PKHA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHA4_HUMAN
• UniProt AC: Q9H4M7
• Protein Name: Pleckstrin homology domain-containing family A member 4
• Gene Name: PLEKHA4
• Organism: Homo sapiens (Human).
• Sequence Length: 779
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein .
• Protein Description: Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides..
• Protein Sequence: MEGSRPRSSLSLASSASTISSLSSLSPKKPTRAVNKIHAFGKRGNALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPARPQPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRARSPDLFTPLSRPPSPLSLPRPRSAPARRPPAPSGDTAPPARPHTPLSRIDVRPPLDWGPQRQTLSRPPTPRRGPPSEAGGGKPPRSPQHWSQEPRTQAHSGSPTYLQLPPRPPGTRASMVLLPGPPLESTFHQSLETDTLLTKLCGQDRLLRRLQEEIDQKQEEKEQLEAALELTRQQLGQATREAGAPGRAWGRQRLLQDRLVSVRATLCHLTQERERVWDTYSGLEQELGTLRETLEYLLHLGSPQDRVSAQQQLWMVEDTLAGLGGPQKPPPHTEPDSPSPVLQGEESSERESLPESLELSSPRSPETDWGRPPGGDKDLASPHLGLGSPRVSRASSPEGRHLPSPQLGTKAPVARPRMSAQEQLERMRRNQECGRPFPRPTSPRLLTLGRTLSPARRQPDVEQRPVVGHSGAQKWLRSSGSWSSPRNTTPYLPTSEGHRERVLSLSQALATEASQWHRMMTGGNLDSQGDPLPGVPLPPSDPTRQETPPPRSPPVANSGSTGFSRRGSGRGGGPTPWGPAWDAGIAPPVLPQDEGAWPLRVTLLQSSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEGSRPRSSLS ----CCCCCCCHHHH	26.30	-
8	Phosphorylation	MEGSRPRSSLSLASS CCCCCCCHHHHHHHC	38.01	28857561
9	Phosphorylation	EGSRPRSSLSLASSA CCCCCCHHHHHHHCH	24.21	26657352
11	Phosphorylation	SRPRSSLSLASSAST CCCCHHHHHHHCHHH	24.68	28857561
14	Phosphorylation	RSSLSLASSASTISS CHHHHHHHCHHHHHH	31.56	28857561
15	Phosphorylation	SSLSLASSASTISSL HHHHHHHCHHHHHHH	22.19	23090842
17	Phosphorylation	LSLASSASTISSLSS HHHHHCHHHHHHHHH	28.37	28348404
18	Phosphorylation	SLASSASTISSLSSL HHHHCHHHHHHHHHC	25.29	28348404
20	Phosphorylation	ASSASTISSLSSLSP HHCHHHHHHHHHCCC	25.89	27251275
21	Phosphorylation	SSASTISSLSSLSPK HCHHHHHHHHHCCCC	28.55	27251275
23	Phosphorylation	ASTISSLSSLSPKKP HHHHHHHHHCCCCCC	31.05	28348404
24	Phosphorylation	STISSLSSLSPKKPT HHHHHHHHCCCCCCC	37.85	24719451
26	Phosphorylation	ISSLSSLSPKKPTRA HHHHHHCCCCCCCHH	36.30	27251275
67	Phosphorylation	WLHKQDSSGLRLWKR ECCCCCCCCCCEECE	50.57	28961369
80	Phosphorylation	KRRWFVLSGHCLFYY CEEEEEEECEEEEEE	22.61	25072903
86	Phosphorylation	LSGHCLFYYKDSREE EECEEEEEECCCCCC	9.17	25072903
87	Phosphorylation	SGHCLFYYKDSREES ECEEEEEECCCCCCE	10.86	25072903
120	Phosphorylation	APRGRRFTFTAEHPG CCCCCCEEEEECCCC	20.47	24719451
159	Phosphorylation	SRAEGDDYGQPRSPA HHCCCCCCCCCCCCC	23.54	24719451
164	Phosphorylation	DDYGQPRSPARPQPG CCCCCCCCCCCCCCC	29.60	30266825
