dbPTM

TNR6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TNR6A_HUMAN
UniProt AC	Q8NDV7
Protein Name	Trinucleotide repeat-containing gene 6A protein
Gene Name	TNRC6A
Organism	Homo sapiens (Human).
Sequence Length	1962
Subcellular Localization	Cytoplasm, P-body . Mammalian P-bodies are also known as GW bodies (GWBs).
Protein Description	Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes..
Protein Sequence	MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSNISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKDGIVADESQNMQFMSSQSMKLPPSNSALPNQALGSIAGLGMQNLNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQQDQQGRPLSVQQQMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSNLNVNMDMNSIKEPQSRLRKWTTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTPGSVINNLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSSSDPRGISSPSPINAFLSVDHLGGGGESM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 4)	Phosphorylation	-	27.25	22210691
17	Phosphorylation	KDVERNLSRDLVQEE HHHHHHHHHHHHHHH	27.57	24719451
22 (in isoform 4)	Phosphorylation	-	60.73	22210691
23 (in isoform 4)	Phosphorylation	-	56.90	22210691
60	Ubiquitination	IKVPEQIKPSVSQPQ CCCCHHHCCCCCCCC	30.82	30230243
69	Ubiquitination	SVSQPQPANSNNGTS CCCCCCCCCCCCCCC	27.17	30230243
132	Phosphorylation	QPQALPRYPREVPPR CCCCCCCCCCCCCCC	12.52	23917254
146	Ubiquitination	RFRHQEHKQLLKRGQ CCCHHHHHHHHHCCC	41.72	-
164	Phosphorylation	VIAANLGSAVKVLNS HEEEHHHHHHHHHCC	32.81	25159151
203	Phosphorylation	SDINHSTSGSHYENS HHCCCCCCCCCCCCC	41.11	28796482
205	Phosphorylation	INHSTSGSHYENSQR CCCCCCCCCCCCCCC	23.74	28796482
207	Phosphorylation	HSTSGSHYENSQRGP CCCCCCCCCCCCCCC	20.64	28796482
210	Phosphorylation	SGSHYENSQRGPVSS CCCCCCCCCCCCCCC	14.87	28796482
273	Phosphorylation	RNITIMASGNTGGEK HCEEEEECCCCCCCC	18.39	24505115
286	Phosphorylation	EKDGLRNSTGLGSQN CCCCCCCCCCCCCCC	19.88	28985074
299	Phosphorylation	QNKFVVGSSSNNVGH CCCEEECCCCCCCCC	20.98	30576142
301	Phosphorylation	KFVVGSSSNNVGHGS CEEECCCCCCCCCCC	33.84	30576142
316	Phosphorylation	STGPWGFSHGAIIST CCCCCCCCCCEEEEE	19.64	30576142
333	Phosphorylation	VSVDAPESKSESSNN EECCCCCCCCCCCCC	40.18	-
337	Phosphorylation	APESKSESSNNRMNA CCCCCCCCCCCCCCE	45.52	30257219
338	Phosphorylation	PESKSESSNNRMNAW CCCCCCCCCCCCCEE	33.79	29449344
422	Phosphorylation	STHGTWGSLQETCES CCCCCCCCHHHHHHC	20.59	-
426	Phosphorylation	TWGSLQETCESEVSG CCCCHHHHHHCCCCC	14.49	-
429	Phosphorylation	SLQETCESEVSGTQK CHHHHHHCCCCCCEE	45.50	-
486	Phosphorylation	NTGAWRVSTMNHPQM CCCCCEEECCCCCCC	17.23	20068231
487	Phosphorylation	TGAWRVSTMNHPQMQ CCCCEEECCCCCCCC	21.09	20068231
