dbPTM

MYH10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYH10_HUMAN
UniProt AC	P35580
Protein Name	Myosin-10
Gene Name	MYH10
Organism	Homo sapiens (Human).
Sequence Length	1976
Subcellular Localization	Cell projection, lamellipodium . Colocalizes with MCC at the leading edge of migrating cells.
Protein Description	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9..
Protein Sequence	MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQRTGLED ------CCCCCCCCC	20.90	-
13	Phosphorylation	GLEDPERYLFVDRAV CCCCHHHEEEEEEEE	11.66	21945579
13 (in isoform 4)	Phosphorylation	-	11.66	27642862
18	Methylation	ERYLFVDRAVIYNPA HHEEEEEEEEEECCC	26.00	58858611
22	Phosphorylation	FVDRAVIYNPATQAD EEEEEEEECCCCCCC	14.43	21945579
22 (in isoform 4)	Phosphorylation	-	14.43	27642862
26	Phosphorylation	AVIYNPATQADWTAK EEEECCCCCCCCCCC	26.08	21712546
31	Phosphorylation	PATQADWTAKKLVWI CCCCCCCCCCCEEEC	29.19	21712546
34	Ubiquitination	QADWTAKKLVWIPSE CCCCCCCCEEECCCC	45.89	-
40	Phosphorylation	KKLVWIPSERHGFEA CCEEECCCCCCCCEE	37.82	21406692
51	Acetylation	GFEAASIKEERGDEV CCEECCCHHHHCCHH	51.53	26051181
51	Ubiquitination	GFEAASIKEERGDEV CCEECCCHHHHCCHH	51.53	-
68	Ubiquitination	ELAENGKKAMVNKDD HHHHCCCEEECCHHH	43.01	-
73	Acetylation	GKKAMVNKDDIQKMN CCEEECCHHHHHHCC	45.42	26051181
73	Ubiquitination	GKKAMVNKDDIQKMN CCEEECCHHHHHHCC	45.42	-
78	Acetylation	VNKDDIQKMNPPKFS CCHHHHHHCCCCCCC	40.76	25953088
83	Ubiquitination	IQKMNPPKFSKVEDM HHHCCCCCCCCHHHH	64.62	-
83 (in isoform 3)	Ubiquitination	-	64.62	-
85	Phosphorylation	KMNPPKFSKVEDMAE HCCCCCCCCHHHHHH	41.75	29514088
86	Ubiquitination	MNPPKFSKVEDMAEL CCCCCCCCHHHHHHH	53.42	-
94	Phosphorylation	VEDMAELTCLNEASV HHHHHHHHHCCHHHH	13.37	-
106	Acetylation	ASVLHNLKDRYYSGL HHHHHHCCCCCCCCE	45.54	25953088
117	Phosphorylation	YSGLIYTYSGLFCVV CCCEEEEECCEEEEE	5.46	-
155	Phosphorylation	HEMPPHIYAISESAY CCCCCCEEEEEHHHH	8.54	-
162	Phosphorylation	YAISESAYRCMLQDR EEEEHHHHHHHCCCC	17.39	22210691
163	Methylation	AISESAYRCMLQDRE EEEHHHHHHHCCCCC	10.09	115385341
173	Phosphorylation	LQDREDQSILCTGES CCCCCCCCEEEECCC	29.83	21712546
176	S-palmitoylation	REDQSILCTGESGAG CCCCCEEEECCCCCC	4.35	29575903
177	Phosphorylation	EDQSILCTGESGAGK CCCCEEEECCCCCCC	40.30	-
184	Ubiquitination	TGESGAGKTENTKKV ECCCCCCCCCCHHHH	52.73	-
194	Phosphorylation	NTKKVIQYLAHVASS CHHHHHHHHHHHHHH	8.50	-
201	Phosphorylation	YLAHVASSHKGRKDH HHHHHHHHCCCCCCC	21.34	-
206	Ubiquitination	ASSHKGRKDHNIPGE HHHCCCCCCCCCCHH	72.51	-
213 (in isoform 1)	Phosphorylation	-	41.94	27251275
