ITB4_HUMAN - dbPTM
ITB4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ITB4_HUMAN
UniProt AC P16144
Protein Name Integrin beta-4
Gene Name ITGB4
Organism Homo sapiens (Human).
Sequence Length 1822
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Cell membrane
Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
Protein Description Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. [PubMed: 20682778 ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling]
Protein Sequence MAGPRPSPWARLLLAALISVSLSGTLANRCKKAPVKSCTECVRVDKDCAYCTDEMFRDRRCNTQAELLAAGCQRESIVVMESSFQITEETQIDTTLRRSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLYILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRPEKLKEPWPNSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCTRDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPSVPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRIRSNLDIRALDSPRGLRTEVTSKMFQKTRTGSFHIRRGEVGIYQVQLRALEHVDGTHVCQLPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGWSGQTCNCSTGSLSDIQPCLREGEDKPCSGRGECQCGHCVCYGEGRYEGQFCEYDNFQCPRTSGFLCNDRGRCSMGQCVCEPGWTGPSCDCPLSNATCIDSNGGICNGRGHCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFKVKMVDELKRAEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPGSFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLMASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCTENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLMAPRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLFIRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGAPQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRTLTTSGTLSTHMDQQFFQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MAGPRPSPWARLLL
-CCCCCCCHHHHHHH		34.0622817900
19PhosphorylationLLLAALISVSLSGTL
HHHHHHHHHHHHCHH		13.4023403867
21PhosphorylationLAALISVSLSGTLAN
HHHHHHHHHHCHHHH		15.2723403867
23PhosphorylationALISVSLSGTLANRC
HHHHHHHHCHHHHHH		23.4023403867
25PhosphorylationISVSLSGTLANRCKK
HHHHHHCHHHHHHCC		21.2223403867
50PhosphorylationRVDKDCAYCTDEMFR
EECCCHHHCCHHHHC		11.3822817900
99PhosphorylationIDTTLRRSQMSPQGL
CCCCHHHHHCCCCCE		24.6530266825
102PhosphorylationTLRRSQMSPQGLRVR
CHHHHHCCCCCEEEE		13.3630266825
128PhosphorylationEVFEPLESPVDLYIL
EEECCCCCCCEEEEE		37.6022210691
139PhosphorylationLYILMDFSNSMSDDL
EEEEEECCCCCCCCH		24.5922210691
141PhosphorylationILMDFSNSMSDDLDN
EEEECCCCCCCCHHH		20.6122210691
164PhosphorylationARVLSQLTSDYTIGF
HHHHHHHHCCCEEEC		16.3528152594
165PhosphorylationRVLSQLTSDYTIGFG
HHHHHHHCCCEEECC		36.8928152594
167PhosphorylationLSQLTSDYTIGFGKF
HHHHHCCCEEECCCC		10.4628152594
168PhosphorylationSQLTSDYTIGFGKFV
HHHHCCCEEECCCCC		21.4428152594
173UbiquitinationDYTIGFGKFVDKVSV
CCEEECCCCCCCCCC		39.7021906983
173 (in isoform 1)Ubiquitination-39.7021906983
173 (in isoform 2)Ubiquitination-39.7021906983
173 (in isoform 3)Ubiquitination-39.7021906983