497	Phosphorylation	HPQMQAPSGMNGTSL CCCCCCCCCCCCCCH	54.40	20068231
502	Phosphorylation	APSGMNGTSLSHLSN CCCCCCCCCHHHCCC	22.84	20068231
503	Phosphorylation	PSGMNGTSLSHLSNG CCCCCCCCHHHCCCC	29.31	20068231
505	Phosphorylation	GMNGTSLSHLSNGES CCCCCCHHHCCCCCC	23.34	20068231
603	Phosphorylation	GSRRGWGTPAQNTGT CCCCCCCCCCCCCCC	14.67	25159151
643	Phosphorylation	TFTNGWKSTEEEDQG CCCCCCCCCCCCCCC	34.24	26471730
644	Phosphorylation	FTNGWKSTEEEDQGS CCCCCCCCCCCCCCC	43.63	26471730
651	Phosphorylation	TEEEDQGSATSQTNE CCCCCCCCCCCCCCC	23.81	26471730
653	Phosphorylation	EEDQGSATSQTNEQS CCCCCCCCCCCCCCC	24.06	26471730
654	Phosphorylation	EDQGSATSQTNEQSS CCCCCCCCCCCCCCC	34.42	26471730
656	Phosphorylation	QGSATSQTNEQSSVW CCCCCCCCCCCCCEE	40.25	28985074
672	Phosphorylation	KTGGTVESDGSTEST ECCCEECCCCCCCCC	42.82	21815630
678	Phosphorylation	ESDGSTESTGRLEEK CCCCCCCCCCCCEEC	35.93	25627689
702	Phosphorylation	RRKIDQHTLLQSIVN HHHCCHHHHHHHHHH	24.43	23403867
706	Phosphorylation	DQHTLLQSIVNRTDL CHHHHHHHHHHCCCC	28.59	22210691
726	Phosphorylation	SNSGWGQTPIKQNTA CCCCCCCCCCCCCCC	24.04	28985074
732	Phosphorylation	QTPIKQNTAWDTETS CCCCCCCCCCCCCCC	26.99	23927012
736	Phosphorylation	KQNTAWDTETSPRGE CCCCCCCCCCCCCCC	30.38	30266825
738	Phosphorylation	NTAWDTETSPRGERK CCCCCCCCCCCCCEE	46.23	30266825
739	Phosphorylation	TAWDTETSPRGERKT CCCCCCCCCCCCEEC	13.33	19664994
770	Phosphorylation	SGACIDKTSPNGNDT CCCCEECCCCCCCCC	45.74	22199227
771	Phosphorylation	GACIDKTSPNGNDTS CCCEECCCCCCCCCC	23.31	22199227
777	Phosphorylation	TSPNGNDTSSVSGWG CCCCCCCCCCCCCCC	27.22	27251275
778	Phosphorylation	SPNGNDTSSVSGWGD CCCCCCCCCCCCCCC	31.44	29978859
779	Phosphorylation	PNGNDTSSVSGWGDP CCCCCCCCCCCCCCC	23.53	29978859
781	Phosphorylation	GNDTSSVSGWGDPKP CCCCCCCCCCCCCCC	30.67	29978859
795	Phosphorylation	PALRWGDSKGSNCQG CCCCCCCCCCCCCCC	34.67	29978859
846	Phosphorylation	WGDGQKSSQGWSVSA CCCCCCCCCCEEEEC	39.48	30576142
850	Phosphorylation	QKSSQGWSVSASDNW CCCCCCEEEECCCCC	17.02	30576142
860	Phosphorylation	ASDNWGETSRNNHWG CCCCCCCCCCCCCCC	29.11	30576142
873	Phosphorylation	WGEANKKSSSGGSDS CCCCCCCCCCCCCCC	31.20	23090842
874	Phosphorylation	GEANKKSSSGGSDSD CCCCCCCCCCCCCCC	41.71	23090842
875	Phosphorylation	EANKKSSSGGSDSDR CCCCCCCCCCCCCCC	55.02	22199227
878	Phosphorylation	KKSSSGGSDSDRSVS CCCCCCCCCCCCCCC	37.15	22199227
880	Phosphorylation	SSSGGSDSDRSVSGW CCCCCCCCCCCCCCC	36.30	23090842
883	Phosphorylation	GGSDSDRSVSGWNEL CCCCCCCCCCCCCCC	26.14	23090842
885	Phosphorylation	SDSDRSVSGWNELGK CCCCCCCCCCCCCCC	39.06	23090842
928	Phosphorylation	GWGDPPKSNQSLGWG CCCCCCCCCCCCCCC	45.97	23403867
