MYO10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO10_HUMAN
• UniProt AC: Q9HD67
• Protein Name: Unconventional myosin-X
• Gene Name: MYO10
• Organism: Homo sapiens (Human).
• Sequence Length: 2058
• Subcellular Localization: Cytoplasm, cytosol . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasm, cytoskeleton . Cell projection, filopodium tip . Cytoplasm, cell cortex . Cell projection, filopodium membrane; Peripheral membrane protein. May be in an inact
• Protein Description: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts.; Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion (By similarity)..
• Protein Sequence: MDNFFTEGTRVWLRENGQHFPSTVNSCAEGIVVFRTDYGQVFTYKQSTITHQKVTAMHPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLILKFLSVISQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEASLQKLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELAESACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTSGIRTSDDSSEEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGDYDYDQDDYEDGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTKENGIDIIMADRTFHLIAESPEDASQWFSVLSQVHASTDQEIQEMHDEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDYTLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGSVVRQKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLFDVECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDERELLFETSEVVDVAKLMKAYISMIVKKRYSTTRSASSQGSSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDNFFTEG -------CCCCCCCC	41.78	22814378
59	Ubiquitination	QKVTAMHPTNEEGVD EEEEEECCCCCCCCC	24.67	21963094
60	Ubiquitination	KVTAMHPTNEEGVDD EEEEECCCCCCCCCC	40.35	21963094
80	Ubiquitination	ELHGGSIMYNLFQRY HHHCHHHHHHHHHHH	1.62	27667366
81	Ubiquitination	LHGGSIMYNLFQRYK HHCHHHHHHHHHHHC	13.67	27667366
93	Phosphorylation	RYKRNQIYTYIGSIL HHCCCCHHHHHHHHH	5.45	-
154	Ubiquitination	RHDNQCILISGESGA HCCCEEEEEECCCCC	3.16	27667366
155	Ubiquitination	HDNQCILISGESGAG CCCEEEEEECCCCCC	2.23	27667366
164	Phosphorylation	GESGAGKTESTKLIL CCCCCCCCHHHHHHH	33.96	-
168	Ubiquitination	AGKTESTKLILKFLS CCCCHHHHHHHHHHH	42.69	29967540
175	Phosphorylation	KLILKFLSVISQQSL HHHHHHHHHHCHHHH	22.12	-
178	Phosphorylation	LKFLSVISQQSLELS HHHHHHHCHHHHHHC	21.73	-
201	Phosphorylation	ERAILESSPIMEAFG HHHHHHCCHHHHHHC	14.74	26437602
211	Ubiquitination	MEAFGNAKTVYNNNS HHHHCCCEEEECCCC	42.39	21963094
212	Phosphorylation	EAFGNAKTVYNNNSS HHHCCCEEEECCCCC	26.30	19664994
218	Phosphorylation	KTVYNNNSSRFGKFV EEEECCCCCCCCEEE	25.64	19664994
232	Ubiquitination	VQLNICQKGNIQGGR EEEEEECCCCCCCHH	49.90	29967540
