CCNG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNG1_HUMAN
• UniProt AC: P51959
• Protein Name: Cyclin-G1
• Gene Name: CCNG1
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Nucleus . DNA replication foci after DNA damage.
• Protein Description: May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity)..
• Protein Sequence: MIEVLTTTDSQKLLHQLNALLEQESRCQPKVCGLRLIESAHDNGLRMTARLRDFEVKDLLSLTQFFGFDTETFSLAVNLLDRFLSKMKVQPKHLGCVGLSCFYLAVKSIEEERNVPLATDLIRISQYRFTVSDLMRMEKIVLEKVCWKVKATTAFQFLQLYYSLLQENLPLERRNSINFERLEAQLKACHCRIIFSKAKPSVLALSIIALEIQAQKCVELTEGIECLQKHSKINGRDLTFWQELVSKCLTEYSSNKCSKPNVQKLKWIVSGRTARQLKHSYYRITHLPTIPEMVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	LTTTDSQKLLHQLNA EECCCHHHHHHHHHH	57.90	7676423
25	Phosphorylation	NALLEQESRCQPKVC HHHHHHHHCCCCCCC	37.74	-
30	Ubiquitination	QESRCQPKVCGLRLI HHHCCCCCCCCEEHH	25.03	-
39	Phosphorylation	CGLRLIESAHDNGLR CCEEHHHHHCCCCCE	24.74	-
48	Phosphorylation	HDNGLRMTARLRDFE CCCCCEEEEECCCCC	11.37	-
53	Ubiquitination	RMTARLRDFEVKDLL EEEEECCCCCHHHHH	48.96	-
132	Phosphorylation	SQYRFTVSDLMRMEK HHCEEEHHHHHHHHH	23.20	24719451
187	Ubiquitination	ERLEAQLKACHCRII HHHHHHHHHHCHHHE	36.57	-
196	Phosphorylation	CHCRIIFSKAKPSVL HCHHHECCCCCHHHH	22.69	24719451
247	Ubiquitination	FWQELVSKCLTEYSS HHHHHHHHHHHHHHC	26.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCNG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	12556559
MDM2_HUMAN	MDM2	physical	12556559
CDN2A_HUMAN	CDKN2A	physical	12556559
ARF_HUMAN	CDKN2A	physical	12556559
P53_HUMAN	TP53	physical	12642871
P73_HUMAN	TP73	physical	12642871
CDK2_HUMAN	CDK2	physical	18632610
A4_HUMAN	APP	physical	21832049
TNIP1_HUMAN	TNIP1	physical	21988832
SHKB1_HUMAN	SHKBP1	physical	21988832
GRN_HUMAN	GRN	physical	21988832
LTBP3_HUMAN	LTBP3	physical	21988832
NFAC4_HUMAN	NFATC4	physical	21988832
AP2C_HUMAN	TFAP2C	physical	21988832
PKHA4_HUMAN	PLEKHA4	physical	21988832
PNMA1_HUMAN	PNMA1	physical	25416956
TNIP1_HUMAN	TNIP1	physical	25416956
RBPMS_HUMAN	RBPMS	physical	25416956
TFP11_HUMAN	TFIP11	physical	25416956
PAK5_HUMAN	PAK7	physical	25416956
HMBX1_HUMAN	HMBOX1	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
ZZEF1_HUMAN	ZZEF1	physical	26186194
CUL4B_HUMAN	CUL4B	physical	26186194
CUL4A_HUMAN	CUL4A	physical	26186194
HECD3_HUMAN	HECTD3	physical	26186194
2A5D_HUMAN	PPP2R5D	physical	26186194
2A5E_HUMAN	PPP2R5E	physical	26186194
2A5G_HUMAN	PPP2R5C	physical	26186194
LAR1B_HUMAN	LARP1B	physical	26186194
2A5D_HUMAN	PPP2R5D	physical	28514442
2A5E_HUMAN	PPP2R5E	physical	28514442
ZZEF1_HUMAN	ZZEF1	physical	28514442
CUL4A_HUMAN	CUL4A	physical	28514442
CUL4B_HUMAN	CUL4B	physical	28514442
2A5G_HUMAN	PPP2R5C	physical	28514442
DDB1_HUMAN	DDB1	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.