SBNO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SBNO1_HUMAN
• UniProt AC: A3KN83
• Protein Name: Protein strawberry notch homolog 1
• Gene Name: SBNO1
• Organism: Homo sapiens (Human).
• Sequence Length: 1393
• Protein Sequence: MVEPGQDLLLAALSESGISPNDLFDIDGGDAGLATPMPTPSVQQSVPLSALELGLETEAAVPVKQEPETVPTPALLNVRQQPPSTTTFVLNQINHLPPLGSTIVMTKTPPVTTNRQTITLTKFIQTTASTRPSVSAPTVRNAMTSAPSKDQVQLKDLLKNNSLNELMKLKPPANIAQPVATAATDVSNGTVKKESSNKEGARMWINDMKMRSFSPTMKVPVVKEDDEPEEEDEEEMGHAETYAEYMPIKLKIGLRHPDAVVETSSLSSVTPPDVWYKTSISEETIDNGWLSALQLEAITYAAQQHETFLPNGDRAGFLIGDGAGVGKGRTIAGIIYENYLLSRKRALWFSVSNDLKYDAERDLRDIGAKNILVHSLNKFKYGKISSKHNGSVKKGVIFATYSSLIGESQSGGKYKTRLKQLLHWCGDDFDGVIVFDECHKAKNLCPVGSSKPTKTGLAVLELQNKLPKARVVYASATGASEPRNMAYMNRLGIWGEGTPFREFSDFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFTGVTFKIEEVLLSQSYVKMYNKAVKLWVIARERFQQAADLIDAEQRMKKSMWGQFWSAHQRFFKYLCIASKVKRVVQLAREEIKNGKCVVIGLQSTGEARTLEALEEGGGELNDFVSTAKGVLQSLIEKHFPAPDRKKLYSLLGIDLTAPSNNSSPRDSPCKENKIKKRKGEEITREAKKARKVGGLTGSSSDDSGSESDASDNEESDYESSKNMSSGDDDDFNPFLDESNEDDENDPWLIRKDHKKNKEKKKKKSIDPDSIQSALLASGLGSKRPSFSSTPVISPAPNSTPANSNTNSNSSLITSQDAVERAQQMKKDLLDKLEKLAEDLPPNTLDELIDELGGPENVAEMTGRKGRVVSNDDGSISYESRSELDVPVEILNITEKQRFMDGDKNIAIISEAASSGISLQADRRAKNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVTAPEYVFLISELAGEQRFASIVAKRLESLGALTHGDRRATESRDLSRFNFDNKYGRNALEIVMKSIVNLDSPMVSPPPDYPGEFFKDVRQGLIGVGLINVEDRSGILTLDKDYNNIGKFLNRILGMEVHQQNALFQYFADTLTAVVQNAKKNGRYDMGILDLGSGDEKVRKSDVKKFLTPGYSTSGHVELYTISVERGMSWEEATKIWAELTGPDDGFYLSLQIRNNKKTAILVKEVNPKKKLFLVYRPNTGKQLKLEIYADLKKKYKKVVSDDALMHWLDQYNSSADTCTHAYWRGNCKKASLGLVCEIGLRCRTYYVLCGSVLSVWTKVEGVLASVSGTNVKMQIVRLRTEDGQRIVGLIIPANCVSPLVNLLSTSDQSQQLAVQQKQLWQQHHPQSITNLSNA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	QEPETVPTPALLNVR CCCCCCCCCCCCCCC	19.50	28555341
84	Phosphorylation	NVRQQPPSTTTFVLN CCCCCCCCCEEEEHH	45.10	20068231
85	Phosphorylation	VRQQPPSTTTFVLNQ CCCCCCCCEEEEHHC	35.31	20068231
86	Phosphorylation	RQQPPSTTTFVLNQI CCCCCCCEEEEHHCC	23.68	20068231
87	Phosphorylation	QQPPSTTTFVLNQIN CCCCCCEEEEHHCCC	16.31	20068231
101	Phosphorylation	NHLPPLGSTIVMTKT CCCCCCCCEEEEECC	23.73	20068231
102	Phosphorylation	HLPPLGSTIVMTKTP CCCCCCCEEEEECCC	18.78	20068231
106	Phosphorylation	LGSTIVMTKTPPVTT CCCEEEEECCCCCCC	22.37	20068231
108	Phosphorylation	STIVMTKTPPVTTNR CEEEEECCCCCCCCC	24.53	20068231
112	O-linked_Glycosylation	MTKTPPVTTNRQTIT EECCCCCCCCCCEEE	24.91	20068230
112	O-linked_Glycosylation	MTKTPPVTTNRQTIT EECCCCCCCCCCEEE	24.91	20068230
