TPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPC_HUMAN
• UniProt AC: Q9HC21
• Protein Name: Mitochondrial thiamine pyrophosphate carrier
• Gene Name: SLC25A19
• Organism: Homo sapiens (Human).
• Sequence Length: 320
• Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.
• Protein Description: Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria..
• Protein Sequence: MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCNVFHCMNRTASQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVGYDPKPDGR ----CCCCCCCCCCC	20.05	20860994
23	Phosphorylation	FQVAVAGSVSGLVTR EEEEEECCHHHHHHH	11.90	23403867
25	Phosphorylation	VAVAGSVSGLVTRAL EEEECCHHHHHHHHH	28.27	23403867
51	Phosphorylation	QLQHERLSRSDPSAK HHHHHHHCCCCCCHH	35.64	19798730
53	Phosphorylation	QHERLSRSDPSAKYH HHHHHCCCCCCHHHH	50.96	-
56	Phosphorylation	RLSRSDPSAKYHGIL HHCCCCCCHHHHHHH	42.24	-
153	Ubiquitination	FAAQGEPKVYNTLRH HHHCCCCCHHHHHHH	53.72	21890473
155	Phosphorylation	AQGEPKVYNTLRHAV HCCCCCHHHHHHHHH	14.46	-
181	Phosphorylation	FYKGLAPTLIAIFPY HHCCCHHHHHHHCCC	25.78	-
188	Phosphorylation	TLIAIFPYAGLQFSC HHHHHCCCCCCCHHH	11.53	-
218	Ubiquitination	GKKNENLQNLLCGSG CCCCCCHHHHHCCCC	50.54	21890473
218	Ubiquitination	GKKNENLQNLLCGSG CCCCCCHHHHHCCCC	50.54	-
234	Phosphorylation	GVISKTLTYPLDLFK CHHHCCCCCCHHHHH	28.46	-
241	Acetylation	TYPLDLFKKRLQVGG CCCHHHHHHHHHHCC	44.26	25038526
263	Acetylation	FGQVRRYKGLMDCAK HHHHHHHHCHHHHHH	43.70	91041
275	Ubiquitination	CAKQVLQKEGALGFF HHHHHHHHCCCCHHH	54.69	21890473
275	Succinylation	CAKQVLQKEGALGFF HHHHHHHHCCCCHHH	54.69	27452117
286	Phosphorylation	LGFFKGLSPSLLKAA CHHHCCCCHHHHHHH	22.55	-
288	Phosphorylation	FFKGLSPSLLKAALS HHCCCCHHHHHHHHH	42.85	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPC_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TPC_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H00990: Microcephaly, Amish type
• OMIM Disease
• 607196: Microcephaly, Amish type (MCPHA)
• 613710: Thiamine metabolism dysfunction syndrome 4, bilateral striatal degeneration and progressive polyneuropathy type (THMD4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.