNSLGEMTKL HHHHHHCCHHHHHHH	30.07	30266825
886	Phosphorylation	RRVSQNSLGEMTKLG HHHHHCCHHHHHHHC	9.87	32142685
889	Sulfoxidation	SQNSLGEMTKLGSKT HHCCHHHHHHHCCCH	3.67	21406390
890	Phosphorylation	QNSLGEMTKLGSKTA HCCHHHHHHHCCCHH	20.86	30266825
891	Ubiquitination	NSLGEMTKLGSKTAL CCHHHHHHHCCCHHH	49.92	23000965
891 (in isoform 1)	Ubiquitination	-	49.92	21890473
891 (in isoform 4)	Ubiquitination	-	49.92	21890473
892	Ubiquitination	SLGEMTKLGSKTALN CHHHHHHHCCCHHHC	7.43	33845483
892 (in isoform 3)	Ubiquitination	-	7.43	21890473
894	Phosphorylation	GEMTKLGSKTALNRR HHHHHHCCCHHHCCH	36.95	23312004
895	Ubiquitination	EMTKLGSKTALNRRD HHHHHCCCHHHCCHH	35.70	23000965
896	Phosphorylation	MTKLGSKTALNRRDT HHHHCCCHHHCCHHH	37.77	23312004
896	Ubiquitination	MTKLGSKTALNRRDT HHHHCCCHHHCCHHH	37.77	32142685
903	Phosphorylation	TALNRRDTYRRRQMQ HHHCCHHHHHHHHHH	19.67	23882029
912	Phosphorylation	RRRQMQRTITRQMSF HHHHHHHHHHHHHCC	15.14	23882029
914	Phosphorylation	RQMQRTITRQMSFDL HHHHHHHHHHHCCCH	17.78	29514088
918	Phosphorylation	RTITRQMSFDLTKLL HHHHHHHCCCHHHHH	13.79	29255136
919	Phosphorylation	TITRQMSFDLTKLLV HHHHHHCCCHHHHHH	8.18	32142685
922	Phosphorylation	RQMSFDLTKLLVTED HHHCCCHHHHHHCCC	22.84	30266825
927	Phosphorylation	DLTKLLVTEDWFSDI CHHHHHHCCCHHHCC	28.35	-
932	Phosphorylation	LVTEDWFSDISPQTM HHCCCHHHCCCHHHH	29.76	-
947	Phosphorylation	RRLLNIVSVTGRLLR HHHHHHHHHHHHHHH	15.34	-
949	Phosphorylation	LLNIVSVTGRLLRAN HHHHHHHHHHHHHHH	14.74	-
965	Ubiquitination	ISFNWDRLASWINLT CCCCHHHHHHHHCCH	4.03	33845483
971	Ubiquitination	RLASWINLTEQWPYR HHHHHHCCHHCCCCC	4.03	32015554
1007	Ubiquitination	TIYERISKNIPTTKD HHHHHHHCCCCCCCC	57.43	33845483
1008	Ubiquitination	IYERISKNIPTTKDV HHHHHHCCCCCCCCC	38.39	33845483
1013	Ubiquitination	SKNIPTTKDVEPLLE HCCCCCCCCCHHHEE	63.35	32015554
1014	Ubiquitination	KNIPTTKDVEPLLEI CCCCCCCCCHHHEEE	48.17	32015554
1033	Phosphorylation	RNFEVFLSSRTPVLV CCEEEHHHCCCCEEE	13.30	23532336
1057	Ubiquitination	CTVNLDPKLREIIAD ECCCCCHHHHHHHHH	60.90	-
1073	Phosphorylation	RAAREQISIGGLAYP HHHHHHCCCCCCCCC	18.18	28555341
1079	Phosphorylation	ISIGGLAYPPLPLHE CCCCCCCCCCCCCCC	15.49	25884760
1125	Phosphorylation	PQPHSSYYSGMTGPQ CCCCCCCCCCCCCCC	10.74	-
1144	Phosphorylation	NRPFFAPYLYTPRYY CCCCCCCEEECCCCC	14.65	25884760
1146	Phosphorylation	PFFAPYLYTPRYYPG CCCCCEEECCCCCCC	14.62	25884760
1149	Methylation	APYLYTPRYYPGGSQ CCEEECCCCCCCCCC	35.50	54557019
1150	Phosphorylation	PYLYTPRYYPGGSQH CEEECCCCCCCCCCC	18.40	25884760