264	Phosphorylation	ERNYHIFYALLAGLE CCCHHHHHHHHHCCC	8.85	30576142
279	Phosphorylation	HEEREEFYLSTPENY HHHHHHHCCCCCCCC	11.74	-
286	Phosphorylation	YLSTPENYHYLNQSG CCCCCCCCCCCCCCC	7.09	-
377	Phosphorylation	TDALTQRSMFLRGEE HHHHHHHHHHHCCCC	12.22	-
387	Phosphorylation	LRGEEILTPLNVQQA HCCCCCCCCCCHHHH	31.24	-
397	Phosphorylation	NVQQAVDSRDSLAMA CHHHHHCCHHHHHHH	31.24	-
419	Phosphorylation	WVIKKINSRIKGNED HHHHHHHHHCCCCCC	38.56	18491316
499	Ubiquitination	CLDLIEKKLGLLALI HHHHHHHHHHHHHHH	34.69	29967540
536	Ubiquitination	ANNHFYVKPRVAVNN CCCCEEECCEEEECC	18.74	29967540
547	Ubiquitination	AVNNFGVKHYAGEVQ EECCCCCCEECEECE	31.14	33845483
549	Phosphorylation	NNFGVKHYAGEVQYD CCCCCCEECEECEEE	15.58	-
555	Phosphorylation	HYAGEVQYDVRGILE EECEECEEEHHHHHH	22.91	-
563	Malonylation	DVRGILEKNRDTFRD EHHHHHHHCCHHHHH	54.56	32601280
567	Ubiquitination	ILEKNRDTFRDDLLN HHHHCCHHHHHHHHH	19.82	21853274
568	Ubiquitination	LEKNRDTFRDDLLNL HHHCCHHHHHHHHHH	10.64	21853274
578	Ubiquitination	DLLNLLRESRFDFIY HHHHHHHHCCCHHHH	46.35	27667366
585	Phosphorylation	ESRFDFIYDLFEHVS HCCCHHHHHHHHHHH	13.44	26356563
599	Phosphorylation	SSRNNQDTLKCGSKH HHCCCCCCCCCCCCC	20.53	30576142
601	Ubiquitination	RNNQDTLKCGSKHRR CCCCCCCCCCCCCCC	38.35	27667366
610	Phosphorylation	GSKHRRPTVSSQFKD CCCCCCCCHHHHHHH	31.07	28555341
673	Phosphorylation	VRIRKAGYAVRRPFQ EHHHHCCCCEECCHH	13.54	-
679	Ubiquitination	GYAVRRPFQDFYKRY CCCEECCHHHHHHHH	11.75	21963094
683	Phosphorylation	RRPFQDFYKRYKVLM ECCHHHHHHHHHHHH	11.66	26074081
686	Phosphorylation	FQDFYKRYKVLMRNL HHHHHHHHHHHHHCC	10.99	26074081
700	Ubiquitination	LALPEDVRGKCTSLL CCCCHHHCCCCHHHH	51.69	27667366
702	Ubiquitination	LPEDVRGKCTSLLQL CCHHHCCCCHHHHHH	24.63	21963094
704	Phosphorylation	EDVRGKCTSLLQLYD HHHCCCCHHHHHHHC	26.37	27251275
705	Phosphorylation	DVRGKCTSLLQLYDA HHCCCCHHHHHHHCC	36.23	27251275
723	Ubiquitination	EWQLGKTKVFLRESL CEECCCHHHHHHHHH	34.18	27667366
733	Ubiquitination	LRESLEQKLEKRREE HHHHHHHHHHHHHHH	49.60	29967540
743	Phosphorylation	KRREEEVSHAAMVIR HHHHHHHHHHHHHHH	15.64	24719451
774	Ubiquitination	YCVVIIQKNYRAFLL EEEEEECCCHHHHHH	45.60	27667366
790	Ubiquitination	RRFLHLKKAAIVFQK HHHHHHHHHHHHHHH	49.78	29967540
797	Ubiquitination	KAAIVFQKQLRGQIA HHHHHHHHHHHHHHH	39.57	27667366
858	Ubiquitination	QQEEETRKQQELEAL HHHHHHHHHHHHHHH	64.85	29967540
880	Ubiquitination	ELTRELEKQKENKQV HHHHHHHHHHHHHHH	78.33	33845483
882	Ubiquitination	TRELEKQKENKQVEE HHHHHHHHHHHHHHH	74.46	33845483
885	Ubiquitination	LEKQKENKQVEEILR HHHHHHHHHHHHHHH	57.73	33845483