173 (in isoform 4)Ubiquitination-39.7021906983
173 (in isoform 5)Ubiquitination-39.7021906983
177UbiquitinationGFGKFVDKVSVPQTD
ECCCCCCCCCCCCCC		30.9821906983
177 (in isoform 1)Ubiquitination-30.9821906983
177 (in isoform 2)Ubiquitination-30.9821906983
177 (in isoform 3)Ubiquitination-30.9821906983
177 (in isoform 4)Ubiquitination-30.9821906983
177 (in isoform 5)Ubiquitination-30.9821906983
179PhosphorylationGKFVDKVSVPQTDMR
CCCCCCCCCCCCCCC		33.5420068231
183PhosphorylationDKVSVPQTDMRPEKL
CCCCCCCCCCCHHHH		26.2020068231
191UbiquitinationDMRPEKLKEPWPNSD
CCCHHHHCCCCCCCC		73.1821906983
191 (in isoform 1)Ubiquitination-73.1821906983
191 (in isoform 2)Ubiquitination-73.1821906983
191 (in isoform 3)Ubiquitination-73.1821906983
191 (in isoform 4)Ubiquitination-73.1821906983
191 (in isoform 5)Ubiquitination-73.1821906983
202PhosphorylationPNSDPPFSFKNVISL
CCCCCCCCHHHHHCC		40.8824719451
204 (in isoform 2)Ubiquitination-49.45-
210PhosphorylationFKNVISLTEDVDEFR
HHHHHCCCCCHHHHH		24.29-
219UbiquitinationDVDEFRNKLQGERIS
CHHHHHHHHCCCCCC		37.6221906983
219 (in isoform 1)Ubiquitination-37.6221906983
219 (in isoform 2)Ubiquitination-37.6221906983
219 (in isoform 3)Ubiquitination-37.6221906983
219 (in isoform 4)Ubiquitination-37.6221906983
219 (in isoform 5)Ubiquitination-37.6221906983
327N-linked_GlycosylationIPIFAVTNYSYSYYE
EEEEEEECCCEEHHH		19.70UniProtKB CARBOHYD
368PhosphorylationEAFNRIRSNLDIRAL
HHHHHHHHCCCHHHC		39.1022817900
377PhosphorylationLDIRALDSPRGLRTE
CCHHHCCCCCCCCHH		19.8322817900
383PhosphorylationDSPRGLRTEVTSKMF
CCCCCCCHHHHHHHC		39.5922817900
387PhosphorylationGLRTEVTSKMFQKTR
CCCHHHHHHHCHHCC		27.5722817900
388UbiquitinationLRTEVTSKMFQKTRT
CCHHHHHHHCHHCCC		34.0821906983
388 (in isoform 1)Ubiquitination-34.0821906983
388 (in isoform 2)Ubiquitination-34.0821906983
388 (in isoform 3)Ubiquitination-34.0821906983
388 (in isoform 4)Ubiquitination-34.0821906983
388 (in isoform 5)Ubiquitination-34.0821906983
397PhosphorylationFQKTRTGSFHIRRGE
CHHCCCCCEEEECCC		17.0324719451
408PhosphorylationRRGEVGIYQVQLRAL
ECCCEEEEEEEEEEE		9.19-
437SumoylationQKGNIHLKPSFSDGL
CCCCEECCCCCCCCC		25.18-
437SumoylationQKGNIHLKPSFSDGL
CCCCEECCCCCCCCC		25.18-
437UbiquitinationQKGNIHLKPSFSDGL
CCCCEECCCCCCCCC		25.1821906983
437 (in isoform 1)Ubiquitination-25.1821906983
437 (in isoform 2)Ubiquitination-25.1821906983
437 (in isoform 3)Ubiquitination-25.1821906983
437 (in isoform 4)Ubiquitination-25.1821906983
437 (in isoform 5)Ubiquitination-25.1821906983
491N-linked_GlycosylationGWSGQTCNCSTGSLS
CCCCCCCCCCCCCHH		26.60UniProtKB CARBOHYD
551S-palmitoylationPRTSGFLCNDRGRCS
CCCCCEECCCCCCCC		4.6829575903
579N-linked_GlycosylationSCDCPLSNATCIDSN
CCCCCCCCCEEECCC		47.13UniProtKB CARBOHYD
617N-linked_GlycosylationTDTICEINYSAIHPG
CCCEEEECHHHCCCC		11.47UniProtKB CARBOHYD