1151	Phosphorylation	YLYTPRYYPGGSQHL EEECCCCCCCCCCCC	9.18	25884760
1155	Phosphorylation	PRYYPGGSQHLISRP CCCCCCCCCCCCCCC	21.97	28152594
1160	Phosphorylation	GGSQHLISRPSVKTS CCCCCCCCCCCCCCC	44.49	29978859
1163	Phosphorylation	QHLISRPSVKTSLPR CCCCCCCCCCCCCCC	34.83	27422710
1165	Ubiquitination	LISRPSVKTSLPRDQ CCCCCCCCCCCCCCC	36.41	-
1166	Phosphorylation	ISRPSVKTSLPRDQN CCCCCCCCCCCCCCC	33.08	22210691
1167	Phosphorylation	SRPSVKTSLPRDQNN CCCCCCCCCCCCCCC	30.56	21712546
1266	Phosphorylation	MNMNFGDWHLFRSTV HCCCCCCHHHHHHHH	7.17	33259812
1272	O-linked_Glycosylation	DWHLFRSTVLEMRNA CHHHHHHHHHHHHCC	25.50	30379171
1279	Ubiquitination	TVLEMRNAESHVVPE HHHHHHCCCCCCCCC	14.87	33845483
1292	Phosphorylation	PEDPRFLSESSSGPA CCCCCCCCCCCCCCC	32.49	21712546
1294	Phosphorylation	DPRFLSESSSGPAPH CCCCCCCCCCCCCCC	26.82	23917254
1295	Phosphorylation	PRFLSESSSGPAPHG CCCCCCCCCCCCCCC	34.95	21712546
1296	Phosphorylation	RFLSESSSGPAPHGE CCCCCCCCCCCCCCC	59.06	21712546
1308	Phosphorylation	HGEPARRASHNELPH CCCCCCCCCCCCCCC	15.02	33259812
1309	Phosphorylation	GEPARRASHNELPHT CCCCCCCCCCCCCCC	25.65	33259812
1312	Phosphorylation	ARRASHNELPHTELS CCCCCCCCCCCCHHC	59.25	32142685
1321	Ubiquitination	PHTELSSQTPYTLNF CCCHHCCCCCEEEEE	43.02	33845483
1322	Ubiquitination	HTELSSQTPYTLNFS CCHHCCCCCEEEEEE	21.88	33845483
1324	Phosphorylation	ELSSQTPYTLNFSFE HHCCCCCEEEEEEHH	27.52	-
1325	Phosphorylation	LSSQTPYTLNFSFEE HCCCCCEEEEEEHHH	19.21	29523821
1329	Phosphorylation	TPYTLNFSFEELNTL CCEEEEEEHHHHHHC	30.58	26657352
1346	Phosphorylation	DEGAPRHSNLSWQSQ CCCCCCCCCCCHHCC	40.52	30266825
1347	Phosphorylation	EGAPRHSNLSWQSQT CCCCCCCCCCHHCCC	31.78	33259812
1349	Phosphorylation	APRHSNLSWQSQTRR CCCCCCCCHHCCCCC	27.59	23663014
1352	Phosphorylation	HSNLSWQSQTRRTPS CCCCCHHCCCCCCCC	27.53	23663014
1354	Phosphorylation	NLSWQSQTRRTPSLS CCCHHCCCCCCCCHH	27.63	23663014
1355	Phosphorylation	LSWQSQTRRTPSLSS CCHHCCCCCCCCHHH	32.60	32142685
1357	Phosphorylation	WQSQTRRTPSLSSLN HHCCCCCCCCHHHCC	17.59	21955146
1359	Phosphorylation	SQTRRTPSLSSLNSQ CCCCCCCCHHHCCCC	40.03	25159151
1359	Ubiquitination	SQTRRTPSLSSLNSQ CCCCCCCCHHHCCCC	40.03	33845483
1360	Ubiquitination	QTRRTPSLSSLNSQD CCCCCCCHHHCCCCC	4.19	33845483
1361	Phosphorylation	TRRTPSLSSLNSQDS CCCCCCHHHCCCCCC	36.80	26055452
1362	Phosphorylation	RRTPSLSSLNSQDSS CCCCCHHHCCCCCCC	36.54	25159151
1365	Phosphorylation	PSLSSLNSQDSSIEI CCHHHCCCCCCCEEH	40.43	21955146
