PUS7L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PUS7L_HUMAN
• UniProt AC: Q9H0K6
• Protein Name: Pseudouridylate synthase 7 homolog-like protein
• Gene Name: PUS7L {ECO:0000312|HGNC:HGNC:25276}
• Organism: Homo sapiens (Human).
• Sequence Length: 701
• Protein Description: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs..
• Protein Sequence: MEEDTDYRIRFSSLCFFNDHVGFHGTIKSSPSDFIVIEIDEQGQLVNKTIDEPIFKISEIQLEPNNFPKKPKLDLQNLSLEDGRNQEVHTLIKYTDGDQNHQSGSEKEDTIVDGTSKCEEKADVLSSFLDEKTHELLNNFACDVREKWLSKTELIGLPPEFSIGRILDKNQRASLHSAIRQKFPFLVTVGKNSEIVVKPNLEYKELCHLVSEEEAFDFFKYLDAKKENSKFTFKPDTNKDHRKAVHHFVNKKFGNLVETKSFSKMNCSAGNPNVVVTVRFREKAHKRGKRPLSECQEGKVIYTAFTLRKENLEMFEAIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKNIEKEIEKKRMNVFNIRSVDDSLRLGQLKGNHFDIVIRNLKKQINDSANLRERIMEAIENVKKKGFVNYYGPQRFGKGRKVHTDQIGLALLKNEMMKAIKLFLTPEDLDDPVNRAKKYFLQTEDAKGTLSLMPEFKVRERALLEALHRFGMTEEGCIQAWFSLPHSMRIFYVHAYTSKIWNEAVSYRLETYGARVVQGDLVCLDEDIDDENFPNSKIHLVTEEEGSANMYAIHQVVLPVLGYNIQYPKNKVGQWYHDILSRDGLQTCRFKVPTLKLNIPGCYRQILKHPCNLSYQLMEDHDIDVKTKGSHIDETALSLLISFDLDASCYATVCLKEIMKHDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEDTDYRIRFS ---CCCCCCCEEEEE	37.90	-
25	Ubiquitination	NDHVGFHGTIKSSPS CCCCEECCEECCCCC	27.20	29967540
28	Ubiquitination	VGFHGTIKSSPSDFI CEECCEECCCCCCEE	44.72	-
49	Phosphorylation	QGQLVNKTIDEPIFK CCCEECCCCCCCCEE	28.58	-
54	Ubiquitination	NKTIDEPIFKISEIQ CCCCCCCCEEEEEEE	5.30	24816145
56	Ubiquitination	TIDEPIFKISEIQLE CCCCCCEEEEEEECC	46.15	29967540
75	Ubiquitination	PKKPKLDLQNLSLED CCCCCCCCCCCCCCC	5.43	-
79	Phosphorylation	KLDLQNLSLEDGRNQ CCCCCCCCCCCCCCC	36.94	25159151
88	Ubiquitination	EDGRNQEVHTLIKYT CCCCCCEEEEEEEEC	2.77	-
88	Ubiquitination	EDGRNQEVHTLIKYT CCCCCCEEEEEEEEC	2.77	29967540
94	Phosphorylation	EVHTLIKYTDGDQNH EEEEEEEECCCCCCC	11.76	28450419
95	Phosphorylation	VHTLIKYTDGDQNHQ EEEEEEECCCCCCCC	28.62	28450419
103	Phosphorylation	DGDQNHQSGSEKEDT CCCCCCCCCCCCCCE	36.41	28450419
105	Phosphorylation	DQNHQSGSEKEDTIV CCCCCCCCCCCCEEC	51.22	28450419
108	Ubiquitination	HQSGSEKEDTIVDGT CCCCCCCCCEECCCC	57.23	-
110	Phosphorylation	SGSEKEDTIVDGTSK CCCCCCCEECCCCCH	24.80	23186163
110	Ubiquitination	SGSEKEDTIVDGTSK CCCCCCCEECCCCCH	24.80	-
121	Ubiquitination	GTSKCEEKADVLSSF CCCHHHHHHHHHHHH	27.82	29967540
127	Phosphorylation	EKADVLSSFLDEKTH HHHHHHHHHHCHHHH	26.18	21082442
146	Ubiquitination	NFACDVREKWLSKTE HHCCHHHHHHHHHCH	48.72	29967540
163	Ubiquitination	GLPPEFSIGRILDKN CCCCCCCHHHHCCCC	5.37	29967540
