LAR1B_HUMAN - dbPTM
LAR1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAR1B_HUMAN
UniProt AC Q659C4
Protein Name La-related protein 1B
Gene Name LARP1B
Organism Homo sapiens (Human).
Sequence Length 914
Subcellular Localization
Protein Description
Protein Sequence MENWPTPSELVNTGFQSVLSQGNKKPQNRKEKEEKVEKRSNSDSKENRETKLNGPGENVSEDEAQSSNQRKRANKHKWVPLHLDVVRSESQERPGSRNSSRCQPEANKPTHNNRRNDTRSWKRDREKRDDQDDVSSVRSEGGNIRGSFRGRGRGRGRGRGRGRGNPRLNFDYSYGYQEHGERTDQPFQTELNTSMMYYYDDGTGVQVYPVEEALLKEYIKRQIEYYFSVENLERDFFLRGKMDEQGFLPISLIAGFQRVQALTTNLNLILEALKDSTEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPNSPRIGSPLSPKKNSETSILQAMSRGLSTSLPDLDSEPWIEVKKRHQPAPVKLRESVSVPEGSLNQLCSSEEPEQEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILIVTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIKQEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQGGVQGVLHIPKKDLTDELAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVKEPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAGSYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEKKFRREIFQDFQEETKKDYESGQLYGLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEFGRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSPRRNISPESSDNSH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationEEKVEKRSNSDSKEN
HHHHHHHCCCCCHHH		52.3228985074
50PhosphorylationDSKENRETKLNGPGE
CCHHHHCCCCCCCCC		37.2827486199
60 (in isoform 2)Phosphorylation-51.4125849741
60PhosphorylationNGPGENVSEDEAQSS
CCCCCCCCHHHHHHH		51.4119664994
66PhosphorylationVSEDEAQSSNQRKRA
CCHHHHHHHHHHHHH		38.0023403867
67PhosphorylationSEDEAQSSNQRKRAN
CHHHHHHHHHHHHHH		25.5423403867
88PhosphorylationLHLDVVRSESQERPG
EEHHHHCCCCCCCCC		29.9524719451
90PhosphorylationLDVVRSESQERPGSR
HHHHCCCCCCCCCCC		38.2923312004
96PhosphorylationESQERPGSRNSSRCQ
CCCCCCCCCCCCCCC		30.8527251275
135PhosphorylationRDDQDDVSSVRSEGG
CCCCCCHHHHHCCCC		30.0629255136
136PhosphorylationDDQDDVSSVRSEGGN
CCCCCHHHHHCCCCC		22.7729255136
138DimethylationQDDVSSVRSEGGNIR
CCCHHHHHCCCCCCC		30.82-
138MethylationQDDVSSVRSEGGNIR
CCCHHHHHCCCCCCC		30.8218938697
145MethylationRSEGGNIRGSFRGRG
HCCCCCCCCCCCCCC		38.41115481791
147PhosphorylationEGGNIRGSFRGRGRG
CCCCCCCCCCCCCCC		11.2630576142
153DimethylationGSFRGRGRGRGRGRG
CCCCCCCCCCCCCCC		30.21-
153MethylationGSFRGRGRGRGRGRG
CCCCCCCCCCCCCCC		30.2118938703
155DimethylationFRGRGRGRGRGRGRG
CCCCCCCCCCCCCCC		30.21-
155MethylationFRGRGRGRGRGRGRG
CCCCCCCCCCCCCCC		30.2118938709
172PhosphorylationNPRLNFDYSYGYQEH
CCCCCCEECCCCHHH		10.3127642862
173PhosphorylationPRLNFDYSYGYQEHG
CCCCCEECCCCHHHC		17.5827251275
174PhosphorylationRLNFDYSYGYQEHGE
CCCCEECCCCHHHCC		17.3927251275
176PhosphorylationNFDYSYGYQEHGERT
CCEECCCCHHHCCCC		11.5127642862
194 (in isoform 2)Ubiquitination-10.6521906983
