UBR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBR4_HUMAN
• UniProt AC: Q5T4S7
• Protein Name: E3 ubiquitin-protein ligase UBR4
• Gene Name: UBR4
• Organism: Homo sapiens (Human).
• Sequence Length: 5183
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Concentrates at the leading edge of membrane structures involved in actin motility.
• Protein Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation..
• Protein Sequence: MATSGGEEAAAAAPAPGTPATGADTTPGWEVAVRPLLSASYSAFEMKELPQLVASVIESESEILHHEKQYEPFYSSFVALSTHYITTVCSLIPRNQLQSVAAACKVLIEFSLLRLENPDEACAVSQKHLILLIKGLCTGCSRLDRTEIITFTAMMKSAKLPQTVKTLSDVEDQKELASPVSPELRQKEVQMNFLNQLTSVFNPRTVASQPISTQTLVEGENDEQSSTDQASAIKTKNVFIAQNVASLQELGGSEKLLRVCLNLPYFLRYINRFQDAVLANSFFIMPATVADATAVRNGFHSLVIDVTMALDTLSLPVLEPLNPSRLQDVTVLSLSCLYAGVSVATCMAILHVGSAQQVRTGSTSSKEDDYESDAATIVQKCLEIYDMIGQAISSSRRAGGEHYQNFQLLGAWCLLNSLFLILNLSPTALADKGKEKDPLAALRVRDILSRTKEGVGSPKLGPGKGHQGFGVLSVILANHAIKLLTSLFQDLQVEALHKGWETDGPPAALSIMAQSTSIQRIQRLIDSVPLMNLLLTLLSTSYRKACVLQRQRKGSMSSDASASTDSNTYYEDDFSSTEEDSSQDDDSEPILGQWFEETISPSKEKAAPPPPPPPPPLESSPRVKSPSKQAPGEKGNILASRKDPELFLGLASNILNFITSSMLNSRNNFIRNYLSVSLSEHHMATLASIIKEVDKDGLKGSSDEEFAAALYHFNHSLVTSDLQSPNLQNTLLQQLGVAPFSEGPWPLYIHPQSLSVLSRLLLIWQHKASAQGDPDVPECLKVWDRFLSTMKQNALQGVVPSETEDLNVEHLQMLLLIFHNFTETGRRAILSLFVQIIQELSVNMDAQMRFVPLILARLLLIFDYLLHQYSKAPVYLFEQVQHNLLSPPFGWASGSQDSNSRRATTPLYHGFKEVEENWSKHFSSDAVPHPRFYCVLSPEASEDDLNRLDSVACDVLFSKLVKYDELYAALTALLAAGSQLDTVRRKENKNVTALEACALQYYFLILWRILGILPPSKTYINQLSMNSPEMSECDILHTLRWSSRLRISSYVNWIKDHLIKQGMKAEHASSLLELASTTKCSSVKYDVEIVEEYFARQISSFCSIDCTTILQLHEIPSLQSIYTLDAAISKVQVSLDEHFSKMAAETDPHKSSEITKNLLPATLQLIDTYASFTRAYLLQNFNEEGTTEKPSKEKLQGFAAVLAIGSSRCKANTLGPTLVQNLPSSVQTVCESWNNINTNEFPNIGSWRNAFANDTIPSESYISAVQAAHLGTLCSQSLPLAASLKHTLLSLVRLTGDLIVWSDEMNPPQVIRTLLPLLLESSTESVAEISSNSLERILGPAESDEFLARVYEKLITGCYNILANHADPNSGLDESILEECLQYLEKQLESSQARKAMEEFFSDSGELVQIMMATANENLSAKFCNRVLKFFTKLFQLTEKSPNPSLLHLCGSLAQLACVEPVRLQAWLTRMTTSPPKDSDQLDVIQENRQLLQLLTTYIVRENSQVGEGVCAVLLGTLTPMATEMLANGDGTGFPELMVVMATLASAGQGAGHLQLHNAAVDWLSRCKKYLSQKNVVEKLNANVMHGKHVMILECTCHIMSYLADVTNALSQSNGQGPSHLSVDGEERAIEVDSDWVEELAVEEEDSQAEDSDEDSLCNKLCTFTITQKEFMNQHWYHCHTCKMVDGVGVCTVCAKVCHKDHEISYAKYGSFFCDCGAKEDGSCLALVKRTPSSGMSSTMKESAFQSEPRISESLVRHASTSSPADKAKVTISDGKVADEEKPKKSSLCRTVEGCREELQNQANFSFAPLVLDMLNFLMDAIQTNFQQASAVGSSSRAQQALSELHTVEKAVEMTDQLMVPTLGSQEGAFENVRMNYSGDQGQTIRQLISAHVLRRVAMCVLSSPHGRRQHLAVSHEKGKITVLQLSALLKQADSSKRKLTLTRLASAPVPFTVLSLTGNPCKEDYLAVCGLKDCHVLTFSSSGSVSDHLVLHPQLATGNFIIKAVWLPGSQTELAIVTADFVKIYDLCVDALSPTFYFLLPSSKIRDVTFLFNEEGKNIIVIMSSAGYIYTQLMEEASSAQQGPFYVTNVLEINHEDLKDSNSQVAGGGVSVYYSHVLQMLFFSYCQGKSFAATISRTTLEVLQLFPINIKSSNGGSKTSPALCQWSEVMNHPGLVCCVQQTTGVPLVVMVKPDTFLIQEIKTLPAKAKIQDMVAIRHTACNEQQRTTMILLCEDGSLRIYMANVENTSYWLQPSLQPSSVISIMKPVRKRKTATITTRTSSQVTFPIDFFEHNQQLTDVEFGGNDLLQVYNAQQIKHRLNSTGMYVANTKPGGFTIEISNNNSTMVMTGMRIQIGTQAIERAPSYIEIFGRTMQLNLSRSRWFDFPFTREEALQADKKLNLFIGASVDPAGVTMIDAVKIYGKTKEQFGWPDEPPEEFPSASVSNICPSNLNQSNGTGDSDSAAPTTTSGTVLERLVVSSLEALESCFAVGPIIEKERNKNAAQELATLLLSLPAPASVQQQSKSLLASLHTSRSAYHSHKDQALLSKAVQCLNTSSKEGKDLDPEVFQRLVITARSIAIMRPNNLVHFTESKLPQMETEGMDEGKEPQKQLEGDCCSFITQLVNHFWKLHASKPKNAFLAPACLPGLTHIEATVNALVDIIHGYCTCELDCINTASKIYMQMLLCPDPAVSFSCKQALIRVLRPRNKRRHVTLPSSPRSNTPMGDKDDDDDDDADEKMQSSGIPNGGHIRQESQEQSEVDHGDFEMVSESMVLETAENVNNGNPSPLEALLAGAEGFPPMLDIPPDADDETMVELAIALSLQQDQQGSSSSALGLQSLGLSGQAPSSSSLDAGTLSDTTASAPASDDEGSTAATDGSTLRTSPADHGGSVGSESGGSAVDSVAGEHSVSGRSSAYGDATAEGHPAGPGSVSSSTGAISTTTGHQEGDGSEGEGEGETEGDVHTSNRLHMVRLMLLERLLQTLPQLRNVGGVRAIPYMQVILMLTTDLDGEDEKDKGALDNLLSQLIAELGMDKKDVSKKNERSALNEVHLVVMRLLSVFMSRTKSGSKSSICESSSLISSATAAALLSSGAVDYCLHVLKSLLEYWKSQQNDEEPVATSQLLKPHTTSSPPDMSPFFLRQYVKGHAADVFEAYTQLLTEMVLRLPYQIKKITDTNSRIPPPVFDHSWFYFLSEYLMIQQTPFVRRQVRKLLLFICGSKEKYRQLRDLHTLDSHVRGIKKLLEEQGIFLRASVVTASSGSALQYDTLISLMEHLKACAEIAAQRTINWQKFCIKDDSVLYFLLQVSFLVDEGVSPVLLQLLSCALCGSKVLAALAASSGSSSASSSSAPVAASSGQATTQSKSSTKKSKKEEKEKEKDGETSGSQEDQLCTALVNQLNKFADKETLIQFLRCFLLESNSSSVRWQAHCLTLHIYRNSSKSQQELLLDLMWSIWPELPAYGRKAAQFVDLLGYFSLKTPQTEKKLKEYSQKAVEILRTQNHILTNHPNSNIYNTLSGLVEFDGYYLESDPCLVCNNPEVPFCYIKLSSIKVDTRYTTTQQVVKLIGSHTISKVTVKIGDLKRTKMVRTINLYYNNRTVQAIVELKNKPARWHKAKKVQLTPGQTEVKIDLPLPIVASNLMIEFADFYENYQASTETLQCPRCSASVPANPGVCGNCGENVYQCHKCRSINYDEKDPFLCNACGFCKYARFDFMLYAKPCCAVDPIENEEDRKKAVSNINTLLDKADRVYHQLMGHRPQLENLLCKVNEAAPEKPQDDSGTAGGISSTSASVNRYILQLAQEYCGDCKNSFDELSKIIQKVFASRKELLEYDLQQREAATKSSRTSVQPTFTASQYRALSVLGCGHTSSTKCYGCASAVTEHCITLLRALATNPALRHILVSQGLIRELFDYNLRRGAAAMREEVRQLMCLLTRDNPEATQQMNDLIIGKVSTALKGHWANPDLASSLQYEMLLLTDSISKEDSCWELRLRCALSLFLMAVNIKTPVVVENITLMCLRILQKLIKPPAPTSKKNKDVPVEALTTVKPYCNEIHAQAQLWLKRDPKASYDAWKKCLPIRGIDGNGKAPSKSELRHLYLTEKYVWRWKQFLSRRGKRTSPLDLKLGHNNWLRQVLFTPATQAARQAACTIVEALATIPSRKQQVLDLLTSYLDELSIAGECAAEYLALYQKLITSAHWKVYLAARGVLPYVGNLITKEIARLLALEEATLSTDLQQGYALKSLTGLLSSFVEVESIKRHFKSRLVGTVLNGYLCLRKLVVQRTKLIDETQDMLLEMLEDMTTGTESETKAFMAVCIETAKRYNLDDYRTPVFIFERLCSIIYPEENEVTEFFVTLEKDPQQEDFLQGRMPGNPYSSNEPGIGPLMRDIKNKICQDCDLVALLEDDSGMELLVNNKIISLDLPVAEVYKKVWCTTNEGEPMRIVYRMRGLLGDATEEFIESLDSTTDEEEDEEEVYKMAGVMAQCGGLECMLNRLAGIRDFKQGRHLLTVLLKLFSYCVKVKVNRQQLVKLEMNTLNVMLGTLNLALVAEQESKDSGGAAVAEQVLSIMEIILDESNAEPLSEDKGNLLLTGDKDQLVMLLDQINSTFVRSNPSVLQGLLRIIPYLSFGEVEKMQILVERFKPYCNFDKYDEDHSGDDKVFLDCFCKIAAGIKNNSNGHQLKDLILQKGITQNALDYMKKHIPSAKNLDADIWKKFLSRPALPFILRLLRGLAIQHPGTQVLIGTDSIPNLHKLEQVSSDEGIGTLAENLLEALREHPDVNKKIDAARRETRAEKKRMAMAMRQKALGTLGMTTNEKGQVVTKTALLKQMEELIEEPGLTCCICREGYKFQPTKVLGIYTFTKRVALEEMENKPRKQQGYSTVSHFNIVHYDCHLAAVRLARGREEWESAALQNANTKCNGLLPVWGPHVPESAFATCLARHNTYLQECTGQREPTYQLNIHDIKLLFLRFAMEQSFSADTGGGGRESNIHLIPYIIHTVLYVLNTTRATSREEKNLQGFLEQPKEKWVESAFEVDGPYYFTVLALHILPPEQWRATRVEILRRLLVTSQARAVAPGGATRLTDKAVKDYSAYRSSLLFWALVDLIYNMFKKVPTSNTEGGWSCSLAEYIRHNDMPIYEAADKALKTFQEEFMPVETFSEFLDVAGLLSEITDPESFLKDLLNSVP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATSGGEEAA -----CCCCCCHHHH	39.50	28348404
4	Phosphorylation	----MATSGGEEAAA ----CCCCCCHHHHH	52.43	28348404
18	Phosphorylation	AAAPAPGTPATGADT HCCCCCCCCCCCCCC	14.53	25159151
59	Phosphorylation	LVASVIESESEILHH HHHHHHHCHHHHHCC	34.99	-
61	Phosphorylation	ASVIESESEILHHEK HHHHHCHHHHHCCCH	38.94	-
99	O-linked_Glycosylation	IPRNQLQSVAAACKV CCHHHHHHHHHHHHH	23.47	30379171
111	Phosphorylation	CKVLIEFSLLRLENP HHHHHHHHHHCCCCC	17.44	-
127	Ubiquitination	EACAVSQKHLILLIK HHHHHCHHHHHHHHH	32.64	33845483
150	Phosphorylation	LDRTEIITFTAMMKS CCHHHHHHHHHHHHH	22.16	28851738
152	Phosphorylation	RTEIITFTAMMKSAK HHHHHHHHHHHHHCC	12.66	28851738
157	Phosphorylation	TFTAMMKSAKLPQTV HHHHHHHHCCCCCHH	16.85	28851738
159	Ubiquitination	TAMMKSAKLPQTVKT HHHHHHCCCCCHHCC	68.72	29967540