931	Phosphorylation	DPPKSNQSLGWGDSS CCCCCCCCCCCCCCC	32.85	26074081
937	Phosphorylation	QSLGWGDSSKPVSSP CCCCCCCCCCCCCCC	36.00	28102081
938	Phosphorylation	SLGWGDSSKPVSSPD CCCCCCCCCCCCCCC	45.80	27794612
942	Phosphorylation	GDSSKPVSSPDWNKQ CCCCCCCCCCCHHHC	44.68	23401153
943	Phosphorylation	DSSKPVSSPDWNKQQ CCCCCCCCCCHHHCC	27.41	25159151
951	Phosphorylation	PDWNKQQDIVGSWGI CCHHHCCCCCCCCCC	34.74	32142685
955	Phosphorylation	KQQDIVGSWGIPPAT HCCCCCCCCCCCCCC	15.96	24247654
962	Phosphorylation	SWGIPPATGKPPGTG CCCCCCCCCCCCCCC	52.06	24247654
985	Phosphorylation	PAKEEEPTGWEEPSP CCCCCCCCCCCCCCH	59.20	30108239
991	Phosphorylation	PTGWEEPSPESIRRK CCCCCCCCHHHHHHH	44.58	19664994
994	Phosphorylation	WEEPSPESIRRKMEI CCCCCHHHHHHHCCC	25.44	30108239
1014	Phosphorylation	AWGDPSKYNYKNVNM CCCCHHHCCCCCCCC	28.23	-
1016	Phosphorylation	GDPSKYNYKNVNMWN CCHHHCCCCCCCCCC	10.80	-
1044	Phosphorylation	AQVHQLLTPASAISN HHHHHHHCHHHHHCC	25.96	25159151
1047	Phosphorylation	HQLLTPASAISNKEA HHHHCHHHHHCCCCC	27.60	28555341
1175	Phosphorylation	PYTKKMSSKGLSGKK HHHHHCCCCCCCCHH	27.52	17287340
1176	Ubiquitination	YTKKMSSKGLSGKKR HHHHCCCCCCCCHHH	57.47	-
1209	Phosphorylation	NPFVKQFSNISFSRD CHHHHHHCCCCCCCC	30.66	22199227
1212	Phosphorylation	VKQFSNISFSRDSPE HHHHCCCCCCCCCHH	22.78	23401153
1214	Phosphorylation	QFSNISFSRDSPEEN HHCCCCCCCCCHHHH	28.52	25849741
1217	Phosphorylation	NISFSRDSPEENVQS CCCCCCCCHHHHHHC	32.85	30266825
1224	Phosphorylation	SPEENVQSNKMDLSG CHHHHHHCCCCCCCC	33.85	30266825
1230	Phosphorylation	QSNKMDLSGGMLQDK HCCCCCCCCCCCCCC	29.09	23917254
1237	Methylation	SGGMLQDKRMEIDKH CCCCCCCCCCEECCC	40.46	115918701
1238	Methylation	GGMLQDKRMEIDKHS CCCCCCCCCEECCCC	35.93	115368403
1245	Phosphorylation	RMEIDKHSLNIGDYN CCEECCCCCCHHHCC	28.93	19664994
1251	Phosphorylation	HSLNIGDYNRTVGKG CCCCHHHCCCCCCCC	11.00	19664994
1254	Phosphorylation	NIGDYNRTVGKGPGS CHHHCCCCCCCCCCC	29.94	28555341
1266	O-linked_Glycosylation	PGSRPQISKESSMER CCCCCCCCCCCCCCC	25.73	30059200
1269	Phosphorylation	RPQISKESSMERNPY CCCCCCCCCCCCCCC	38.43	23186163
1270	Phosphorylation	PQISKESSMERNPYF CCCCCCCCCCCCCCC	26.25	25159151
1276	Phosphorylation	SSMERNPYFDKDGIV CCCCCCCCCCCCCCC	28.14	23186163
1303	Phosphorylation	QSMKLPPSNSALPNQ CCCCCCCCCCCCCCH	41.29	22210691
1345	Methylation	GNTAAQPRGMQQPPA CCCCCCCCCCCCCCC	40.93	115918705
1356	Phosphorylation	QPPAQPLSSSQPNLR CCCCCCCCCCCCCHH	34.33	27251275
1357	Phosphorylation	PPAQPLSSSQPNLRA CCCCCCCCCCCCHHC	40.45	28985074
1358	Phosphorylation	PAQPLSSSQPNLRAQ CCCCCCCCCCCHHCC	46.40	27050516
1372	Phosphorylation	QVPPPLLSPQVPVSL CCCCCCCCCCCCHHH	22.44	28122231
