dbPTM

BRWD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRWD1_HUMAN
UniProt AC	Q9NSI6
Protein Name	Bromodomain and WD repeat-containing protein 1
Gene Name	BRWD1
Organism	Homo sapiens (Human).
Sequence Length	2320
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape..
Protein Sequence	MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQYQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTSLLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTGCSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYFNMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRPLIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQLGYVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLSNGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRRVVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKSDSVVLVSQSRQRTCRRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSESSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEISTENLSPPKRRRKRKKENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQMGDEVIYFRQGHEAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCCLKLAFIDPATGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDAWWFGTVLSQEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVTTDELEKLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYPTDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIKNQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKKQCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEFCKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQRFKQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSAGISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESKESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNNSLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASAVARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDLRVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKAESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEMNPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRKRVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSKNGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNGDSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRTFSSESTLAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSHPELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRKEFVPRDREPNTKVRTCMHNQKDAVQMPSETLKAKMVPEKVPRRCATVAANKIKIMSNLKETISGPENVWIRKSSRKLPHRNASAAAKKKLLNVYKEDDTTINSESEKELEDINRKMLFLRGFRSWKENAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEPSSARRPVP ---CCCCCCCCCCCC	28.30	20860994
6	O-linked_Glycosylation	--MAEPSSARRPVPL --CCCCCCCCCCCCC	36.19	30379171
6	Phosphorylation	--MAEPSSARRPVPL --CCCCCCCCCCCCC	36.19	20860994
16	Phosphorylation	RPVPLIESELYFLIA CCCCCHHHHHHHHHH	26.38	24719451
19	Phosphorylation	PLIESELYFLIARYL CCHHHHHHHHHHHHH	7.71	18083107
25	Phosphorylation	LYFLIARYLSAGPCR HHHHHHHHHCCCHHH	8.93	24719451
44	Ubiquitination	VLVQELEQYQLLPKR HHHHHHHHHCCCCCC	43.85	22817900
48	Ubiquitination	ELEQYQLLPKRLDWE HHHHHCCCCCCCCCC	2.51	21890473
50	Ubiquitination	EQYQLLPKRLDWEGN HHHCCCCCCCCCCCC	66.61	-