165	Ubiquitination	AKLPQTVKTLSDVED CCCCCHHCCCCHHHH	47.32	29967540
166	Phosphorylation	KLPQTVKTLSDVEDQ CCCCHHCCCCHHHHH	27.45	24117733
168	Phosphorylation	PQTVKTLSDVEDQKE CCHHCCCCHHHHHHH	44.86	24117733
174	Ubiquitination	LSDVEDQKELASPVS CCHHHHHHHHCCCCC	68.00	21906983
174 (in isoform 1)	Ubiquitination	-	68.00	21890473
174 (in isoform 2)	Ubiquitination	-	68.00	21890473
174 (in isoform 3)	Ubiquitination	-	68.00	21890473
174 (in isoform 4)	Ubiquitination	-	68.00	21890473
174 (in isoform 5)	Ubiquitination	-	68.00	21890473
178	Phosphorylation	EDQKELASPVSPELR HHHHHHCCCCCHHHH	38.16	19664994
181	Phosphorylation	KELASPVSPELRQKE HHHCCCCCHHHHHHH	18.95	19664994
187	Ubiquitination	VSPELRQKEVQMNFL CCHHHHHHHHHHHHH	54.11	-
187 (in isoform 2)	Ubiquitination	-	54.11	-
205	Phosphorylation	TSVFNPRTVASQPIS HHCCCCCCCCCCCCC	22.98	25693802
208	Phosphorylation	FNPRTVASQPISTQT CCCCCCCCCCCCCCE	31.95	25693802
212	Phosphorylation	TVASQPISTQTLVEG CCCCCCCCCCEEECC	22.58	25693802
213	Phosphorylation	VASQPISTQTLVEGE CCCCCCCCCEEECCC	26.71	25693802
215	Phosphorylation	SQPISTQTLVEGEND CCCCCCCEEECCCCC	32.62	25693802
234	Ubiquitination	TDQASAIKTKNVFIA CCHHHHHHHCCEEEE	53.84	21906983
234 (in isoform 1)	Ubiquitination	-	53.84	21890473
234 (in isoform 2)	Ubiquitination	-	53.84	21890473
234 (in isoform 3)	Ubiquitination	-	53.84	21890473
234 (in isoform 4)	Ubiquitination	-	53.84	21890473
234 (in isoform 5)	Ubiquitination	-	53.84	21890473
236	Ubiquitination	QASAIKTKNVFIAQN HHHHHHHCCEEEEEC	46.22	22817900
236 (in isoform 2)	Ubiquitination	-	46.22	-
246	Phosphorylation	FIAQNVASLQELGGS EEEECHHHHHHCCCC	26.71	30622161
255	Ubiquitination	QELGGSEKLLRVCLN HHCCCCHHHHHHHHC	55.29	-
255 (in isoform 2)	Ubiquitination	-	55.29	-
360	Phosphorylation	GSAQQVRTGSTSSKE CCCCCCCCCCCCCCC	36.31	23927012
362	Phosphorylation	AQQVRTGSTSSKEDD CCCCCCCCCCCCCCC	25.22	20201521
363	Phosphorylation	QQVRTGSTSSKEDDY CCCCCCCCCCCCCCC	38.06	23927012
364	Phosphorylation	QVRTGSTSSKEDDYE CCCCCCCCCCCCCCH	40.90	23927012
365	Phosphorylation	VRTGSTSSKEDDYES CCCCCCCCCCCCCHH	39.90	23927012
366	Ubiquitination	RTGSTSSKEDDYESD CCCCCCCCCCCCHHH	66.00	21906983
366 (in isoform 1)	Ubiquitination	-	66.00	21890473
366 (in isoform 2)	Ubiquitination	-	66.00	21890473
366 (in isoform 3)	Ubiquitination	-	66.00	21890473
366 (in isoform 4)	Ubiquitination	-	66.00	21890473
366 (in isoform 5)	Ubiquitination	-	66.00	21890473
370	Phosphorylation	TSSKEDDYESDAATI CCCCCCCCHHHHHHH	29.65	23927012
372	Phosphorylation	SKEDDYESDAATIVQ CCCCCCHHHHHHHHH	26.73	23927012
376	Phosphorylation	DYESDAATIVQKCLE CCHHHHHHHHHHHHH	24.33	23927012
385	Phosphorylation	VQKCLEIYDMIGQAI HHHHHHHHHHHHHHH	7.06	28348404
393	Phosphorylation	DMIGQAISSSRRAGG HHHHHHHHHCCCCCC	25.85	24905233
394	Phosphorylation	MIGQAISSSRRAGGE HHHHHHHHCCCCCCC	23.04	24905233
395	Phosphorylation	IGQAISSSRRAGGEH HHHHHHHCCCCCCCC	20.99	32142685
434	Malonylation	TALADKGKEKDPLAA HHHHCCCCCCCHHHH	68.29	26320211
434 (in isoform 2)	Malonylation	-	68.29	26320211
436	Ubiquitination	LADKGKEKDPLAALR HHCCCCCCCHHHHHH	69.04	29967540
436 (in isoform 2)	Ubiquitination	-	69.04	-
452	Ubiquitination	RDILSRTKEGVGSPK HHHHHHCCCCCCCCC	51.89	27667366
457	Phosphorylation	RTKEGVGSPKLGPGK HCCCCCCCCCCCCCC	19.22	30576142
459	Ubiquitination	KEGVGSPKLGPGKGH CCCCCCCCCCCCCCC	68.71	29967540
485	Phosphorylation	NHAIKLLTSLFQDLQ HHHHHHHHHHHHHHH	33.54	-
486	Phosphorylation	HAIKLLTSLFQDLQV HHHHHHHHHHHHHHH	27.44	-
555	Phosphorylation	LQRQRKGSMSSDASA HHHHHCCCCCCCCCC	20.66	22817900
557	Phosphorylation	RQRKGSMSSDASAST HHHCCCCCCCCCCCC	27.11	-
600	Phosphorylation	QWFEETISPSKEKAA HHHHHCCCCCHHCCC	30.46	24719451
603	Ubiquitination	EETISPSKEKAAPPP HHCCCCCHHCCCCCC	67.62	22817900
605	Ubiquitination	TISPSKEKAAPPPPP CCCCCHHCCCCCCCC	54.29	22817900
605 (in isoform 1)	Ubiquitination	-	54.29	21890473
605 (in isoform 2)	Ubiquitination	-	54.29	21890473
605 (in isoform 3)	Ubiquitination	-	54.29	21890473
605 (in isoform 4)	Ubiquitination	-	54.29	21890473
605 (in isoform 5)	Ubiquitination	-	54.29	21890473
619	Phosphorylation	PPPPPLESSPRVKSP CCCCCCCCCCCCCCC	54.01	29255136
620	Phosphorylation	PPPPLESSPRVKSPS CCCCCCCCCCCCCCC	13.83	19664994
624	Ubiquitination	LESSPRVKSPSKQAP CCCCCCCCCCCCCCC	58.91	24816145
625	Phosphorylation	ESSPRVKSPSKQAPG CCCCCCCCCCCCCCC	31.39	22617229
627	Phosphorylation	SPRVKSPSKQAPGEK CCCCCCCCCCCCCCC	44.48	23911959
628	Ubiquitination	PRVKSPSKQAPGEKG CCCCCCCCCCCCCCC	54.59	27667366
634	Ubiquitination	SKQAPGEKGNILASR CCCCCCCCCCCCCCC	64.27	33845483
634 (in isoform 2)	Ubiquitination	-	64.27	-
640	Phosphorylation	EKGNILASRKDPELF CCCCCCCCCCCHHHH	36.10	23312004
665	Phosphorylation	ITSSMLNSRNNFIRN HHHHHHHCCCCHHHH	32.21	-
688	Phosphorylation	HHMATLASIIKEVDK HHHHHHHHHHHHHCC	28.14	24719451
781	Ubiquitination	PDVPECLKVWDRFLS CCHHHHHHHHHHHHH	53.60	29967540
904	Phosphorylation	DSNSRRATTPLYHGF CCCCCCCCCCCCCCH	27.43	23898821
905	Phosphorylation	SNSRRATTPLYHGFK CCCCCCCCCCCCCHH	15.43	28122231
908	Phosphorylation	RRATTPLYHGFKEVE CCCCCCCCCCHHHHH	10.91	23403867
919	Phosphorylation	KEVEENWSKHFSSDA HHHHHHHHHHCCCCC	28.03	23312004
920	Ubiquitination	EVEENWSKHFSSDAV HHHHHHHHHCCCCCC	40.04	29967540
920 (in isoform 2)	Ubiquitination	-	40.04	-
958	Phosphorylation	VACDVLFSKLVKYDE HHHHHHHHHHCCHHH	22.40	24719451
963	Phosphorylation	LFSKLVKYDELYAAL HHHHHCCHHHHHHHH	13.73	-
1001	Phosphorylation	LEACALQYYFLILWR HHHHHHHHHHHHHHH	9.31	-
1002	Phosphorylation	EACALQYYFLILWRI HHHHHHHHHHHHHHH	4.48	-
1060	Ubiquitination	WIKDHLIKQGMKAEH HHHHHHHHHCCCHHH	47.35	29967540
1064	Ubiquitination	HLIKQGMKAEHASSL HHHHHCCCHHHHHHH	58.40	29967540
1069	Phosphorylation	GMKAEHASSLLELAS CCCHHHHHHHHHHHC	24.35	20068231
1070	Phosphorylation	MKAEHASSLLELAST CCHHHHHHHHHHHCC	37.44	20068231
1076	Phosphorylation	SSLLELASTTKCSSV HHHHHHHCCCCCCCC	49.59	20068231
1077	Phosphorylation	SLLELASTTKCSSVK HHHHHHCCCCCCCCC	25.35	20068231
1078	Phosphorylation	LLELASTTKCSSVKY HHHHHCCCCCCCCCC	27.79	20068231
1079	Ubiquitination	LELASTTKCSSVKYD HHHHCCCCCCCCCCC	32.01	21963094
1079 (in isoform 2)	Ubiquitination	-	32.01	-
1084	Acetylation	TTKCSSVKYDVEIVE CCCCCCCCCCHHHHH	37.37	19608861
1084	Ubiquitination	TTKCSSVKYDVEIVE CCCCCCCCCCHHHHH	37.37	22817900
1141	Ubiquitination	SLDEHFSKMAAETDP CHHHHHHHHHHCCCC	31.45	29967540
1146	Phosphorylation	FSKMAAETDPHKSSE HHHHHHCCCCCCCCH	50.53	25954137
1150	Acetylation	AAETDPHKSSEITKN HHCCCCCCCCHHHHC	62.15	25953088
1150	Ubiquitination	AAETDPHKSSEITKN HHCCCCCCCCHHHHC	62.15	22817900
1150 (in isoform 1)	Ubiquitination	-	62.15	21890473