1378	Phosphorylation	LSPQVPVSLLKYAPN CCCCCCHHHHCCCCC	23.16	24719451
1431	Phosphorylation	QRAQSQRSVPSGNRP HHHHHHCCCCCCCCC	30.64	-
1434	Phosphorylation	QSQRSVPSGNRPQQD HHHCCCCCCCCCCCC	46.69	-
1448	Phosphorylation	DQQGRPLSVQQQMMQ CCCCCCCHHHHHHHH	22.14	30266825
1457	Phosphorylation	QQQMMQQSRQLDPNL HHHHHHHHHCCCCCH	12.71	30266825
1470	Phosphorylation	NLLVKQQTPPSQQQP CHHHCCCCCHHHCCC	34.37	22199227
1473	Phosphorylation	VKQQTPPSQQQPLHQ HCCCCCHHHCCCCCC	41.65	28985074
1484	Ubiquitination	PLHQPAMKSFLDNVM CCCCHHHHHHHHHCC	39.91	-
1494	Phosphorylation	LDNVMPHTTPELQKG HHHCCCCCCHHHHCC	37.87	22199227
1495	Phosphorylation	DNVMPHTTPELQKGP HHCCCCCCHHHHCCC	16.25	22199227
1503	Phosphorylation	PELQKGPSPINAFSN HHHHCCCCCCCCCCC	47.26	26074081
1509	Phosphorylation	PSPINAFSNFPIGLN CCCCCCCCCCCCCCC	34.84	18669648
1533	Phosphorylation	NSIKEPQSRLRKWTT CCCCCHHHHHCCCEE	43.95	18669648
1539	Phosphorylation	QSRLRKWTTVDSISV HHHHCCCEECCEEEE	21.70	24114839
1540	Phosphorylation	SRLRKWTTVDSISVN HHHCCCEECCEEEEC	22.62	24114839
1545	Phosphorylation	WTTVDSISVNTSLDQ CEECCEEEECCCCCC	17.17	-
1548	Phosphorylation	VDSISVNTSLDQNSS CCEEEECCCCCCCCC	28.63	-
1549	Phosphorylation	DSISVNTSLDQNSSK CEEEECCCCCCCCCC	25.42	-
1554	Phosphorylation	NTSLDQNSSKHGAIS CCCCCCCCCCCCCCC	34.82	-
1555	Phosphorylation	TSLDQNSSKHGAISS CCCCCCCCCCCCCCC	35.90	24114839
1556	Phosphorylation	SLDQNSSKHGAISSG CCCCCCCCCCCCCCC	45.97	32142685
1562	Phosphorylation	SKHGAISSGFRLEES CCCCCCCCCEECCCC	35.52	28555341
1565	Phosphorylation	GAISSGFRLEESPFV CCCCCCEECCCCCCC	44.72	32142685
1569	Phosphorylation	SGFRLEESPFVPYDF CCEECCCCCCCCCCC	17.79	20068231
1574	Phosphorylation	EESPFVPYDFMNSST CCCCCCCCCCCCCCC	19.26	20068231
1579	Phosphorylation	VPYDFMNSSTSPASP CCCCCCCCCCCCCCC	24.17	20068231
1580	Phosphorylation	PYDFMNSSTSPASPP CCCCCCCCCCCCCCC	28.09	20068231
1581	Phosphorylation	YDFMNSSTSPASPPG CCCCCCCCCCCCCCC	38.25	25159151
1582	Phosphorylation	DFMNSSTSPASPPGS CCCCCCCCCCCCCCC	22.03	20068231
1585	Phosphorylation	NSSTSPASPPGSIGD CCCCCCCCCCCCCCC	34.70	25159151
1589	Phosphorylation	SPASPPGSIGDGWPR CCCCCCCCCCCCCCC	29.22	20068231
1599	Phosphorylation	DGWPRAKSPNGSSSV CCCCCCCCCCCCCCC	23.71	23663014
1603	Phosphorylation	RAKSPNGSSSVNWPP CCCCCCCCCCCCCCC	26.53	23663014
1604	Phosphorylation	AKSPNGSSSVNWPPE CCCCCCCCCCCCCCC	39.44	23663014
1605	Phosphorylation	KSPNGSSSVNWPPEF CCCCCCCCCCCCCCC	22.59	23663014
1621	Phosphorylation	PGEPWKGYPNIDPET CCCCCCCCCCCCCCC	6.86	29978859
1628	Phosphorylation	YPNIDPETDPYVTPG CCCCCCCCCCCCCCC	47.89	29978859
1631	Phosphorylation	IDPETDPYVTPGSVI CCCCCCCCCCCCHHH	21.55	29978859
1633	Phosphorylation	PETDPYVTPGSVINN CCCCCCCCCCHHHCC	18.98	29978859
