MYO5C_HUMAN - dbPTM
MYO5C_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYO5C_HUMAN
UniProt AC Q9NQX4
Protein Name Unconventional myosin-Vc
Gene Name MYO5C
Organism Homo sapiens (Human).
Sequence Length 1742
Subcellular Localization
Protein Description May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues..
Protein Sequence MAVAELYTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPLRNPDILVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPFGSMITVKSAKQVIKPNSKHFRTTVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFSDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQLTYRVQRLQKKLEDQNKENHGLVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRMLLEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQHLVEGEHVTSDGLKAEVARLSKQVKTISEFEKEIELLQAQKIDVEKHVQSQKREMREKMSEITKQLLESYDIEDVRSRLSVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQKLFREENDINESIRHEVTRLTSENMMIPDFKQQISELEKQKQDLEIRLNEQAEKMKGKLEELSNQLHRSQEEEGTQRKALEAQNEIHTKEKEKLIDKIQEMQEASDHLKKQFETESEVKCNFRQEASRLTLENRDLEEELDMKDRVIKKLQDQVKTLSKTIGKANDVHSSSGPKEYLGMLQYKREDEAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLKSLMNSTINGIKQVVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCLNNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSSSIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKGMQIRCNISYLEEWLKDKNLQNSLAKETLEPLSQAAWLLQVKKTTDSDAKEIYERCTSLSAVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLDTKYLFQVTFPFTPSPHALEMIQIPSSFKLGFLNRL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAVAELYTQ
------CCHHHHHHH		22.11-
23UbiquitinationPDPEEVWKSAEIAKD
CCHHHHHHHHHHHHH		44.9929967540
94PhosphorylationLRIRFAESKLIYTYS
HHHEECCCCEEEEEC		29.3620860994
98PhosphorylationFAESKLIYTYSGIIL
ECCCCEEEEECCEEE		15.2926356563
99PhosphorylationAESKLIYTYSGIILV
CCCCEEEEECCEEEE		12.2926356563
100PhosphorylationESKLIYTYSGIILVA
CCCEEEEECCEEEEE		6.4726356563
101PhosphorylationSKLIYTYSGIILVAM
CCEEEEECCEEEEEC		18.7326356563
111PhosphorylationILVAMNPYKQLPIYG
EEEECCCCCCCCCCC		13.3326356563
125PhosphorylationGDAIIHAYSGQNMGD
CCEEEHHCCCCCCCC		10.12-
126PhosphorylationDAIIHAYSGQNMGDM
CEEEHHCCCCCCCCC		34.39-
156PhosphorylationARNNRNQSIIVSGES
HHHCCCCEEEEECCC		20.17-
163PhosphorylationSIIVSGESGAGKTVS
EEEEECCCCCCCCHH		37.1522210691
168PhosphorylationGESGAGKTVSARYAM
CCCCCCCCHHHHHHH		20.8322210691
170PhosphorylationSGAGKTVSARYAMRY
CCCCCCHHHHHHHHH		16.5622210691
208UbiquitinationTEAVGNAKTTRNDNS
CCHHCCCCCCCCCCC		55.2021906983
208UbiquitinationTEAVGNAKTTRNDNS
CCHHCCCCCCCCCCC		55.2021890473
215PhosphorylationKTTRNDNSSRFGKYT