1150 (in isoform 2)	Ubiquitination	-	62.15	21890473
1150 (in isoform 3)	Ubiquitination	-	62.15	21890473
1150 (in isoform 4)	Ubiquitination	-	62.15	21890473
1150 (in isoform 5)	Ubiquitination	-	62.15	21890473
1151	Phosphorylation	AETDPHKSSEITKNL HCCCCCCCCHHHHCH	30.12	25954137
1152	Phosphorylation	ETDPHKSSEITKNLL CCCCCCCCHHHHCHH	37.51	25954137
1155	Phosphorylation	PHKSSEITKNLLPAT CCCCCHHHHCHHHHH	15.16	25954137
1156	Ubiquitination	HKSSEITKNLLPATL CCCCHHHHCHHHHHH	51.78	21906983
1156 (in isoform 1)	Ubiquitination	-	51.78	21890473
1156 (in isoform 2)	Ubiquitination	-	51.78	21890473
1156 (in isoform 3)	Ubiquitination	-	51.78	21890473
1156 (in isoform 4)	Ubiquitination	-	51.78	21890473
1156 (in isoform 5)	Ubiquitination	-	51.78	21890473
1176	Phosphorylation	YASFTRAYLLQNFNE HHHHHHHHHHHHCCC	12.49	26546556
1189	Ubiquitination	NEEGTTEKPSKEKLQ CCCCCCCCCCHHHHH	53.12	21906983
1189 (in isoform 1)	Ubiquitination	-	53.12	21890473
1189 (in isoform 2)	Ubiquitination	-	53.12	21890473
1189 (in isoform 3)	Ubiquitination	-	53.12	21890473
1189 (in isoform 4)	Ubiquitination	-	53.12	21890473
1189 (in isoform 5)	Ubiquitination	-	53.12	21890473
1192	Ubiquitination	GTTEKPSKEKLQGFA CCCCCCCHHHHHHHH	68.35	22817900
1194	Ubiquitination	TEKPSKEKLQGFAAV CCCCCHHHHHHHHHH	50.26	22817900
1194 (in isoform 2)	Ubiquitination	-	50.26	-
1287	Phosphorylation	LAASLKHTLLSLVRL HHHHHHHHHHHHHHH	28.01	21406692
1290	Phosphorylation	SLKHTLLSLVRLTGD HHHHHHHHHHHHHCC	28.12	24719451
1331	Phosphorylation	ESVAEISSNSLERIL CHHHHHCCCCHHHHH	35.78	26699800
1333	Phosphorylation	VAEISSNSLERILGP HHHHCCCCHHHHHCC	33.29	26699800
1343	O-linked_Glycosylation	RILGPAESDEFLARV HHHCCCCCHHHHHHH	44.54	30379171
1391	Phosphorylation	LEKQLESSQARKAME HHHHHHHHHHHHHHH	20.62	23828894
1402	Phosphorylation	KAMEEFFSDSGELVQ HHHHHHHCCHHHHHH	35.87	-
1404	Phosphorylation	MEEFFSDSGELVQIM HHHHHCCHHHHHHHH	32.73	28188228
1414	Phosphorylation	LVQIMMATANENLSA HHHHHHHHCCCCCCH	16.48	28188228
1420	Phosphorylation	ATANENLSAKFCNRV HHCCCCCCHHHHHHH	40.78	28188228
1477	Ubiquitination	RMTTSPPKDSDQLDV HCCCCCCCCHHHHHH	73.56	21906983
1477 (in isoform 1)	Ubiquitination	-	73.56	21890473
1477 (in isoform 2)	Ubiquitination	-	73.56	21890473
1477 (in isoform 3)	Ubiquitination	-	73.56	21890473
1477 (in isoform 4)	Ubiquitination	-	73.56	21890473
1477 (in isoform 5)	Ubiquitination	-	73.56	21890473
1569	Ubiquitination	DWLSRCKKYLSQKNV HHHHHHHHHHCCCCH	55.86	22817900
1570	Phosphorylation	WLSRCKKYLSQKNVV HHHHHHHHHCCCCHH	9.33	28258704
1574	Ubiquitination	CKKYLSQKNVVEKLN HHHHHCCCCHHHHHC	48.62	21906983
1574 (in isoform 1)	Ubiquitination	-	48.62	21890473
1574 (in isoform 2)	Ubiquitination	-	48.62	21890473
1574 (in isoform 3)	Ubiquitination	-	48.62	21890473
1574 (in isoform 4)	Ubiquitination	-	48.62	21890473
1574 (in isoform 5)	Ubiquitination	-	48.62	21890473
1579	Ubiquitination	SQKNVVEKLNANVMH CCCCHHHHHCHHHCC	35.12	22817900
1579 (in isoform 2)	Ubiquitination	-	35.12	-
1596	Phosphorylation	HVMILECTCHIMSYL CEEEEEHHHHHHHHH	9.57	28787133
1601	Phosphorylation	ECTCHIMSYLADVTN EHHHHHHHHHHHHHH	19.18	28787133
1602	Phosphorylation	CTCHIMSYLADVTNA HHHHHHHHHHHHHHH	6.63	28787133
1607	Phosphorylation	MSYLADVTNALSQSN HHHHHHHHHHHHHCC	18.47	28787133
1611	Phosphorylation	ADVTNALSQSNGQGP HHHHHHHHHCCCCCC	29.20	28787133
1613	Phosphorylation	VTNALSQSNGQGPSH HHHHHHHCCCCCCCC	39.28	28787133
1619	Phosphorylation	QSNGQGPSHLSVDGE HCCCCCCCCCEECCC	43.83	27251789
1622	Phosphorylation	GQGPSHLSVDGEERA CCCCCCCEECCCCCE	16.85	27251789
1634	Phosphorylation	ERAIEVDSDWVEELA CCEEEECCHHHHHHH	38.25	25137130
1647	Phosphorylation	LAVEEEDSQAEDSDE HHCCCCCCCCCCCCH	34.27	25137130
1652	Phosphorylation	EDSQAEDSDEDSLCN CCCCCCCCCHHHHHH	34.11	25137130
1656	Phosphorylation	AEDSDEDSLCNKLCT CCCCCHHHHHHHHHE	32.54	28102081
1684	Sulfoxidation	YHCHTCKMVDGVGVC EECCCCCCCCCCEEE	3.46	21406390
1696	Acetylation	GVCTVCAKVCHKDHE EEEEHHHHHCCCCCC	40.02	25953088
1729	Acetylation	GSCLALVKRTPSSGM CCEEEEEEECCCCCC	51.94	25953088
1729	Ubiquitination	GSCLALVKRTPSSGM CCEEEEEEECCCCCC	51.94	29967540
1731	Phosphorylation	CLALVKRTPSSGMSS EEEEEEECCCCCCCC	23.08	25159151
1733	Phosphorylation	ALVKRTPSSGMSSTM EEEEECCCCCCCCHH	38.62	28450419
1734	Phosphorylation	LVKRTPSSGMSSTMK EEEECCCCCCCCHHH	39.45	28450419
1737	Phosphorylation	RTPSSGMSSTMKESA ECCCCCCCCHHHHHH	26.61	28450419
1738	Phosphorylation	TPSSGMSSTMKESAF CCCCCCCCHHHHHHC	24.51	28450419
1739	Phosphorylation	PSSGMSSTMKESAFQ CCCCCCCHHHHHHCC	25.59	28450419
1741	Ubiquitination	SGMSSTMKESAFQSE CCCCCHHHHHHCCCC	48.91	22817900
1741 (in isoform 1)	Ubiquitination	-	48.91	21890473
1741 (in isoform 2)	Ubiquitination	-	48.91	21890473
1741 (in isoform 3)	Ubiquitination	-	48.91	21890473
1741 (in isoform 4)	Ubiquitination	-	48.91	21890473
1741 (in isoform 5)	Ubiquitination	-	48.91	21890473
1743	Phosphorylation	MSSTMKESAFQSEPR CCCHHHHHHCCCCCC	28.94	23882029
1747	Phosphorylation	MKESAFQSEPRISES HHHHHCCCCCCCCHH	43.01	21815630
1752	Phosphorylation	FQSEPRISESLVRHA CCCCCCCCHHHHHHC	23.55	21815630
1754	Phosphorylation	SEPRISESLVRHAST CCCCCCHHHHHHCCC	25.93	29514088
1760	Phosphorylation	ESLVRHASTSSPADK HHHHHHCCCCCHHHH	23.77	27273156
1761	Phosphorylation	SLVRHASTSSPADKA HHHHHCCCCCHHHHC	33.73	27273156
1762	Phosphorylation	LVRHASTSSPADKAK HHHHCCCCCHHHHCE	31.65	27273156
1763	Phosphorylation	VRHASTSSPADKAKV HHHCCCCCHHHHCEE	24.97	27273156
1769	Ubiquitination	SSPADKAKVTISDGK CCHHHHCEEEECCCC	45.73	29967540
1773	Phosphorylation	DKAKVTISDGKVADE HHCEEEECCCCCCCC	30.83	-
1776	Ubiquitination	KVTISDGKVADEEKP EEEECCCCCCCCCCC	38.96	33845483
1854	Sulfoxidation	TVEKAVEMTDQLMVP CHHHHHHCCCCCCCC	3.93	30846556
1859	Sulfoxidation	VEMTDQLMVPTLGSQ HHCCCCCCCCCCCCC	2.56	30846556
1875	Sulfoxidation	GAFENVRMNYSGDQG CCCCCEECCCCCCCH	4.87	21406390
1877	Phosphorylation	FENVRMNYSGDQGQT CCCEECCCCCCCHHH	12.51	23186163
1878	Phosphorylation	ENVRMNYSGDQGQTI CCEECCCCCCCHHHH	30.78	23917254
1884	Phosphorylation	YSGDQGQTIRQLISA CCCCCHHHHHHHHHH	25.59	-
1903	Phosphorylation	RVAMCVLSSPHGRRQ HHHHHHHCCCCCCCC	22.79	23186163
1904	Phosphorylation	VAMCVLSSPHGRRQH HHHHHHCCCCCCCCE	19.43	28985074
1922	Phosphorylation	SHEKGKITVLQLSAL ECCCCCEEHHHHHHH	20.74	20068231
1927	Phosphorylation	KITVLQLSALLKQAD CEEHHHHHHHHHHCC	12.15	20068231
1931	Acetylation	LQLSALLKQADSSKR HHHHHHHHHCCCCCC	44.27	25953088
1931	Ubiquitination	LQLSALLKQADSSKR HHHHHHHHHCCCCCC	44.27	29967540
1939	Ubiquitination	QADSSKRKLTLTRLA HCCCCCCCCCHHHHH	49.95	27667366
1939 (in isoform 2)	Ubiquitination	-	49.95	-
1941	Phosphorylation	DSSKRKLTLTRLASA CCCCCCCCHHHHHCC	29.17	-