213 (in isoform 5)	Phosphorylation	-	41.94	27251275
214 (in isoform 2)	Phosphorylation	-	9.01	30266825
214 (in isoform 4)	Phosphorylation	-	9.01	30266825
222 (in isoform 2)	Phosphorylation	-	15.93	30622161
224 (in isoform 2)	Phosphorylation	-	7.18	30622161
227	Phosphorylation	QANPILESFGNAKTV HHCHHHHHHCCCCCC	34.70	20068231
227 (in isoform 2)	Phosphorylation	-	34.70	30622161
232	Ubiquitination	LESFGNAKTVKNDNS HHHHCCCCCCCCCCC	58.83	21906983
232 (in isoform 1)	Ubiquitination	-	58.83	21890473
232 (in isoform 3)	Ubiquitination	-	58.83	21890473
233	Phosphorylation	ESFGNAKTVKNDNSS HHHCCCCCCCCCCCC	34.01	20068231
235	Ubiquitination	FGNAKTVKNDNSSRF HCCCCCCCCCCCCCC	64.91	-
239	Phosphorylation	KTVKNDNSSRFGKFI CCCCCCCCCCCCEEE	26.25	29514088
240	Phosphorylation	TVKNDNSSRFGKFIR CCCCCCCCCCCEEEE	37.57	29514088
244	Ubiquitination	DNSSRFGKFIRINFD CCCCCCCEEEEEEEE	34.60	-
248 (in isoform 2)	Ubiquitination	-	5.28	21890473
255	Phosphorylation	INFDVTGYIVGANIE EEEECCEEEECCCHH	5.31	18767875
268	Ubiquitination	IETYLLEKSRAVRQA HHHHHHHHHHHHHHH	45.25	-
269	Phosphorylation	ETYLLEKSRAVRQAK HHHHHHHHHHHHHHC	18.98	18767875
285	Phosphorylation	ERTFHIFYQLLSGAG CCHHHHHHHHHHCCC	9.54	-
307	Phosphorylation	LLEGFNNYRFLSNGY HHCCCCCCEECCCCE	12.12	-
360	Phosphorylation	VLQFGNISFKKERNT HHHHCCCEEECCCCC	34.71	24719451
362	Acetylation	QFGNISFKKERNTDQ HHCCCEEECCCCCCC	47.11	25953088
367	Phosphorylation	SFKKERNTDQASMPE EEECCCCCCCCCCCH	35.39	21406692
371	Phosphorylation	ERNTDQASMPENTVA CCCCCCCCCCHHHHH	29.27	21406692
372	Sulfoxidation	RNTDQASMPENTVAQ CCCCCCCCCHHHHHH	5.60	21406390
376	Phosphorylation	QASMPENTVAQKLCH CCCCCHHHHHHHHHH	18.63	21406692
407	Phosphorylation	RIKVGRDYVQKAQTK CCCCCHHHHHHHCCH	11.92	28152594
410	Acetylation	VGRDYVQKAQTKEQA CCHHHHHHHCCHHHH	32.20	30786423
410	Ubiquitination	VGRDYVQKAQTKEQA CCHHHHHHHCCHHHH	32.20	21906983
410 (in isoform 1)	Ubiquitination	-	32.20	21890473
410 (in isoform 3)	Ubiquitination	-	32.20	21890473
426 (in isoform 2)	Ubiquitination	-	41.95	21890473
442	Acetylation	WLVHRINKALDRTKR HHHHHHHHHHHHHHH	48.21	19608861
442	Malonylation	WLVHRINKALDRTKR HHHHHHHHHHHHHHH	48.21	26320211
451	Acetylation	LDRTKRQGASFIGIL HHHHHHCCCCEEEEE	27.50	19608861
491	Sulfoxidation	QQLFNHTMFILEQEE HHHHHHCHHHCCHHH	1.21	28183972
547	Acetylation	WFPKATDKTFVEKLV CCCCCCCHHHHHHHH	39.24	25953088
552	Acetylation	TDKTFVEKLVQEQGS CCHHHHHHHHHHCCC	48.97	19608861
559	Phosphorylation	KLVQEQGSHSKFQKP HHHHHCCCCCCCCCC	25.04	29514088
561	Acetylation	VQEQGSHSKFQKPRQ HHHCCCCCCCCCCCC	36.54	19608861