CCCCCCCCCCCEEEE		26.2529514088
216PhosphorylationTTRNDNSSRFGKYTE
CCCCCCCCCCEEEEE		37.5729514088
244UbiquitinationMSTYLLEKSRVVFQS
HHHHHHHHCEEEEEC		43.4629901268
292PhosphorylationYTRMGGNTVIEGVND
CEEECCCEEEECCCC		26.57-
306PhosphorylationDRAEMVETQKTFTLL
CHHHHHHCHHHHEEE		24.77-
380PhosphorylationLCNRKIVTSSETVVK
HHCCCCCCCCCEEEC		29.9720860994
382PhosphorylationNRKIVTSSETVVKPM
CCCCCCCCCEEECCC		28.1120860994
384PhosphorylationKIVTSSETVVKPMTR
CCCCCCCEEECCCCC		32.3320860994
387UbiquitinationTSSETVVKPMTRPQA
CCCCEEECCCCCHHH		25.4129967540
400UbiquitinationQAVNARDALAKKIYA
HHCCHHHHHHHHHHH		12.1327667366
447UbiquitinationETFDVNSFEQFCINY
CEECCCCHHHHHHHH		7.8421890473
475PhosphorylationFKLEQEEYMKEDIPW
HHHCHHHHHHHCCCC		16.8530177828
526PhosphorylationENWLQKLYNNFVNRN
HHHHHHHHHHCCCCC		18.3321403953
569PhosphorylationFLEKNRDTVYDMLVE
HHHHCHHHHHHHHHH		20.0920068231
571PhosphorylationEKNRDTVYDMLVEIL
HHCHHHHHHHHHHHH		9.5720068231
577UbiquitinationVYDMLVEILRASKFH
HHHHHHHHHHHCCCC		2.1627667366
598PhosphorylationQENPTPPSPFGSMIT
CCCCCCCCCCCCCEE		33.7826657352
602PhosphorylationTPPSPFGSMITVKSA
CCCCCCCCCEEEEEC		13.8524719451
605PhosphorylationSPFGSMITVKSAKQV
CCCCCCEEEEECCEE		17.1524719451
624UbiquitinationSKHFRTTVGSKFRSS
CCCCCHHCHHHHHHH		8.8921890473
630PhosphorylationTVGSKFRSSLYLLME
HCHHHHHHHHHHHHH		28.0320049867
631PhosphorylationVGSKFRSSLYLLMET
CHHHHHHHHHHHHHH		19.4420049867
633PhosphorylationSKFRSSLYLLMETLN
HHHHHHHHHHHHHHC		10.3524719451
638PhosphorylationSLYLLMETLNATTPH
HHHHHHHHHCCCCCC		16.0224719451
642PhosphorylationLMETLNATTPHYVRC
HHHHHCCCCCCEEEE		39.5224719451
646PhosphorylationLNATTPHYVRCIKPN
HCCCCCCEEEEECCC		7.2720049867
735UbiquitinationSNQYQFGKTKIFFRA
CCCCCCCCEEEEEEC		48.1929967540
747PhosphorylationFRAGQVAYLEKLRLD
EECCHHHHHHHHCHH		19.28-
819UbiquitinationIIIQKHCRGYLVRSL
HHHHHHCCHHHHHHH		36.1927667366
821PhosphorylationIQKHCRGYLVRSLYQ
HHHHCCHHHHHHHHH		5.2229978859
825PhosphorylationCRGYLVRSLYQLIRM
CCHHHHHHHHHHHHH		24.7729978859
827PhosphorylationGYLVRSLYQLIRMAT
HHHHHHHHHHHHHHH		11.5229978859
834PhosphorylationYQLIRMATITMQAYS
HHHHHHHHHHHHHHH		13.9829978859
836UbiquitinationLIRMATITMQAYSRG
HHHHHHHHHHHHHHH		10.0127667366
836PhosphorylationLIRMATITMQAYSRG
HHHHHHHHHHHHHHH		10.0129978859
840PhosphorylationATITMQAYSRGFLAR
HHHHHHHHHHHHHHH		5.0829978859
841PhosphorylationTITMQAYSRGFLARR
HHHHHHHHHHHHHHH		29.0122210691
858UbiquitinationRKMLEEHKAVILQKY
HHHHHHHHHHHHHHH		47.8629967540
864UbiquitinationHKAVILQKYARAWLA
HHHHHHHHHHHHHHH		37.1227667366
864AcetylationHKAVILQKYARAWLA