112	Phosphorylation	MTKTPPVTTNRQTIT EECCCCCCCCCCEEE	24.91	20068231
113	Phosphorylation	TKTPPVTTNRQTITL ECCCCCCCCCCEEEE	28.74	20068231
119	Phosphorylation	TTNRQTITLTKFIQT CCCCCEEEEEEHHHH	31.59	22210691
119	Ubiquitination	TTNRQTITLTKFIQT CCCCCEEEEEEHHHH	31.59	21890473
120	Ubiquitination	TNRQTITLTKFIQTT CCCCEEEEEEHHHHC	4.30	21890473
121	Phosphorylation	NRQTITLTKFIQTTA CCCEEEEEEHHHHCC	18.43	22210691
130	Phosphorylation	FIQTTASTRPSVSAP HHHHCCCCCCCCCCC	44.10	28555341
133	Phosphorylation	TTASTRPSVSAPTVR HCCCCCCCCCCCCHH	25.97	28555341
144	Phosphorylation	PTVRNAMTSAPSKDQ CCHHHHHCCCCCCCH	21.23	23186163
145	Phosphorylation	TVRNAMTSAPSKDQV CHHHHHCCCCCCCHH	25.71	23186163
148	Acetylation	NAMTSAPSKDQVQLK HHHCCCCCCCHHHHH	48.89	19608861
148	Phosphorylation	NAMTSAPSKDQVQLK HHHCCCCCCCHHHHH	48.89	23403867
149	Acetylation	AMTSAPSKDQVQLKD HHCCCCCCCHHHHHH	51.63	19608861
149	Ubiquitination	AMTSAPSKDQVQLKD HHCCCCCCCHHHHHH	51.63	19608861
152	Ubiquitination	SAPSKDQVQLKDLLK CCCCCCHHHHHHHHH	11.75	21890473
153	Ubiquitination	APSKDQVQLKDLLKN CCCCCHHHHHHHHHC	36.84	21890473
153 (in isoform 3)	Ubiquitination	-	36.84	21890473
154	Ubiquitination	PSKDQVQLKDLLKNN CCCCHHHHHHHHHCC	4.97	21890473
154 (in isoform 2)	Ubiquitination	-	4.97	21890473
154 (in isoform 4)	Ubiquitination	-	4.97	21890473
155	Ubiquitination	SKDQVQLKDLLKNNS CCCHHHHHHHHHCCC	29.28	21890473
155 (in isoform 1)	Ubiquitination	-	29.28	21890473
162	Phosphorylation	KDLLKNNSLNELMKL HHHHHCCCHHHHHCC	41.80	25159151
167	Sulfoxidation	NNSLNELMKLKPPAN CCCHHHHHCCCCCCC	3.78	21406390
190	Phosphorylation	ATDVSNGTVKKESSN CEECCCCCCCCCCCC	33.14	28555341
195	Phosphorylation	NGTVKKESSNKEGAR CCCCCCCCCCCCCCE	48.36	29449344
196	Phosphorylation	GTVKKESSNKEGARM CCCCCCCCCCCCCEE	53.68	29449344
212	Phosphorylation	INDMKMRSFSPTMKV HHCHHCCCCCCCCCC	26.95	30266825
214	Phosphorylation	DMKMRSFSPTMKVPV CHHCCCCCCCCCCCE	22.25	23401153
216	Phosphorylation	KMRSFSPTMKVPVVK HCCCCCCCCCCCEEC	28.55	30266825
291	Ubiquitination	TIDNGWLSALQLEAI HCCCCHHHHHHHHHH	22.03	24816145
292	Ubiquitination	IDNGWLSALQLEAIT CCCCHHHHHHHHHHH	9.35	24816145
324	Ubiquitination	FLIGDGAGVGKGRTI EEECCCCCCCCCCCC	33.95	24816145
325	Ubiquitination	LIGDGAGVGKGRTIA EECCCCCCCCCCCCH	7.69	24816145
326	Ubiquitination	IGDGAGVGKGRTIAG ECCCCCCCCCCCCHH	26.28	24816145
327	Ubiquitination	GDGAGVGKGRTIAGI CCCCCCCCCCCCHHH	42.70	24816145
342	Ubiquitination	IYENYLLSRKRALWF HHHCHHHCCCCCCEE	32.91	21890473
343	Ubiquitination	YENYLLSRKRALWFS HHCHHHCCCCCCEEE	32.23	21890473