895	Ubiquitination	EEILRLEKEIEDLQR HHHHHHHHHHHHHHH	69.45	29967540
904	Ubiquitination	IEDLQRMKEQQELSL HHHHHHHHHHHHHHH	55.34	33845483
910	Phosphorylation	MKEQQELSLTEASLQ HHHHHHHHHCHHHHH	32.28	28555341
915	Phosphorylation	ELSLTEASLQKLQER HHHHCHHHHHHHHHH	25.71	25159151
918	Ubiquitination	LTEASLQKLQERRDQ HCHHHHHHHHHHHHH	58.39	29967540
960	Phosphorylation	CVRNIERSLSVGSEF HHHHHHHHHCCCHHH	16.53	27251275
962	Phosphorylation	RNIERSLSVGSEFSS HHHHHHHCCCHHHHH	26.19	29507054
965	Phosphorylation	ERSLSVGSEFSSELA HHHHCCCHHHHHHHH	33.06	25159151
968	Phosphorylation	LSVGSEFSSELAESA HCCCHHHHHHHHHHH	20.89	27251275
969	Phosphorylation	SVGSEFSSELAESAC CCCHHHHHHHHHHHH	41.78	27251275
1007	Phosphorylation	DDDAFKDSPNPSEHG CCHHHCCCCCCCCCC	27.45	17081983
1020	Phosphorylation	HGHSDQRTSGIRTSD CCCCCCCCCCCCCCC	26.18	30576142
1021	Phosphorylation	GHSDQRTSGIRTSDD CCCCCCCCCCCCCCC	34.12	30576142
1118	Phosphorylation	NSYGSQWSPDYRCSV CCCCCCCCCCCEEEE	10.56	-
1121	Phosphorylation	GSQWSPDYRCSVGTY CCCCCCCCEEEEECC	19.53	-
1124	Phosphorylation	WSPDYRCSVGTYNSS CCCCCEEEEECCCCC	18.00	26356563
1127	Phosphorylation	DYRCSVGTYNSSGAY CCEEEEECCCCCCCE	19.85	27251275
1128	Phosphorylation	YRCSVGTYNSSGAYR CEEEEECCCCCCCEE	13.71	25884760
1130	Phosphorylation	CSVGTYNSSGAYRFS EEEECCCCCCCEEEC	21.53	27273156
1131	Phosphorylation	SVGTYNSSGAYRFSS EEECCCCCCCEEECC	24.65	26356563
1134	Phosphorylation	TYNSSGAYRFSSEGA CCCCCCCEEECCCCC	18.73	25884760
1137	Phosphorylation	SSGAYRFSSEGAQSS CCCCEEECCCCCCCC	20.62	23663014
1138	Phosphorylation	SGAYRFSSEGAQSSF CCCEEECCCCCCCCC	37.02	23663014
1143	Phosphorylation	FSSEGAQSSFEDSEE ECCCCCCCCCCCCHH	36.14	23663014
1144	Phosphorylation	SSEGAQSSFEDSEED CCCCCCCCCCCCHHH	22.15	23663014
1148	Phosphorylation	AQSSFEDSEEDFDSR CCCCCCCCHHHHHHC	35.37	23663014
1154	Phosphorylation	DSEEDFDSRFDTDDE CCHHHHHHCCCCCCC	34.54	-
1158	Phosphorylation	DFDSRFDTDDELSYR HHHHCCCCCCCCCCC	42.51	19664994
1163	Phosphorylation	FDTDDELSYRRDSVY CCCCCCCCCCCCCHH	17.97	20873877
1168	Phosphorylation	ELSYRRDSVYSCVTL CCCCCCCCHHHHHHH	22.57	27422710
1170	Phosphorylation	SYRRDSVYSCVTLPY CCCCCCHHHHHHHHH	10.58	-
1171	Phosphorylation	YRRDSVYSCVTLPYF CCCCCHHHHHHHHHH	10.43	27422710
1187	Ubiquitination	SFLYMKGGLMNSWKR HHHHHCCCCCCCCEE	19.08	21853274
1191	Phosphorylation	MKGGLMNSWKRRWCV HCCCCCCCCEEEEEE	21.73	24719451
1210	Ubiquitination	TFLWFRSKQEALKQG EEEEECCHHHHHHHC	48.15	21853274
1215	Ubiquitination	RSKQEALKQGWLHKK CCHHHHHHHCCCCCC	54.54	29967540
1228	Phosphorylation	KKGGGSSTLSRRNWK CCCCCCCCCCCCHHH	30.37	30576142