71	Ubiquitination	EELVLSNKHVAPDHL HHHHHHCCCCCHHHH	35.76	29967540
101	Phosphorylation	PPSISRVTSLLGAGR CCCHHHHHHHHCCHH	16.73	22985185
102	Phosphorylation	PSISRVTSLLGAGRQ CCHHHHHHHHCCHHH	20.81	22985185
110	Phosphorylation	LLGAGRQSLLRTAKD HHCCHHHHHHHHHHH	28.19	24719451
121	Phosphorylation	TAKDCRHTVWKGSAF HHHHHHCHHHCHHHH	14.54	24719451
143	Phosphorylation	PPEMPVNYGSPPNLV CCCCCCCCCCCCCCE	21.15	20068231
145	Phosphorylation	EMPVNYGSPPNLVEI CCCCCCCCCCCCEEE	27.16	20068231
159	Phosphorylation	IHRGKQLTGCSTFST EECCCCCCCCCCCCC	33.38	23663014
162	Phosphorylation	GKQLTGCSTFSTAFP CCCCCCCCCCCCCCC	33.56	23663014
163	Phosphorylation	KQLTGCSTFSTAFPG CCCCCCCCCCCCCCC	26.19	23663014
165	Phosphorylation	LTGCSTFSTAFPGTM CCCCCCCCCCCCCHH	20.93	23663014
166	Phosphorylation	TGCSTFSTAFPGTMY CCCCCCCCCCCCHHH	28.29	23663014
171	Phosphorylation	FSTAFPGTMYQHIKM CCCCCCCHHHHHHHH	16.97	23663014
173	Phosphorylation	TAFPGTMYQHIKMHR CCCCCHHHHHHHHHH	9.22	23663014
228	Phosphorylation	LSTLRGHSAEISDMA HHHHCCCCCCHHHCE	30.35	-
238	Phosphorylation	ISDMAVNYENTMIAA HHHCEEECCCCEEEC	12.17	-
291	Phosphorylation	GSQRYMVSTGADGTV CCCEEEEEECCCCEE	12.47	20860994
311	Phosphorylation	DLESLKFSPRPLKFT EHHHCCCCCCCCCCC	20.57	20860994
382	Methylation	QFCNNGDRFLSGSRD EECCCCCCCCCCCCC	35.49	115388895
388	Methylation	DRFLSGSRDGTARIW CCCCCCCCCCCCEEE	50.32	115388903
393	Methylation	GSRDGTARIWRFEQL CCCCCCCEEEEEHHH	28.92	115388911
418	Phosphorylation	TRISGDLSSEEERFM HHHCCCCCHHHHHHC	40.21	21815630
419	Phosphorylation	RISGDLSSEEERFMK HHCCCCCHHHHHHCC	57.22	20068231
551	Phosphorylation	GFGCSKPYEKIPDQM ECCCCCCHHHCCCCC	33.32	-
580	Phosphorylation	NYVLDEQTQQAPHLM CEECCCCCCCCCCCC	22.17	-
602	Phosphorylation	VDGNPHPTKYQRLVP CCCCCCCCCCCCCCC	39.07	-
649	Phosphorylation	TNDNDERSPESSILD CCCCCCCCHHHHHHH	30.85	25850435
682	Phosphorylation	DTIPRGLSNGEETPR CCCCCCCCCCCCCCC	45.68	28674151
687	Phosphorylation	GLSNGEETPRRGFRR CCCCCCCCCCCCCCC	20.14	29255136
696	Phosphorylation	RRGFRRLSLDIQSPP CCCCCCEEEECCCCC	23.37	30266825
696 (in isoform 2)	Phosphorylation	-	23.37	18669648
701	Phosphorylation	RLSLDIQSPPNIGLR CEEEECCCCCCCCCC	42.53	29255136
701 (in isoform 2)	Phosphorylation	-	42.53	18669648
710	Phosphorylation	PNIGLRRSGQVEGVR CCCCCCCCCCCCHHH	27.43	20068231
753	Ubiquitination	VPLGIFRKLEDFRLE CCCHHHHHHHHHCCC	45.54	22817900
757	Ubiquitination	IFRKLEDFRLEKGEE HHHHHHHHCCCCCCC	7.58	21890473
777	Phosphorylation	IIGRKRKTLQLSHKS EEECCCCEEECCCCC	24.62	30622161
781	Phosphorylation	KRKTLQLSHKSDSVV CCCEEECCCCCCEEE	18.86	30257219
784	Phosphorylation	TLQLSHKSDSVVLVS EEECCCCCCEEEEEE	29.69	30257219
786	Phosphorylation	QLSHKSDSVVLVSQS ECCCCCCEEEEEECC	22.63	28348404
791	Phosphorylation	SDSVVLVSQSRQRTC CCEEEEEECCCCHHH	20.48	21815630
791 (in isoform 2)	Phosphorylation	-	20.48	18669648
793	Phosphorylation	SVVLVSQSRQRTCRR EEEEEECCCCHHHHH	23.91	21815630
805	Phosphorylation	CRRKYPNYGRRNRSW HHHHCCCCCCCCCCH	13.91	-
811	Phosphorylation	NYGRRNRSWRELSSG CCCCCCCCHHHHCCC	33.75	-
816	Phosphorylation	NRSWRELSSGNESSS CCCHHHHCCCCCCCC	31.29	30576142
817	Phosphorylation	RSWRELSSGNESSSS CCHHHHCCCCCCCCC	59.26	30576142
821	Phosphorylation	ELSSGNESSSSVRHE HHCCCCCCCCCCCCC	39.25	30576142
829	Phosphorylation	SSSVRHETSCDQSEG CCCCCCCCCCCCCCC	28.64	27251789
830	Phosphorylation	SSVRHETSCDQSEGS CCCCCCCCCCCCCCC	16.83	30576142
834	Phosphorylation	HETSCDQSEGSGSSE CCCCCCCCCCCCCCH	30.58	20873877
837	Phosphorylation	SCDQSEGSGSSEEDE CCCCCCCCCCCHHHH	31.30	20873877
839	Phosphorylation	DQSEGSGSSEEDEWR CCCCCCCCCHHHHHH	35.95	27251789
840	Phosphorylation	QSEGSGSSEEDEWRS CCCCCCCCHHHHHHC	48.83	20873877
851	Phosphorylation	EWRSDRKSESYSESS HHHCCCCCCCCCCCC	32.44	29083192
853	Phosphorylation	RSDRKSESYSESSSD HCCCCCCCCCCCCCC	40.84	29083192
854	Phosphorylation	SDRKSESYSESSSDS CCCCCCCCCCCCCCC	16.65	29083192
855	Phosphorylation	DRKSESYSESSSDSS CCCCCCCCCCCCCCC	40.04	29083192
857	Phosphorylation	KSESYSESSSDSSSR CCCCCCCCCCCCCCC	29.24	29083192
858	Phosphorylation	SESYSESSSDSSSRY CCCCCCCCCCCCCCC	33.83	29083192
859	Phosphorylation	ESYSESSSDSSSRYS CCCCCCCCCCCCCCC	51.28	29083192
861	Phosphorylation	YSESSSDSSSRYSDW CCCCCCCCCCCCCCC	31.96	29083192
862	Phosphorylation	SESSSDSSSRYSDWT CCCCCCCCCCCCCCC	24.67	29083192
863	Phosphorylation	ESSSDSSSRYSDWTA CCCCCCCCCCCCCCC	38.91	29083192
893	Phosphorylation	RRITRFCSSSEDEIS HHHHHHHCCCCCCCC	33.90	23663014
894	Phosphorylation	RITRFCSSSEDEIST HHHHHHCCCCCCCCC	38.64	23663014
895	Phosphorylation	ITRFCSSSEDEISTE HHHHHCCCCCCCCCC	32.54	23663014
900	Phosphorylation	SSSEDEISTENLSPP CCCCCCCCCCCCCCC	27.85	23663014
901	Phosphorylation	SSEDEISTENLSPPK CCCCCCCCCCCCCCH	34.26	23663014
905	Phosphorylation	EISTENLSPPKRRRK CCCCCCCCCCHHHHH	51.22	24719451
946	Ubiquitination	YEFHPPVWITDTTLR HHHCCCEEEECCCCC	8.11	22817900
950	Ubiquitination	PPVWITDTTLRKSPF CCEEEECCCCCCCCC	21.05	21890473
1033	Ubiquitination	FIDPATGKLMDKSFS EECCCCCCCCCCEEC	35.96	22817900
1037	Ubiquitination	ATGKLMDKSFSIRYH CCCCCCCCEECEEEC	39.16	21890473
1037	Methylation	ATGKLMDKSFSIRYH CCCCCCCCEECEEEC	39.16	-
1037	Ubiquitination	ATGKLMDKSFSIRYH CCCCCCCCEECEEEC	39.16	21890473
1037 (in isoform 1)	Ubiquitination	-	39.16	21890473
1037 (in isoform 2)	Ubiquitination	-	39.16	21890473
1037 (in isoform 3)	Ubiquitination	-	39.16	21890473
1038	Phosphorylation	TGKLMDKSFSIRYHD CCCCCCCEECEEECC	21.69	24719451
1040	Phosphorylation	KLMDKSFSIRYHDMP CCCCCEECEEECCCC	17.16	24719451
1209	Phosphorylation	AYPTDLYTIRMRLVN ECCCCHHHHHHHHHH	14.92	24719451
1223	Phosphorylation	NRFYRRLSALVWEVR HHHHHHHHHHHHHHH	20.11	27251275
1267	Phosphorylation	FIKNQHCTNISELSN HHHCCCCCCHHHHCC	33.20	23663014
1270	Phosphorylation	NQHCTNISELSNTSE CCCCCCHHHHCCCCC	34.26	23663014
1273	Phosphorylation	CTNISELSNTSENDE CCCHHHHCCCCCCCH	33.73	23663014
1275	Phosphorylation	NISELSNTSENDEQN CHHHHCCCCCCCHHC	33.76	30278072
1275 (in isoform 2)	Phosphorylation	-	33.76	18669648
1276	Phosphorylation	ISELSNTSENDEQNA HHHHCCCCCCCHHCH	38.36	23663014
1289	Phosphorylation	NAEDLDDSDLPKTSS CHHHCCCCCCCCCCC	40.49	30278072
1289 (in isoform 2)	Phosphorylation	-	40.49	18669648
1366	Phosphorylation	DFGTVRETLDAGNYD CCCCHHHCCCCCCCC	21.26	20068231