656UbiquitinationEECNFKVKMVDELKR
HHCCCEEEEHHHHHC		33.52-
656 (in isoform 2)Ubiquitination-33.52-
662UbiquitinationVKMVDELKRAEEVVV
EEEHHHHHCCEEEEE		47.7321906983
662 (in isoform 1)Ubiquitination-47.7321906983
662 (in isoform 2)Ubiquitination-47.7321906983
662 (in isoform 3)Ubiquitination-47.7321906983
662 (in isoform 4)Ubiquitination-47.7321906983
662 (in isoform 5)Ubiquitination-47.7321906983
681PhosphorylationRDEDDDCTYSYTMEG
CCCCCCCEEEEEECC		23.61-
695N-linked_GlycosylationGDGAPGPNSTVLVHK
CCCCCCCCCEEEEEC		57.1116335952
732S-palmitoylationLALLLLLCWKYCACC
HHHHHHHHHHHHHHH		2.7314517202
736S-palmitoylationLLLCWKYCACCKACL
HHHHHHHHHHHHHHH		1.7614517202
738S-palmitoylationLCWKYCACCKACLAL
HHHHHHHHHHHHHHH		1.8714517202
739S-palmitoylationCWKYCACCKACLALL
HHHHHHHHHHHHHHH		1.3414517202
742S-palmitoylationYCACCKACLALLPCC
HHHHHHHHHHHHHHC		1.0814517202
748S-palmitoylationACLALLPCCNRGHMV
HHHHHHHHCCCCCCC		3.0314517202
749S-palmitoylationCLALLPCCNRGHMVG
HHHHHHHCCCCCCCC		3.5314517202
758UbiquitinationRGHMVGFKEDHYMLR
CCCCCCCCHHHHHHH		57.1921906983
758 (in isoform 1)Ubiquitination-57.1921906983
758 (in isoform 2)Ubiquitination-57.1921906983
758 (in isoform 3)Ubiquitination-57.1921906983
758 (in isoform 4)Ubiquitination-57.1921906983
758 (in isoform 5)Ubiquitination-57.1921906983
762PhosphorylationVGFKEDHYMLRENLM
CCCCHHHHHHHHHHH		15.35-
771PhosphorylationLRENLMASDHLDTPM
HHHHHHCCCCCCCCC		16.1727251275
776PhosphorylationMASDHLDTPMLRSGN
HCCCCCCCCCCCCCC		19.56-
785UbiquitinationMLRSGNLKGRDVVRW
CCCCCCCCCCCEEEE		56.7721906983
785 (in isoform 1)Ubiquitination-56.7721906983
785 (in isoform 2)Ubiquitination-56.7721906983
785 (in isoform 3)Ubiquitination-56.7721906983
785 (in isoform 4)Ubiquitination-56.7721906983
785 (in isoform 5)Ubiquitination-56.7721906983
795PhosphorylationDVVRWKVTNNMQRPG
CEEEEEEECCCCCCC		19.6920639409
805PhosphorylationMQRPGFATHAASINP
CCCCCEEEEEECCCH		15.1320639409
809PhosphorylationGFATHAASINPTELV
CEEEEEECCCHHHCC		24.5527050516
813PhosphorylationHAASINPTELVPYGL
EEECCCHHHCCCCHH		37.1520639409
818PhosphorylationNPTELVPYGLSLRLA
CHHHCCCCHHHHHHH		24.1820639409
821PhosphorylationELVPYGLSLRLARLC
HCCCCHHHHHHHHHH		13.6923403867
829PhosphorylationLRLARLCTENLLKPD
HHHHHHHHHHCCCCC		32.2827050516
834UbiquitinationLCTENLLKPDTRECA
HHHHHCCCCCHHHHH		43.97-
837PhosphorylationENLLKPDTRECAQLR
HHCCCCCHHHHHHHH		36.5722817900
855PhosphorylationEENLNEVYRQISGVH
HHHHHHHHHHHHHHH		7.2227259358
863UbiquitinationRQISGVHKLQQTKFR
HHHHHHHHHHHCCCC		45.65-
868UbiquitinationVHKLQQTKFRQQPNA
HHHHHHCCCCCCCCC		33.92-
886PhosphorylationQDHTIVDTVLMAPRS
CCCCEEEEEEECCCC		12.4922817900
893PhosphorylationTVLMAPRSAKPALLK
EEEECCCCCCHHHHH		39.3223312004
895UbiquitinationLMAPRSAKPALLKLT
EECCCCCCHHHHHHC		31.8821906983
895 (in isoform 1)Ubiquitination-31.8821906983
895 (in isoform 2)Ubiquitination-31.8821906983
