dbPTM

XPR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	XPR1_HUMAN
UniProt AC	Q9UBH6
Protein Name	Xenotropic and polytropic retrovirus receptor 1
Gene Name	XPR1
Organism	Homo sapiens (Human).
Sequence Length	696
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. [PubMed: 23791524]
Protein Sequence	MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAIVQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIEDTDDEANT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48 (in isoform 2)	Ubiquitination	-	43.40	21890473
48 (in isoform 1)	Ubiquitination	-	43.40	21890473
48	Ubiquitination	VTDEDTVKRYFAKFE CCCHHHHHHHHHHHH	43.40	21906983
50	Phosphorylation	DEDTVKRYFAKFEEK CHHHHHHHHHHHHHH	11.37	18212344
57	Ubiquitination	YFAKFEEKFFQTCEK HHHHHHHHHHHHHHH	44.26	-
64	Ubiquitination	KFFQTCEKELAKINT HHHHHHHHHHHHHHH	61.24	-
76 (in isoform 2)	Ubiquitination	-	47.24	21890473
76 (in isoform 1)	Ubiquitination	-	47.24	21890473
76	Ubiquitination	INTFYSEKLAEAQRR HHHHHHHHHHHHHHH	47.24	21906983
99	Ubiquitination	QSSLDAQKESTGVTT HHHHHHHHHHHCCCH	56.18	-
99 (in isoform 2)	Ubiquitination	-	56.18	-
102	Phosphorylation	LDAQKESTGVTTLRQ HHHHHHHHCCCHHHH	36.44	29255136
105	Phosphorylation	QKESTGVTTLRQRRK HHHHHCCCHHHHHCC	22.81	29255136
106	Phosphorylation	KESTGVTTLRQRRKP HHHHCCCHHHHHCCC	19.96	29255136
162	Ubiquitination	GFRKILKKHDKILET CHHHHHHHCHHHHHH	54.30	-
165	Ubiquitination	KILKKHDKILETSRG HHHHHCHHHHHHCCC	49.24	-
273	Methylation	WPLIRIYRGGFLLIE HHHHHHHHCCCHHHH	36.07	24377067
273	Dimethylation	WPLIRIYRGGFLLIE HHHHHHHHCCCHHHH	36.07	-
474 (in isoform 2)	Ubiquitination	-	4.56	-
483	Phosphorylation	HLVNAGKYSTTFFMV HHHHCCCCCCHHHHH	15.44	-
498	Phosphorylation	TFAALYSTHKERGHS HHHHHHHHHHHCCCC	24.34	-
539	Ubiquitination	MDWGLFDKNAGENTF CCCCCCCCCCCCCCE	41.17	-
574	Phosphorylation	VILRFAWTIQISITS HHHHHHEEEEEEEEE	10.28	-
594	Phosphorylation	HSGDIIATVFAPLEV CCCCEEEEEECCHHH	13.02	-
597 (in isoform 2)	Ubiquitination	-	11.93	21890473
619 (in isoform 2)	Ubiquitination	-	41.34	21890473
660	Phosphorylation	RNRQKNRSWKYNQSI HHHHHHHCCCCCCCC	37.00	19581576
662	Ubiquitination	RQKNRSWKYNQSISL HHHHHCCCCCCCCCC	35.25	21890473
662 (in isoform 1)	Ubiquitination	-	35.25	21890473
663	Phosphorylation	QKNRSWKYNQSISLR HHHHCCCCCCCCCCC	16.51	22167270
666	Phosphorylation	RSWKYNQSISLRRPR HCCCCCCCCCCCCCC	15.54	22167270
668	Phosphorylation	WKYNQSISLRRPRLA CCCCCCCCCCCCCHH	22.52	22167270
676	Phosphorylation	LRRPRLASQSKARDT CCCCCHHCCCCCCCC	39.31	26074081
678	Phosphorylation	RPRLASQSKARDTKV CCCHHCCCCCCCCEE	26.28	26074081
684	Ubiquitination	QSKARDTKVLIEDTD CCCCCCCEEEEECCC	39.06	2190698
684 (in isoform 1)	Ubiquitination	-	39.06	21890473
690	Phosphorylation	TKVLIEDTDDEANT- CEEEEECCCCCCCC-	32.34	30266825
696	Phosphorylation	DTDDEANT------- CCCCCCCC-------	47.22	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of XPR1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of XPR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of XPR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
KDIS_HUMAN	KIDINS220	physical	28514442
B3A2_HUMAN	SLC4A2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616413	Basal ganglia calcification, idiopathic, 6 (IBGC6)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of XPR1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-668 AND THR-690, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-666; SER-668 ANDTHR-690, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-690, AND MASSSPECTROMETRY.	19413330 [Abstract]