LOX12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LOX12_HUMAN
• UniProt AC: P18054
• Protein Name: Arachidonate 12-lipoxygenase, 12S-type
• Gene Name: ALOX12
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Subcellular Localization: Cytoplasm, cytosol. Membrane. Membrane association is stimulated by EGF.
• Protein Description: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation..
• Protein Sequence: MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
151	Phosphorylation	WKEGLPLTIAADRKD HHCCCEEEEEECCCC	13.46	46162589
244	Phosphorylation	NPMLLRRSTSLPSRL CCCHHCCCCCCCCCE	18.86	20363803
245	Phosphorylation	PMLLRRSTSLPSRLV CCHHCCCCCCCCCEE	32.26	20363803
246	Phosphorylation	MLLRRSTSLPSRLVL CHHCCCCCCCCCEEC	39.26	22617229
249	Phosphorylation	RRSTSLPSRLVLPSG CCCCCCCCCEECCCC	43.47	20363803
255	Phosphorylation	PSRLVLPSGMEELQA CCCEECCCCHHHHHH	46.76	46162577
295	Phosphorylation	VIRGEKQYLAAPLVM CCCCCCHHEECCEEE	14.91	69101761
405	Phosphorylation	EINTRARTQLISDGG ECCCCCCEEEECCCC	27.09	21406692
409	Phosphorylation	RARTQLISDGGIFDK CCCEEEECCCCCCCC	38.50	21406692
419	Phosphorylation	GIFDKAVSTGGGGHV CCCCCHHCCCCCHHH	26.62	26074081
420	Phosphorylation	IFDKAVSTGGGGHVQ CCCCHHCCCCCHHHH	32.99	26074081
437	Phosphorylation	RRAAAQLTYCSLCPP HHHHHHCCCHHCCCH	15.48	26074081
438	Phosphorylation	RAAAQLTYCSLCPPD HHHHHCCCHHCCCHH	6.66	26074081
440	Phosphorylation	AAQLTYCSLCPPDDL HHHCCCHHCCCHHHH	23.69	26074081
598	Phosphorylation	MAISWHLSRRQPDMV HHHHHHHHCCCCCCE	16.72	25332170
616	Phosphorylation	HHKEKYFSGPKPKAV CCCCCCCCCCCCHHH	51.61	10409585
639	O-linked_Glycosylation	EKLEKEITARNEQLD HHHHHHHHHHHHCCC	22.21	30379171

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LOX12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LOX12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LOX12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMNA_HUMAN	LMNA	physical	10727209
ITB4_HUMAN	ITGB4	physical	10727209
TRIB1_HUMAN	TRIB1	physical	10727209
K2C5_HUMAN	KRT5	physical	10727209
LOX12_HUMAN	ALOX12	physical	18155727

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 133239: Esophageal cancer (ESCR)
• 114500: Colorectal cancer (CRC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.