895 (in isoform 3)Ubiquitination-31.8821906983
895 (in isoform 4)Ubiquitination-31.8821906983
904UbiquitinationALLKLTEKQVEQRAF
HHHHHCHHHHHHHHH		55.1721906983
904 (in isoform 1)Ubiquitination-55.1721906983
904 (in isoform 2)Ubiquitination-55.1721906983
904 (in isoform 3)Ubiquitination-55.1721906983
904 (in isoform 4)Ubiquitination-55.1721906983
915UbiquitinationQRAFHDLKVAPGYYT
HHHHCCCCCCCCEEE		42.2721906983
915 (in isoform 1)Ubiquitination-42.2721906983
915 (in isoform 2)Ubiquitination-42.2721906983
915 (in isoform 3)Ubiquitination-42.2721906983
915 (in isoform 4)Ubiquitination-42.2721906983
920PhosphorylationDLKVAPGYYTLTADQ
CCCCCCCEEEEECCC		7.6928152594
921PhosphorylationLKVAPGYYTLTADQD
CCCCCCEEEEECCCC		10.9428152594
922PhosphorylationKVAPGYYTLTADQDA
CCCCCEEEEECCCCC		14.7828152594
924PhosphorylationAPGYYTLTADQDARG
CCCEEEEECCCCCCC		22.0128152594
958UbiquitinationRPEDDDEKQLLVEAI
CCCCCCHHEEEEEEE		53.9221906983
958 (in isoform 1)Ubiquitination-53.9221906983
958 (in isoform 2)Ubiquitination-53.9221906983
958 (in isoform 3)Ubiquitination-53.9221906983
958 (in isoform 4)Ubiquitination-53.9221906983
971PhosphorylationAIDVPAGTATLGRRL
EEECCCCCCCCCHHH		20.6927050516
973PhosphorylationDVPAGTATLGRRLVN
ECCCCCCCCCHHHEE		29.5927050516
982PhosphorylationGRRLVNITIIKEQAR
CHHHEEEEEEEHHHC		16.08-
993PhosphorylationEQARDVVSFEQPEFS
HHHCCCCCCCCCCCC		23.9420639409
1000PhosphorylationSFEQPEFSVSRGDQV
CCCCCCCCCCCCCCE		19.9521082442
1002PhosphorylationEQPEFSVSRGDQVAR
CCCCCCCCCCCCEEE		29.3720639409
1021UbiquitinationRRVLDGGKSQVSYRT
EEECCCCCCEEEEEC		43.1521906983
1021 (in isoform 1)Ubiquitination-43.1521906983
1021 (in isoform 2)Ubiquitination-43.1521906983
1021 (in isoform 3)Ubiquitination-43.1521906983
1021 (in isoform 4)Ubiquitination-43.1521906983
1039PhosphorylationTAQGNRDYIPVEGEL
CCCCCCCEECEEEEE		12.14-
1055UbiquitinationFQPGEAWKELQVKLL
ECCCHHHHHHHHHHH		56.44-
1055 (in isoform 2)Ubiquitination-56.44-
1060UbiquitinationAWKELQVKLLELQEV
HHHHHHHHHHHHHHH		34.102190698
1060 (in isoform 1)Ubiquitination-34.1021906983
1060 (in isoform 2)Ubiquitination-34.1021906983
1060 (in isoform 3)Ubiquitination-34.1021906983
1060 (in isoform 4)Ubiquitination-34.1021906983
1069PhosphorylationLELQEVDSLLRGRQV
HHHHHHHHHHCCCCE		34.1828355574
1084PhosphorylationRRFHVQLSNPKFGAH
EEEEEECCCCCCCCC		33.7129802988
1097PhosphorylationAHLGQPHSTTIIIRD
CCCCCCCCEEEEECC		33.65-
1098PhosphorylationHLGQPHSTTIIIRDP
CCCCCCCEEEEECCH		20.98-
1099PhosphorylationLGQPHSTTIIIRDPD
CCCCCCEEEEECCHH		17.13-
1111PhosphorylationDPDELDRSFTSQMLS
CHHHCCHHHHHHHHH		32.3223663014
1113PhosphorylationDELDRSFTSQMLSSQ
HHCCHHHHHHHHHCC		21.2123663014
1114PhosphorylationELDRSFTSQMLSSQP
HCCHHHHHHHHHCCC		16.1626657352
1118PhosphorylationSFTSQMLSSQPPPHG
HHHHHHHHCCCCCCC		22.9123312004
1119PhosphorylationFTSQMLSSQPPPHGD