HHHHHHHHHHHHHHH		37.12133231
866UbiquitinationAVILQKYARAWLARR
HHHHHHHHHHHHHHH		11.1821890473
877PhosphorylationLARRRFQSIRRFVLN
HHHHHHHHHHHHHHH		18.4924719451
883UbiquitinationQSIRRFVLNIQLTYR
HHHHHHHHHHHHHHH		4.2621890473
911UbiquitinationENHGLVEKLTSLAAL
CCCCHHHHHHHHHHH		49.9722817900
913PhosphorylationHGLVEKLTSLAALRA
CCHHHHHHHHHHHHC		32.5320068231
914PhosphorylationGLVEKLTSLAALRAG
CHHHHHHHHHHHHCC		26.8420068231
928UbiquitinationGDVEKIQKLEAELEK
CCHHHHHHHHHHHHH		52.3329967540
963UbiquitinationEKLAKLQKHNSELET
HHHHHHHHHCHHHHH		56.0129967540
966PhosphorylationAKLQKHNSELETQKE
HHHHHHCHHHHHHHH		43.1928348404
972UbiquitinationNSELETQKEQIQLKL
CHHHHHHHHHHHHHH		60.0329967540
1003UbiquitinationQLFDDVQKEERQRML
HHHHHHHHHHHHHHH		62.4829967540
1018UbiquitinationLEKSFELKTQDYEKQ
HHHHHHHCCHHHHHH		36.6229967540
1076UbiquitinationKTISEFEKEIELLQA
CCHHHHHHHHHHHHH		70.1229967540
1104PhosphorylationREMREKMSEITKQLL
HHHHHHHHHHHHHHH		36.5922817900
1121PhosphorylationYDIEDVRSRLSVEDL
CCHHHHHHCCCHHHH		37.1027251275
1124PhosphorylationEDVRSRLSVEDLEHL
HHHHHCCCHHHHHHH		23.5027251275
1157PhosphorylationVLESHFQSQKDCYEK
HHHHHHHCCHHHHHH		37.9518077418
1164UbiquitinationSQKDCYEKEIEALNF
CCHHHHHHHHHHHCC		37.2029967540
1202PhosphorylationESIRHEVTRLTSENM
HHHHHHHHHHHHCCC		19.5829759185
1206PhosphorylationHEVTRLTSENMMIPD
HHHHHHHHCCCCCCC		31.4029759185
1247PhosphorylationKGKLEELSNQLHRSQ
HHHHHHHHHHHHHHH		26.3030001349
1327UbiquitinationLEEELDMKDRVIKKL
HHHHHCHHHHHHHHH		41.8929967540
1347AcetylationTLSKTIGKANDVHSS
HHHHHHCCHHHCCCC		39.9220167786
1358AcetylationVHSSSGPKEYLGMLQ
CCCCCCCHHHHCCCE		63.6220167786
1360PhosphorylationSSSGPKEYLGMLQYK
CCCCCHHHHCCCEEC		18.0621406692
1366PhosphorylationEYLGMLQYKREDEAK
HHHCCCEECCHHHHH		14.1921406692
1383UbiquitinationQNLILDLKPRGVVVN
HHHHHHCCCCCEEEE		32.1333845483
1422PhosphorylationMLKSLMNSTINGIKQ
HHHHHHHHHHHHHHH		19.3922210691
1423PhosphorylationLKSLMNSTINGIKQV
HHHHHHHHHHHHHHH		17.2922210691
1611PhosphorylationMQIRCNISYLEEWLK
CEEEECHHHHHHHHH		15.0727762562
1649PhosphorylationQVKKTTDSDAKEIYE
HHHCCCCCCHHHHHH		37.0630631047
1655PhosphorylationDSDAKEIYERCTSLS
CCCHHHHHHHHCCCC		9.83-
1660PhosphorylationEIYERCTSLSAVQII
HHHHHHCCCCHHHHH		24.7730631047
1673PhosphorylationIIKILNSYTPIDDFE
HHHHHHCCCCCCHHH		18.57-
1684PhosphorylationDDFEKRVTPSFVRKV
CHHHHCCCHHHHHHH		19.7628348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYO5C_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYO5C_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYO5C_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB8A_HUMANRAB8Aphysical
17507647
POTE1_HUMANPOT1physical
21988832
ACTG_HUMANACTG1physical
26496610
ACTN4_HUMANACTN4physical
26496610
AP2A1_HUMANAP2A1physical
26496610
CAZA1_HUMANCAPZA1physical
26496610
CAZA2_HUMANCAPZA2physical
26496610
CAPZB_HUMANCAPZBphysical
26496610
CLIC1_HUMANCLIC1physical
26496610
CLCB_HUMANCLTBphysical
26496610
DAPK3_HUMANDAPK3physical
26496610
DSG2_HUMANDSG2physical
26496610
SRC8_HUMANCTTNphysical
26496610
FLII_HUMANFLIIphysical
26496610
FLNA_HUMANFLNAphysical
26496610
ERG7_HUMANLSSphysical
26496610
MYO1B_HUMANMYO1Bphysical
26496610
MYO1E_HUMANMYO1Ephysical
26496610
MYO5A_HUMANMYO5Aphysical
26496610
MYO6_HUMANMYO6physical
26496610
MYPT1_HUMANPPP1R12Aphysical
26496610
PGK1_HUMANPGK1physical
26496610
PP1A_HUMANPPP1CAphysical
26496610
SPTN1_HUMANSPTAN1physical
26496610
SPTB2_HUMANSPTBN1physical
26496610
SVIL_HUMANSVILphysical
26496610
TMOD1_HUMANTMOD1physical
26496610
TPM2_HUMANTPM2physical
26496610
TPM3_HUMANTPM3physical
26496610
LUZP1_HUMANLUZP1physical
26496610
MPZL1_HUMANMPZL1physical
26496610
LRRF2_HUMANLRRFIP2physical
26496610
ABCG2_HUMANABCG2physical
26496610
RHGBA_HUMANARHGAP11Aphysical
26496610
ARPC5_HUMANARPC5physical
26496610
ARPC3_HUMANARPC3physical
26496610
ARC1B_HUMANARPC1Bphysical
26496610
ARP3_HUMANACTR3physical
26496610
ARP2_HUMANACTR2physical
26496610
ARPC2_HUMANARPC2physical
26496610
AKAP2_HUMANAKAP2physical
26496610
SYNPO_HUMANSYNPOphysical
26496610
CE162_HUMANCEP162physical
26496610
N4BP3_HUMANN4BP3physical
26496610
SIN3B_HUMANSIN3Bphysical
26496610
CYTSA_HUMANSPECC1Lphysical
26496610
POC1A_HUMANPOC1Aphysical
26496610
RAI14_HUMANRAI14physical
26496610
ATP5S_HUMANATP5Sphysical
26496610
TMOD3_HUMANTMOD3physical
26496610
LIMA1_HUMANLIMA1physical
26496610
BRWD1_HUMANBRWD1physical
26496610
T161A_HUMANTMEM161Aphysical
26496610
COR1B_HUMANCORO1Bphysical
26496610
CING_HUMANCGNphysical
26496610
RHG21_HUMANARHGAP21physical
26496610
AFAP1_HUMANAFAP1physical
26496610
INF2_HUMANINF2physical
26496610
ACTL8_HUMANACTL8physical
26496610
ARP5L_HUMANARPC5Lphysical
26496610
ACBD5_HUMANACBD5physical
26496610
NEXN_HUMANNEXNphysical
26496610
CYTSB_HUMANSPECC1physical
26496610
MISP_HUMANMISPphysical
26496610
CD109_HUMANCD109physical
26496610
TPRN_HUMANTPRNphysical
26496610
MY18A_HUMANMYO18Aphysical
26496610
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYO5C_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1104, AND MASSSPECTROMETRY.

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