184	Phosphorylation	PGGPPEVSRGEEGRI CCCCCCCCCCCCCCC	32.67	23312004
192	Phosphorylation	RGEEGRISESPEVTR CCCCCCCCCCHHHHH	30.57	23403867
194	Phosphorylation	EEGRISESPEVTRLS CCCCCCCCHHHHHCC	21.41	29255136
198	Phosphorylation	ISESPEVTRLSRGRG CCCCHHHHHCCCCCC	25.00	29255136
201	Phosphorylation	SPEVTRLSRGRGRPR CHHHHHCCCCCCCCC	29.42	29255136
211	Phosphorylation	RGRPRLLTPSPTTDL CCCCCCCCCCCCCCH	26.72	29255136
213	Phosphorylation	RPRLLTPSPTTDLHS CCCCCCCCCCCCHHH	29.64	29255136
215	Phosphorylation	RLLTPSPTTDLHSGL CCCCCCCCCCHHHHC	36.96	29255136
216	Phosphorylation	LLTPSPTTDLHSGLQ CCCCCCCCCHHHHCC	39.69	29255136
220	Phosphorylation	SPTTDLHSGLQMRRA CCCCCHHHHCCCHHC	48.79	23403867
229	Phosphorylation	LQMRRARSPDLFTPL CCCHHCCCCCCCCCC	23.06	26657352
234	Phosphorylation	ARSPDLFTPLSRPPS CCCCCCCCCCCCCCC	30.53	29255136
237	Phosphorylation	PDLFTPLSRPPSPLS CCCCCCCCCCCCCCC	43.90	26657352
241	Phosphorylation	TPLSRPPSPLSLPRP CCCCCCCCCCCCCCC	40.95	26657352
244	Phosphorylation	SRPPSPLSLPRPRSA CCCCCCCCCCCCCCC	39.45	29255136
260	Phosphorylation	ARRPPAPSGDTAPPA CCCCCCCCCCCCCCC	51.94	23312004
263	Phosphorylation	PPAPSGDTAPPARPH CCCCCCCCCCCCCCC	44.59	28857561
271	Phosphorylation	APPARPHTPLSRIDV CCCCCCCCCCCCCCC	28.71	29255136
274	Phosphorylation	ARPHTPLSRIDVRPP CCCCCCCCCCCCCCC	28.52	25850435
279	Methylation	PLSRIDVRPPLDWGP CCCCCCCCCCCCCCC	24.30	115487823
290	Phosphorylation	DWGPQRQTLSRPPTP CCCCCCCCCCCCCCC	28.96	29255136
292	Phosphorylation	GPQRQTLSRPPTPRR CCCCCCCCCCCCCCC	46.24	29255136
296	Phosphorylation	QTLSRPPTPRRGPPS CCCCCCCCCCCCCCH	31.91	29255136
303	Phosphorylation	TPRRGPPSEAGGGKP CCCCCCCHHCCCCCC	43.12	23312004
313	Phosphorylation	GGGKPPRSPQHWSQE CCCCCCCCCCCCCCC	34.38	28857561
318	Phosphorylation	PRSPQHWSQEPRTQA CCCCCCCCCCCCCCC	23.65	27794612
327	Phosphorylation	EPRTQAHSGSPTYLQ CCCCCCCCCCCCEEE	43.94	25002506
329	Phosphorylation	RTQAHSGSPTYLQLP CCCCCCCCCCEEECC	19.65	27642862
331	Phosphorylation	QAHSGSPTYLQLPPR CCCCCCCCEEECCCC	38.26	25002506
332	Phosphorylation	AHSGSPTYLQLPPRP CCCCCCCEEECCCCC	8.88	23312004
345	Phosphorylation	RPPGTRASMVLLPGP CCCCCCEEEEEECCC	13.21	29255136
402	Phosphorylation	LEAALELTRQQLGQA HHHHHHHHHHHHHHH	19.63	23403867
410	Phosphorylation	RQQLGQATREAGAPG HHHHHHHHHHHCCCC	22.58	22985185
432	Phosphorylation	LLQDRLVSVRATLCH HHHHHHHHHHHHHHH	15.52	24719451
473	Phosphorylation	EYLLHLGSPQDRVSA HHHHHCCCHHHHCCH	26.25	21712546
523	Phosphorylation	EESSERESLPESLEL CCCCCCCCCCCHHCC	56.28	29255136
527	Phosphorylation	ERESLPESLELSSPR CCCCCCCHHCCCCCC	25.79	29255136
531	Phosphorylation	LPESLELSSPRSPET CCCHHCCCCCCCCCC	28.99	27794612
