dbPTM

BMP2K_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BMP2K_HUMAN
UniProt AC	Q9NSY1
Protein Name	BMP-2-inducible protein kinase
Gene Name	BMP2K
Organism	Homo sapiens (Human).
Sequence Length	1161
Subcellular Localization	Nucleus .
Protein Description	May be involved in osteoblast differentiation..
Protein Sequence	MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSAQLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFDEITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARRHKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLSWHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQSQQSQPVELDPFGAAPFPSKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKKFSRMPKSEG ---CCCCCCCCCCCC	36.23	28857561
10	Phosphorylation	KFSRMPKSEGGSGGG CCCCCCCCCCCCCCC	35.29	21082442
14	Phosphorylation	MPKSEGGSGGGAAGG CCCCCCCCCCCCCCC	45.16	30175587
34	Phosphorylation	GAGAGCGSGGSSVGV CCCCCCCCCCCCCEE	44.02	28450419
37	Phosphorylation	AGCGSGGSSVGVRVF CCCCCCCCCCEEEEE	25.94	23186163
38	Phosphorylation	GCGSGGSSVGVRVFA CCCCCCCCCEEEEEE	26.60	25954137
93	Ubiquitination	MPDLNVCKREITIMK CCCCCCCHHHHHHHH	49.10	29967540
173	Ubiquitination	VARLHQCKTPIIHRD HHHHHCCCCCEECCC	51.25	29967540
182	Ubiquitination	PIIHRDLKVENILLN CEECCCCEEEEEEEC	52.36	29967540
211	Ubiquitination	NKFLNPQKDGVNVVE CCCCCCCCCCCCCCH	58.67	29967540
222	Ubiquitination	NVVEEEIKKYTTLSY CCCHHHHHHHCCCCC	42.90	29967540
223	Ubiquitination	VVEEEIKKYTTLSYR CCHHHHHHHCCCCCC	54.19	29967540
225	Phosphorylation	EEEIKKYTTLSYRAP HHHHHHHCCCCCCCC	30.09	21082442
226	Phosphorylation	EEIKKYTTLSYRAPE HHHHHHCCCCCCCCH	15.60	21082442
241	Ubiquitination	MINLYGGKPITTKAD HHHHCCCCCCCCHHH	28.96	29967540
257	Phosphorylation	WALGCLLYKLCFFTL HHHHHHHHHHHHHHC	6.75	20068231
357 (in isoform 3)	Phosphorylation	-	4.96	22210691
358	Phosphorylation	SQIKARITDTIGPTE HHHHHHCCCCCCCCC	22.87	23403867
359 (in isoform 3)	Phosphorylation	-	33.67	22210691
367	Phosphorylation	TIGPTETSIAPRQRP CCCCCCCCCCCCCCC	15.55	24719451
378	Phosphorylation	RQRPKANSATTATPS CCCCCCCCCCCCCCC	31.67	26307563
380	Phosphorylation	RPKANSATTATPSVL CCCCCCCCCCCCCEE	19.45	26307563
381	Phosphorylation	PKANSATTATPSVLT CCCCCCCCCCCCEEE	28.40	24719451
383	Phosphorylation	ANSATTATPSVLTIQ CCCCCCCCCCEEEEE	17.63	26307563
385	Phosphorylation	SATTATPSVLTIQSS CCCCCCCCEEEEECC	25.96	26307563
388	Phosphorylation	TATPSVLTIQSSATP CCCCCEEEEECCCCC	18.15	26307563
391	Phosphorylation	PSVLTIQSSATPVKV CCEEEEECCCCCEEE	20.35	26307563
392	Phosphorylation	SVLTIQSSATPVKVL CEEEEECCCCCEEEE	21.56	21815630
394	Phosphorylation	LTIQSSATPVKVLAP EEEECCCCCEEEECC	30.48	21815630
594	Phosphorylation	GTIMDSSYSANRSVA CCHHCCCCCCCCCCC	18.76	-
613	Ubiquitination	IANFTNQKNISNPPD HHHHCCCCCCCCCCC	59.32	29967540
616	Phosphorylation	FTNQKNISNPPDMSG HCCCCCCCCCCCCCC	53.31	27251275
650	Phosphorylation	REFDLLRSNRLEERA HHHHHHHHCHHHHHH	26.69	26657352
651	Phosphorylation	EFDLLRSNRLEERAS HHHHHHHCHHHHHHC	46.23	27251275
651 (in isoform 2)	Phosphorylation	-	46.23	27251275
656	Ubiquitination	RSNRLEERASSDKNV HHCHHHHHHCCCCCC	30.32	29967540