1943	Phosphorylation	SKRKLTLTRLASAPV CCCCCCHHHHHCCCC	20.57	-
1947	Phosphorylation	LTLTRLASAPVPFTV CCHHHHHCCCCCEEE	37.38	28348404
1958	Phosphorylation	PFTVLSLTGNPCKED CEEEEECCCCCCCCC	31.38	-
2087	Phosphorylation	SAQQGPFYVTNVLEI HCCCCCEEEEEEEEE	14.97	22817900
2131	Phosphorylation	FSYCQGKSFAATISR HHHHCCCCHHHHHCH	27.26	-
2140	Phosphorylation	AATISRTTLEVLQLF HHHHCHHHHHHHHHE	21.58	-
2196	Phosphorylation	VVMVKPDTFLIQEIK EEEECCCCEEHHHHH	28.94	-
2204	Phosphorylation	FLIQEIKTLPAKAKI EEHHHHHHCCCCHHH	43.57	-
2208	Ubiquitination	EIKTLPAKAKIQDMV HHHHCCCCHHHHHHE	48.55	27667366
2209	Ubiquitination	IKTLPAKAKIQDMVA HHHCCCCHHHHHHEE	19.11	27667366
2210	Ubiquitination	KTLPAKAKIQDMVAI HHCCCCHHHHHHEEE	39.95	-
2210 (in isoform 2)	Ubiquitination	-	39.95	-
2213	Ubiquitination	PAKAKIQDMVAIRHT CCCHHHHHHEEEEEC	36.68	27667366
2214	Ubiquitination	AKAKIQDMVAIRHTA CCHHHHHHEEEEECC	0.95	27667366
2227	Dimethylation	TACNEQQRTTMILLC CCCCCCCCEEEEEEE	31.68	-
2227	Methylation	TACNEQQRTTMILLC CCCCCCCCEEEEEEE	31.68	115390671
2242	Phosphorylation	EDGSLRIYMANVENT CCCCEEEEEEECCCC	5.46	25072903
2249	Phosphorylation	YMANVENTSYWLQPS EEEECCCCCEECCCC	15.08	25072903
2250	Phosphorylation	MANVENTSYWLQPSL EEECCCCCEECCCCC	26.37	25072903
2251	Phosphorylation	ANVENTSYWLQPSLQ EECCCCCEECCCCCC	14.22	25072903
2256	Phosphorylation	TSYWLQPSLQPSSVI CCEECCCCCCCCHHH	27.03	25072903
2260	Phosphorylation	LQPSLQPSSVISIMK CCCCCCCCHHHEEEE	25.03	25072903
2261	Phosphorylation	QPSLQPSSVISIMKP CCCCCCCHHHEEEEC	30.10	25072903
2264	Phosphorylation	LQPSSVISIMKPVRK CCCCHHHEEEECCCC	17.93	25072903
2273	Ubiquitination	MKPVRKRKTATITTR EECCCCCCEEEEEEC	45.61	24816145
2274	Ubiquitination	KPVRKRKTATITTRT ECCCCCCEEEEEECC	32.82	24816145
2278	Phosphorylation	KRKTATITTRTSSQV CCCEEEEEECCCCCE	13.08	17081983
2278	Ubiquitination	KRKTATITTRTSSQV CCCEEEEEECCCCCE	13.08	24816145
2279	Phosphorylation	RKTATITTRTSSQVT CCEEEEEECCCCCEE	28.26	17081983
2279	Ubiquitination	RKTATITTRTSSQVT CCEEEEEECCCCCEE	28.26	24816145
2327	Phosphorylation	RLNSTGMYVANTKPG HHCCCCCEEEECCCC	9.58	23917254
2366	Phosphorylation	QAIERAPSYIEIFGR HHHHHCCHHHHHHCE	37.44	26503514
2367	Phosphorylation	AIERAPSYIEIFGRT HHHHCCHHHHHHCEE	11.08	26503514
2374	Phosphorylation	YIEIFGRTMQLNLSR HHHHHCEEEEEECCC	15.06	26503514
2375	Sulfoxidation	IEIFGRTMQLNLSRS HHHHCEEEEEECCCC	4.04	21406390
2380	Phosphorylation	RTMQLNLSRSRWFDF EEEEEECCCCCCCCC	27.43	26503514
2468	Phosphorylation	DSDSAAPTTTSGTVL CCCCCCCCCCCHHHH	37.67	-
2468 (in isoform 3)	Phosphorylation	-	37.67	19276368
2470	Phosphorylation	DSAAPTTTSGTVLER CCCCCCCCCHHHHHH	27.86	-
2470 (in isoform 3)	Phosphorylation	-	27.86	19276368
2473	Phosphorylation	APTTTSGTVLERLVV CCCCCCHHHHHHHHH	22.99	-
2473 (in isoform 3)	Phosphorylation	-	22.99	19276368
2502	Ubiquitination	IIEKERNKNAAQELA HHHHHCCCCHHHHHH	54.94	-
2502 (in isoform 2)	Ubiquitination	-	54.94	-
2531	Phosphorylation	QSKSLLASLHTSRSA HHHHHHHHHHHCHHH	22.20	28857561
2539	Phosphorylation	LHTSRSAYHSHKDQA HHHCHHHHHCHHHHH	12.71	-
2541	Phosphorylation	TSRSAYHSHKDQALL HCHHHHHCHHHHHHH	21.40	-
2543	Ubiquitination	RSAYHSHKDQALLSK HHHHHCHHHHHHHHH	55.33	29967540
2543 (in isoform 2)	Ubiquitination	-	55.33	-
2549	Phosphorylation	HKDQALLSKAVQCLN HHHHHHHHHHHHHHC	21.30	-
2550	Ubiquitination	KDQALLSKAVQCLNT HHHHHHHHHHHHHCC	53.17	29967540
2560	Ubiquitination	QCLNTSSKEGKDLDP HHHCCCCCCCCCCCH	70.97	29967540
2560 (in isoform 2)	Ubiquitination	-	70.97	-
2563	Ubiquitination	NTSSKEGKDLDPEVF CCCCCCCCCCCHHHH	57.09	29967540
2563 (in isoform 2)	Ubiquitination	-	57.09	-
2599	Sulfoxidation	TESKLPQMETEGMDE ECCCCCCCCCCCCCC	6.94	21406390
2608	Ubiquitination	TEGMDEGKEPQKQLE CCCCCCCCCCHHHHC	65.26	-
2698	Ubiquitination	PAVSFSCKQALIRVL HHHCCHHHHHHHHHH	37.09	-
2698 (in isoform 2)	Ubiquitination	-	37.09	-
2715	Phosphorylation	RNKRRHVTLPSSPRS CCCCCCCCCCCCCCC	27.16	22167270
2718	Phosphorylation	RRHVTLPSSPRSNTP CCCCCCCCCCCCCCC	56.96	29255136
2719	Phosphorylation	RHVTLPSSPRSNTPM CCCCCCCCCCCCCCC	23.53	29255136
2722	Phosphorylation	TLPSSPRSNTPMGDK CCCCCCCCCCCCCCC	48.73	23927012
2724	Phosphorylation	PSSPRSNTPMGDKDD CCCCCCCCCCCCCCC	18.85	20201521
2743	Phosphorylation	DADEKMQSSGIPNGG CHHHHHHHCCCCCCC	27.34	25159151
2744	Phosphorylation	ADEKMQSSGIPNGGH HHHHHHHCCCCCCCC	24.69	23403867
2756	Phosphorylation	GGHIRQESQEQSEVD CCCCCCCCCCCCCCC	30.58	-
2788	Phosphorylation	NVNNGNPSPLEALLA HCCCCCCCHHHHHHH	46.23	26074081
2852	Phosphorylation	GQAPSSSSLDAGTLS CCCCCCCCCCCCCCC	32.01	25137130
2857	Phosphorylation	SSSLDAGTLSDTTAS CCCCCCCCCCCCCCC	25.47	25137130
2859	Phosphorylation	SLDAGTLSDTTASAP CCCCCCCCCCCCCCC	32.52	25137130
2864	Phosphorylation	TLSDTTASAPASDDE CCCCCCCCCCCCCCC	32.47	29460479
2868	Phosphorylation	TTASAPASDDEGSTA CCCCCCCCCCCCCCC	44.53	25137130
2873	Phosphorylation	PASDDEGSTAATDGS CCCCCCCCCCCCCCC	16.90	25137130
2884	Phosphorylation	TDGSTLRTSPADHGG CCCCCCCCCCCCCCC	42.02	23927012
2885	Phosphorylation	DGSTLRTSPADHGGS CCCCCCCCCCCCCCC	16.20	23927012
2892	Phosphorylation	SPADHGGSVGSESGG CCCCCCCCCCCCCCC	28.09	30278072
2895	Phosphorylation	DHGGSVGSESGGSAV CCCCCCCCCCCCCCC	26.83	23927012
2897	Phosphorylation	GGSVGSESGGSAVDS CCCCCCCCCCCCCHH	50.59	23927012
2900	Phosphorylation	VGSESGGSAVDSVAG CCCCCCCCCCHHCCC	28.75	23927012
2904	Phosphorylation	SGGSAVDSVAGEHSV CCCCCCHHCCCCCCC	13.78	29255136
2910	Phosphorylation	DSVAGEHSVSGRSSA HHCCCCCCCCCCCCC	17.42	29255136
2912	Phosphorylation	VAGEHSVSGRSSAYG CCCCCCCCCCCCCCC	31.35	29255136
2915	Phosphorylation	EHSVSGRSSAYGDAT CCCCCCCCCCCCCCC	23.89	23927012
2916	Phosphorylation	HSVSGRSSAYGDATA CCCCCCCCCCCCCCC	24.93	30576142
2918	Phosphorylation	VSGRSSAYGDATAEG CCCCCCCCCCCCCCC	19.93	23927012
2922	Phosphorylation	SSAYGDATAEGHPAG CCCCCCCCCCCCCCC	29.95	30576142
2932	Phosphorylation	GHPAGPGSVSSSTGA CCCCCCCCCCCCCCC	23.20	23927012
2934	Phosphorylation	PAGPGSVSSSTGAIS CCCCCCCCCCCCCEE	21.92	23927012
2935	Phosphorylation	AGPGSVSSSTGAIST CCCCCCCCCCCCEEE	29.75	26074081
2936	Phosphorylation	GPGSVSSSTGAISTT CCCCCCCCCCCEEEC	24.29	30576142
2937	Phosphorylation	PGSVSSSTGAISTTT CCCCCCCCCCEEECC	32.36	23927012
2941	Phosphorylation	SSSTGAISTTTGHQE CCCCCCEEECCCCCC	21.11	30576142
2942	Phosphorylation	SSTGAISTTTGHQEG CCCCCEEECCCCCCC	23.43	23927012
2943	Phosphorylation	STGAISTTTGHQEGD CCCCEEECCCCCCCC	24.80	23927012
2944	Phosphorylation	TGAISTTTGHQEGDG CCCEEECCCCCCCCC	32.52	28464451
2952	Phosphorylation	GHQEGDGSEGEGEGE CCCCCCCCCCCCCCC	47.36	23927012
2960	Phosphorylation	EGEGEGETEGDVHTS CCCCCCCCCCCCCHH	57.00	30576142
2966	Phosphorylation	ETEGDVHTSNRLHMV CCCCCCCHHHHHHHH	27.78	28787133