HHHHHHHCCCCCCCC		42.6223312004
1140PhosphorylationPNAKAAGSRKIHFNW
CCCCCCCCCCEEEEE		26.19-
1160UbiquitinationKPMGYRVKYWIQGDS
CCCCEEEEEEECCCC		26.35-
1160 (in isoform 2)Ubiquitination-26.35-
1167PhosphorylationKYWIQGDSESEAHLL
EEEECCCCHHHHHHH		50.2627251275
1169PhosphorylationWIQGDSESEAHLLDS
EECCCCHHHHHHHCC		43.9927251275
1180PhosphorylationLLDSKVPSVELTNLY
HHCCCCCCEEEECCC		31.0726356563
1184PhosphorylationKVPSVELTNLYPYCD
CCCCEEEECCCCCCC		15.0726356563
1187PhosphorylationSVELTNLYPYCDYEM
CEEEECCCCCCCCEE		8.3326356563
1188PhosphorylationVELTNLYPYCDYEMK
EEEECCCCCCCCEEE		26.8317016520
1189PhosphorylationELTNLYPYCDYEMKV
EEECCCCCCCCEEEE		5.6127259358
1192PhosphorylationNLYPYCDYEMKVCAY
CCCCCCCCEEEEECC		17.8628442448
1198PhosphorylationDYEMKVCAYGAQGEG
CCEEEEECCCCCCCC		14.5817016520
1199PhosphorylationYEMKVCAYGAQGEGP
CEEEEECCCCCCCCC		14.1028152594
1206PhosphorylationYGAQGEGPYSSLVSC
CCCCCCCCCHHEEEC		22.8717016520
1207PhosphorylationGAQGEGPYSSLVSCR
CCCCCCCCHHEEECC		23.0327273156
1208PhosphorylationAQGEGPYSSLVSCRT
CCCCCCCHHEEECCC		21.9628152594
1209PhosphorylationQGEGPYSSLVSCRTH
CCCCCCHHEEECCCC		27.2621082442
1212PhosphorylationGPYSSLVSCRTHQEV
CCCHHEEECCCCCCC		11.8128152594
1246PhosphorylationSWAEPAETNGEITAY
CCCCCCCCCCCEEEE		51.1022817900
1257PhosphorylationITAYEVCYGLVNDDN
EEEEEEHHEEECCCC		20.7611438664
1297PhosphorylationESQPYRYTVKARNGA
CCCCEEEEEECCCCC		13.4122817900
1318PhosphorylationEAIINLATQPKRPMS
HEEEEECCCCCCCCC		48.8722817900
1325PhosphorylationTQPKRPMSIPIIPDI
CCCCCCCCCCCCCCC		28.0920639409
1339PhosphorylationIPIVDAQSGEDYDSF
CCEECCCCCCCCHHH		45.9620639409
1343PhosphorylationDAQSGEDYDSFLMYS
CCCCCCCCHHHEEEC		14.8020639409
1345PhosphorylationQSGEDYDSFLMYSDD
CCCCCCHHHEEECCC		17.6620639409
1349PhosphorylationDYDSFLMYSDDVLRS
CCHHHEEECCCCCCC		15.8720639409
1350PhosphorylationYDSFLMYSDDVLRSP
CHHHEEECCCCCCCC		17.2320639409
1356PhosphorylationYSDDVLRSPSGSQRP
ECCCCCCCCCCCCCC		21.1815121854
1356 (in isoform 2)Phosphorylation-21.1823927012
1356 (in isoform 3)Phosphorylation-21.1823927012
1356 (in isoform 4)Phosphorylation-21.1823927012
1358PhosphorylationDDVLRSPSGSQRPSV
CCCCCCCCCCCCCCC		52.9323663014
1358 (in isoform 2)Phosphorylation-52.9323663014
1358 (in isoform 3)Phosphorylation-52.9323663014
1358 (in isoform 4)Phosphorylation-52.9323663014
1360PhosphorylationVLRSPSGSQRPSVSD
CCCCCCCCCCCCCCC		27.6115121854
1360 (in isoform 2)Phosphorylation-27.6123663014
1360 (in isoform 3)Phosphorylation-27.6123663014
1360 (in isoform 4)Phosphorylation-27.6123663014
1364PhosphorylationPSGSQRPSVSDDTGC
CCCCCCCCCCCCCCC		36.1226657352
1364 (in isoform 2)Phosphorylation-36.1223927012
1364 (in isoform 3)Phosphorylation-36.1223927012
1364 (in isoform 4)Phosphorylation-36.1223927012
1366PhosphorylationGSQRPSVSDDTGCGW
CCCCCCCCCCCCCCC		33.8227251275