658	Phosphorylation	NRLEERASSDKNVDS CHHHHHHCCCCCCCC	45.34	20873877
659	Phosphorylation	RLEERASSDKNVDSL HHHHHHCCCCCCCCC	52.17	20873877
665	Phosphorylation	SSDKNVDSLSAPHNH CCCCCCCCCCCCCCC	21.68	20873877
666 (in isoform 3)	Phosphorylation	-	4.35	27251275
667	Phosphorylation	DKNVDSLSAPHNHPP CCCCCCCCCCCCCCC	43.64	20873877
680	Phosphorylation	PPEDPFGSVPFISHS CCCCCCCCCCCCCCC	27.31	25867546
685	Phosphorylation	FGSVPFISHSGSPEK CCCCCCCCCCCCHHH	16.39	29255136
687	Phosphorylation	SVPFISHSGSPEKKA CCCCCCCCCCHHHHH	33.89	29255136
689	Phosphorylation	PFISHSGSPEKKAEH CCCCCCCCHHHHHCC	32.66	29255136
697	Phosphorylation	PEKKAEHSSINQENG HHHHHCCCCCCCCCC	25.15	18691976
698	Phosphorylation	EKKAEHSSINQENGT HHHHCCCCCCCCCCC	27.71	28985074
705	Phosphorylation	SINQENGTANPIKNG CCCCCCCCCCCCCCC	34.54	28348404
714	Phosphorylation	NPIKNGKTSPASKDQ CCCCCCCCCCCCCCC	41.14	26699800
715	Phosphorylation	PIKNGKTSPASKDQR CCCCCCCCCCCCCCC	23.19	26699800
718	Phosphorylation	NGKTSPASKDQRTGK CCCCCCCCCCCCCCC	39.90	28985074
727	Phosphorylation	DQRTGKKTSVQGQVQ CCCCCCEEEECCCCC	37.30	18691976
728	Phosphorylation	QRTGKKTSVQGQVQK CCCCCEEEECCCCCC	22.71	25159151
740	Phosphorylation	VQKGNDESESDFESD CCCCCCCCCCCCCCC	45.31	23186163
742	Phosphorylation	KGNDESESDFESDPP CCCCCCCCCCCCCCC	57.80	28985074
746	Phosphorylation	ESESDFESDPPSPKS CCCCCCCCCCCCCCC	56.25	25262027
750	Phosphorylation	DFESDPPSPKSSEEE CCCCCCCCCCCCHHH	50.80	27251275
791	Phosphorylation	HRPLLMDSEDEEEEE CCCCCCCCCCHHHHH	32.74	27499020
804	Phosphorylation	EEKHSSDSDYEQAKA HHHHCCCCHHHHHHH	44.00	28985074
813	Phosphorylation	YEQAKAKYSDMSSVY HHHHHHHHHCCHHHC	18.11	28796482
814	Phosphorylation	EQAKAKYSDMSSVYR HHHHHHHHCCHHHCC	26.57	28796482
817	Phosphorylation	KAKYSDMSSVYRDRS HHHHHCCHHHCCCCC	22.95	28796482
818	Phosphorylation	AKYSDMSSVYRDRSG HHHHCCHHHCCCCCC	19.27	23401153
820	Phosphorylation	YSDMSSVYRDRSGSG HHCCHHHCCCCCCCC	14.56	28796482
824	Phosphorylation	SSVYRDRSGSGPTQD HHHCCCCCCCCCCCC	41.42	30278072
826	Phosphorylation	VYRDRSGSGPTQDLN HCCCCCCCCCCCCHH	42.73	30278072
829	Phosphorylation	DRSGSGPTQDLNTIL CCCCCCCCCCHHHHH	37.94	23663014
834	Phosphorylation	GPTQDLNTILLTSAQ CCCCCHHHHHHHHHH	21.94	23663014
838	Phosphorylation	DLNTILLTSAQLSSD CHHHHHHHHHHHCCC	20.69	23663014
839	Phosphorylation	LNTILLTSAQLSSDV HHHHHHHHHHHCCCC	17.62	23663014
843	Phosphorylation	LLTSAQLSSDVAVET HHHHHHHCCCCCCCC	16.65	23663014
928	Phosphorylation	TIPGYPKSVDVFGST CCCCCCCCEECCCCC	21.03	27251275
934	Phosphorylation	KSVDVFGSTPFQPFL CCEECCCCCCCCCCC	22.80	28857561
935	Phosphorylation	SVDVFGSTPFQPFLT CEECCCCCCCCCCCC	28.62	28464451
942	Phosphorylation	TPFQPFLTSTSKSES CCCCCCCCCCCCCCC	30.27	28464451
943	Phosphorylation	PFQPFLTSTSKSESN CCCCCCCCCCCCCCC	32.60	26074081
944	Phosphorylation	FQPFLTSTSKSESNE CCCCCCCCCCCCCCC	34.63	26074081
945	Phosphorylation	QPFLTSTSKSESNED CCCCCCCCCCCCCCC	33.67	26074081
947	Phosphorylation	FLTSTSKSESNEDLF CCCCCCCCCCCCCCC	46.13	30278072
949	Phosphorylation	TSTSKSESNEDLFGL CCCCCCCCCCCCCCC	53.24	30278072