2967	Phosphorylation	TEGDVHTSNRLHMVR CCCCCCHHHHHHHHH	12.69	28787133
3007	Phosphorylation	MQVILMLTTDLDGED HHHEEHHHCCCCCCC	12.33	30576142
3126	Ubiquitination	VATSQLLKPHTTSSP CCHHHHCCCCCCCCC	43.26	29967540
3126 (in isoform 2)	Ubiquitination	-	43.26	-
3132	Phosphorylation	LKPHTTSSPPDMSPF CCCCCCCCCCCCCHH	38.06	-
3169	Phosphorylation	EMVLRLPYQIKKITD HHHHHCCHHHEECCC	27.71	25884760
3172	Acetylation	LRLPYQIKKITDTNS HHCCHHHEECCCCCC	23.69	25953088
3173	Ubiquitination	RLPYQIKKITDTNSR HCCHHHEECCCCCCC	53.09	-
3173 (in isoform 2)	Ubiquitination	-	53.09	-
3175	Phosphorylation	PYQIKKITDTNSRIP CHHHEECCCCCCCCC	45.72	20068231
3177	Phosphorylation	QIKKITDTNSRIPPP HHEECCCCCCCCCCC	26.83	20068231
3179	Phosphorylation	KKITDTNSRIPPPVF EECCCCCCCCCCCCC	33.41	20068231
3220	Phosphorylation	LLLFICGSKEKYRQL HHHHHHCCHHHHHHH	32.98	22496350
3254	Phosphorylation	QGIFLRASVVTASSG CCCEEEEEEEECCCC	15.64	29970186
3257	Phosphorylation	FLRASVVTASSGSAL EEEEEEEECCCCCCC	20.75	29970186
3259	Phosphorylation	RASVVTASSGSALQY EEEEEECCCCCCCCH	26.35	29970186
3262	Phosphorylation	VVTASSGSALQYDTL EEECCCCCCCCHHHH	27.96	29970186
3268	Phosphorylation	GSALQYDTLISLMEH CCCCCHHHHHHHHHH	22.51	29970186
3271	Phosphorylation	LQYDTLISLMEHLKA CCHHHHHHHHHHHHH	25.44	29970186
3292	Ubiquitination	QRTINWQKFCIKDDS HCCCCCCHHCCCCHH	33.54	29967540
3316	Phosphorylation	FLVDEGVSPVLLQLL HHHCCCCCHHHHHHH	21.83	26074081
3339	Phosphorylation	VLAALAASSGSSSAS HHHHHHHHCCCCCCC	29.62	-
3346	Phosphorylation	SSGSSSASSSSAPVA HCCCCCCCCCCCCCC	32.47	-
3347	Phosphorylation	SGSSSASSSSAPVAA CCCCCCCCCCCCCCC	28.20	-
3349	Phosphorylation	SSSASSSSAPVAASS CCCCCCCCCCCCCCC	38.24	-
3360	Phosphorylation	AASSGQATTQSKSST CCCCCCCCCCCCCCC	19.92	24173317
3361	Phosphorylation	ASSGQATTQSKSSTK CCCCCCCCCCCCCCC	33.58	24173317
3366	Phosphorylation	ATTQSKSSTKKSKKE CCCCCCCCCCCCHHH	48.24	-
3366	Ubiquitination	ATTQSKSSTKKSKKE CCCCCCCCCCCCHHH	48.24	22817900
3367	Phosphorylation	TTQSKSSTKKSKKEE CCCCCCCCCCCHHHH	49.97	-
3370	Ubiquitination	SKSSTKKSKKEEKEK CCCCCCCCHHHHHHH	50.98	21890473
3379	Ubiquitination	KEEKEKEKDGETSGS HHHHHHHCCCCCCCC	80.33	29967540
3381 (in isoform 3)	Ubiquitination	-	51.67	21890473
3383	Phosphorylation	EKEKDGETSGSQEDQ HHHCCCCCCCCHHHH	43.87	25627689
3383	Ubiquitination	EKEKDGETSGSQEDQ HHHCCCCCCCCHHHH	43.87	22817900
3386	Phosphorylation	KDGETSGSQEDQLCT CCCCCCCCHHHHHHH	30.11	21712546
3387	Ubiquitination	DGETSGSQEDQLCTA CCCCCCCHHHHHHHH	62.91	21890473
3398 (in isoform 4)	Ubiquitination	-	38.64	21890473
3399	Ubiquitination	CTALVNQLNKFADKE HHHHHHHHHHHCCHH	6.76	22817900
3400	Ubiquitination	TALVNQLNKFADKET HHHHHHHHHHCCHHH	27.86	22817900
3401	Ubiquitination	ALVNQLNKFADKETL HHHHHHHHHCCHHHH	50.99	22817900
3403	Ubiquitination	VNQLNKFADKETLIQ HHHHHHHCCHHHHHH	28.68	21890473
3404	Ubiquitination	NQLNKFADKETLIQF HHHHHHCCHHHHHHH	53.08	21890473
3405	Acetylation	QLNKFADKETLIQFL HHHHHCCHHHHHHHH	49.52	25953088
3405	Ubiquitination	QLNKFADKETLIQFL HHHHHCCHHHHHHHH	49.52	21890473
3405 (in isoform 1)	Ubiquitination	-	49.52	21890473
3405 (in isoform 2)	Ubiquitination	-	49.52	21890473
3407	Ubiquitination	NKFADKETLIQFLRC HHHCCHHHHHHHHHH	34.60	22817900
3411	Ubiquitination	DKETLIQFLRCFLLE CHHHHHHHHHHHHHC	3.54	21890473
3412	Ubiquitination	KETLIQFLRCFLLES HHHHHHHHHHHHHCC	2.39	22817900
3413	Ubiquitination	ETLIQFLRCFLLESN HHHHHHHHHHHHCCC	15.49	22817900
3415	Ubiquitination	LIQFLRCFLLESNSS HHHHHHHHHHCCCCC	7.63	21890473
3416	Ubiquitination	IQFLRCFLLESNSSS HHHHHHHHHCCCCCC	6.25	21890473
3417	Ubiquitination	QFLRCFLLESNSSSV HHHHHHHHCCCCCCH	3.21	21890473
3418	Ubiquitination	FLRCFLLESNSSSVR HHHHHHHCCCCCCHH	50.44	22817900
3422	Ubiquitination	FLLESNSSSVRWQAH HHHCCCCCCHHHHHH	36.78	21890473
3423	Ubiquitination	LLESNSSSVRWQAHC HHCCCCCCHHHHHHE	18.60	22817900
3424	Ubiquitination	LESNSSSVRWQAHCL HCCCCCCHHHHHHEE	8.56	22817900
3427	Ubiquitination	NSSSVRWQAHCLTLH CCCCHHHHHHEEEEE	15.63	21890473
3428	Ubiquitination	SSSVRWQAHCLTLHI CCCHHHHHHEEEEEH	6.60	21890473
3432	Phosphorylation	RWQAHCLTLHIYRNS HHHHHEEEEEHHCCC	22.99	18691976
3436	Ubiquitination	HCLTLHIYRNSSKSQ HEEEEEHHCCCCHHH	7.93	22817900
3440	Phosphorylation	LHIYRNSSKSQQELL EEHHCCCCHHHHHHH	39.62	24719451
3440	Ubiquitination	LHIYRNSSKSQQELL EEHHCCCCHHHHHHH	39.62	21890473
3441	Ubiquitination	HIYRNSSKSQQELLL EHHCCCCHHHHHHHH	52.70	22817900
3444	Ubiquitination	RNSSKSQQELLLDLM CCCCHHHHHHHHHHH	50.85	22817900
3445	Ubiquitination	NSSKSQQELLLDLMW CCCHHHHHHHHHHHH	33.47	21890473
3446	Ubiquitination	SSKSQQELLLDLMWS CCHHHHHHHHHHHHH	5.10	22817900
3447	Ubiquitination	SKSQQELLLDLMWSI CHHHHHHHHHHHHHH	3.26	22817900
3448	Ubiquitination	KSQQELLLDLMWSIW HHHHHHHHHHHHHHH	8.10	21890473
3449	Ubiquitination	SQQELLLDLMWSIWP HHHHHHHHHHHHHHC	34.15	21890473
3450	Ubiquitination	QQELLLDLMWSIWPE HHHHHHHHHHHHHCC	3.70	21890473
3451	Ubiquitination	QELLLDLMWSIWPEL HHHHHHHHHHHHCCC	2.35	21890473
3452	Ubiquitination	ELLLDLMWSIWPELP HHHHHHHHHHHCCCC	8.25	22817900
3455	Ubiquitination	LDLMWSIWPELPAYG HHHHHHHHCCCCCCC	3.77	21890473
3456	Ubiquitination	DLMWSIWPELPAYGR HHHHHHHCCCCCCCH	31.41	21890473
3464	Ubiquitination	ELPAYGRKAAQFVDL CCCCCCHHHHHHHHH	43.65	33845483
3464 (in isoform 2)	Ubiquitination	-	43.65	-
3479	O-linked_Glycosylation	LGYFSLKTPQTEKKL HHHHHCCCCHHHHHH	26.39	30379171
3485	Ubiquitination	KTPQTEKKLKEYSQK CCCHHHHHHHHHHHH	59.57	29967540
3487	Ubiquitination	PQTEKKLKEYSQKAV CHHHHHHHHHHHHHH	64.58	29967540
3489	Phosphorylation	TEKKLKEYSQKAVEI HHHHHHHHHHHHHHH	18.14	20068231
3490	Phosphorylation	EKKLKEYSQKAVEIL HHHHHHHHHHHHHHH	26.71	20068231
3548	Phosphorylation	PFCYIKLSSIKVDTR CEEEEEECCCCCCCC	25.64	24719451
3551	Malonylation	YIKLSSIKVDTRYTT EEEECCCCCCCCCCC	35.69	26320211
3551	Ubiquitination	YIKLSSIKVDTRYTT EEEECCCCCCCCCCC	35.69	29967540
3551 (in isoform 2)	Malonylation	-	35.69	26320211
3556	Phosphorylation	SIKVDTRYTTTQQVV CCCCCCCCCCHHHHH	15.55	23403867
3557	Phosphorylation	IKVDTRYTTTQQVVK CCCCCCCCCHHHHHH	21.78	23403867
3558	Phosphorylation	KVDTRYTTTQQVVKL CCCCCCCCHHHHHHH	17.42	23403867
3559	Phosphorylation	VDTRYTTTQQVVKLI CCCCCCCHHHHHHHH	14.81	23403867
3573	Ubiquitination	IGSHTISKVTVKIGD HCCCCCEEEEEEECC	37.77	33845483
3577	Ubiquitination	TISKVTVKIGDLKRT CCEEEEEEECCCCCC	31.44	29967540
3606	Ubiquitination	VQAIVELKNKPARWH EHHHHHHCCCCCCCC	49.79	-
3606 (in isoform 2)	Ubiquitination	-	49.79	-
3608	Ubiquitination	AIVELKNKPARWHKA HHHHHCCCCCCCCCC	38.17	-
3608 (in isoform 2)	Ubiquitination	-	38.17	-
3617	Ubiquitination	ARWHKAKKVQLTPGQ CCCCCCCCCCCCCCC	39.82	29967540
3625	Phosphorylation	VQLTPGQTEVKIDLP CCCCCCCEEEEEECC	48.97	27251789