1244	Phosphorylation	RWFVLRQSKLMYFEN HEEEEEECEEEEEEC	22.71	28348404
1248	Phosphorylation	LRQSKLMYFENDSEE EEECEEEEEECCCHH	20.41	-
1253	Phosphorylation	LMYFENDSEEKLKGT EEEEECCCHHHHCCE	60.27	21712546
1258	Ubiquitination	NDSEEKLKGTVEVRT CCCHHHHCCEEEEEE	64.70	33845483
1267	Ubiquitination	TVEVRTAKEIIDNTT EEEEEEHHHHHHCCC	49.16	33845483
1275	Ubiquitination	EIIDNTTKENGIDII HHHHCCCHHCCEEEE	47.33	33845483
1368	Phosphorylation	VLHCNADTPEEMHHW EEECCCCCHHHHHHH	30.14	27174698
1377	Phosphorylation	EEMHHWITLLQRSKG HHHHHHHHHHHHCCC	19.07	27174698
1382	Phosphorylation	WITLLQRSKGDTRVE HHHHHHHCCCCCCCC	28.20	27174698
1386	Phosphorylation	LQRSKGDTRVEGQEF HHHCCCCCCCCCCEE	45.33	27174698
1410	Phosphorylation	VKNSPKMSSLKLKKR HCCCCCCCCCCCCCC	38.35	22210691
1411	Phosphorylation	KNSPKMSSLKLKKRW CCCCCCCCCCCCCCE	26.48	29214152
1413	Ubiquitination	SPKMSSLKLKKRWFV CCCCCCCCCCCCEEE	61.27	-
1415	Ubiquitination	KMSSLKLKKRWFVLT CCCCCCCCCCEEEEE	38.41	-
1428	Phosphorylation	LTHNSLDYYKSSEKN EECCHHHHHHCCCCC	20.34	20049867
1429	Phosphorylation	THNSLDYYKSSEKNA ECCHHHHHHCCCCCH	12.22	20049867
1469	Phosphorylation	GYWNVTVYGRKHCYR CCEEEEEECHHHHHH	11.22	-
1499	Ubiquitination	IQNVTDTKAPIDTPT HHHCCCCCCCCCCHH	55.78	29967540
1514	Ubiquitination	QQLIQDIKENCLNSD HHHHHHHHHHCCCCH	51.68	29967540
1528	Ubiquitination	DVVEQIYKRNPILRY HHHHHHHHHCCCHHE	47.53	29967540
1560	Ubiquitination	NLNLLKDKGYTTLQD CHHHHCCCCCCCHHH	52.83	33845483
1747	Phosphorylation	NMFALFEYNGHVDKA CCCHHEEECCCHHHH	21.07	20068231
1757	Phosphorylation	HVDKAIESRTVVADV CHHHHHHCCHHHHHH	27.43	20068231
1759	Phosphorylation	DKAIESRTVVADVLA HHHHHCCHHHHHHHH	28.72	-
1767	Ubiquitination	VVADVLAKFEKLAAT HHHHHHHHHHHHHCC	50.31	29967540
1770	Ubiquitination	DVLAKFEKLAATSEV HHHHHHHHHHCCCCC	46.70	29967540
1842	Phosphorylation	LQYLQGDYTLHAAIP HHHHCCCCEEEEECC	20.30	-
1882	Phosphorylation	ERLEKRRTSFLEGTL HHHHHHHHCHHHHHH	28.06	25850435
1883	Phosphorylation	RLEKRRTSFLEGTLR HHHHHHHCHHHHHHH	26.48	21712546
1888	Phosphorylation	RTSFLEGTLRRSFRT HHCHHHHHHHHHHCC	14.02	25850435
1892	Phosphorylation	LEGTLRRSFRTGSVV HHHHHHHHHCCCCCH	16.79	-
2036	Phosphorylation	VAKLMKAYISMIVKK HHHHHHHHHHHHHHH	6.49	25072903
2038	Phosphorylation	KLMKAYISMIVKKRY HHHHHHHHHHHHHCC	6.98	25072903
2042	Acetylation	AYISMIVKKRYSTTR HHHHHHHHHCCCCCC	22.17	19813581

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECM29_HUMAN	KIAA0368	physical	20682791

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-960; SER-962; SER-968;SER-969 AND SER-1007, AND MASS SPECTROMETRY.
PubMed: 17081983