1660	Phosphorylation	RDRNSGSSSSLNTTL CCCCCCCCCCCCCCC	27.72	30576142
1661	Phosphorylation	DRNSGSSSSLNTTLP CCCCCCCCCCCCCCC	40.31	-
1662	Phosphorylation	RNSGSSSSLNTTLPS CCCCCCCCCCCCCCC	27.82	32142685
1665	Phosphorylation	GSSSSLNTTLPSTSA CCCCCCCCCCCCCCH	34.70	30576142
1666	Phosphorylation	SSSSLNTTLPSTSAW CCCCCCCCCCCCCHH	35.28	-
1671	O-linked_Glycosylation	NTTLPSTSAWSSIRA CCCCCCCCHHHHHHH	31.88	30059200
1671	Phosphorylation	NTTLPSTSAWSSIRA CCCCCCCCHHHHHHH	31.88	32142685
1675	Phosphorylation	PSTSAWSSIRASNYN CCCCHHHHHHHHCCC	12.85	30576142
1681	Phosphorylation	SSIRASNYNVPLSST HHHHHHCCCCCCCCC	18.29	27642862
1687	O-linked_Glycosylation	NYNVPLSSTAQSTSA CCCCCCCCCCCCCCC	35.13	30059200
1688	O-linked_Glycosylation	YNVPLSSTAQSTSAR CCCCCCCCCCCCCCC	25.91	30059200
1693	O-linked_Glycosylation	SSTAQSTSARNSDSK CCCCCCCCCCCCCCC	30.40	30059200
1693	Phosphorylation	SSTAQSTSARNSDSK CCCCCCCCCCCCCCC	30.40	28555341
1702	Phosphorylation	RNSDSKLTWSPGSVT CCCCCCCEECCCCCC	27.86	28450419
1704	Phosphorylation	SDSKLTWSPGSVTNT CCCCCEECCCCCCCC	17.72	28450419
1707	O-linked_Glycosylation	KLTWSPGSVTNTSLA CCEECCCCCCCCHHH	29.20	30059200
1707	Phosphorylation	KLTWSPGSVTNTSLA CCEECCCCCCCCHHH	29.20	28450419
1709	Phosphorylation	TWSPGSVTNTSLAHE EECCCCCCCCHHHHH	34.18	28450419
1711	O-linked_Glycosylation	SPGSVTNTSLAHELW CCCCCCCCHHHHHHH	18.76	30059200
1711	Phosphorylation	SPGSVTNTSLAHELW CCCCCCCCHHHHHHH	18.76	22199227
1712	O-linked_Glycosylation	PGSVTNTSLAHELWK CCCCCCCHHHHHHHC	26.15	30059200
1712	Phosphorylation	PGSVTNTSLAHELWK CCCCCCCHHHHHHHC	26.15	22199227
1738	Phosphorylation	SRPPPGLTGQKPPLS CCCCCCCCCCCCCCC	43.40	29523821
1741	Ubiquitination	PPGLTGQKPPLSTWD CCCCCCCCCCCCCCC	50.36	-
1745	Phosphorylation	TGQKPPLSTWDNSPL CCCCCCCCCCCCCCC	32.97	29523821
1746	Phosphorylation	GQKPPLSTWDNSPLR CCCCCCCCCCCCCCE	44.51	29523821
1750	Phosphorylation	PLSTWDNSPLRIGGG CCCCCCCCCCEECCC	23.88	30576142
1761	Phosphorylation	IGGGWGNSDARYTPG ECCCCCCCCCCCCCC	28.80	-
1765	Phosphorylation	WGNSDARYTPGSSWG CCCCCCCCCCCCCCC	21.00	29396449
1766	Phosphorylation	GNSDARYTPGSSWGE CCCCCCCCCCCCCCC	18.67	28674419
1786	Ubiquitination	ITNWLVLKNLTPQID EEEEEEECCCCCCCC	42.29	-
1823	Phosphorylation	HGNALVRYSSKEEVV CCCEEEEECCHHHHH	15.15	29496907
1824	Phosphorylation	GNALVRYSSKEEVVK CCEEEEECCHHHHHH	25.11	23879269
1826	Ubiquitination	ALVRYSSKEEVVKAQ EEEEECCHHHHHHHH	52.53	-
1835	Phosphorylation	EVVKAQKSLHMCVLG HHHHHHHHHCEEEEC	16.07	23879269
1863	Phosphorylation	ISRFFAQSQSLTPSP HHHHHHHCCCCCCCC	20.50	28634298
1865	Phosphorylation	RFFAQSQSLTPSPGW HHHHHCCCCCCCCCC	39.18	20068231