3699	Ubiquitination	YDEKDPFLCNACGFC CCCCCCCCCCCCCCC	2.40	24816145
3707	Acetylation	CNACGFCKYARFDFM CCCCCCCCCCCCCEE	39.42	25953088
3716	Ubiquitination	ARFDFMLYAKPCCAV CCCCEEEECCCCCCC	10.78	24816145
3732	Ubiquitination	PIENEEDRKKAVSNI CCCCHHHHHHHHHHH	45.73	24816145
3733	Ubiquitination	IENEEDRKKAVSNIN CCCHHHHHHHHHHHH	58.36	24816145
3734	Ubiquitination	ENEEDRKKAVSNINT CCHHHHHHHHHHHHH	55.72	24816145
3740	Ubiquitination	KKAVSNINTLLDKAD HHHHHHHHHHHHHHH	28.99	24816145
3744	Ubiquitination	SNINTLLDKADRVYH HHHHHHHHHHHHHHH	47.40	24816145
3745	Ubiquitination	NINTLLDKADRVYHQ HHHHHHHHHHHHHHH	52.75	24816145
3745 (in isoform 2)	Ubiquitination	-	52.75	-
3746	Ubiquitination	INTLLDKADRVYHQL HHHHHHHHHHHHHHH	14.98	24816145
3751	Ubiquitination	DKADRVYHQLMGHRP HHHHHHHHHHCCCCH	16.08	24816145
3756	Ubiquitination	VYHQLMGHRPQLENL HHHHHCCCCHHHHHH	25.04	24816145
3757	Ubiquitination	YHQLMGHRPQLENLL HHHHCCCCHHHHHHH	18.22	24816145
3769	Ubiquitination	NLLCKVNEAAPEKPQ HHHHHHHHCCCCCCC	49.55	24816145
3774	Ubiquitination	VNEAAPEKPQDDSGT HHHCCCCCCCCCCCC	47.09	24816145
3777	Ubiquitination	AAPEKPQDDSGTAGG CCCCCCCCCCCCCCC	61.65	24816145
3778	Ubiquitination	APEKPQDDSGTAGGI CCCCCCCCCCCCCCC	43.66	24816145
3779	Ubiquitination	PEKPQDDSGTAGGIS CCCCCCCCCCCCCCC	46.46	24816145
3780	Ubiquitination	EKPQDDSGTAGGISS CCCCCCCCCCCCCCC	26.95	24816145
3784	Ubiquitination	DDSGTAGGISSTSAS CCCCCCCCCCCCHHH	17.72	24816145
3785	Ubiquitination	DSGTAGGISSTSASV CCCCCCCCCCCHHHH	2.62	24816145
3786	Phosphorylation	SGTAGGISSTSASVN CCCCCCCCCCHHHHH	30.73	29632367
3787	Phosphorylation	GTAGGISSTSASVNR CCCCCCCCCHHHHHH	25.18	29632367
3788	Phosphorylation	TAGGISSTSASVNRY CCCCCCCCHHHHHHH	22.86	29632367
3789	Phosphorylation	AGGISSTSASVNRYI CCCCCCCHHHHHHHH	22.09	29632367
3791	Ubiquitination	GISSTSASVNRYILQ CCCCCHHHHHHHHHH	21.49	24816145
3808	Ubiquitination	QEYCGDCKNSFDELS HHHHHCCCCCHHHHH	61.44	24816145
3816	Acetylation	NSFDELSKIIQKVFA CCHHHHHHHHHHHHH	57.35	25953088
3816	Ubiquitination	NSFDELSKIIQKVFA CCHHHHHHHHHHHHH	57.35	29967540
3816 (in isoform 2)	Ubiquitination	-	57.35	-
3820	Acetylation	ELSKIIQKVFASRKE HHHHHHHHHHHCCHH	28.98	25953088
3820	Ubiquitination	ELSKIIQKVFASRKE HHHHHHHHHHHCCHH	28.98	29967540
3824	Ubiquitination	IIQKVFASRKELLEY HHHHHHHCCHHHHHH	32.21	24816145
3825	Ubiquitination	IQKVFASRKELLEYD HHHHHHCCHHHHHHH	32.79	24816145
3826	Ubiquitination	QKVFASRKELLEYDL HHHHHCCHHHHHHHH	50.66	24816145
3826 (in isoform 2)	Ubiquitination	-	50.66	-
3832	Ubiquitination	RKELLEYDLQQREAA CHHHHHHHHHHHHHH	28.73	24816145
3836	Ubiquitination	LEYDLQQREAATKSS HHHHHHHHHHHHHCC	23.66	24816145
3837	Ubiquitination	EYDLQQREAATKSSR HHHHHHHHHHHHCCC	38.01	24816145
3838	Ubiquitination	YDLQQREAATKSSRT HHHHHHHHHHHCCCC	23.71	24816145
3842	Phosphorylation	QREAATKSSRTSVQP HHHHHHHCCCCCCCC	22.24	-
3843	O-linked_Glycosylation	REAATKSSRTSVQPT HHHHHHCCCCCCCCC	40.93	30379171
3843	Ubiquitination	REAATKSSRTSVQPT HHHHHHCCCCCCCCC	40.93	24816145
3845	Phosphorylation	AATKSSRTSVQPTFT HHHHCCCCCCCCCCC	34.89	22210691
3846	Phosphorylation	ATKSSRTSVQPTFTA HHHCCCCCCCCCCCH	20.04	28555341
3848	Ubiquitination	KSSRTSVQPTFTASQ HCCCCCCCCCCCHHH	30.96	24816145
3849	Ubiquitination	SSRTSVQPTFTASQY CCCCCCCCCCCHHHH	27.59	24816145
3850	Phosphorylation	SRTSVQPTFTASQYR CCCCCCCCCCHHHHH	19.27	25693802
3852	Phosphorylation	TSVQPTFTASQYRAL CCCCCCCCHHHHHHH	28.07	25693802
3854	Phosphorylation	VQPTFTASQYRALSV CCCCCCHHHHHHHHE	25.37	27732954
3856	Phosphorylation	PTFTASQYRALSVLG CCCCHHHHHHHHEEC	8.71	25693802
3860	Phosphorylation	ASQYRALSVLGCGHT HHHHHHHHEECCCCC	17.82	25159151
3861	Ubiquitination	SQYRALSVLGCGHTS HHHHHHHEECCCCCC	5.76	24816145
3866	Ubiquitination	LSVLGCGHTSSTKCY HHEECCCCCCCCCCC	27.01	24816145
3867	Phosphorylation	SVLGCGHTSSTKCYG HEECCCCCCCCCCCC	15.06	27251275
3868	Phosphorylation	VLGCGHTSSTKCYGC EECCCCCCCCCCCCC	30.27	27251275
3869	Phosphorylation	LGCGHTSSTKCYGCA ECCCCCCCCCCCCCH	32.80	27251275
3869	Ubiquitination	LGCGHTSSTKCYGCA ECCCCCCCCCCCCCH	32.80	24816145
3870	Phosphorylation	GCGHTSSTKCYGCAS CCCCCCCCCCCCCHH	25.54	27251275
3870	Ubiquitination	GCGHTSSTKCYGCAS CCCCCCCCCCCCCHH	25.54	24816145
3871	Ubiquitination	CGHTSSTKCYGCASA CCCCCCCCCCCCHHH	27.66	24816145
3872	Ubiquitination	GHTSSTKCYGCASAV CCCCCCCCCCCHHHH	3.41	24816145
3876	Ubiquitination	STKCYGCASAVTEHC CCCCCCCHHHHHHHH	9.00	24816145
3877	Phosphorylation	TKCYGCASAVTEHCI CCCCCCHHHHHHHHH	27.61	28985074
3877	Ubiquitination	TKCYGCASAVTEHCI CCCCCCHHHHHHHHH	27.61	24816145
3885	Phosphorylation	AVTEHCITLLRALAT HHHHHHHHHHHHHHC	25.74	28985074
3892	Phosphorylation	TLLRALATNPALRHI HHHHHHHCCHHHHHH	42.45	21406692
3902	Phosphorylation	ALRHILVSQGLIREL HHHHHHHHCHHHHHH	18.32	24505115
3997	Ubiquitination	LRCALSLFLMAVNIK HHHHHHHHHHHCCCC	3.83	22817900
3998	Ubiquitination	RCALSLFLMAVNIKT HHHHHHHHHHCCCCC	2.33	22817900
4000	Ubiquitination	ALSLFLMAVNIKTPV HHHHHHHHCCCCCCH	8.05	21890473
4005	Phosphorylation	LMAVNIKTPVVVENI HHHCCCCCCHHHHHH	19.95	-
4011 (in isoform 3)	Ubiquitination	-	22.42	21890473
4013	Phosphorylation	PVVVENITLMCLRIL CHHHHHHHHHHHHHH	21.74	-
4014	Ubiquitination	VVVENITLMCLRILQ HHHHHHHHHHHHHHH	1.70	22817900
4015	Ubiquitination	VVENITLMCLRILQK HHHHHHHHHHHHHHH	1.19	22817900
4017	Ubiquitination	ENITLMCLRILQKLI HHHHHHHHHHHHHHC	2.08	21890473
4028 (in isoform 4)	Ubiquitination	-	28.64	21890473
4030	Ubiquitination	LIKPPAPTSKKNKDV HCCCCCCCCCCCCCC	56.11	22817900
4031	Ubiquitination	IKPPAPTSKKNKDVP CCCCCCCCCCCCCCC	40.34	22817900
4032	Ubiquitination	KPPAPTSKKNKDVPV CCCCCCCCCCCCCCH	63.94	22817900
4033	Ubiquitination	PPAPTSKKNKDVPVE CCCCCCCCCCCCCHH	69.83	21890473
4034	Ubiquitination	PAPTSKKNKDVPVEA CCCCCCCCCCCCHHH	49.88	21890473
4035	Ubiquitination	APTSKKNKDVPVEAL CCCCCCCCCCCHHHH	69.82	22817900
4035 (in isoform 1)	Ubiquitination	-	69.82	21890473
4035 (in isoform 2)	Ubiquitination	-	69.82	21890473
4038	Ubiquitination	SKKNKDVPVEALTTV CCCCCCCCHHHHEEC	28.50	22817900
4039	Ubiquitination	KKNKDVPVEALTTVK CCCCCCCHHHHEECH	7.26	22817900
4041	Ubiquitination	NKDVPVEALTTVKPY CCCCCHHHHEECHHH	15.50	21890473
4042	Ubiquitination	KDVPVEALTTVKPYC CCCCHHHHEECHHHH	2.33	22817900
4043	Ubiquitination	DVPVEALTTVKPYCN CCCHHHHEECHHHHC	36.27	22817900
4044	Ubiquitination	VPVEALTTVKPYCNE CCHHHHEECHHHHCH	27.64	22817900
4045	Ubiquitination	PVEALTTVKPYCNEI CHHHHEECHHHHCHH	5.04	21890473
4046	Ubiquitination	VEALTTVKPYCNEIH HHHHEECHHHHCHHH	28.33	21890473
4047	Ubiquitination	EALTTVKPYCNEIHA HHHEECHHHHCHHHH	34.27	21890473
4049	Ubiquitination	LTTVKPYCNEIHAQA HEECHHHHCHHHHHH	5.10	22817900
4050	Ubiquitination	TTVKPYCNEIHAQAQ EECHHHHCHHHHHHH	45.47	22817900