561	Phosphorylation	VQEQGSHSKFQKPRQ HHHCCCCCCCCCCCC	36.54	29514088
562	Ubiquitination	QEQGSHSKFQKPRQL HHCCCCCCCCCCCCC	46.52	-
572	Acetylation	KPRQLKDKADFCIIH CCCCCCCCCCEEEEE	48.55	23749302
572	Ubiquitination	KPRQLKDKADFCIIH CCCCCCCCCCEEEEE	48.55	-
572 (in isoform 3)	Ubiquitination	-	48.55	-
576	Glutathionylation	LKDKADFCIIHYAGK CCCCCCEEEEECCCC	2.69	22555962
580	Phosphorylation	ADFCIIHYAGKVDYK CCEEEEECCCCCCCC	13.47	28152594
587	Ubiquitination	YAGKVDYKADEWLMK CCCCCCCCCCHHHHH	44.92	-
587 (in isoform 3)	Ubiquitination	-	44.92	-
594	Methylation	KADEWLMKNMDPLND CCCHHHHHCCCCCCH	47.12	-
613	Methylation	LLHQSSDRFVAELWK HHHHCHHHHHHHHHH	29.86	115484131
620	Acetylation	RFVAELWKDVDRIVG HHHHHHHHCHHHHCC	61.57	25953088
620	Ubiquitination	RFVAELWKDVDRIVG HHHHHHHHCHHHHCC	61.57	-
634	Sulfoxidation	GLDQVTGMTETAFGS CCHHHCCCCHHHCCC	1.92	30846556
637	Phosphorylation	QVTGMTETAFGSAYK HHCCCCHHHCCCCHH	20.37	29255136
641	Phosphorylation	MTETAFGSAYKTKKG CCHHHCCCCHHCCCC	23.21	29255136
643	Phosphorylation	ETAFGSAYKTKKGMF HHHCCCCHHCCCCCC	22.38	24173317
644	Ubiquitination	TAFGSAYKTKKGMFR HHCCCCHHCCCCCCC	54.29	-
652	Phosphorylation	TKKGMFRTVGQLYKE CCCCCCCCHHHHHHH	20.09	20068231
657	Phosphorylation	FRTVGQLYKESLTKL CCCHHHHHHHHHHHH	12.57	20068231
658	Acetylation	RTVGQLYKESLTKLM CCHHHHHHHHHHHHH	49.79	26051181
658	Methylation	RTVGQLYKESLTKLM CCHHHHHHHHHHHHH	49.79	66722909
663	Acetylation	LYKESLTKLMATLRN HHHHHHHHHHHHHHH	41.37	25953088
667	Phosphorylation	SLTKLMATLRNTNPN HHHHHHHHHHHCCCC	16.57	30622161
668 (in isoform 4)	Phosphorylation	-	2.63	27251275
671	Phosphorylation	LMATLRNTNPNFVRC HHHHHHHCCCCCEEE	45.69	30622161
678	Glutathionylation	TNPNFVRCIIPNHEK CCCCCEEEECCCCHH	2.51	22555962
678	S-palmitoylation	TNPNFVRCIIPNHEK CCCCCEEEECCCCHH	2.51	29575903
689	Acetylation	NHEKRAGKLDPHLVL CCHHHCCCCCHHHHH	49.05	23749302
689	Ubiquitination	NHEKRAGKLDPHLVL CCHHHCCCCCHHHHH	49.05	21890473
689 (in isoform 1)	Ubiquitination	-	49.05	21890473
705 (in isoform 2)	Ubiquitination	-	5.45	21890473
710 (in isoform 3)	Ubiquitination	-	1.83	21890473
718	Methylation	CRQGFPNRIVFQEFR HHCCCCCCCCHHHHH	27.04	-
732	Phosphorylation	RQRYEILTPNAIPKG HHHHCCCCCCCCCCC	21.84	26471730
738 (in isoform 1)	Ubiquitination	-	59.68	21890473
738	Ubiquitination	LTPNAIPKGFMDGKQ CCCCCCCCCCCCHHH	59.68	21890473
738	Ubiquitination	LTPNAIPKGFMDGKQ CCCCCCCCCCCCHHH	59.68	21890473
744	Acetylation	PKGFMDGKQACERMI CCCCCCHHHHHHHHH	30.38	26051181
744	Ubiquitination	PKGFMDGKQACERMI CCCCCCHHHHHHHHH	30.38	-
754 (in isoform 2)	Ubiquitination	-	4.89	21890473