1366	Phosphorylation	SLSSLNSQDSSIEIS CHHHCCCCCCCEEHH	54.23	33259812
1368	Phosphorylation	SSLNSQDSSIEISKL HHCCCCCCCEEHHHH	26.11	21955146
1369	Phosphorylation	SLNSQDSSIEISKLT HCCCCCCCEEHHHHH	32.31	28450419
1373	Phosphorylation	QDSSIEISKLTDKVQ CCCCEEHHHHHHHHH	14.60	21955146
1378	Ubiquitination	EISKLTDKVQAEYRD EHHHHHHHHHHHHHH	30.89	22053931
1379	Ubiquitination	ISKLTDKVQAEYRDA HHHHHHHHHHHHHHH	7.89	33845483
1383	Phosphorylation	TDKVQAEYRDAYREY HHHHHHHHHHHHHHH	19.46	29978859
1387	Phosphorylation	QAEYRDAYREYIAQM HHHHHHHHHHHHHHH	14.31	22817900
1390	Phosphorylation	YRDAYREYIAQMSQL HHHHHHHHHHHHHHC	7.80	23403867
1392	Phosphorylation	DAYREYIAQMSQLEG HHHHHHHHHHHHCCC	9.71	32142685
1393	Phosphorylation	AYREYIAQMSQLEGG HHHHHHHHHHHCCCC	23.62	32142685
1395	Phosphorylation	REYIAQMSQLEGGPG HHHHHHHHHCCCCCC	21.38	28555341
1403	Phosphorylation	QLEGGPGSTTISGRS HCCCCCCCCEECCCC	26.05	26074081
1404	Phosphorylation	LEGGPGSTTISGRSS CCCCCCCCEECCCCC	33.78	26074081
1405	Phosphorylation	EGGPGSTTISGRSSP CCCCCCCEECCCCCC	18.16	26074081
1407	Phosphorylation	GPGSTTISGRSSPHS CCCCCEECCCCCCCC	26.51	26074081
1410	Phosphorylation	STTISGRSSPHSTYY CCEECCCCCCCCEEE	52.31	21945579
1411	Phosphorylation	TTISGRSSPHSTYYM CEECCCCCCCCEEEC	25.85	21945579
1412	Phosphorylation	TISGRSSPHSTYYMG EECCCCCCCCEEECE	27.05	32142685
1414	Phosphorylation	SGRSSPHSTYYMGQS CCCCCCCCEEECEEC	22.84	21945579
1415	Phosphorylation	GRSSPHSTYYMGQSS CCCCCCCEEECEECC	18.68	21945579
1416	Phosphorylation	RSSPHSTYYMGQSSS CCCCCCEEECEECCC	8.41	21945579
1417	Phosphorylation	SSPHSTYYMGQSSSG CCCCCEEECEECCCC	8.54	21945579
1421	Phosphorylation	STYYMGQSSSGGSIH CEEECEECCCCCCCC	22.27	21945579
1422	Phosphorylation	TYYMGQSSSGGSIHS EEECEECCCCCCCCC	25.72	21945579
1423	Phosphorylation	YYMGQSSSGGSIHSN EECEECCCCCCCCCC	53.04	21945579
1426	Phosphorylation	GQSSSGGSIHSNLEQ EECCCCCCCCCCCHH	22.21	21945579
1427	Phosphorylation	QSSSGGSIHSNLEQE ECCCCCCCCCCCHHH	4.70	32142685
1429	Phosphorylation	SSGGSIHSNLEQEKG CCCCCCCCCCHHHCC	41.25	21945579
1456	Phosphorylation	SFLMKRGDVIDYSSS HHHHCCCCEEEECCC	37.93	32142685
1460	Phosphorylation	KRGDVIDYSSSGVST CCCCEEEECCCCCCC	10.18	25884760
1466	Phosphorylation	DYSSSGVSTNDASPL EECCCCCCCCCCCCC	25.64	26471730
1467	Phosphorylation	YSSSGVSTNDASPLD ECCCCCCCCCCCCCC	34.41	26471730
1469	Phosphorylation	SSGVSTNDASPLDPI CCCCCCCCCCCCCCC	48.81	32142685
1470	Phosphorylation	SGVSTNDASPLDPIT CCCCCCCCCCCCCCC	18.34	32142685
1471	Phosphorylation	GVSTNDASPLDPITE CCCCCCCCCCCCCCC	28.94	30576142