4052	Ubiquitination	VKPYCNEIHAQAQLW CHHHHCHHHHHHHHH	1.71	21890473
4054	Ubiquitination	PYCNEIHAQAQLWLK HHHCHHHHHHHHHHH	16.44	22817900
4055	Ubiquitination	YCNEIHAQAQLWLKR HHCHHHHHHHHHHHC	18.58	22817900
4056	Ubiquitination	CNEIHAQAQLWLKRD HCHHHHHHHHHHHCC	13.76	22817900
4057	Ubiquitination	NEIHAQAQLWLKRDP CHHHHHHHHHHHCCC	22.53	21890473
4058	Ubiquitination	EIHAQAQLWLKRDPK HHHHHHHHHHHCCCC	6.92	21890473
4065	Ubiquitination	LWLKRDPKASYDAWK HHHHCCCCCCHHHHH	55.01	29967540
4067	Ubiquitination	LKRDPKASYDAWKKC HHCCCCCCHHHHHHC	29.67	22817900
4068	Phosphorylation	KRDPKASYDAWKKCL HCCCCCCHHHHHHCE	17.97	23917254
4068	Ubiquitination	KRDPKASYDAWKKCL HCCCCCCHHHHHHCE	17.97	22817900
4070	Ubiquitination	DPKASYDAWKKCLPI CCCCCHHHHHHCEEC	16.26	21890473
4072	Ubiquitination	KASYDAWKKCLPIRG CCCHHHHHHCEECCC	35.02	22817900
4073	Ubiquitination	ASYDAWKKCLPIRGI CCHHHHHHCEECCCC	30.24	22817900
4075	Ubiquitination	YDAWKKCLPIRGIDG HHHHHHCEECCCCCC	5.62	21890473
4076	Ubiquitination	DAWKKCLPIRGIDGN HHHHHCEECCCCCCC	24.57	22817900
4077	Ubiquitination	AWKKCLPIRGIDGNG HHHHCEECCCCCCCC	3.98	22817900
4078	Methylation	WKKCLPIRGIDGNGK HHHCEECCCCCCCCC	33.79	115919457
4078	Ubiquitination	WKKCLPIRGIDGNGK HHHCEECCCCCCCCC	33.79	21890473
4079	Ubiquitination	KKCLPIRGIDGNGKA HHCEECCCCCCCCCC	24.06	21890473
4080	Ubiquitination	KCLPIRGIDGNGKAP HCEECCCCCCCCCCC	4.38	21890473
4081	Ubiquitination	CLPIRGIDGNGKAPS CEECCCCCCCCCCCC	47.53	21890473
4082	Ubiquitination	LPIRGIDGNGKAPSK EECCCCCCCCCCCCH	42.75	22817900
4083	Ubiquitination	PIRGIDGNGKAPSKS ECCCCCCCCCCCCHH	45.07	22817900
4084	Ubiquitination	IRGIDGNGKAPSKSE CCCCCCCCCCCCHHH	32.79	22817900
4085	Ubiquitination	RGIDGNGKAPSKSEL CCCCCCCCCCCHHHH	62.21	21890473
4086	Ubiquitination	GIDGNGKAPSKSELR CCCCCCCCCCHHHHH	18.26	21890473
4087	Ubiquitination	IDGNGKAPSKSELRH CCCCCCCCCHHHHHH	45.86	21890473
4088	Phosphorylation	DGNGKAPSKSELRHL CCCCCCCCHHHHHHH	54.39	22798277
4089	Ubiquitination	GNGKAPSKSELRHLY CCCCCCCHHHHHHHH	47.06	29967540
4091	Ubiquitination	GKAPSKSELRHLYLT CCCCCHHHHHHHHHH	54.26	24816145
4095	Ubiquitination	SKSELRHLYLTEKYV CHHHHHHHHHHHHHH	2.79	24816145
4096	Phosphorylation	KSELRHLYLTEKYVW HHHHHHHHHHHHHHH	12.88	28152594
4096	Ubiquitination	KSELRHLYLTEKYVW HHHHHHHHHHHHHHH	12.88	24816145
4097	Ubiquitination	SELRHLYLTEKYVWR HHHHHHHHHHHHHHH	6.67	24816145
4098	Phosphorylation	ELRHLYLTEKYVWRW HHHHHHHHHHHHHHH	19.51	28152594
4098 (in isoform 3)	Ubiquitination	-	19.51	21890473
4100	Ubiquitination	RHLYLTEKYVWRWKQ HHHHHHHHHHHHHHH	39.61	-
4100 (in isoform 2)	Ubiquitination	-	39.61	-
4102	Ubiquitination	LYLTEKYVWRWKQFL HHHHHHHHHHHHHHH	4.07	24816145
4104	Ubiquitination	LTEKYVWRWKQFLSR HHHHHHHHHHHHHHH	22.22	21890473
4106	Ubiquitination	EKYVWRWKQFLSRRG HHHHHHHHHHHHHCC	23.69	-
4106 (in isoform 2)	Ubiquitination	-	23.69	-
4107	Ubiquitination	KYVWRWKQFLSRRGK HHHHHHHHHHHHCCC	37.24	24816145
4108	Ubiquitination	YVWRWKQFLSRRGKR HHHHHHHHHHHCCCC	6.25	24816145
4115 (in isoform 4)	Ubiquitination	-	43.17	21890473
4116	Phosphorylation	LSRRGKRTSPLDLKL HHHCCCCCCCCCEEC	37.88	23186163
4117	Phosphorylation	SRRGKRTSPLDLKLG HHCCCCCCCCCEECC	27.74	25159151
4120	Ubiquitination	GKRTSPLDLKLGHNN CCCCCCCCEECCCCH	45.18	21890473
4121	Ubiquitination	KRTSPLDLKLGHNNW CCCCCCCEECCCCHH	6.94	21890473
4122	Ubiquitination	RTSPLDLKLGHNNWL CCCCCCEECCCCHHH	52.68	22817900
4122 (in isoform 1)	Ubiquitination	-	52.68	21890473
4122 (in isoform 2)	Ubiquitination	-	52.68	21890473
4125	Ubiquitination	PLDLKLGHNNWLRQV CCCEECCCCHHHHHH	34.58	24816145
4128	Ubiquitination	LKLGHNNWLRQVLFT EECCCCHHHHHHHCC	9.76	21890473
4129	Ubiquitination	KLGHNNWLRQVLFTP ECCCCHHHHHHHCCH	2.74	24816145
4130	Ubiquitination	LGHNNWLRQVLFTPA CCCCHHHHHHHCCHH	19.04	24816145
4131	Ubiquitination	GHNNWLRQVLFTPAT CCCHHHHHHHCCHHH	33.81	24816145
4132	Ubiquitination	HNNWLRQVLFTPATQ CCHHHHHHHCCHHHH	3.71	21890473
4133	Ubiquitination	NNWLRQVLFTPATQA CHHHHHHHCCHHHHH	2.75	21890473
4134	Ubiquitination	NWLRQVLFTPATQAA HHHHHHHCCHHHHHH	8.92	21890473
4135	Ubiquitination	WLRQVLFTPATQAAR HHHHHHCCHHHHHHH	14.09	24816145
4136	Ubiquitination	LRQVLFTPATQAARQ HHHHHCCHHHHHHHH	26.44	24816145
4139	Ubiquitination	VLFTPATQAARQAAC HHCCHHHHHHHHHHH	34.82	21890473
4144	Ubiquitination	ATQAARQAACTIVEA HHHHHHHHHHHHHHH	10.03	21890473
4145	Ubiquitination	TQAARQAACTIVEAL HHHHHHHHHHHHHHH	5.22	21890473
4157	Ubiquitination	EALATIPSRKQQVLD HHHHCCCHHHHHHHH	48.54	21890473
4158	Methylation	ALATIPSRKQQVLDL HHHCCCHHHHHHHHH	35.13	115386931
4162	Ubiquitination	IPSRKQQVLDLLTSY CCHHHHHHHHHHHHH	4.09	21890473
4165	Ubiquitination	RKQQVLDLLTSYLDE HHHHHHHHHHHHHHH	5.00	21890473
4166	Ubiquitination	KQQVLDLLTSYLDEL HHHHHHHHHHHHHHH	2.74	21890473
4167	Ubiquitination	QQVLDLLTSYLDELS HHHHHHHHHHHHHHH	23.71	21890473
4168	Ubiquitination	QVLDLLTSYLDELSI HHHHHHHHHHHHHHH	24.54	21890473
4172	Ubiquitination	LLTSYLDELSIAGEC HHHHHHHHHHHHHHH	41.65	21890473
4173	Ubiquitination	LTSYLDELSIAGECA HHHHHHHHHHHHHHH	4.47	21890473
4180	Ubiquitination	LSIAGECAAEYLALY HHHHHHHHHHHHHHH	10.06	21890473
4191 (in isoform 3)	Ubiquitination	-	3.54	21890473
4197	Ubiquitination	LITSAHWKVYLAARG HHHHHHHHHHHHHCC	15.90	21890473
4208 (in isoform 4)	Ubiquitination	-	19.48	21890473
4213	Ubiquitination	LPYVGNLITKEIARL HHCHHHHHHHHHHHH	6.32	21890473
4214	Ubiquitination	PYVGNLITKEIARLL HCHHHHHHHHHHHHH	26.28	21890473
4215	Ubiquitination	YVGNLITKEIARLLA CHHHHHHHHHHHHHH	39.88	22817900
4215 (in isoform 1)	Ubiquitination	-	39.88	21890473
4215 (in isoform 2)	Ubiquitination	-	39.88	21890473
4221	Ubiquitination	TKEIARLLALEEATL HHHHHHHHHHHHHCC	4.21	21890473
4225	Ubiquitination	ARLLALEEATLSTDL HHHHHHHHHCCCCCH	48.05	21890473
4226	Ubiquitination	RLLALEEATLSTDLQ HHHHHHHHCCCCCHH	12.41	21890473
4227	Ubiquitination	LLALEEATLSTDLQQ HHHHHHHCCCCCHHH	25.23	21890473
4232	Ubiquitination	EATLSTDLQQGYALK HHCCCCCHHHHHHHH	4.08	21890473
4237	Ubiquitination	TDLQQGYALKSLTGL CCHHHHHHHHHHHHH	18.48	21890473
4238	Ubiquitination	DLQQGYALKSLTGLL CHHHHHHHHHHHHHH	2.66	21890473
4240	Phosphorylation	QQGYALKSLTGLLSS HHHHHHHHHHHHHHH	31.82	21406692
4242	Phosphorylation	GYALKSLTGLLSSFV HHHHHHHHHHHHHCC	32.64	21406692
4246	Phosphorylation	KSLTGLLSSFVEVES HHHHHHHHHCCCHHH	27.11	21406692
4247	Phosphorylation	SLTGLLSSFVEVESI HHHHHHHHCCCHHHH	33.03	21406692
4250	Ubiquitination	GLLSSFVEVESIKRH HHHHHCCCHHHHHHH	38.26	21890473
4253	Phosphorylation	SSFVEVESIKRHFKS HHCCCHHHHHHHHHH	38.29	21406692
4255	Ubiquitination	FVEVESIKRHFKSRL CCCHHHHHHHHHHHH	49.45	21890473
4258	Ubiquitination	VESIKRHFKSRLVGT HHHHHHHHHHHHHHH	9.99	21890473
