| UniProt ID | CLH1_BOVIN | |
|---|---|---|
| UniProt AC | P49951 | |
| Protein Name | Clathrin heavy chain 1 | |
| Gene Name | CLTC | |
| Organism | Bos taurus (Bovine). | |
| Sequence Length | 1675 | |
| Subcellular Localization |
Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side. Membrane, coated pit Peripheral membrane protein Cytoplasmic side. Melanosome. Cytoplasm, cytoskeleton, spindle . Cytoplasmic face of coated pits and vesicles. In complex |
|
| Protein Description | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation.. | |
| Protein Sequence | MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPAYGQPQPGFGYSM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAQILPIRF ------CCCCCCCCH | - | ||
| 67 | Phosphorylation | NPIRRPISADSAIMN CCCCCCCCCCHHHCC | - | ||
| 105 | Phosphorylation | KMKAHTMTDDVTFWK HCCCCCCCCCCCHHH | - | ||
| 184 | Phosphorylation | VVGAMQLYSVDRKVS CCCCEEEEECCCCCC | - | ||
| 394 | Phosphorylation | APKGILRTPDTIRRF CCCCCCCCHHHHHHH | - | ||
| 634 | Phosphorylation | LEHFTDLYDIKRAVV HHHHHHHHHHHHHHH | - | ||
| 737 | Succinylation | KYIQAACKTGQIKEV HHHHHHHHCCCHHHH | - | ||
| 737 | Succinylation | KYIQAACKTGQIKEV HHHHHHHHCCCHHHH | - | ||
| 856 | Acetylation | VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH | - | ||
| 899 | Phosphorylation | RFLRENPYYDSRVVG HHHCCCCCCCHHHHH | - | ||
| 1167 | Phosphorylation | ARKKARESYVETELI HHHHHHHHHHHHHHH | - | ||
| 1206 | Phosphorylation | QQVGDRCYDEKMYDA HHHHHHHCCHHHHHH | - | ||
| 1229 | Phosphorylation | SNFGRLASTLVHLGE CHHHHHHHHHHHHHC | - | ||
| 1441 | Acetylation | RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC | - | ||
| 1441 | Succinylation | RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC | - | ||
| 1441 | Succinylation | RAVNYFSKVKQLPLV HHHHHHHHCCCCCCC | - | ||
| 1477 | Phosphorylation | LFITEEDYQALRTSI CCCCHHHHHHHHHHH | - | ||
| 1487 | Phosphorylation | LRTSIDAYDNFDNIS HHHHHHHCCCCCCCC | - | ||
| 1494 | Phosphorylation | YDNFDNISLAQRLEK CCCCCCCCHHHHHHH | - | ||
| 1501 | Acetylation | SLAQRLEKHELIEFR CHHHHHHHHCHHHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLH1_BOVIN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLH1_BOVIN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLH1_BOVIN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CLH1_BOVIN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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