350	Phosphorylation	RKRALWFSVSNDLKY CCCCCEEECCCCCCC	17.04	20873877
352	Phosphorylation	RALWFSVSNDLKYDA CCCEEECCCCCCCCH	24.35	20873877
356	Acetylation	FSVSNDLKYDAERDL EECCCCCCCCHHHHH	43.90	30592141
368	Ubiquitination	RDLRDIGAKNILVHS HHHHHHCHHHEEEEE	11.32	29967540
369	Acetylation	DLRDIGAKNILVHSL HHHHHCHHHEEEEEC	39.03	30592147
369	Ubiquitination	DLRDIGAKNILVHSL HHHHHCHHHEEEEEC	39.03	29967540
375	Ubiquitination	AKNILVHSLNKFKYG HHHEEEEECCCCCCC	26.59	21890473
376	Ubiquitination	KNILVHSLNKFKYGK HHEEEEECCCCCCCC	4.95	21890473
376 (in isoform 3)	Ubiquitination	-	4.95	21890473
377	Ubiquitination	NILVHSLNKFKYGKI HEEEEECCCCCCCCC	51.21	21890473
377 (in isoform 2)	Ubiquitination	-	51.21	21890473
377 (in isoform 4)	Ubiquitination	-	51.21	21890473
378	Acetylation	ILVHSLNKFKYGKIS EEEEECCCCCCCCCC	48.83	30592153
378	Ubiquitination	ILVHSLNKFKYGKIS EEEEECCCCCCCCCC	48.83	21890473
378 (in isoform 1)	Ubiquitination	-	48.83	21890473
380	Ubiquitination	VHSLNKFKYGKISSK EEECCCCCCCCCCCC	55.49	-
391	Phosphorylation	ISSKHNGSVKKGVIF CCCCCCCCCCCEEEE	35.76	24173317
393	Acetylation	SKHNGSVKKGVIFAT CCCCCCCCCEEEEEE	45.57	30592159
400	Phosphorylation	KKGVIFATYSSLIGE CCEEEEEEHHHHHCC	17.12	28270605
401	Phosphorylation	KGVIFATYSSLIGES CEEEEEEHHHHHCCC	7.88	28270605
402	Phosphorylation	GVIFATYSSLIGESQ EEEEEEHHHHHCCCC	17.83	28270605
403	Phosphorylation	VIFATYSSLIGESQS EEEEEHHHHHCCCCC	17.37	28270605
408	Phosphorylation	YSSLIGESQSGGKYK HHHHHCCCCCCCCHH	25.16	28270605
410	Phosphorylation	SLIGESQSGGKYKTR HHHCCCCCCCCHHHH	59.81	28270605
412	Acetylation	IGESQSGGKYKTRLK HCCCCCCCCHHHHHH	35.05	19608861
413	Acetylation	GESQSGGKYKTRLKQ CCCCCCCCHHHHHHH	47.28	19608861
465	Ubiquitination	AVLELQNKLPKARVV HHHHHHHCCCCCEEE	53.88	-
475	Phosphorylation	KARVVYASATGASEP CCEEEEEECCCCCCC	14.53	22210691
588	Phosphorylation	AEQRMKKSMWGQFWS HHHHHHHHHHHHHHH	17.78	-
595	Phosphorylation	SMWGQFWSAHQRFFK HHHHHHHHHHHHHHH	19.70	-
608	Phosphorylation	FKYLCIASKVKRVVQ HHHHHHHHHHHHHHH	20.33	24719451
663	Phosphorylation	TAKGVLQSLIEKHFP HHHHHHHHHHHHHCC	27.44	24719451
678	Phosphorylation	APDRKKLYSLLGIDL CCCHHHHHHHHCCCC	13.22	20068231
679	Phosphorylation	PDRKKLYSLLGIDLT CCHHHHHHHHCCCCC	27.79	20068231
686	Phosphorylation	SLLGIDLTAPSNNSS HHHCCCCCCCCCCCC	32.54	23401153
689	Phosphorylation	GIDLTAPSNNSSPRD CCCCCCCCCCCCCCC	46.29	23401153
692	Phosphorylation	LTAPSNNSSPRDSPC CCCCCCCCCCCCCCC	46.07	26503892
693	Phosphorylation	TAPSNNSSPRDSPCK CCCCCCCCCCCCCCC	26.52	26503892
697	Phosphorylation	NNSSPRDSPCKENKI CCCCCCCCCCCCCCC	33.21	26503892
713	Phosphorylation	KRKGEEITREAKKAR HCCHHHHHHHHHHHH	26.24	-
754	Phosphorylation	YESSKNMSSGDDDDF HHHHCCCCCCCCCCC	40.33	22617229
755	Phosphorylation	ESSKNMSSGDDDDFN HHHCCCCCCCCCCCC	35.16	22617229
768	Phosphorylation	FNPFLDESNEDDEND CCHHCCCCCCCCCCC	45.23	22496350
794	Phosphorylation	KEKKKKKSIDPDSIQ HHHHCCCCCCHHHHH	40.89	23927012
799	Phosphorylation	KKSIDPDSIQSALLA CCCCCHHHHHHHHHH	28.10	23927012
802	Phosphorylation	IDPDSIQSALLASGL CCHHHHHHHHHHCCC	21.15	23927012
807	Phosphorylation	IQSALLASGLGSKRP HHHHHHHCCCCCCCC	34.22	25159151
811	Phosphorylation	LLASGLGSKRPSFSS HHHCCCCCCCCCCCC	30.45	23927012
812	Acetylation	LASGLGSKRPSFSST HHCCCCCCCCCCCCC	67.54	25953088
815	Phosphorylation	GLGSKRPSFSSTPVI CCCCCCCCCCCCCEE	41.62	23401153
817	Phosphorylation	GSKRPSFSSTPVISP CCCCCCCCCCCEEEC	37.33	25159151
818	Phosphorylation	SKRPSFSSTPVISPA CCCCCCCCCCEEECC	34.42	25159151
819	Phosphorylation	KRPSFSSTPVISPAP CCCCCCCCCEEECCC	22.00	25159151
822	Phosphorylation	SFSSTPVISPAPNST CCCCCCEEECCCCCC	4.26	33259812
823	Phosphorylation	FSSTPVISPAPNSTP CCCCCEEECCCCCCC	18.42	25159151
828	Phosphorylation	VISPAPNSTPANSNT EEECCCCCCCCCCCC	34.41	28450419
829	Phosphorylation	ISPAPNSTPANSNTN EECCCCCCCCCCCCC	32.82	28450419
833	Phosphorylation	PNSTPANSNTNSNSS CCCCCCCCCCCCCCC	47.33	28450419
835	Phosphorylation	STPANSNTNSNSSLI CCCCCCCCCCCCCCC	39.58	28450419
837	Phosphorylation	PANSNTNSNSSLITS CCCCCCCCCCCCCCC	35.73	30576142
839	Phosphorylation	NSNTNSNSSLITSQD CCCCCCCCCCCCCHH	26.75	28450419
840	Phosphorylation	SNTNSNSSLITSQDA CCCCCCCCCCCCHHH	28.21	28450419
843	Phosphorylation	NSNSSLITSQDAVER CCCCCCCCCHHHHHH	26.15	28450419
844	Phosphorylation	SNSSLITSQDAVERA CCCCCCCCHHHHHHH	21.04	30576142
860	Ubiquitination	QMKKDLLDKLEKLAE HHHHHHHHHHHHHHH	61.87	29967540
861	Ubiquitination	MKKDLLDKLEKLAED HHHHHHHHHHHHHHH	59.52	29967540
899	Phosphorylation	GRKGRVVSNDDGSIS CCCCCEEECCCCCCE	31.52	27251275
904	Phosphorylation	VVSNDDGSISYESRS EEECCCCCCEEECCC	18.50	25627689
906	Phosphorylation	SNDDGSISYESRSEL ECCCCCCEEECCCCC	25.25	25627689
909	Phosphorylation	DGSISYESRSELDVP CCCCEEECCCCCCCC	32.64	27251275
911	Phosphorylation	SISYESRSELDVPVE CCEEECCCCCCCCEE	52.36	27732954
924	Ubiquitination	VEILNITEKQRFMDG EEEEECCCCHHCCCC	43.31	29967540
925	Ubiquitination	EILNITEKQRFMDGD EEEECCCCHHCCCCC	37.82	29967540
939	Phosphorylation	DKNIAIISEAASSGI CCCEEEEEHHHHCCC	18.31	22210691
944	Phosphorylation	IISEAASSGISLQAD EEEHHHHCCCCHHHH	35.10	22210691