172	Ubiquitination	RILDKNQRASLHSAI HHCCCCHHHHHHHHH	35.22	-
261	Phosphorylation	GNLVETKSFSKMNCS CCEEECCCCCCCCCC	42.02	24719451
264	Methylation	VETKSFSKMNCSAGN EECCCCCCCCCCCCC	31.93	115975943
293	Phosphorylation	KRGKRPLSECQEGKV HCCCCCHHHHHCCCC	38.72	25159151
306	Phosphorylation	KVIYTAFTLRKENLE CCEEEEEEECHHHHH	24.16	24719451
321	Ubiquitination	MFEAIGFLAIKLGVI HHHHHHHHHHHHCCC	3.98	-
338	Ubiquitination	DFSYAGLKDKKAITY CCCCCCCCCCCCEEE	67.59	29967540
341	Ubiquitination	YAGLKDKKAITYQAM CCCCCCCCCEEEEEE	55.97	-
341	Acetylation	YAGLKDKKAITYQAM CCCCCCCCCEEEEEE	55.97	24888479
344	Phosphorylation	LKDKKAITYQAMVVR CCCCCCEEEEEEEEE	17.91	22210691
345	Phosphorylation	KDKKAITYQAMVVRK CCCCCEEEEEEEEEC	6.53	22210691
352	Acetylation	YQAMVVRKVTPERLK EEEEEEECCCHHHHH	38.56	24888487
367	Ubiquitination	NIEKEIEKKRMNVFN HHHHHHHHHCCCCCC	51.87	24816145
376	Ubiquitination	RMNVFNIRSVDDSLR CCCCCCCCCCCCCCC	31.56	24816145
377	Phosphorylation	MNVFNIRSVDDSLRL CCCCCCCCCCCCCCH	26.54	29396449
379	Ubiquitination	VFNIRSVDDSLRLGQ CCCCCCCCCCCCHHC	40.82	24816145
381	Phosphorylation	NIRSVDDSLRLGQLK CCCCCCCCCCHHCCC	15.78	29396449
388	Ubiquitination	SLRLGQLKGNHFDIV CCCHHCCCCCHHHHH	50.18	-
388	Methylation	SLRLGQLKGNHFDIV CCCHHCCCCCHHHHH	50.18	115975949
401	Ubiquitination	IVIRNLKKQINDSAN HHHHHHHHHCCCCHH	60.62	29967540
421	Ubiquitination	MEAIENVKKKGFVNY HHHHHHHHHCCCCCC	61.42	-
422	Ubiquitination	EAIENVKKKGFVNYY HHHHHHHHCCCCCCC	54.57	-
423	Ubiquitination	AIENVKKKGFVNYYG HHHHHHHCCCCCCCC	52.44	-
428	Phosphorylation	KKKGFVNYYGPQRFG HHCCCCCCCCCCCCC	12.42	-
429	Phosphorylation	KKGFVNYYGPQRFGK HCCCCCCCCCCCCCC	19.68	29496907
459	Ubiquitination	NEMMKAIKLFLTPED HHHHHHHHHHCCHHH	37.74	29967540
476	Ubiquitination	DPVNRAKKYFLQTED CHHHHHHHHHCCCCC	40.00	29967540
485	Ubiquitination	FLQTEDAKGTLSLMP HCCCCCCCCCCCCCC	65.82	-
489	Phosphorylation	EDAKGTLSLMPEFKV CCCCCCCCCCCCHHH	23.59	-
614	Phosphorylation	KNKVGQWYHDILSRD CCCCCHHHHHHHCCC	5.03	30206219
619	Phosphorylation	QWYHDILSRDGLQTC HHHHHHHCCCCCCCC	28.76	30206219
625	Phosphorylation	LSRDGLQTCRFKVPT HCCCCCCCCEEECCC	15.64	30206219
634	Ubiquitination	RFKVPTLKLNIPGCY EEECCCEECCCCCHH	41.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PUS7L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PUS7L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PUS7L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TRI41_HUMAN	TRIM41	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.