532	Phosphorylation	PESLELSSPRSPETD CCHHCCCCCCCCCCC	36.64	17081983
534	Phosphorylation	SLELSSPRSPETDWG HHCCCCCCCCCCCCC	67.78	32142685
535	Phosphorylation	LELSSPRSPETDWGR HCCCCCCCCCCCCCC	30.39	25002506
538	Phosphorylation	SSPRSPETDWGRPPG CCCCCCCCCCCCCCC	40.20	25002506
550	Phosphorylation	PPGGDKDLASPHLGL CCCCCCCCCCCCCCC	6.65	32142685
550 (in isoform 2)	Phosphorylation	-	6.65	29507054
552	Phosphorylation	GGDKDLASPHLGLGS CCCCCCCCCCCCCCC	21.83	29255136
557 (in isoform 2)	Phosphorylation	-	8.48	-
559	Phosphorylation	SPHLGLGSPRVSRAS CCCCCCCCCCCCCCC	17.99	29255136
566	Phosphorylation	SPRVSRASSPEGRHL CCCCCCCCCCCCCCC	45.36	26699800
567	Phosphorylation	PRVSRASSPEGRHLP CCCCCCCCCCCCCCC	26.45	26699800
570 (in isoform 2)	Phosphorylation	-	26.20	27251275
575	Phosphorylation	PEGRHLPSPQLGTKA CCCCCCCCCCCCCCC	31.47	29255136
580 (in isoform 2)	Phosphorylation	-	32.40	25850435
580	Phosphorylation	LPSPQLGTKAPVARP CCCCCCCCCCCCCCC	32.40	23403867
612	Phosphorylation	GRPFPRPTSPRLLTL CCCCCCCCCCCEECC	53.28	29255136
613	Phosphorylation	RPFPRPTSPRLLTLG CCCCCCCCCCEECCC	15.65	29255136
622	Phosphorylation	RLLTLGRTLSPARRQ CEECCCCCCCHHHHC	29.77	24719451
624	Phosphorylation	LTLGRTLSPARRQPD ECCCCCCCHHHHCCC	18.85	23312004
641	Phosphorylation	QRPVVGHSGAQKWLR HCCCCCCCHHHHHHH	29.87	28555341
649	Phosphorylation	GAQKWLRSSGSWSSP HHHHHHHCCCCCCCC	36.56	30301811
650	Phosphorylation	AQKWLRSSGSWSSPR HHHHHHCCCCCCCCC	30.34	30301811
652	Phosphorylation	KWLRSSGSWSSPRNT HHHHCCCCCCCCCCC	26.23	30301811
654	Phosphorylation	LRSSGSWSSPRNTTP HHCCCCCCCCCCCCC	31.96	30301811
655	Phosphorylation	RSSGSWSSPRNTTPY HCCCCCCCCCCCCCC	22.94	30301811
660	Phosphorylation	WSSPRNTTPYLPTSE CCCCCCCCCCCCCCH	17.31	30576142
662	Phosphorylation	SPRNTTPYLPTSEGH CCCCCCCCCCCCHHH	24.18	30576142
665	Phosphorylation	NTTPYLPTSEGHRER CCCCCCCCCHHHHHH	36.49	30576142
675	Phosphorylation	GHRERVLSLSQALAT HHHHHHHHHHHHHHH	24.10	25106551
677	Phosphorylation	RERVLSLSQALATEA HHHHHHHHHHHHHHH	15.27	25106551
723	Phosphorylation	QETPPPRSPPVANSG CCCCCCCCCCCCCCC	39.05	26657352
735	Phosphorylation	NSGSTGFSRRGSGRG CCCCCCCCCCCCCCC	23.55	29507054
777	Phosphorylation	LRVTLLQSSF----- CEEEEEECCC-----	33.41	28348404
778	Phosphorylation	RVTLLQSSF------ EEEEEECCC------	23.24	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKHA4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1G_HUMAN	EEF1G	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
AAPK1_HUMAN	PRKAA1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.