754	Ubiquitination	CERMIRALELDPNLY HHHHHHHHCCCCCHH	4.89	21890473
759	Ubiquitination	RALELDPNLYRIGQS HHHCCCCCHHHCCCC	49.74	21890473
759 (in isoform 3)	Ubiquitination	-	49.74	21890473
759	Ubiquitination	RALELDPNLYRIGQS HHHCCCCCHHHCCCC	49.74	21890473
761	Phosphorylation	LELDPNLYRIGQSKI HCCCCCHHHCCCCCH	13.56	23917254
766	Phosphorylation	NLYRIGQSKIFFRAG CHHHCCCCCHHHHHH	23.62	-
767	Acetylation	LYRIGQSKIFFRAGV HHHCCCCCHHHHHHH	35.33	25825284
767	Ubiquitination	LYRIGQSKIFFRAGV HHHCCCCCHHHHHHH	35.33	-
788 (in isoform 3)	Ubiquitination	-	33.30	-
809	Ubiquitination	ARKAFAKKQQQLSAL HHHHHHHHHHHHHHH	50.32	-
814	Phosphorylation	AKKQQQLSALKVLQR HHHHHHHHHHHHHHH	27.50	26074081
817	Ubiquitination	QQQLSALKVLQRNCA HHHHHHHHHHHHHHH	40.39	21890473
823	S-nitrosylation	LKVLQRNCAAYLKLR HHHHHHHHHHHHHHH	2.20	2212679
826	Phosphorylation	LQRNCAAYLKLRHWQ HHHHHHHHHHHHCHH	5.95	28152594
828	Acetylation	RNCAAYLKLRHWQWW HHHHHHHHHHCHHHH	30.69	24502331
828	Ubiquitination	RNCAAYLKLRHWQWW HHHHHHHHHHCHHHH	30.69	21906983
828 (in isoform 1)	Ubiquitination	-	30.69	21890473
838 (in isoform 3)	Ubiquitination	-	4.03	-
840	Ubiquitination	QWWRVFTKVKPLLQV HHHHHHHCHHHHHHC	36.48	21890473
842	Ubiquitination	WRVFTKVKPLLQVTR HHHHHCHHHHHHCHH	31.35	-
844 (in isoform 2)	Ubiquitination	-	4.29	21890473
849 (in isoform 3)	Ubiquitination	-	42.95	21890473
857	Acetylation	QEEELQAKDEELLKV CHHHHHHCCHHHHHH	53.35	26051181
857	Ubiquitination	QEEELQAKDEELLKV CHHHHHHCCHHHHHH	53.35	-
878	Sulfoxidation	VEGELEEMERKHQQL HHHHHHHHHHHHHHH	4.39	21406390
881	Ubiquitination	ELEEMERKHQQLLEE HHHHHHHHHHHHHHH	32.24	-
929	Phosphorylation	EILHDLESRVEEEEE HHHHHHHHHHHHHHH	49.26	30301811
948	Sulfoxidation	LQNEKKKMQAHIQDL HHHHHHHHHHHHHHH	6.13	30846556
968	Ubiquitination	EEEGARQKLQLEKVT HHHHHHHHHHHHHHH	32.42	-
995	Phosphorylation	LLLEDQNSKFIKEKK HHHCCCCCHHHHHHH	24.26	-
1007	Methylation	EKKLMEDRIAECSSQ HHHHHHHHHHHHHHH	19.40	115484123
1011	Glutathionylation	MEDRIAECSSQLAEE HHHHHHHHHHHHHHH	3.33	22555962
1012	Phosphorylation	EDRIAECSSQLAEEE HHHHHHHHHHHHHHH	16.78	21406692
1013	Phosphorylation	DRIAECSSQLAEEEE HHHHHHHHHHHHHHH	40.65	17525332
1021	Acetylation	QLAEEEEKAKNLAKI HHHHHHHHHHHHHHH	68.86	23749302
1021	Malonylation	QLAEEEEKAKNLAKI HHHHHHHHHHHHHHH	68.86	26320211
1031	Ubiquitination	NLAKIRNKQEVMISD HHHHHHCCHHHHHHH	37.68	-
1035	Sulfoxidation	IRNKQEVMISDLEER HHCCHHHHHHHHHHH	2.09	21406390
1037	Phosphorylation	NKQEVMISDLEERLK CCHHHHHHHHHHHHH	20.32	21406692
1044 (in isoform 4)	Phosphorylation	-	65.44	27251275