4259	Ubiquitination	ESIKRHFKSRLVGTV HHHHHHHHHHHHHHH	28.65	21890473
4260	Ubiquitination	SIKRHFKSRLVGTVL HHHHHHHHHHHHHHH	29.87	21890473
4261	Ubiquitination	IKRHFKSRLVGTVLN HHHHHHHHHHHHHHH	33.70	21890473
4265	Phosphorylation	FKSRLVGTVLNGYLC HHHHHHHHHHHHHHH	17.84	20068231
4265	Ubiquitination	FKSRLVGTVLNGYLC HHHHHHHHHHHHHHH	17.84	21890473
4266	Ubiquitination	KSRLVGTVLNGYLCL HHHHHHHHHHHHHHH	3.00	21890473
4270	Phosphorylation	VGTVLNGYLCLRKLV HHHHHHHHHHHHHHH	7.99	20068231
4281	Phosphorylation	RKLVVQRTKLIDETQ HHHHHHHHHHCHHHH	17.08	25332170
4299	Phosphorylation	LEMLEDMTTGTESET HHHHHHCCCCCHHHH	34.10	30177828
4300	Phosphorylation	EMLEDMTTGTESETK HHHHHCCCCCHHHHH	35.15	30177828
4302	Phosphorylation	LEDMTTGTESETKAF HHHCCCCCHHHHHHH	33.96	30177828
4304	Phosphorylation	DMTTGTESETKAFMA HCCCCCHHHHHHHHH	50.86	30177828
4306	Phosphorylation	TTGTESETKAFMAVC CCCCHHHHHHHHHHH	36.63	30177828
4316	Phosphorylation	FMAVCIETAKRYNLD HHHHHHHHHHHCCCC	19.98	-
4325	Phosphorylation	KRYNLDDYRTPVFIF HHCCCCCCCCHHHHH	18.96	-
4416	Phosphorylation	LVNNKIISLDLPVAE EECCEEEEECCCHHH	21.21	20071362
4425	Phosphorylation	DLPVAEVYKKVWCTT CCCHHHHHHHEEEEC	9.15	22817900
4427	Ubiquitination	PVAEVYKKVWCTTNE CHHHHHHHEEEECCC	24.23	-
4442	Phosphorylation	GEPMRIVYRMRGLLG CCCCCHHHHHCCCCC	9.05	22817900
4491	Methylation	GLECMLNRLAGIRDF CHHHHHHHHCCCCCH	23.19	115386939
4496	Methylation	LNRLAGIRDFKQGRH HHHHCCCCCHHHCHH	42.25	115386947
4513	Phosphorylation	TVLLKLFSYCVKVKV HHHHHHHHHHHHHCC	28.23	27135362
4532	Phosphorylation	LVKLEMNTLNVMLGT HHHHHHHHHHHHHHH	20.56	24043423
4539	Phosphorylation	TLNVMLGTLNLALVA HHHHHHHHHHHHHHC	14.44	24043423
4550	Phosphorylation	ALVAEQESKDSGGAA HHHCCHHCCCCCCHH	41.27	24043423
4685	Ubiquitination	LKDLILQKGITQNAL HHHHHHHCCCCHHHH	49.16	-
4685 (in isoform 2)	Ubiquitination	-	49.16	-
4688	Phosphorylation	LILQKGITQNALDYM HHHHCCCCHHHHHHH	25.16	20068231
4696	Ubiquitination	QNALDYMKKHIPSAK HHHHHHHHHHCCCCC	34.66	29967540
4701	Phosphorylation	YMKKHIPSAKNLDAD HHHHHCCCCCCCCHH	51.80	24719451
4703	Ubiquitination	KKHIPSAKNLDADIW HHHCCCCCCCCHHHH	63.48	29967540
4711	Ubiquitination	NLDADIWKKFLSRPA CCCHHHHHHHHCCCH	33.70	29967540
4712	Ubiquitination	LDADIWKKFLSRPAL CCHHHHHHHHCCCHH	36.22	-
4712 (in isoform 2)	Ubiquitination	-	36.22	-
4744	Ubiquitination	QVLIGTDSIPNLHKL EEEEECCCCCCHHHC	39.52	24816145
4755	Phosphorylation	LHKLEQVSSDEGIGT HHHCCCCCCCCCHHH	31.59	-
4761	Ubiquitination	VSSDEGIGTLAENLL CCCCCCHHHHHHHHH	26.07	24816145
4762	Phosphorylation	SSDEGIGTLAENLLE CCCCCHHHHHHHHHH	22.37	-
4777	Ubiquitination	ALREHPDVNKKIDAA HHHHCCCHHHHHHHH	15.49	24816145
4778	Ubiquitination	LREHPDVNKKIDAAR HHHCCCHHHHHHHHH	47.48	24816145
4779	Ubiquitination	REHPDVNKKIDAARR HHCCCHHHHHHHHHH	51.45	24816145
4785	Ubiquitination	NKKIDAARRETRAEK HHHHHHHHHHHHHHH	38.39	24816145
4789	Ubiquitination	DAARRETRAEKKRMA HHHHHHHHHHHHHHH	35.68	24816145
4790	Ubiquitination	AARRETRAEKKRMAM HHHHHHHHHHHHHHH	40.14	24816145
4791	Ubiquitination	ARRETRAEKKRMAMA HHHHHHHHHHHHHHH	56.68	24816145
4796	Ubiquitination	RAEKKRMAMAMRQKA HHHHHHHHHHHHHHH	6.14	24816145
4801	Ubiquitination	RMAMAMRQKALGTLG HHHHHHHHHHHHHCC	23.45	24816145
4802	Ubiquitination	MAMAMRQKALGTLGM HHHHHHHHHHHHCCC	34.90	24816145
4802 (in isoform 2)	Ubiquitination	-	34.90	-
4809	Sulfoxidation	KALGTLGMTTNEKGQ HHHHHCCCCCCCCCC	4.74	21406390
4810	Phosphorylation	ALGTLGMTTNEKGQV HHHHCCCCCCCCCCE	25.35	28555341
4814	Ubiquitination	LGMTTNEKGQVVTKT CCCCCCCCCCEECHH	57.63	24816145
4814 (in isoform 2)	Ubiquitination	-	57.63	-
4819	Phosphorylation	NEKGQVVTKTALLKQ CCCCCEECHHHHHHH	24.66	29396449
4819	Ubiquitination	NEKGQVVTKTALLKQ CCCCCEECHHHHHHH	24.66	24816145
4820	Ubiquitination	EKGQVVTKTALLKQM CCCCEECHHHHHHHH	21.86	29967540
4820 (in isoform 2)	Ubiquitination	-	21.86	-
4821	Phosphorylation	KGQVVTKTALLKQME CCCEECHHHHHHHHH	17.11	29396449
4822	Ubiquitination	GQVVTKTALLKQMEE CCEECHHHHHHHHHH	16.68	24816145
4823	Ubiquitination	QVVTKTALLKQMEEL CEECHHHHHHHHHHH	8.11	24816145
4824	Ubiquitination	VVTKTALLKQMEELI EECHHHHHHHHHHHH	3.16	24816145
4825	Ubiquitination	VTKTALLKQMEELIE ECHHHHHHHHHHHHH	48.74	24816145
4829	Ubiquitination	ALLKQMEELIEEPGL HHHHHHHHHHHCCCC	50.10	24816145
4830	Ubiquitination	LLKQMEELIEEPGLT HHHHHHHHHHCCCCE	3.68	24816145
4846	Acetylation	CICREGYKFQPTKVL EEECCCCCCCCCEEE	48.67	25953088
4856	Phosphorylation	PTKVLGIYTFTKRVA CCEEEEEEEEHHHHH	8.26	29083192
4857	Phosphorylation	TKVLGIYTFTKRVAL CEEEEEEEEHHHHHH	23.94	29083192
4859	Phosphorylation	VLGIYTFTKRVALEE EEEEEEEHHHHHHHH	15.33	29083192
4860	Ubiquitination	LGIYTFTKRVALEEM EEEEEEHHHHHHHHH	40.46	-
4860 (in isoform 2)	Ubiquitination	-	40.46	-
4934	Phosphorylation	VPESAFATCLARHNT CCHHHHHHHHHHCCC	11.12	24275569
4941	Phosphorylation	TCLARHNTYLQECTG HHHHHCCCHHHHHCC	21.34	24275569
4942	Phosphorylation	CLARHNTYLQECTGQ HHHHCCCHHHHHCCC	16.23	24275569
4973	Phosphorylation	LRFAMEQSFSADTGG HHHHHHHCCCCCCCC	14.09	-
4975	Phosphorylation	FAMEQSFSADTGGGG HHHHHCCCCCCCCCC	30.40	22210691
4978	Phosphorylation	EQSFSADTGGGGRES HHCCCCCCCCCCCCC	37.13	22210691
5022	Ubiquitination	QGFLEQPKEKWVESA HHHHHCCHHHHHHHH	72.17	29967540
5065	Phosphorylation	ILRRLLVTSQARAVA HHHHHHHHHCCCCCC	18.32	22210691
5066	Phosphorylation	LRRLLVTSQARAVAP HHHHHHHHCCCCCCC	17.86	22210691
5135	Phosphorylation	RHNDMPIYEAADKAL HHCCCCHHHHHHHHH	8.14	23917254
5173	Phosphorylation	SEITDPESFLKDLLN HHCCCHHHHHHHHHH	41.07	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2932	S	Phosphorylation	Kinase	MTOR	P42345	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RB_HUMAN	RB1	physical	16214886
USP9X_HUMAN	USP9X	physical	22939629
ZEB1_HUMAN	ZEB1	physical	22939629
VIME_HUMAN	VIM	physical	22939629
FLNB_HUMAN	FLNB	physical	22863883
SYLC_HUMAN	LARS	physical	22863883
PHOCN_HUMAN	MOB4	physical	22863883
PRS8_HUMAN	PSMC5	physical	22863883
PRS10_HUMAN	PSMC6	physical	22863883
ACLY_HUMAN	ACLY	physical	23932781
AAR2_HUMAN	AAR2	physical	26344197
DDX46_HUMAN	DDX46	physical	26344197
IF2P_HUMAN	EIF5B	physical	26344197
KCMF1_HUMAN	KCMF1	physical	26344197
SBNO1_HUMAN	SBNO1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1084, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-181, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619 AND SER-620, ANDMASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-181; THR-2715AND SER-2718, AND MASS SPECTROMETRY.
PubMed: 18669648

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2718, AND MASSSPECTROMETRY.
PubMed: 17924679

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-360, AND MASSSPECTROMETRY.
PubMed: 19369195