225PhosphorylationYIKRQIEYYFSVENL
HHHHHHHHHEECCCC		16.0728270605
226PhosphorylationIKRQIEYYFSVENLE
HHHHHHHHEECCCCC		4.0628270605
228PhosphorylationRQIEYYFSVENLERD
HHHHHHEECCCCCCC		16.6428270605
241 (in isoform 1)Ubiquitination-36.4221906983
241 (in isoform 3)Ubiquitination-36.4221906983
241 (in isoform 4)Ubiquitination-36.4221906983
241 (in isoform 9)Ubiquitination-36.4221906983
241UbiquitinationRDFFLRGKMDEQGFL
CCEECCCCCCCCCCC		36.422190698
285UbiquitinationEVEIVDEKMRKKIEP
CEEECCHHHHHHCCH		39.27-
303MethylationPIPGPPPRSVPPTDF
CCCCCCCCCCCCCCH		56.9430762507
303DimethylationPIPGPPPRSVPPTDF
CCCCCCCCCCCCCCH		56.94-
304PhosphorylationIPGPPPRSVPPTDFS
CCCCCCCCCCCCCHH		44.7630177828
308PhosphorylationPPRSVPPTDFSQLID
CCCCCCCCCHHHHCC		43.5430177828
311PhosphorylationSVPPTDFSQLIDCPE
CCCCCCHHHHCCCCC		27.2130177828
327PhosphorylationVPGQAFCSHTESAPN
CCCCCCCCCCCCCCC		27.3026657352
329PhosphorylationGQAFCSHTESAPNSP
CCCCCCCCCCCCCCC		18.4918669648
331PhosphorylationAFCSHTESAPNSPRI
CCCCCCCCCCCCCCC		50.6226657352
335PhosphorylationHTESAPNSPRIGSPL
CCCCCCCCCCCCCCC		17.9428348404
340PhosphorylationPNSPRIGSPLSPKKN
CCCCCCCCCCCCCCC		21.9429255136
343PhosphorylationPRIGSPLSPKKNSET
CCCCCCCCCCCCCHH		37.7529255136
348PhosphorylationPLSPKKNSETSILQA
CCCCCCCCHHHHHHH		51.6528464451
350PhosphorylationSPKKNSETSILQAMS
CCCCCCHHHHHHHHH		22.3823927012
351PhosphorylationPKKNSETSILQAMSR
CCCCCHHHHHHHHHC		19.7623927012
361PhosphorylationQAMSRGLSTSLPDLD
HHHHCCCCCCCCCCC		20.8330278072
362PhosphorylationAMSRGLSTSLPDLDS
HHHCCCCCCCCCCCC		39.0530278072
363PhosphorylationMSRGLSTSLPDLDSE
HHCCCCCCCCCCCCC		34.2330278072
369PhosphorylationTSLPDLDSEPWIEVK
CCCCCCCCCCCEEEH		53.5128102081
391PhosphorylationVKLRESVSVPEGSLN
CEEECCCCCCCCCHH		41.0327251275
427PhosphorylationEQIGRKNTFTDWSDN
HHHCCCCCCCCCCCC		30.8322199227
429PhosphorylationIGRKNTFTDWSDNDS
HCCCCCCCCCCCCCC		34.2222199227
432PhosphorylationKNTFTDWSDNDSDYE
CCCCCCCCCCCCCCE		29.3722617229
436PhosphorylationTDWSDNDSDYEIDDQ
CCCCCCCCCCEECHH		48.6322617229
438PhosphorylationWSDNDSDYEIDDQDL
CCCCCCCCEECHHHH		20.8023663014
452PhosphorylationLNKILIVTQTPPYVK
HCEEEEEECCCCCCC		21.5223403867
454PhosphorylationKILIVTQTPPYVKKH
EEEEEECCCCCCCCC		19.5025159151
457PhosphorylationIVTQTPPYVKKHPGG
EEECCCCCCCCCCCC		26.5523403867
467PhosphorylationKHPGGDRTGTHMSRA
CCCCCCCCCCCHHHH		51.69-
478PhosphorylationMSRAKITSELAKVIN
HHHHHHHHHHHHHHH		33.80-
516UbiquitinationQEVENFKKLNLISKE
HHHHHHHHHCCCCHH		38.17-
575PhosphorylationAQKLFDVSEITSAAM
HHHHCCHHHHHHHHH		25.7327080861
578PhosphorylationLFDVSEITSAAMVHS
HCCHHHHHHHHHHHC		14.3027080861
579PhosphorylationFDVSEITSAAMVHSL
CCHHHHHHHHHHHCC		21.4927080861
585PhosphorylationTSAAMVHSLPTAVPE
HHHHHHHCCCCCCCC		25.3227080861