1366 (in isoform 2)Phosphorylation-33.8223927012
1366 (in isoform 3)Phosphorylation-33.8223927012
1366 (in isoform 4)Phosphorylation-33.8223927012
1369 (in isoform 2)Phosphorylation-39.0923927012
1369 (in isoform 3)Phosphorylation-39.0923927012
1369 (in isoform 4)Phosphorylation-39.0923927012
1384 (in isoform 2)Phosphorylation-41.2125849741
1384 (in isoform 3)Phosphorylation-41.2125849741
1384 (in isoform 4)Phosphorylation-41.2125849741
1403PhosphorylationLIPRLSASSGRSSDA
HHHHHHCCCCCCCCC		29.9222817900
1404PhosphorylationIPRLSASSGRSSDAE
HHHHHCCCCCCCCCC		37.6317081983
1407PhosphorylationLSASSGRSSDAEAPH
HHCCCCCCCCCCCCC		35.7728985074
1428PhosphorylationGAGGKGGSLPRSATP
CCCCCCCCCCCCCCC		43.8223927012
1432PhosphorylationKGGSLPRSATPGPPG
CCCCCCCCCCCCCCC		34.2624719451
1434PhosphorylationGSLPRSATPGPPGEH
CCCCCCCCCCCCCCC		29.9922817900
1440 (in isoform 3)Phosphorylation-39.5627259358
1454PhosphorylationMDFAFPGSTNSLHRM
CCEECCCCCCCCCCC		25.3423927012
1455PhosphorylationDFAFPGSTNSLHRMT
CEECCCCCCCCCCCC		34.4422167270
1457PhosphorylationAFPGSTNSLHRMTTT
ECCCCCCCCCCCCCC		26.1622167270
1462PhosphorylationTNSLHRMTTTSAAAY
CCCCCCCCCCCHHHH		27.2123403867
1463PhosphorylationNSLHRMTTTSAAAYG
CCCCCCCCCCHHHHC		14.9223927012
1464PhosphorylationSLHRMTTTSAAAYGT
CCCCCCCCCHHHHCC		13.7523927012
1465PhosphorylationLHRMTTTSAAAYGTH
CCCCCCCCHHHHCCC		17.5123927012
1469PhosphorylationTTTSAAAYGTHLSPH
CCCCHHHHCCCCCCC		20.1723927012
1471PhosphorylationTSAAAYGTHLSPHVP
CCHHHHCCCCCCCCC		13.6323927012
1474PhosphorylationAAYGTHLSPHVPHRV
HHHCCCCCCCCCCCC		12.8328731282
1483O-linked_GlycosylationHVPHRVLSTSSTLTR
CCCCCCCCCCCCCCC		24.3229237092
1483PhosphorylationHVPHRVLSTSSTLTR
CCCCCCCCCCCCCCC		24.3228731282
1484O-linked_GlycosylationVPHRVLSTSSTLTRD
CCCCCCCCCCCCCCC		23.6429237092
1484PhosphorylationVPHRVLSTSSTLTRD
CCCCCCCCCCCCCCC		23.6423927012
1485O-linked_GlycosylationPHRVLSTSSTLTRDY
CCCCCCCCCCCCCCC		20.2529237092
1485PhosphorylationPHRVLSTSSTLTRDY
CCCCCCCCCCCCCCC		20.2523927012
1486O-linked_GlycosylationHRVLSTSSTLTRDYN
CCCCCCCCCCCCCCC		27.7629237092
1486PhosphorylationHRVLSTSSTLTRDYN
CCCCCCCCCCCCCCC		27.7623927012
1487PhosphorylationRVLSTSSTLTRDYNS
CCCCCCCCCCCCCCC		31.7323927012
1488 (in isoform 3)Phosphorylation-3.9026657352
1489PhosphorylationLSTSSTLTRDYNSLT
CCCCCCCCCCCCCCC		22.9123927012
1492PhosphorylationSSTLTRDYNSLTRSE
CCCCCCCCCCCCCCC		11.8922167270
1494PhosphorylationTLTRDYNSLTRSEHS
CCCCCCCCCCCCCCC		25.5322167270
1496PhosphorylationTRDYNSLTRSEHSHS
CCCCCCCCCCCCCCC		31.7822167270
1498PhosphorylationDYNSLTRSEHSHSTT
CCCCCCCCCCCCCCC		34.1323927012
1501PhosphorylationSLTRSEHSHSTTLPR
CCCCCCCCCCCCCCC		18.3223927012
1503PhosphorylationTRSEHSHSTTLPRDY
CCCCCCCCCCCCCCH		26.5423927012
1504PhosphorylationRSEHSHSTTLPRDYS
CCCCCCCCCCCCCHH		27.2523927012
1505PhosphorylationSEHSHSTTLPRDYST
CCCCCCCCCCCCHHC		37.4723927012
