CAR10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAR10_HUMAN
• UniProt AC: Q9BWT7
• Protein Name: Caspase recruitment domain-containing protein 10
• Gene Name: CARD10
• Organism: Homo sapiens (Human).
• Sequence Length: 1032
• Subcellular Localization: Cytoplasm.
• Protein Description: Activates NF-kappa-B via BCL10 and IKK..
• Protein Sequence: MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGACLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCLPSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVECGSSRGCPSSSEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	EEEAGAGSGSEAEED HHHCCCCCCCHHHHH	38.31	28985074
20	Phosphorylation	EAGAGSGSEAEEDAL HCCCCCCCHHHHHHH	35.02	28985074
174	Methylation	ERAGLEQRLRDQQQA HHHHHHHHHHHHHHH	23.47	-
220	Ubiquitination	LAQLSEEKNSAVLRS HHHCCHHHCHHHHHH	52.75	29967540
270	Ubiquitination	EKEKEKEKEKEPDNV HHHHHHHHHCCCCCH	82.33	29967540
272	Ubiquitination	EKEKEKEKEPDNVDL HHHHHHHCCCCCHHH	82.62	29967540
330	Ubiquitination	HDWREAQDSRQELCQ HCHHHHHHHHHHHHH	53.49	21890473
356	Phosphorylation	AEELRDQYLQEMEDL HHHHHHHHHHHHHHH	18.03	-
412	Phosphorylation	IQLQYSQSLIEKDQY HHHHHHHHHHHHHHH	25.93	24719451
416	Ubiquitination	YSQSLIEKDQYRKQV HHHHHHHHHHHHHHH	43.04	29967540
421	Ubiquitination	IEKDQYRKQVRGLEA HHHHHHHHHHCCCHH	48.49	29967540
435	Phosphorylation	AERDELLTTLTSLEG HHHHHHHHHHHHHHH	32.17	18767875
439	Phosphorylation	ELLTTLTSLEGTKAL HHHHHHHHHHHHHHH	27.77	23312004
443	Phosphorylation	TLTSLEGTKALLEVQ HHHHHHHHHHHHHHH	12.08	18767875
492	Ubiquitination	PLGGPEATGEAAVMG CCCCCCCCCCCCCCC	33.61	21890473
527	Phosphorylation	SILPFPPSAGSILRR HCCCCCCCHHHHHHH	45.56	22617229
546	Phosphorylation	DPAPPKRSFSSMSDI CCCCCCCCCCCCCCC	35.29	23898821
548	Phosphorylation	APPKRSFSSMSDITG CCCCCCCCCCCCCCC	26.78	23898821
549	Phosphorylation	PPKRSFSSMSDITGS CCCCCCCCCCCCCCC	21.94	23898821
551	Phosphorylation	KRSFSSMSDITGSVT CCCCCCCCCCCCCEE	28.01	23898821
554	Phosphorylation	FSSMSDITGSVTLKP CCCCCCCCCCEEECC	28.52	30177828
556	Phosphorylation	SMSDITGSVTLKPWS CCCCCCCCEEECCCC	11.86	30177828
558	Phosphorylation	SDITGSVTLKPWSPG CCCCCCEEECCCCCC	30.66	30177828
563	Phosphorylation	SVTLKPWSPGLSSSS CEEECCCCCCCCCCC	20.02	23090842
567	Phosphorylation	KPWSPGLSSSSSSDS CCCCCCCCCCCCCCC	33.80	23090842
568	Phosphorylation	PWSPGLSSSSSSDSV CCCCCCCCCCCCCCC	39.00	23090842
569	Phosphorylation	WSPGLSSSSSSDSVW CCCCCCCCCCCCCCC	30.75	23090842
570	Phosphorylation	SPGLSSSSSSDSVWP CCCCCCCCCCCCCCC	35.49	23090842
571	Phosphorylation	PGLSSSSSSDSVWPL CCCCCCCCCCCCCCC	39.86	22496350
572	Phosphorylation	GLSSSSSSDSVWPLG CCCCCCCCCCCCCCC	35.53	23090842
574	Phosphorylation	SSSSSSDSVWPLGKP CCCCCCCCCCCCCCC	28.20	23090842
603	Phosphorylation	RSLAIRVSGRSPPGG CCEEEECCCCCCCCC	20.74	23403867
606	Phosphorylation	AIRVSGRSPPGGPEP EEECCCCCCCCCCCC	38.68	23663014
616	Ubiquitination	GGPEPQDKGPDGLSF CCCCCCCCCCCCCCC	68.07	21906983
622	Phosphorylation	DKGPDGLSFYGDRWS CCCCCCCCCCCCCCC	23.19	23403867
624	Phosphorylation	GPDGLSFYGDRWSGA CCCCCCCCCCCCCHH	18.10	28674419
638	Phosphorylation	AVVRRVLSGPGSARM HHHHHHHCCCCCCCC	39.83	30266825
642	Phosphorylation	RVLSGPGSARMEPRE HHHCCCCCCCCCHHH	18.81	30266825
700	Ubiquitination	EALEAWAKGPGAEPF HHHHHHHHCCCCCCE	55.74	21963094
727	Ubiquitination	DPHALCVKAQEILRL CHHHHHHHHHHHHHH	43.27	23000965
740	Ubiquitination	RLVDSAYKRRQEWFC HHHHHHHHHHHHHCC	40.60	33845483
778	Ubiquitination	QLLEVQEKCLPSSRH HHHHHHHHHCCCCCC	24.79	22817900
830	Phosphorylation	PCAEPERSLRPYSLV ECCCCCCCCCCHHHH	27.37	24719451
834	Phosphorylation	PERSLRPYSLVRPLL CCCCCCCHHHHHHHH	14.27	24719451
835	Phosphorylation	ERSLRPYSLVRPLLV CCCCCCHHHHHHHHH	24.07	28176486
901	Phosphorylation	APKAQPATPGLGSRI CCCCCCCCCCHHHHH	25.27	23312004
914	Phosphorylation	RIRAIQESVGKKHCL HHHHHHHHHCCCHHH	21.57	23403867
917	Ubiquitination	AIQESVGKKHCLLEL HHHHHHCCCHHHHHH	36.87	27667366
918	Ubiquitination	IQESVGKKHCLLELG HHHHHCCCHHHHHHH	33.35	29967540
949	Ubiquitination	IHVEVTEKNVREVRG EEEEECCCCHHHHHH	51.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAR10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAR10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAR10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEMO_HUMAN	IKBKG	physical	15184390
CAR10_HUMAN	CARD10	physical	15184390
BCL10_HUMAN	BCL10	physical	15184390
KLH12_HUMAN	KLHL12	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.