1472	Phosphorylation	VSTNDASPLDPITEE CCCCCCCCCCCCCCC	42.37	32142685
1477	Phosphorylation	ASPLDPITEEDEKSD CCCCCCCCCCHHHCC	38.42	25849741
1483	Phosphorylation	ITEEDEKSDQSGSKL CCCCHHHCCCCCCCC	38.54	25921289
1486	Phosphorylation	EDEKSDQSGSKLLPG CHHHCCCCCCCCCCC	50.45	25921289
1488	Phosphorylation	EKSDQSGSKLLPGKK HHCCCCCCCCCCCCC	25.94	25921289
1497	Phosphorylation	LLPGKKSSERSSLFQ CCCCCCCCCCCHHCH	46.00	28122231
1498	Phosphorylation	LPGKKSSERSSLFQT CCCCCCCCCCHHCHH	64.77	32142685
1499	Phosphorylation	PGKKSSERSSLFQTD CCCCCCCCCHHCHHC	33.23	32142685
1500	Phosphorylation	GKKSSERSSLFQTDL CCCCCCCCHHCHHCC	27.60	28122231
1501	Phosphorylation	KKSSERSSLFQTDLK CCCCCCCHHCHHCCC	39.15	24173317
1502	Phosphorylation	KSSERSSLFQTDLKL CCCCCCHHCHHCCCC	3.78	32142685
1503	Phosphorylation	SSERSSLFQTDLKLK CCCCCHHCHHCCCCC	8.75	32142685
1507	Phosphorylation	SSLFQTDLKLKGSGL CHHCHHCCCCCCCCC	8.76	32142685
1508	Phosphorylation	SLFQTDLKLKGSGLR HHCHHCCCCCCCCCC	51.46	32142685
1509	Phosphorylation	LFQTDLKLKGSGLRY HCHHCCCCCCCCCCE	11.18	32142685
1510	Phosphorylation	FQTDLKLKGSGLRYQ CHHCCCCCCCCCCEE	49.82	32142685
1516	Phosphorylation	LKGSGLRYQKLPSDE CCCCCCCEEECCCCC	18.29	23403867
1521	Phosphorylation	LRYQKLPSDEDESGT CCEEECCCCCCCCCC	65.16	29255136
1526	Phosphorylation	LPSDEDESGTEESDN CCCCCCCCCCCCCCC	64.44	29255136
1527	Phosphorylation	PSDEDESGTEESDNT CCCCCCCCCCCCCCC	34.79	32142685
1528	Phosphorylation	SDEDESGTEESDNTP CCCCCCCCCCCCCCC	45.95	29255136
1529	Phosphorylation	DEDESGTEESDNTPL CCCCCCCCCCCCCCC	60.06	32142685
1531	Phosphorylation	DESGTEESDNTPLLK CCCCCCCCCCCCCCC	29.90	22167270
1534	Phosphorylation	GTEESDNTPLLKDDK CCCCCCCCCCCCCCC	21.94	23927012
1536	Phosphorylation	EESDNTPLLKDDKDR CCCCCCCCCCCCCCC	9.75	32142685
1537	Phosphorylation	ESDNTPLLKDDKDRK CCCCCCCCCCCCCCC	6.35	32142685
1540	Phosphorylation	NTPLLKDDKDRKAEG CCCCCCCCCCCCCCC	53.84	32142685
1541	Phosphorylation	TPLLKDDKDRKAEGK CCCCCCCCCCCCCCC	70.35	32142685
1555	Phosphorylation	KVERVPKSPEHSAEP CCEECCCCCCCCCCC	29.47	29255136
1556	Phosphorylation	VERVPKSPEHSAEPI CEECCCCCCCCCCCH	49.82	32142685
1559	Phosphorylation	VPKSPEHSAEPIRTF CCCCCCCCCCCHHHH	32.44	30266825
1560	Phosphorylation	PKSPEHSAEPIRTFI CCCCCCCCCCHHHHH	28.61	32142685
1565	Phosphorylation	HSAEPIRTFIKAKEY CCCCCHHHHHHHHHH	30.36	23312004
1572	Phosphorylation	TFIKAKEYLSDALLD HHHHHHHHHHHHHHC	15.70	25884760
1574	Phosphorylation	IKAKEYLSDALLDKK HHHHHHHHHHHHCCC	21.67	29978859