1509PhosphorylationHSTTLPRDYSTLTSV
CCCCCCCCHHCCEEC		39.5317016520
1510PhosphorylationSTTLPRDYSTLTSVS
CCCCCCCHHCCEECC		12.5823927012
1511PhosphorylationTTLPRDYSTLTSVSS
CCCCCCHHCCEECCC		22.6423927012
1512PhosphorylationTLPRDYSTLTSVSSH
CCCCCHHCCEECCCC		28.0323927012
1514PhosphorylationPRDYSTLTSVSSHDS
CCCHHCCEECCCCCC		27.4623927012
1515PhosphorylationRDYSTLTSVSSHDSR
CCHHCCEECCCCCCC		24.1023927012
1517PhosphorylationYSTLTSVSSHDSRLT
HHCCEECCCCCCCCC		23.0223927012
1518PhosphorylationSTLTSVSSHDSRLTA
HCCEECCCCCCCCCC		29.2028355574
1521PhosphorylationTSVSSHDSRLTAGVP
EECCCCCCCCCCCCC		24.6223927012
1524PhosphorylationSSHDSRLTAGVPDTP
CCCCCCCCCCCCCCC		21.9130266825
1530PhosphorylationLTAGVPDTPTRLVFS
CCCCCCCCCCEEEEE		22.0830266825
1532PhosphorylationAGVPDTPTRLVFSAL
CCCCCCCCEEEEECC		38.4330266825
1537PhosphorylationTPTRLVFSALGPTSL
CCCEEEEECCCCCEE		18.3327050516
1542PhosphorylationVFSALGPTSLRVSWQ
EEECCCCCEEEEEEC		38.3027966365
1543PhosphorylationFSALGPTSLRVSWQE
EECCCCCEEEEEECC		19.8127542207
1547PhosphorylationGPTSLRVSWQEPRCE
CCCEEEEEECCCCCC		19.3328731282
1561PhosphorylationERPLQGYSVEYQLLN
CCCCCCEEEEEEEEC		18.4622210691
1564PhosphorylationLQGYSVEYQLLNGGE
CCCEEEEEEEECCCC		11.4211438664
1595PhosphorylationEDLLPNHSYVFRVRA
EECCCCCEEEEEEEE		29.63-
1596PhosphorylationDLLPNHSYVFRVRAQ
ECCCCCEEEEEEEEE		8.9622817900
1604PhosphorylationVFRVRAQSQEGWGRE
EEEEEEECCCCCCCC		29.2528188228
1643 (in isoform 2)Ubiquitination-17.80-
1653PhosphorylationPLVFTALSPDSLQLS
CEEEEEECCCCEEEE		24.9722817900
1674PhosphorylationPNGDIVGYLVTCEMA
CCCCEEEEEEEEEEC		6.26-
1688PhosphorylationAQGGGPATAFRVDGD
CCCCCCCCEEEECCC		29.4823090842
1696PhosphorylationAFRVDGDSPESRLTV
EEEECCCCCCCCCCC		35.7823927012
1699PhosphorylationVDGDSPESRLTVPGL
ECCCCCCCCCCCCCC		35.6523927012
1702PhosphorylationDSPESRLTVPGLSEN
CCCCCCCCCCCCCCC		24.4423090842
1707PhosphorylationRLTVPGLSENVPYKF
CCCCCCCCCCCCEEE		32.8022817900
1712PhosphorylationGLSENVPYKFKVQAR
CCCCCCCEEEEEEEE		25.44-
1713UbiquitinationLSENVPYKFKVQART
CCCCCCEEEEEEEEE		32.41-
1720PhosphorylationKFKVQARTTEGFGPE
EEEEEEEECCCCCCC		32.0124719451
1721PhosphorylationFKVQARTTEGFGPER
EEEEEEECCCCCCCC		28.67-
1747PhosphorylationGPFPQLGSRAGLFQH
CCCCCCCCCCCCCCC		27.7820639409
1758PhosphorylationLFQHPLQSEYSSITT
CCCCCCHHCCCCCCC		46.30-
1760PhosphorylationQHPLQSEYSSITTTH
CCCCHHCCCCCCCCC		16.99-
1761PhosphorylationHPLQSEYSSITTTHT
CCCHHCCCCCCCCCC		15.94-
1762PhosphorylationPLQSEYSSITTTHTS
CCHHCCCCCCCCCCC		24.0522817900
1764PhosphorylationQSEYSSITTTHTSAT
HHCCCCCCCCCCCCC		27.82-
1765PhosphorylationSEYSSITTTHTSATE
HCCCCCCCCCCCCCC		18.2122817900
1766PhosphorylationEYSSITTTHTSATEP
CCCCCCCCCCCCCCC		17.9522817900
1771PhosphorylationTTTHTSATEPFLVDG
CCCCCCCCCCEEECC		43.91-
1780PhosphorylationPFLVDGLTLGAQHLE
CEEECCEEEECHHHH		28.7727251275
1791PhosphorylationQHLEAGGSLTRHVTQ