947	Phosphorylation	EAASSGISLQADRRA HHHHCCCCHHHHHHH	20.25	22210691
1011	Ubiquitination	RFASIVAKRLESLGA HHHHHHHHHHHHCCC	46.77	-
1015	Phosphorylation	IVAKRLESLGALTHG HHHHHHHHCCCCCCC	36.37	-
1040	Acetylation	SRFNFDNKYGRNALE HHCCCCCCCCHHHHH	51.42	25953088
1050	Sulfoxidation	RNALEIVMKSIVNLD HHHHHHHHHHHHCCC	3.28	21406390
1058	Phosphorylation	KSIVNLDSPMVSPPP HHHHCCCCCCCCCCC	20.33	29523821
1062	Phosphorylation	NLDSPMVSPPPDYPG CCCCCCCCCCCCCCC	25.99	29523821
1067	Phosphorylation	MVSPPPDYPGEFFKD CCCCCCCCCCHHHHH	20.93	28102081
1119	Ubiquitination	GMEVHQQNALFQYFA CCHHHHHHHHHHHHH	31.85	24816145
1120	Ubiquitination	MEVHQQNALFQYFAD CHHHHHHHHHHHHHH	12.86	24816145
1151	Phosphorylation	MGILDLGSGDEKVRK EEEEECCCCCCHHCH	50.82	20873877
1152	Ubiquitination	GILDLGSGDEKVRKS EEEECCCCCCHHCHH	45.35	24816145
1153	Ubiquitination	ILDLGSGDEKVRKSD EEECCCCCCHHCHHH	55.00	24816145
1154	Ubiquitination	LDLGSGDEKVRKSDV EECCCCCCHHCHHHH	57.91	24816145
1155	Ubiquitination	DLGSGDEKVRKSDVK ECCCCCCHHCHHHHH	52.67	24816145
1166	Phosphorylation	SDVKKFLTPGYSTSG HHHHHHCCCCCCCCC	20.14	-
1221	Acetylation	NKKTAILVKEVNPKK CCCEEEEEEECCCCC	3.98	19608861
1221	Ubiquitination	NKKTAILVKEVNPKK CCCEEEEEEECCCCC	3.98	29967540
1222	Acetylation	KKTAILVKEVNPKKK CCEEEEEEECCCCCE	53.12	19608861
1222	Ubiquitination	KKTAILVKEVNPKKK CCEEEEEEECCCCCE	53.12	19608861
1252	Acetylation	EIYADLKKKYKKVVS EEEHHHHHHHHHHCC	69.50	25953088
1313	Phosphorylation	VLCGSVLSVWTKVEG HHCCCHHHHHHCCCE	17.29	-
1324	Phosphorylation	KVEGVLASVSGTNVK CCCEEEEECCCCCEE	16.80	-
1326	Phosphorylation	EGVLASVSGTNVKMQ CEEEEECCCCCEEEE	37.09	-
1328	Phosphorylation	VLASVSGTNVKMQIV EEEECCCCCEEEEEE	29.36	-
1386	Phosphorylation	WQQHHPQSITNLSNA HHHHCCHHHHHCCCC	35.51	14702039
1388	Phosphorylation	QHHPQSITNLSNA-- HHCCHHHHHCCCC--	35.04	23186163
1391	Phosphorylation	PQSITNLSNA----- CHHHHHCCCC-----	32.55	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SBNO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SBNO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SBNO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBM25_HUMAN	RBM25	physical	26344197
RTN4_HUMAN	RTN4	physical	26344197
NS1BP_HUMAN	IVNS1ABP	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-149; LYS-413 AND LYS-1222,AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-794 AND SER-815, ANDMASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 AND SER-794, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692; SER-693 ANDSER-697, AND MASS SPECTROMETRY.
PubMed: 17081983