588PhosphorylationAMVHSLPTAVPESPR
HHHHCCCCCCCCCCC		45.6529255136
593PhosphorylationLPTAVPESPRIHPTR
CCCCCCCCCCCCCCC		17.2629255136
599PhosphorylationESPRIHPTRTPKTPR
CCCCCCCCCCCCCCC		32.7722617229
601PhosphorylationPRIHPTRTPKTPRTP
CCCCCCCCCCCCCCC		31.4528348404
604PhosphorylationHPTRTPKTPRTPRLQ
CCCCCCCCCCCCCCC		21.1423403867
607PhosphorylationRTPKTPRTPRLQDPN
CCCCCCCCCCCCCCC		17.6023403867
616PhosphorylationRLQDPNKTPRFYPVV
CCCCCCCCCCCCCCC		26.7427251275
633PhosphorylationPKAIDVKSPRKRKTR
CCCCCCCCCCCCCCC		29.7723898821
670PhosphorylationGTSSVSTSNASPSEG
CCCCCCCCCCCCCCC		23.92-
673PhosphorylationSVSTSNASPSEGAPL
CCCCCCCCCCCCCCC		32.9627251275
771PhosphorylationDAKENYRYGLECLFR
HHHHHHHHHHHHHHH		18.72-
804PhosphorylationQEETKKDYESGQLYG
HHHHHHHHHHCCCCC		22.37-
821PhosphorylationKFWAYLKYSQSKTQS
HHHHHHHHCCCCCCC		14.8922985185
862PhosphorylationEFGRKRHSSTSGEES
CCCCCCCCCCCCCCC		39.0726699800
863PhosphorylationFGRKRHSSTSGEESN
CCCCCCCCCCCCCCC		22.0726699800
864PhosphorylationGRKRHSSTSGEESNR
CCCCCCCCCCCCCCC		43.7126699800
865PhosphorylationRKRHSSTSGEESNRH
CCCCCCCCCCCCCCC		46.2726699800
878PhosphorylationRHRLPPNSSTKPPNA
CCCCCCCCCCCCCCC		45.2025627689
879PhosphorylationHRLPPNSSTKPPNAA
CCCCCCCCCCCCCCC		47.2725954137
880PhosphorylationRLPPNSSTKPPNAAK
CCCCCCCCCCCCCCC		47.6025627689
889PhosphorylationPPNAAKPTSTSELQV
CCCCCCCCCCCEEEC		43.8825954137
890PhosphorylationPNAAKPTSTSELQVP
CCCCCCCCCCEEECC		38.1625954137
891PhosphorylationNAAKPTSTSELQVPI
CCCCCCCCCEEECCC		28.7925954137
892PhosphorylationAAKPTSTSELQVPIN
CCCCCCCCEEECCCC		35.7627732954
900PhosphorylationELQVPINSPRRNISP
EEECCCCCCCCCCCC		22.0925849741
906PhosphorylationNSPRRNISPESSDNS
CCCCCCCCCCCCCCC		26.6023401153
909PhosphorylationRRNISPESSDNSH--
CCCCCCCCCCCCC--		46.5022496350
910PhosphorylationRNISPESSDNSH---
CCCCCCCCCCCC---		38.8722496350
913PhosphorylationSPESSDNSH------
CCCCCCCCC------		35.2527794612
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAR1B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAR1B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAR1B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
RPB11_HUMANPOLR2Jphysical
21988832
TRI69_HUMANTRIM69physical
25416956
LARP1_HUMANLARP1physical
28514442
ROA1_HUMANHNRNPA1physical
28514442
H14_HUMANHIST1H1Ephysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAR1B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60 AND SER-432, AND MASSSPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, AND MASSSPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-340; SER-343 ANDTHR-454, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-340 AND SER-343,AND MASS SPECTROMETRY.

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