HHHHCCCCHHHCHHH		26.1627251275
1793PhosphorylationLEAGGSLTRHVTQEF
HHCCCCHHHCHHHHH		22.0427251275
1797PhosphorylationGSLTRHVTQEFVSRT
CCHHHCHHHHHHHCC		19.0920639409
1804PhosphorylationTQEFVSRTLTTSGTL
HHHHHHCCCCCCCCE		22.4323090842
1806PhosphorylationEFVSRTLTTSGTLST
HHHHCCCCCCCCEEH		20.5023090842
1807PhosphorylationFVSRTLTTSGTLSTH
HHHCCCCCCCCEEHH		28.4223090842
1808PhosphorylationVSRTLTTSGTLSTHM
HHCCCCCCCCEEHHC		25.2523090842
1810PhosphorylationRTLTTSGTLSTHMDQ
CCCCCCCCEEHHCHH		19.8023090842
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1356SPhosphorylationKinasePRKCAP17252
GPS
1356SPhosphorylationKinaseMAPK3P27361
GPS
1360SPhosphorylationKinasePRKCAP17252
GPS
1364SPhosphorylationKinasePRKACAP17612
GPS
1364SPhosphorylationKinasePRKCAP17252
GPS
1364SPhosphorylationKinaseRPS6KA1Q15418
GPS
1424SPhosphorylationKinasePKCAP17252
PSP
1494SPhosphorylationKinasePRKCAP17252
GPS
1564YPhosphorylationKinaseFGFR1P11362
PSP
1736TPhosphorylationKinasePRKD1Q15139
PSP
1736TPhosphorylationKinasePRKD2Q9BZL6
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ITB4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ITB4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF6_HUMANEIF6physical
9374518
ERBIN_HUMANERBB2IPphysical
11375975
COHA1_HUMANCOL17A1physical
9660880
ITA3_HUMANITGA3physical
16878156
PLEC_HUMANPLECphysical
22939629
PLAK_HUMANJUPphysical
22939629
SE1L1_HUMANSEL1Lphysical
24324549
LOX12_HUMANALOX12physical
26037302
Drug and Disease Associations
Kegg Disease
H00586 Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H
OMIM Disease
226730Epidermolysis bullosa letalis, with pyloric atresia (EB-PA)
226650Generalized atrophic benign epidermolysis bullosa (GABEB)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ITB4_HUMAN

loading...

Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-695, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1000 AND THR-1530, ANDMASS SPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1084, AND MASSSPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1530, AND MASSSPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1530, AND MASSSPECTROMETRY.
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1189; TYR-1207; TYR-1469AND TYR-1510, AND MASS SPECTROMETRY.
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks.";
Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.;
Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1207 AND TYR-1510, ANDMASS SPECTROMETRY.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1207, AND MASSSPECTROMETRY.
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules.";
Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.;
Mol. Cell. Proteomics 4:1240-1250(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1207, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory