GA2L3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GA2L3_HUMAN
• UniProt AC: Q86XJ1
• Protein Name: GAS2-like protein 3
• Gene Name: GAS2L3
• Organism: Homo sapiens (Human).
• Sequence Length: 694
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Localizes to microtubule and actin cytoskeletons.
• Protein Description: Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network..
• Protein Sequence: MQPAIQVWFGEDLPLSPRSPLTPRHGPGLANVCQYDEWIAVRHEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEESGNFPMRKVPCKKDAASGSFFARDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEPPVLVKLEKEIELEETLLNTSGPEDSISIPKSCCRHEELHEAVKHIAEDPPCSCSHRFSIEYLSEGRYRLGDKILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQFATLEQKILAFQKGVSNESVPDSPARTPQPPEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVPASSLKGGNLGSMSVRSKLPNSPAASSHPKLKSSKGITKKPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCISSPNTPKAKVIPAQNSADLPESTLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQSSAKMTKTSSKTIATGLGTQSQPSDGAPQAKPVPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGPSSLKSPGRTPLSIVSLPQSSTKTQTAPKSAQTVAKSQHSTKGPPRSGKTPASIRKPPSSVKDADSGDKKPTAKKKEDDDHYFVMTGSKKPRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	FGEDLPLSPRSPLTP ECCCCCCCCCCCCCC	19.14	22199227
19	Phosphorylation	DLPLSPRSPLTPRHG CCCCCCCCCCCCCCC	27.87	22199227
22	Phosphorylation	LSPRSPLTPRHGPGL CCCCCCCCCCCCCCH	22.97	22199227
116	Phosphorylation	PCKKDAASGSFFARD CCCCCCCCCCCCCCC	36.37	27134283
190	Phosphorylation	KEIELEETLLNTSGP CEEEHHHHHHCCCCC	27.46	20068231
194	Phosphorylation	LEETLLNTSGPEDSI HHHHHHCCCCCCCCC	34.72	20068231
195	Phosphorylation	EETLLNTSGPEDSIS HHHHHCCCCCCCCCC	51.80	20068231
200	Phosphorylation	NTSGPEDSISIPKSC CCCCCCCCCCCCHHH	19.30	20068231
202	Phosphorylation	SGPEDSISIPKSCCR CCCCCCCCCCHHHCC	36.47	20068231
227	Phosphorylation	IAEDPPCSCSHRFSI HHCCCCCCCCCCCEE	25.16	28348404
229	Phosphorylation	EDPPCSCSHRFSIEY CCCCCCCCCCCEEEE	11.03	28348404
233	Phosphorylation	CSCSHRFSIEYLSEG CCCCCCCEEEEHHCC	17.92	28348404
242	Phosphorylation	EYLSEGRYRLGDKIL EEHHCCCEECCCEEE	22.50	22817900
297	Ubiquitination	QKILAFQKGVSNESV HHHHHHHCCCCCCCC	55.62	-
300	Phosphorylation	LAFQKGVSNESVPDS HHHHCCCCCCCCCCC	43.48	22199227
303	Phosphorylation	QKGVSNESVPDSPAR HCCCCCCCCCCCCCC	43.11	29255136
307	Phosphorylation	SNESVPDSPARTPQP CCCCCCCCCCCCCCC	17.87	29255136
311	Phosphorylation	VPDSPARTPQPPEMN CCCCCCCCCCCCCCC	28.51	22199227
321	Phosphorylation	PPEMNPLSAVNMFQK CCCCCHHHHHHHHHH	31.28	22199227
331	Phosphorylation	NMFQKQNSKPSVPVS HHHHHCCCCCCCCCC	43.37	28857561
338	Phosphorylation	SKPSVPVSIPKSKEK CCCCCCCCCCCCHHC	27.40	22817900
358	Phosphorylation	GALVPASSLKGGNLG CCEEEHHHCCCCCCC	35.89	28555341
366	Phosphorylation	LKGGNLGSMSVRSKL CCCCCCCCCCHHHCC	15.85	28857561
368	Phosphorylation	GGNLGSMSVRSKLPN CCCCCCCCHHHCCCC	18.97	28857561
371	Phosphorylation	LGSMSVRSKLPNSPA CCCCCHHHCCCCCCC	36.07	29396449
376	Phosphorylation	VRSKLPNSPAASSHP HHHCCCCCCCHHCCC	17.61	25159151
380	Phosphorylation	LPNSPAASSHPKLKS CCCCCCHHCCCCCCC	31.14	23403867
381	Phosphorylation	PNSPAASSHPKLKSS CCCCCHHCCCCCCCC	38.80	24732914
384	Acetylation	PAASSHPKLKSSKGI CCHHCCCCCCCCCCC	64.22	30588891
387	Phosphorylation	SSHPKLKSSKGITKK HCCCCCCCCCCCCCC	47.95	-
399	Phosphorylation	TKKPQAPSNNASSSL CCCCCCCCCCCCCCH	45.81	29978859
403	Phosphorylation	QAPSNNASSSLASLN CCCCCCCCCCHHHCC	23.68	29978859
404	Phosphorylation	APSNNASSSLASLNP CCCCCCCCCHHHCCC	27.28	29978859