1576	Phosphorylation	AKEYLSDALLDKKDS HHHHHHHHHHCCCCC	13.47	32142685
1577	Phosphorylation	KEYLSDALLDKKDSS HHHHHHHHHCCCCCC	8.36	32142685
1580	2-Hydroxyisobutyrylation	LSDALLDKKDSSDSG HHHHHHCCCCCCCCC	59.45	-
1580	Phosphorylation	LSDALLDKKDSSDSG HHHHHHCCCCCCCCC	59.45	32142685
1580	Ubiquitination	LSDALLDKKDSSDSG HHHHHHCCCCCCCCC	59.45	29967540
1583	Phosphorylation	ALLDKKDSSDSGVRS HHHCCCCCCCCCCCC	44.95	28450419
1584	Phosphorylation	LLDKKDSSDSGVRSS HHCCCCCCCCCCCCC	46.02	28450419
1586	Phosphorylation	DKKDSSDSGVRSSES CCCCCCCCCCCCCCC	40.93	25849741
1590	Phosphorylation	SSDSGVRSSESSPNH CCCCCCCCCCCCCCC	35.73	25159151
1591	Phosphorylation	SDSGVRSSESSPNHS CCCCCCCCCCCCCCC	30.82	25159151
1593	Phosphorylation	SGVRSSESSPNHSLH CCCCCCCCCCCCCCC	53.71	25159151
1594	Phosphorylation	GVRSSESSPNHSLHN CCCCCCCCCCCCCCC	26.18	25159151
1598	Phosphorylation	SESSPNHSLHNEVAD CCCCCCCCCCCCCCC	37.65	25159151
1607	Phosphorylation	HNEVADDSQLEKANL CCCCCCHHHHHHCCC	36.89	30576142
1614	Phosphorylation	SQLEKANLIELEDDS HHHHHCCCEEECCCC	3.73	32142685
1615	Phosphorylation	QLEKANLIELEDDSH HHHHCCCEEECCCCC	5.95	32142685
1621	Phosphorylation	LIELEDDSHSGKRGI CEEECCCCCCCCCCC	31.69	30266825
1622	Phosphorylation	IELEDDSHSGKRGIP EEECCCCCCCCCCCC	47.79	32142685
1623	Phosphorylation	ELEDDSHSGKRGIPH EECCCCCCCCCCCCC	50.38	30266825
1625	Phosphorylation	EDDSHSGKRGIPHSL CCCCCCCCCCCCCCC	50.93	32645325
1625	Ubiquitination	EDDSHSGKRGIPHSL CCCCCCCCCCCCCCC	50.93	29967540
1626	Phosphorylation	DDSHSGKRGIPHSLS CCCCCCCCCCCCCCC	52.37	32645325
1631	Phosphorylation	GKRGIPHSLSGLQDP CCCCCCCCCCCCCCC	20.90	23898821
1633	Phosphorylation	RGIPHSLSGLQDPII CCCCCCCCCCCCCHH	40.24	25159151
1634	Phosphorylation	GIPHSLSGLQDPIIA CCCCCCCCCCCCHHH	32.43	32142685
1644	Phosphorylation	DPIIARMSICSEDKK CCHHHHHHHCCCCCC	18.19	21815630
1647	Phosphorylation	IARMSICSEDKKSPS HHHHHHCCCCCCCHH	47.35	25002506
1652	Phosphorylation	ICSEDKKSPSECSLI HCCCCCCCHHHCCCC	39.12	25850435
1654	Phosphorylation	SEDKKSPSECSLIAS CCCCCCHHHCCCCCC	59.32	25850435
1657	Phosphorylation	KKSPSECSLIASSPE CCCHHHCCCCCCCCC	20.82	25850435
1660	Phosphorylation	PSECSLIASSPEENW HHHCCCCCCCCCCCC	14.84	32142685
1661	Phosphorylation	SECSLIASSPEENWP HHCCCCCCCCCCCCH	39.16	23663014
1662	Phosphorylation	ECSLIASSPEENWPA HCCCCCCCCCCCCHH	27.58	23663014
1663	Phosphorylation	CSLIASSPEENWPAC CCCCCCCCCCCCHHH	50.88	32645325
1664	Phosphorylation	SLIASSPEENWPACQ CCCCCCCCCCCHHHH	66.95	32645325
1674	Phosphorylation	WPACQKAYNLNRTPS CHHHHHHHCCCCCCC	27.50	25884760
1679	Phosphorylation	KAYNLNRTPSTVTLN HHHCCCCCCCEEEEC	22.10	30266825
1680	Phosphorylation	AYNLNRTPSTVTLNN HHCCCCCCCEEEECC	25.43	32142685
1681	Phosphorylation	YNLNRTPSTVTLNNN HCCCCCCCEEEECCC	34.59	30266825
1682	Phosphorylation	NLNRTPSTVTLNNNS CCCCCCCEEEECCCC	20.79	30266825
1683	Phosphorylation	LNRTPSTVTLNNNSA CCCCCCEEEECCCCC	7.22	32645325
1684	Phosphorylation	NRTPSTVTLNNNSAP CCCCCEEEECCCCCC	24.69	25159151
1689	Phosphorylation	TVTLNNNSAPANRAN EEEECCCCCCCCCCC	37.44	30576142
1708	Phosphorylation	EMEGIRETSQVILRP HHCCHHHCCEEEECC	18.01	23312004
1709	Phosphorylation	MEGIRETSQVILRPS HCCHHHCCEEEECCC	20.07	28985074
1716	Phosphorylation	SQVILRPSSSPNPTT CEEEECCCCCCCCCC	36.69	25159151
1717	Phosphorylation	QVILRPSSSPNPTTI EEEECCCCCCCCCCC	53.12	25159151
1718	Phosphorylation	VILRPSSSPNPTTIQ EEECCCCCCCCCCCC	32.79	25159151
1722	Phosphorylation	PSSSPNPTTIQNENL CCCCCCCCCCCCCCH	43.07	20068231
1723	Phosphorylation	SSSPNPTTIQNENLK CCCCCCCCCCCCCHH	23.09	23312004
1731	Phosphorylation	IQNENLKSMTHKRSQ CCCCCHHHHCCCHHH	31.89	-
1735	Acetylation	NLKSMTHKRSQRSSY CHHHHCCCHHHHHHC	44.57	7971431
1737	Phosphorylation	KSMTHKRSQRSSYTR HHHCCCHHHHHHCCC	34.45	-
1740	Phosphorylation	THKRSQRSSYTRLSK CCCHHHHHHCCCCCC	21.76	27080861
1741	Phosphorylation	HKRSQRSSYTRLSKD CCHHHHHHCCCCCCC	32.48	28102081
1742	Phosphorylation	KRSQRSSYTRLSKDP CHHHHHHCCCCCCCC	9.34	22817900
1743	Phosphorylation	RSQRSSYTRLSKDPP HHHHHHCCCCCCCCH	27.38	27080861
1746	Phosphorylation	RSSYTRLSKDPPELH HHHCCCCCCCCHHHH	31.55	26471730
1757	Phosphorylation	PELHAAASSESTGFG HHHHHHHCCCCCCCC	29.88	25849741
1758	Phosphorylation	ELHAAASSESTGFGE HHHHHHCCCCCCCCC	30.73	26471730
1760	Phosphorylation	HAAASSESTGFGEER HHHHCCCCCCCCCHH	35.46	25849741
1761	Phosphorylation	AAASSESTGFGEERE HHHCCCCCCCCCHHH	32.26	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KDIS_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
918	S	Phosphorylation		18669648
Phosphorylation at Ser-918 is induced by phorbol ester treatment.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KDIS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KDIS_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KDIS_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918; SER-1359; SER-1362;SER-1365; SER-1521 AND SER-1526, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1294, AND MASSSPECTROMETRY.	18220336 [Abstract]

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