1059	Ubiquitination	ELEKAKRKLDGETTD HHHHHHHHCCCCCCC	50.66	-
1129	Phosphorylation	ELQEDFESEKASRNK HHHHHHHHHHHHHHH	44.37	27499020
1145	O-linked_Glycosylation	EKQKRDLSEELEALK HHHHHHHHHHHHHHH	33.06	23301498
1145	Phosphorylation	EKQKRDLSEELEALK HHHHHHHHHHHHHHH	33.06	22617229
1153	Phosphorylation	EELEALKTELEDTLD HHHHHHHHHHHHHHC	46.80	21406692
1158	Phosphorylation	LKTELEDTLDTTAAQ HHHHHHHHHCHHHHH	19.70	21406692
1160 (in isoform 4)	Phosphorylation	-	44.07	27251275
1161	Phosphorylation	ELEDTLDTTAAQQEL HHHHHHCHHHHHHHH	22.80	21406692
1162	Phosphorylation	LEDTLDTTAAQQELR HHHHHCHHHHHHHHH	21.47	21406692
1170	Phosphorylation	AAQQELRTKREQEVA HHHHHHHHHHHHHHH	47.26	21406692
1176 (in isoform 4)	Phosphorylation	-	5.11	27251275
1187	Phosphorylation	KKALEEETKNHEAQI HHHHHHHHHHHHHHH	40.19	-
1188	Acetylation	KALEEETKNHEAQIQ HHHHHHHHHHHHHHH	60.63	26051181
1198	Methylation	EAQIQDMRQRHATAL HHHHHHHHHHHHHHH	38.38	115385333
1203	Phosphorylation	DMRQRHATALEELSE HHHHHHHHHHHHHHH	26.17	29116813
1216	Acetylation	SEQLEQAKRFKANLE HHHHHHHHHHHHHHH	59.05	25953088
1219	Malonylation	LEQAKRFKANLEKNK HHHHHHHHHHHHHHH	40.16	26320211
1224	Acetylation	RFKANLEKNKQGLET HHHHHHHHHHCCCCC	73.02	69725
1231	Phosphorylation	KNKQGLETDNKELAC HHHCCCCCCCHHHHH	50.33	21406692
1234	Acetylation	QGLETDNKELACEVK CCCCCCCHHHHHHHH	57.84	26051181
1234 (in isoform 4)	Phosphorylation	-	57.84	27251275
1238	Glutathionylation	TDNKELACEVKVLQQ CCCHHHHHHHHHHHH	10.91	22555962
1241	Acetylation	KELACEVKVLQQVKA HHHHHHHHHHHHHHC	18.22	23236377
1241	Malonylation	KELACEVKVLQQVKA HHHHHHHHHHHHHHC	18.22	26320211
1247	Acetylation	VKVLQQVKAESEHKR HHHHHHHHCCCHHHH	41.94	19608861
1255	Acetylation	AESEHKRKKLDAQVQ CCCHHHHHHHHHHHH	63.59	25953088
1256	Acetylation	ESEHKRKKLDAQVQE CCHHHHHHHHHHHHH	56.48	26051181
1256	Malonylation	ESEHKRKKLDAQVQE CCHHHHHHHHHHHHH	56.48	26320211
1267	Acetylation	QVQELHAKVSEGDRL HHHHHHHHCCCCHHH	35.23	25953088
1267	Ubiquitination	QVQELHAKVSEGDRL HHHHHHHHCCCCHHH	35.23	-
1281	Acetylation	LRVELAEKASKLQNE HHHHHHHHHHHHHHH	52.96	25953088
1301	Acetylation	TLLEEAEKKGIKFAK HHHHHHHHHCCCHHH	64.45	26051181
1312	Phosphorylation	KFAKDAASLESQLQD CHHHHHHHHHHHHHH	34.10	28348404
1315	Phosphorylation	KDAASLESQLQDTQE HHHHHHHHHHHHHHH	41.29	28348404
1335	Phosphorylation	TRQKLNLSSRIRQLE HHHHCCHHHHHHHHH	19.25	24719451
1343 (in isoform 4)	Phosphorylation	-	80.84	27251275
1345	Acetylation	IRQLEEEKNSLQEQQ HHHHHHHHHHHHHHH	55.93	88535
1347	Phosphorylation	QLEEEKNSLQEQQEE HHHHHHHHHHHHHHH	42.36	26471730
1376	Phosphorylation	LQSQLADTKKKVDDD HHHHHHHHHHHHCCC	38.87	19060867
1379	Acetylation	QLADTKKKVDDDLGT HHHHHHHHHCCCCHH	53.07	11791257
1386	Phosphorylation	KVDDDLGTIESLEEA HHCCCCHHHHHHHHH	28.95	21406692
1389	Phosphorylation	DDLGTIESLEEAKKK CCCHHHHHHHHHHHH	36.91	21406692
1396	Acetylation	SLEEAKKKLLKDAEA HHHHHHHHHHHHHHH	59.34	11791269
1399	Ubiquitination	EAKKKLLKDAEALSQ HHHHHHHHHHHHHHH	66.39	-
1411	Acetylation	LSQRLEEKALAYDKL HHHHHHHHHHHHHHH	39.05	25953088
1415	Phosphorylation	LEEKALAYDKLEKTK HHHHHHHHHHHHHHH	17.92	21082442
1417	Acetylation	EKALAYDKLEKTKNR HHHHHHHHHHHHHHH	45.96	25953088
1421	Phosphorylation	AYDKLEKTKNRLQQE HHHHHHHHHHHHHHH	24.95	-
1444	Phosphorylation	DHQRQVASNLEKKQK HHHHHHHHHHHHHHH	42.99	-
1446 (in isoform 4)	Phosphorylation	-	10.66	27251275
1448	Acetylation	QVASNLEKKQKKFDQ HHHHHHHHHHHHHHH	64.77	23749302
1451	Acetylation	SNLEKKQKKFDQLLA HHHHHHHHHHHHHHH	65.37	7666121
1452	Acetylation	NLEKKQKKFDQLLAE HHHHHHHHHHHHHHH	52.24	7666133
1452	Methylation	NLEKKQKKFDQLLAE HHHHHHHHHHHHHHH	52.24	7666133
1452	Ubiquitination	NLEKKQKKFDQLLAE HHHHHHHHHHHHHHH	52.24	-
1461	Acetylation	DQLLAEEKSISARYA HHHHHHHHCHHHHHH	44.59	25953088
1462	Phosphorylation	QLLAEEKSISARYAE HHHHHHHCHHHHHHH	25.67	23403867
1464	Phosphorylation	LAEEKSISARYAEER HHHHHCHHHHHHHHH	17.49	23403867
1467	Phosphorylation	EKSISARYAEERDRA HHCHHHHHHHHHHHH	20.34	23403867
1473 (in isoform 3)	Ubiquitination	-	40.32	-
1484	Acetylation	EAREKETKALSLARA HHHHHHHHHHHHHHH	48.71	11922547
1484	Ubiquitination	EAREKETKALSLARA HHHHHHHHHHHHHHH	48.71	-
1487	Phosphorylation	EKETKALSLARALEE HHHHHHHHHHHHHHH	25.50	28060719
1499	Acetylation	LEEALEAKEEFERQN HHHHHHHHHHHHHHH	48.69	26051181
1505 (in isoform 3)	Ubiquitination	-	55.03	-
1513	Sulfoxidation	NKQLRADMEDLMSSK HHHHHHHHHHHHCCC	4.16	30846556
1517	Sulfoxidation	RADMEDLMSSKDDVG HHHHHHHHCCCCHHH	7.04	30846556
1532	Acetylation	KNVHELEKSKRALEQ HHHHHHHHHHHHHHH	74.11	25953088
1544	Sulfoxidation	LEQQVEEMRTQLEEL HHHHHHHHHHHHHHH	3.39	30846556
1545	Methylation	EQQVEEMRTQLEELE HHHHHHHHHHHHHHH	23.70	115484147
1546	Phosphorylation	QQVEEMRTQLEELED HHHHHHHHHHHHHHH	35.87	21082442
1558	Phosphorylation	LEDELQATEDAKLRL HHHHHHCCHHHHHHH	22.80	-
1562	Ubiquitination	LQATEDAKLRLEVNM HHCCHHHHHHHHHHH	46.60	-
1582	Phosphorylation	QFERDLQTRDEQNEE HHHHHHHCHHHCCHH	47.59	27251275
1596	Acetylation	EKKRLLIKQVRELEA HHHHHHHHHHHHHHH	42.59	25953088
1609	Methylation	EAELEDERKQRALAV HHHCHHHHHHHHHHH	53.37	115484115
1613 (in isoform 4)	Phosphorylation	-	9.44	27251275
1619	Acetylation	RALAVASKKKMEIDL HHHHHHCCCCCCCCH	46.83	25953088
1645	Acetylation	KARDEVIKQLRKLQA HHHHHHHHHHHHHHH	48.75	19608861
1645	Malonylation	KARDEVIKQLRKLQA HHHHHHHHHHHHHHH	48.75	26320211
1649	Ubiquitination	EVIKQLRKLQAQMKD HHHHHHHHHHHHHHH	54.25	-
1654	Acetylation	LRKLQAQMKDYQREL HHHHHHHHHHHHHHH	3.90	19608861
1667	Phosphorylation	ELEEARASRDEIFAQ HHHHHHHCHHHHHHC	34.41	26437602
1684	Phosphorylation	ESEKKLKSLEAEILQ HHHHHHHHHHHHHHH	41.71	25693802
1698	Phosphorylation	QLQEELASSERARRH HHHHHHHCHHHHHHH	45.41	25693802
1699	Phosphorylation	LQEELASSERARRHA HHHHHHCHHHHHHHH	26.04	25693802
1720	Phosphorylation	LADEITNSASGKSAL HHHHHHHCCCCHHHH	18.37	28674419
1750	O-linked_Glycosylation	EELEEEQSNMELLND HHHHHHHHHHHHHHH	41.23	23301498
1750	Phosphorylation	EELEEEQSNMELLND HHHHHHHHHHHHHHH	41.23	27732954
1752	Sulfoxidation	LEEEQSNMELLNDRF HHHHHHHHHHHHHHH	4.68	30846556
1762	Phosphorylation	LNDRFRKTTLQVDTL HHHHHHHCCCCHHHH	28.60	21406692
1763	Phosphorylation	NDRFRKTTLQVDTLN HHHHHHCCCCHHHHH	20.44	21406692
1768	Phosphorylation	KTTLQVDTLNAELAA HCCCCHHHHHHHHHH	24.05	21406692
1783	Phosphorylation	ERSAAQKSDNARQQL HHHHHHHCHHHHHHH	24.82	27470641
1800	Acetylation	QNKELKAKLQELEGA HHHHHHHHHHHHHHH	49.46	23749302
1800	Malonylation	QNKELKAKLQELEGA HHHHHHHHHHHHHHH	49.46	26320211
1800	Ubiquitination	QNKELKAKLQELEGA HHHHHHHHHHHHHHH	49.46	-
1809	Acetylation	QELEGAVKSKFKATI HHHHHHHHHHHHHHH	47.60	25953088
1809	Malonylation	QELEGAVKSKFKATI HHHHHHHHHHHHHHH	47.60	26320211
1842	Acetylation	KERAAANKLVRRTEK HHHHHHHHHHHHHHH	43.57	25953088
1842	Malonylation	KERAAANKLVRRTEK HHHHHHHHHHHHHHH	43.57	26320211
1856	Sulfoxidation	KKLKEIFMQVEDERR HHHHHHHHHHHHHHH	5.54	21406390
1872	Sulfoxidation	ADQYKEQMEKANARM HHHHHHHHHHHHHHH	6.30	30846556
1874	Acetylation	QYKEQMEKANARMKQ HHHHHHHHHHHHHHH	41.41	12437743
1894	Phosphorylation	EEAEEEATRANASRR HHHHHHHHHHHHHHH	33.33	23403867
1899	Phosphorylation	EATRANASRRKLQRE HHHHHHHHHHHHHHH	32.21	-
1922	Phosphorylation	EGLSREVSTLKNRLR HHHHHHHHHHHHHHH	24.22	-
1923	Phosphorylation	GLSREVSTLKNRLRR HHHHHHHHHHHHHHC	47.10	-
1930	Methylation	TLKNRLRRGGPISFS HHHHHHHCCCCCCCC	60.04	16187485
1935	Phosphorylation	LRRGGPISFSSSRSG HHCCCCCCCCCCCCC	23.39	30266825
1937	Phosphorylation	RGGPISFSSSRSGRR CCCCCCCCCCCCCCC	22.18	29255136
1938	Phosphorylation	GGPISFSSSRSGRRQ CCCCCCCCCCCCCCE	27.97	30266825
1939	Phosphorylation	GPISFSSSRSGRRQL CCCCCCCCCCCCCEE	29.30	29255136
1940	Methylation	PISFSSSRSGRRQLH CCCCCCCCCCCCEEE	45.11	58858623
1941	Phosphorylation	ISFSSSRSGRRQLHL CCCCCCCCCCCEEEE	38.30	21406692
1952	Phosphorylation	QLHLEGASLELSDDD EEEEECCEEECCCCC	32.98	29255136
