LTBP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LTBP3_HUMAN
• UniProt AC: Q9NS15
• Protein Name: Latent-transforming growth factor beta-binding protein 3
• Gene Name: LTBP3
• Organism: Homo sapiens (Human).
• Sequence Length: 1303
• Subcellular Localization: Secreted. Secretion occurs after coexpression with TGFB1 and requires complexing with 'Cys-33' of the TGFB1 propeptide..
• Protein Description: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM)..
• Protein Sequence: MPGPRGAAGGLAPEMRGAGAAGLLALLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQRRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Ubiquitination	ALARERFKVVFAPVI HHHHHHEEEEEEEEE	43.65	-
72	Ubiquitination	VFAPVICKRTCLKGQ EEEEEEECCHHCCCC	39.35	-
77	Ubiquitination	ICKRTCLKGQCRDSC EECCHHCCCCCHHHH	49.43	-
89	N-linked_Glycosylation	DSCQQGSNMTLIGEN HHHHCCCCEEEECCC	33.99	UniProtKB CARBOHYD
91	Phosphorylation	CQQGSNMTLIGENGH HHCCCCEEEECCCCC	21.34	28787133
99	Phosphorylation	LIGENGHSTDTLTGS EECCCCCCCCCCCCC	29.40	28787133
166	O-linked_Glycosylation	SRTGALSTGALPPLA CCCCCCCCCCCCCCC	27.59	OGP
218	Phosphorylation	PLGPGQISAEVQAPP ECCCCCEEEEEECCC	15.53	27251275
239	O-linked_Glycosylation	VHHPPEASVQVHRIE EECCCCCEEEEEEEE	16.06	55829405
349	N-linked_Glycosylation	PQGYKRLNSTHCQDI CHHHHCCCCCCCCCH	49.23	UniProtKB CARBOHYD
390	Phosphorylation	PGHSLGPSRTQCIAD CCCCCCCCCCCCCCC	46.27	24719451
410	Phosphorylation	SLCFRLVSPEHQCQH CEEEEECCHHHHCCC	29.21	23898821
513	O-linked_Glycosylation	TEEERGVTTDSPVSE CCCCCCCCCCCCCCH	27.92	55834797
514	O-linked_Glycosylation	EEERGVTTDSPVSEE CCCCCCCCCCCCCHH	31.88	55834803
516	Phosphorylation	ERGVTTDSPVSEERS CCCCCCCCCCCHHHC	25.72	28985074
519	O-linked_Glycosylation	VTTDSPVSEERSVQQ CCCCCCCCHHHCCCC	36.80	55834807
523	Phosphorylation	SPVSEERSVQQSHPT CCCCHHHCCCCCCCC	27.79	22468782
532	O-linked_Glycosylation	QQSHPTATTTPARPY CCCCCCCCCCCCCCC	33.41	OGP
533	Phosphorylation	QSHPTATTTPARPYP CCCCCCCCCCCCCCH	28.46	22468782
534	O-linked_Glycosylation	SHPTATTTPARPYPE CCCCCCCCCCCCCHH	15.59	OGP
539	Phosphorylation	TTTPARPYPELISRP CCCCCCCCHHHHCCC	12.09	18491316
544	Phosphorylation	RPYPELISRPSPPTM CCCHHHHCCCCCCCC	51.25	24719451
561	O-linked_Glycosylation	FLPDLPPSRSAVEIA CCCCCCCCCCCEEEC	36.61	55824415
570	O-linked_Glycosylation	SAVEIAPTQVTETDE CCEEECCCCCCCCCH	27.01	55828163
635	Phosphorylation	GRGICMNTGGSYNCH CCCEECCCCCCCCCC	18.94	-
638	Phosphorylation	ICMNTGGSYNCHCNR EECCCCCCCCCCCCC	17.95	-
639	Phosphorylation	CMNTGGSYNCHCNRG ECCCCCCCCCCCCCC	25.69	-
845	N-linked_Glycosylation	GGDCINTNGSYRCLC CCCCCCCCCCEEEEC	32.69	UniProtKB CARBOHYD
936	N-linked_Glycosylation	CDSVLATNVTQQECC CCCCCCCCCCCCCCC	29.27	UniProtKB CARBOHYD
978	O-linked_Glycosylation	CPDGKGYTQDNNIVN CCCCCCCCCCCCCCC	37.81	55829835
1002	Phosphorylation	DECMLFGSEICKEGK HHHHHHCCHHHCCCC	19.22	19664995
1126	Phosphorylation	RDCQLPESPAERAPE CCCCCCCCHHHHCCC	27.72	29214152
1140	Phosphorylation	ERRDVCWSQRGEDGM CCCCCCCHHCCCCCC	12.60	22210691
1184	Phosphorylation	CPPRGAGSHCPTSQS CCCCCCCCCCCCCCC	22.76	25002506
1188	Phosphorylation	GAGSHCPTSQSESNS CCCCCCCCCCCCCCC	44.80	25002506
1189	Phosphorylation	AGSHCPTSQSESNSF CCCCCCCCCCCCCCC	19.49	25002506
1191	Phosphorylation	SHCPTSQSESNSFWD CCCCCCCCCCCCCCC	42.64	25002506
1193	Phosphorylation	CPTSQSESNSFWDTS CCCCCCCCCCCCCCC	42.92	25002506
1195	Phosphorylation	TSQSESNSFWDTSPL CCCCCCCCCCCCCCC	36.67	25002506
1199	Phosphorylation	ESNSFWDTSPLLLGK CCCCCCCCCCCCCCC	23.88	25002506
1200	Phosphorylation	SNSFWDTSPLLLGKP CCCCCCCCCCCCCCC	15.86	25002506
1213	Phosphorylation	KPPRDEDSSEEDSDE CCCCCCCCCCCCCCC	37.29	25002506
1214	Phosphorylation	PPRDEDSSEEDSDEC CCCCCCCCCCCCCCC	58.28	25002506
1218	Phosphorylation	EDSSEEDSDECRCVS CCCCCCCCCCCEEEC	38.29	25002506
1275	N-linked_Glycosylation	CKSERCVNTSGSFRC ECCCEEECCCCCEEE	31.95	UniProtKB CARBOHYD
1276	Phosphorylation	KSERCVNTSGSFRCV CCCEEECCCCCEEEE	17.67	27251275
1277	Phosphorylation	SERCVNTSGSFRCVC CCEEECCCCCEEEEE	27.51	27251275
1279	Phosphorylation	RCVNTSGSFRCVCKA EEECCCCCEEEEEEC	14.86	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LTBP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LTBP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LTBP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAC1_HUMAN	RAC1	physical	21988832
P85B_HUMAN	PIK3R2	physical	21988832
PELI2_HUMAN	PELI2	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613097: Tooth agenesis selective 6 (STHAG6)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.