1867	Phosphorylation	FAQSQSLTPSPGWQS HHHCCCCCCCCCCHH	27.28	25159151
1869	Phosphorylation	QSQSLTPSPGWQSLG HCCCCCCCCCCHHCC	30.70	25159151
1874	Phosphorylation	TPSPGWQSLGSSQSR CCCCCCHHCCCCCHH	28.34	28102081
1877	Phosphorylation	PGWQSLGSSQSRLGS CCCHHCCCCCHHCCC	30.42	27251275
1878	Phosphorylation	GWQSLGSSQSRLGSL CCHHCCCCCHHCCCC	30.31	27251275
1880	Phosphorylation	QSLGSSQSRLGSLDC HHCCCCCHHCCCCCC	31.27	27251275
1884	Phosphorylation	SSQSRLGSLDCSHSF CCCHHCCCCCCCCCC	26.15	23403867
1888	Phosphorylation	RLGSLDCSHSFSSRT HCCCCCCCCCCCCCC	23.10	23403867
1890	Phosphorylation	GSLDCSHSFSSRTDL CCCCCCCCCCCCCCC	15.55	28348404
1892	Phosphorylation	LDCSHSFSSRTDLNH CCCCCCCCCCCCCCC	23.17	23403867
1893	Phosphorylation	DCSHSFSSRTDLNHW CCCCCCCCCCCCCCC	36.87	23403867
1934	Phosphorylation	SLWGPPSSSDPRGIS CCCCCCCCCCCCCCC	44.53	-
1941	Phosphorylation	SSDPRGISSPSPINA CCCCCCCCCCCCCCE	38.73	23403867
1942	Phosphorylation	SDPRGISSPSPINAF CCCCCCCCCCCCCEE	27.72	22617229
1944	Phosphorylation	PRGISSPSPINAFLS CCCCCCCCCCCEEEC	40.12	22617229
1951	Phosphorylation	SPINAFLSVDHLGGG CCCCEEECCCCCCCC	21.03	23403867
1961	Phosphorylation	HLGGGGESM------ CCCCCCCCC------	32.82	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM65	Q6PJ69	PMID:24778252

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TNR6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TNR6A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGO4_ARATH	AGO4	physical	17938239
AGO2_HUMAN	AGO2	physical	17938239
PABP1_HUMAN	PABPC1	physical	21063388
AGO2_HUMAN	AGO2	physical	24778252
AGO1_HUMAN	AGO1	physical	24778252
TRI65_HUMAN	TRIM65	physical	24778252
CNOT1_HUMAN	CNOT1	physical	21984185
CNOT3_HUMAN	CNOT3	physical	21984185
CNO6L_HUMAN	CNOT6L	physical	21984185
CNOT7_HUMAN	CNOT7	physical	21984185
CNO10_HUMAN	CNOT10	physical	21984185
PABP1_HUMAN	PABPC1	physical	21984185
PAN2_HUMAN	PAN2	physical	21984185
CNOT1_HUMAN	CNOT1	physical	21981923
CNOT2_HUMAN	CNOT2	physical	21981923
CNOT6_HUMAN	CNOT6	physical	21981923
CNO6L_HUMAN	CNOT6L	physical	21981923
CNOT7_HUMAN	CNOT7	physical	21981923
CNOT8_HUMAN	CNOT8	physical	21981923
CNOT3_HUMAN	CNOT3	physical	21981923
PAN3_HUMAN	PAN3	physical	21981923
CNOT1_HUMAN	CNOT1	physical	23172285
PABP1_HUMAN	PABPC1	physical	23172285
ITB4_HUMAN	ITGB4	physical	26496610
FANCM_HUMAN	FANCM	physical	26496610
K2013_HUMAN	KIAA2013	physical	26496610
CNOT9_HUMAN	RQCD1	physical	24768540

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TNR6A_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1585, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1470, AND MASSSPECTROMETRY.	18669648 [Abstract]