1956	Phosphorylation	EGASLELSDDDTESK ECCEEECCCCCCCCC	29.62	29255136
1960	Phosphorylation	LELSDDDTESKTSDV EECCCCCCCCCCCCC	49.50	29255136
1962	Phosphorylation	LSDDDTESKTSDVNE CCCCCCCCCCCCCCC	43.24	29255136
1964	Phosphorylation	DDDTESKTSDVNETQ CCCCCCCCCCCCCCC	39.16	23927012
1965	Phosphorylation	DDTESKTSDVNETQP CCCCCCCCCCCCCCC	43.21	23927012
1966 (in isoform 4)	Phosphorylation	-	53.12	27251275
1968 (in isoform 4)	Phosphorylation	-	52.14	27251275
1969 (in isoform 4)	Phosphorylation	-	48.98	27251275
1970	Phosphorylation	KTSDVNETQPPQSE- CCCCCCCCCCCCCC-	40.97	23927012
1975	Phosphorylation	NETQPPQSE------ CCCCCCCCC------	100.00	23927012
1983 (in isoform 4)	Phosphorylation	-		27251275
1987 (in isoform 4)	Phosphorylation	-		27251275
1991 (in isoform 4)	Phosphorylation	-		27251275
1995 (in isoform 4)	Phosphorylation	-		27251275
2001 (in isoform 4)	Phosphorylation	-		27251275
2006 (in isoform 4)	Phosphorylation	-		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1937	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1952	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1956	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1960	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1965	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1975	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYH10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYH10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PBX1_HUMAN	PBX1	physical	12724421
MYH9_HUMAN	MYH9	physical	22939629
RB11A_HUMAN	RAB11A	physical	22939629
MYO1C_HUMAN	MYO1C	physical	22939629
RALA_HUMAN	RALA	physical	22939629
SEPT7_HUMAN	SEPT7	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYH10_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-1964; SER-1965 AND SER-1975, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-442; LYS-552; LYS-1247 ANDLYS-1645, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939; SER-1952 ANDSER-1956, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-1964; SER-1965 AND SER-1975, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1939; SER-1952 ANDSER-1956, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1956 AND SER-1975, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1013, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1376, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1960, AND MASSSPECTROMETRY.	17081983 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1415, AND MASSSPECTROMETRY.	18083107 [Abstract]