963	Phosphorylation	LVPFDEITGSQQQKV CCCHHHCCCCHHHHH	28.82	19651622
965	Phosphorylation	PFDEITGSQQQKVKQ CHHHCCCCHHHHHHH	19.03	19651622
974	Phosphorylation	QQKVKQRSLQKLSSR HHHHHHHHHHHHHHH	32.43	20164059
979	Phosphorylation	QRSLQKLSSRQRRTK HHHHHHHHHHHHHHH	30.43	20164059
980	Phosphorylation	RSLQKLSSRQRRTKQ HHHHHHHHHHHHHHH	42.75	20164059
991	Ubiquitination	RTKQDMSKSNGKRHH HHHHHHHHHCCCCCC	41.10	-
1000	Phosphorylation	NGKRHHGTPTSTKKT CCCCCCCCCCCCCCC	21.02	24706070
1002	Phosphorylation	KRHHGTPTSTKKTLK CCCCCCCCCCCCCCC	49.19	17192257
1003	Phosphorylation	RHHGTPTSTKKTLKP CCCCCCCCCCCCCCC	39.16	18691976
1007	Phosphorylation	TPTSTKKTLKPTYRT CCCCCCCCCCCCCCC	41.38	23403867
1011	Phosphorylation	TKKTLKPTYRTPERA CCCCCCCCCCCHHHH	24.85	23401153
1012	Phosphorylation	KKTLKPTYRTPERAR CCCCCCCCCCHHHHH	22.48	27794612
1014	Phosphorylation	TLKPTYRTPERARRH CCCCCCCCHHHHHHH	21.06	27794612
1029	Phosphorylation	KKVGRRDSQSSNEFL HCCCCCCCCCCCCCE	30.10	29255136
1031	Phosphorylation	VGRRDSQSSNEFLTI CCCCCCCCCCCCEEE	38.80	29255136
1032	Phosphorylation	GRRDSQSSNEFLTIS CCCCCCCCCCCEEEE	32.51	29255136
1037	Phosphorylation	QSSNEFLTISDSKEN CCCCCCEEEECCCCC	24.61	23927012
1039	Phosphorylation	SNEFLTISDSKENIS CCCCEEEECCCCCEE	30.51	23927012
1041	Phosphorylation	EFLTISDSKENISVA CCEEEECCCCCEEEE	34.77	23927012
1046	Phosphorylation	SDSKENISVALTDGK ECCCCCEEEEECCCC	16.96	27251275
1064	Phosphorylation	NVLQPEESLLDPFGA CCCCCHHHHCCCCCC	32.35	23898821
1076	Phosphorylation	FGAKPFHSPDLSWHP CCCCCCCCCCCCCCC	22.08	25159151
1080	Phosphorylation	PFHSPDLSWHPPHQG CCCCCCCCCCCCCCC	30.62	25850435
1089	Phosphorylation	HPPHQGLSDIRADHN CCCCCCCCCCCCCCC	37.50	25159151
1097	Phosphorylation	DIRADHNTVLPGRPR CCCCCCCCCCCCCCC	21.72	-
1107	Phosphorylation	PGRPRQNSLHGSFHS CCCCCCCCCCCCCCC	17.26	23401153
1111	Phosphorylation	RQNSLHGSFHSADVL CCCCCCCCCCCCCEE	14.72	25159151
1114	Phosphorylation	SLHGSFHSADVLKMD CCCCCCCCCCEECCC	24.93	23403867
1135	Phosphorylation	FTELVVQSITPHQSQ HHEEEEEECCCCCCC	19.47	26074081
1137	Phosphorylation	ELVVQSITPHQSQQS EEEEEECCCCCCCCC	21.69	26074081
1141	Phosphorylation	QSITPHQSQQSQPVE EECCCCCCCCCCCCC	27.44	26074081
1144	Phosphorylation	TPHQSQQSQPVELDP CCCCCCCCCCCCCCC	28.90	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BMP2K_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BMP2K_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BMP2K_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of BMP2K_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BMP2K_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1029 AND SER-1032, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-14; SER-378;SER-665; SER-680; SER-685; SER-728; SER-824; THR-942; SER-947;SER-1029; SER-1031; SER-1032; SER-1107 AND SER-1111, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-947, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-824; SER-826; SER-979;THR-1002; THR-1011; SER-1029; SER-1031; SER-1032; SER-1041; SER-1076;SER-1107 AND SER-1111, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, AND MASSSPECTROMETRY.	17081983 [Abstract]