HIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HIP1_HUMAN
• UniProt AC: O00291
• Protein Name: Huntingtin-interacting protein 1
• Gene Name: HIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1037
• Subcellular Localization: Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
• Protein Description: Plays a role in clathrin-mediated endocytosis and trafficking. [PubMed: 11532990]
• Protein Sequence: MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Methylation	-----MDRMASSMKQ -----CCHHHHHCCC	34.13	115478527
6	Phosphorylation	--MDRMASSMKQVPN --CCHHHHHCCCCCC	22.94	20068231
7	Phosphorylation	-MDRMASSMKQVPNP -CCHHHHHCCCCCCC	22.06	26074081
9	Ubiquitination	DRMASSMKQVPNPLP CHHHHHCCCCCCCHH	50.52	21890473
9	Ubiquitination	DRMASSMKQVPNPLP CHHHHHCCCCCCCHH	50.52	21890473
17	Ubiquitination	QVPNPLPKVLSRRGV CCCCCHHHHHHHCCC	64.59	21890473
17	Ubiquitination	QVPNPLPKVLSRRGV CCCCCHHHHHHHCCC	64.59	21890473
35	Phosphorylation	LEAAERESFERTQTV CHHHHHHCHHCCCEE	38.33	20058876
46	Ubiquitination	TQTVSINKAINTQEV CCEEEEHHHCCCCHH	49.31	-
50	O-linked_Glycosylation	SINKAINTQEVAVKE EEHHHCCCCHHHHHH	21.72	30379171
56	Malonylation	NTQEVAVKEKHARTC CCCHHHHHHHHCCEE	51.84	26320211
112	Malonylation	DGHPNVLKDSLRYRN CCCCCHHHHHHHHHH	40.77	32601280
114	Phosphorylation	HPNVLKDSLRYRNEL CCCHHHHHHHHHHHH	17.10	20873877
140	Phosphorylation	EGYGQLCSIYLKLLR CHHHHHHHHHHHHHH	23.90	29759185
142	Phosphorylation	YGQLCSIYLKLLRTK HHHHHHHHHHHHHHH	4.98	29759185
144	Ubiquitination	QLCSIYLKLLRTKME HHHHHHHHHHHHHHC	28.62	21890473
152	Phosphorylation	LLRTKMEYHTKNPRF HHHHHHCHHCCCCCC	15.99	-
155	Ubiquitination	TKMEYHTKNPRFPGN HHHCHHCCCCCCCCC	52.20	21890473
267	Phosphorylation	DRFMEQFTKLKDLFY HHHHHHHHHHHHHHH	34.85	24719451
283	Ubiquitination	SSNLQYFKRLIQIPQ HCCHHHHHHHHCCCC	41.16	-
302	Phosphorylation	PPNFLRASALSEHIS CCCCHHHHHHHCCCC	24.25	25850435
305	Phosphorylation	FLRASALSEHISPVV CHHHHHHHCCCCCEE	27.18	28450419
309	Phosphorylation	SALSEHISPVVVIPA HHHHCCCCCEEEEEC	17.35	25850435
319	Phosphorylation	VVIPAEASSPDSEPV EEEECCCCCCCCCCC	33.63	29255136
320	Phosphorylation	VIPAEASSPDSEPVL EEECCCCCCCCCCCC	39.51	29255136
323	Phosphorylation	AEASSPDSEPVLEKD CCCCCCCCCCCCCCC	47.38	29255136
338	Phosphorylation	DLMDMDASQQNLFDN CCCCCCHHHCHHCCC	28.21	25159151
381	Phosphorylation	DHLIERLYREISGLK HHHHHHHHHHHHCHH	16.66	28152594
385	Phosphorylation	ERLYREISGLKAQLE HHHHHHHHCHHHHHH	33.06	28152594
395	Ubiquitination	KAQLENMKTESQRVV HHHHHHCCCHHHHHH	61.80	-
396	Phosphorylation	AQLENMKTESQRVVL HHHHHCCCHHHHHHH	30.05	28111955
398	Phosphorylation	LENMKTESQRVVLQL HHHCCCHHHHHHHHH	28.63	28111955
453	Phosphorylation	DTEKAQRSLSEIERK HHHHHHHHHHHHHHH	24.94	23403867
455	Phosphorylation	EKAQRSLSEIERKAQ HHHHHHHHHHHHHHH	37.46	23403867
516	Phosphorylation	EKKELEDSLERISDQ HHHHHHHHHHHHHHH	23.82	21815630
521	Phosphorylation	EDSLERISDQGQRKT HHHHHHHHHHHHHHH	30.06	26074081
537	Phosphorylation	EQLEVLESLKQELAT HHHHHHHHHHHHHHH	36.38	24719451
579	Phosphorylation	ELEKERDSLVSGAAH HHHHHHHHHHCCHHH	36.57	28674419
612	Sulfoxidation	LASTEESMCQLAKDQ HHCCHHHHHHHHHHH	1.59	21406390
851	Phosphorylation	LQREIVESGRGTASP HHHHHHHCCCCCCCH	23.93	27251275
855	Phosphorylation	IVESGRGTASPKEFY HHHCCCCCCCHHHHH	23.70	23312004
857	Phosphorylation	ESGRGTASPKEFYAK HCCCCCCCHHHHHHH	36.02	25159151
862	Phosphorylation	TASPKEFYAKNSRWT CCCHHHHHHHCCCCC	20.11	26330541
866	Phosphorylation	KEFYAKNSRWTEGLI HHHHHHCCCCCHHHH	28.61	26330541
869	Phosphorylation	YAKNSRWTEGLISAS HHHCCCCCHHHHCHH	21.04	26330541
929	Phosphorylation	KVKADKDSPNLAQLQ HCCCCCCCCCHHHHH	22.79	28555341
1009	Phosphorylation	GELRKKHYELAGVAE HHHHHHHHHHHCHHC	22.86	20068231
1022	Phosphorylation	AEGWEEGTEASPPTL HCCCCCCCCCCCCCH	31.49	28348404
1025	Phosphorylation	WEEGTEASPPTLQEV CCCCCCCCCCCHHHH	25.77	20068231
1028	Phosphorylation	GTEASPPTLQEVVTE CCCCCCCCHHHHHHC	44.45	20068231
1034	Phosphorylation	PTLQEVVTEKE---- CCHHHHHHCCC----	46.65	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
152	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HD_HUMAN	HTT	physical	11063258
HIP1R_HUMAN	HIP1R	physical	11889126
CLH1_HUMAN	CLTC	physical	11604514
IFT57_HUMAN	IFT57	physical	11788820
CASP8_HUMAN	CASP8	physical	11788820
CLH1_HUMAN	CLTC	physical	11532990
HD_HUMAN	HTT	physical	15383276
BFAR_HUMAN	BFAR	physical	14502241
CLH1_BOVIN	CLTC	physical	22820750
CLH1_HUMAN	CLTC	physical	22820750
HIP1_HUMAN	HIP1	physical	25416956
REL_HUMAN	REL	physical	25416956
DAZP2_HUMAN	DAZAP2	physical	25416956
CLH1_HUMAN	CLTC	physical	25241761
EGFR_HUMAN	EGFR	physical	17440072

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.