405	Phosphorylation	PSNNASSSLASLNPV CCCCCCCCHHHCCCC	26.01	29978859
408	Phosphorylation	NASSSLASLNPVGKN CCCCCHHHCCCCCCC	33.69	29978859
416	Phosphorylation	LNPVGKNTSSPALPR CCCCCCCCCCCCCCC	33.78	22199227
417	Phosphorylation	NPVGKNTSSPALPRT CCCCCCCCCCCCCCC	43.66	25159151
418	Phosphorylation	PVGKNTSSPALPRTA CCCCCCCCCCCCCCC	16.50	25159151
424	Phosphorylation	SSPALPRTAPCISES CCCCCCCCCCCCCCC	32.77	20068231
429	Phosphorylation	PRTAPCISESPRKCI CCCCCCCCCCCCHHC	38.44	22199227
431	Phosphorylation	TAPCISESPRKCISS CCCCCCCCCCHHCCC	24.18	25159151
437	Phosphorylation	ESPRKCISSPNTPKA CCCCHHCCCCCCCCC	49.57	22199227
438	Phosphorylation	SPRKCISSPNTPKAK CCCHHCCCCCCCCCE	11.40	22199227
441	Phosphorylation	KCISSPNTPKAKVIP HHCCCCCCCCCEEEC	29.56	22199227
452	Phosphorylation	KVIPAQNSADLPEST EEECCCCCCCCCCCC	15.87	28857561
480	Phosphorylation	YLKHNHISSRDNAVS CCCCCCCCCCCHHHH	16.27	30576142
487	Phosphorylation	SSRDNAVSHLAAHSN CCCCHHHHHHHHHCC	15.46	30576142
493	Phosphorylation	VSHLAAHSNSSSKCP HHHHHHHCCCCCCCC	33.41	25159151
495	Phosphorylation	HLAAHSNSSSKCPKL HHHHHCCCCCCCCCC	38.72	25159151
496	Phosphorylation	LAAHSNSSSKCPKLP HHHHCCCCCCCCCCC	37.76	30576142
497	Phosphorylation	AAHSNSSSKCPKLPK HHHCCCCCCCCCCCC	37.79	-
514	Phosphorylation	IPVRPKPSFQSSAKM CCCCCCCCHHCCCCC	41.88	28555341
526	Phosphorylation	AKMTKTSSKTIATGL CCCCCCCCCEECCCC	38.76	20201521
528	Phosphorylation	MTKTSSKTIATGLGT CCCCCCCEECCCCCC	20.14	20201521
555	Methylation	PVPAQKLKSALNLNQ CCCHHHHHHHHCCCC	40.49	-
565	Phosphorylation	LNLNQPVSVSSVSPV HCCCCCCCCCCCCCC	23.98	24732914
567	Phosphorylation	LNQPVSVSSVSPVKA CCCCCCCCCCCCCCC	19.95	21712546
568	Phosphorylation	NQPVSVSSVSPVKAT CCCCCCCCCCCCCCC	25.18	21712546
570	Phosphorylation	PVSVSSVSPVKATQK CCCCCCCCCCCCCCC	26.39	25159151
575	Phosphorylation	SVSPVKATQKSKDKN CCCCCCCCCCCCCCC	30.71	27174698
578	Phosphorylation	PVKATQKSKDKNIVS CCCCCCCCCCCCCCC	35.95	24173317
585	Phosphorylation	SKDKNIVSATKKQPQ CCCCCCCCCCCCCCC	26.82	26307563
587	Phosphorylation	DKNIVSATKKQPQNK CCCCCCCCCCCCCCH	31.13	26307563
607	Phosphorylation	TGPSSLKSPGRTPLS HCCCCCCCCCCCCCE	37.57	30576142
611	Phosphorylation	SLKSPGRTPLSIVSL CCCCCCCCCCEEEEC	34.20	22199227
614	Phosphorylation	SPGRTPLSIVSLPQS CCCCCCCEEEECCCC	23.34	30576142
617	Phosphorylation	RTPLSIVSLPQSSTK CCCCEEEECCCCCCC	32.44	22199227
621	Phosphorylation	SIVSLPQSSTKTQTA EEEECCCCCCCCCCC	37.73	25159151
622	Phosphorylation	IVSLPQSSTKTQTAP EEECCCCCCCCCCCC	28.77	30576142
623	Phosphorylation	VSLPQSSTKTQTAPK EECCCCCCCCCCCCC	43.27	30576142
638	Phosphorylation	SAQTVAKSQHSTKGP HHHHHHHHCCCCCCC	24.32	29396449
641	Phosphorylation	TVAKSQHSTKGPPRS HHHHHCCCCCCCCCC	24.95	29396449
642	Phosphorylation	VAKSQHSTKGPPRSG HHHHCCCCCCCCCCC	37.58	29396449
648	Phosphorylation	STKGPPRSGKTPASI CCCCCCCCCCCCHHH	50.87	29396449
660	Phosphorylation	ASIRKPPSSVKDADS HHHCCCCCCCCCCCC	57.18	20068231
661	Phosphorylation	SIRKPPSSVKDADSG HHCCCCCCCCCCCCC	38.67	20068231
683	Phosphorylation	KKEDDDHYFVMTGSK CCCCCCCEEEECCCC	12.59	25348954
687	Phosphorylation	DDHYFVMTGSKKPRK CCCEEEECCCCCCCC	32.76	25348954
689	Phosphorylation	HYFVMTGSKKPRK-- CEEEECCCCCCCC--	28.48	25348954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GA2L3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GA2L3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GA2L3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GA2L3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-438; THR-441 ANDSER-570, AND MASS SPECTROMETRY.
PubMed: 18669648