1372	Phosphorylation	ETLDAGNYDSPLEFC HCCCCCCCCCHHHHH	19.51	20068231
1374	Phosphorylation	LDAGNYDSPLEFCKD CCCCCCCCHHHHHHH	22.48	20068231
1398	Phosphorylation	AYTPNKRSKIYSMTL CCCCCCCHHHHHHHH	25.64	23403867
1401	Phosphorylation	PNKRSKIYSMTLRLS CCCCHHHHHHHHHHH	8.98	-
1402	Phosphorylation	NKRSKIYSMTLRLSA CCCHHHHHHHHHHHH	14.57	23403867
1464	Phosphorylation	LKPKRLKSQTKIIPE CCHHHHHHCCCCCHH	47.91	-
1466	Phosphorylation	PKRLKSQTKIIPELV HHHHHHCCCCCHHHC	31.16	-
1475	Phosphorylation	IIPELVGSPTQSTSS CCHHHCCCCCCCCCC	19.79	29255136
1475 (in isoform 2)	Phosphorylation	-	19.79	18669648
1477	Phosphorylation	PELVGSPTQSTSSRT HHHCCCCCCCCCCCE	36.53	29255136
1477 (in isoform 2)	Phosphorylation	-	36.53	18669648
1479	Phosphorylation	LVGSPTQSTSSRTAY HCCCCCCCCCCCEEE	32.51	30278072
1480	Phosphorylation	VGSPTQSTSSRTAYL CCCCCCCCCCCEEEE	22.39	30278072
1480 (in isoform 2)	Phosphorylation	-	22.39	18669648
1481	Phosphorylation	GSPTQSTSSRTAYLG CCCCCCCCCCEEEEE	24.06	25159151
1482	Phosphorylation	SPTQSTSSRTAYLGT CCCCCCCCCEEEEEE	33.47	30278072
1484	Phosphorylation	TQSTSSRTAYLGTHK CCCCCCCEEEEEECC	22.92	25159151
1486	Phosphorylation	STSSRTAYLGTHKTS CCCCCEEEEEECCCC	12.68	20068231
1489	Phosphorylation	SRTAYLGTHKTSAGI CCEEEEEECCCCCCC	20.01	30576142
1501	Phosphorylation	AGISSGVTSGDSSDS CCCCCCCCCCCCCCC	30.44	-
1511	Phosphorylation	DSSDSAESSERRKRN CCCCCHHHHHHHHHC	36.90	-
1512	Phosphorylation	SSDSAESSERRKRNR CCCCHHHHHHHHHCC	26.99	20068231
1542	Phosphorylation	SLATSLSSSASSSSE HHHHHHHCCCCCCCH	34.91	-
1543	Phosphorylation	LATSLSSSASSSSEE HHHHHHCCCCCCCHH	28.88	-
1603	Phosphorylation	KATRKRVYLSDSDNN CCCCCEEEECCCCCC	12.43	28450419
1605	Phosphorylation	TRKRVYLSDSDNNSL CCCEEEECCCCCCCC	19.85	25159151
1605 (in isoform 2)	Phosphorylation	-	19.85	18669648
1607	Phosphorylation	KRVYLSDSDNNSLET CEEEECCCCCCCCCH	38.57	25159151
1607 (in isoform 2)	Phosphorylation	-	38.57	18669648
1611	Phosphorylation	LSDSDNNSLETGEIL ECCCCCCCCCHHHHH	33.56	25159151
1614	Phosphorylation	SDNNSLETGEILKAR CCCCCCCHHHHHHHH	45.46	28450419
1678	Phosphorylation	RKKLLHNSEDEQSLK HHHHHCCCCCHHHHH	35.36	28355574
1683	Phosphorylation	HNSEDEQSLKSEIEE CCCCCHHHHHHHHHH	35.40	23927012
1686	Phosphorylation	EDEQSLKSEIEEEEL CCHHHHHHHHHHHHH	49.45	28355574
1703	Phosphorylation	ENQLLPVSSSHTAQS CCCCCCCCCCHHCCC	24.96	-
1715	Phosphorylation	AQSNVDESENRDSES CCCCCCCCCCCCCCC	35.39	-
1720	Phosphorylation	DESENRDSESESDLR CCCCCCCCCCHHHHH	39.52	22468782
1722	Phosphorylation	SENRDSESESDLRVA CCCCCCCCHHHHHHH	46.48	22468782
1755	Phosphorylation	TKFLKIESSEEDSKS CCEEEECCCCCHHHC	46.66	25849741
1756	Phosphorylation	KFLKIESSEEDSKSH CEEEECCCCCHHHCC	32.01	25849741
1760	Phosphorylation	IESSEEDSKSHDSDH ECCCCCHHHCCCCCC	39.06	23322592
1762	Phosphorylation	SSEEDSKSHDSDHAC CCCCHHHCCCCCCCC	36.16	25849741
1765	Phosphorylation	EDSKSHDSDHACNRT CHHHCCCCCCCCCCC	26.35	25849741
1776	Phosphorylation	CNRTAGPSTSVQKLK CCCCCCCCHHHHHHH	32.18	29396449
1777	Phosphorylation	NRTAGPSTSVQKLKA CCCCCCCHHHHHHHH	35.73	29396449
1778	Phosphorylation	RTAGPSTSVQKLKAE CCCCCCHHHHHHHHH	27.21	21815630
1786	O-linked_Glycosylation	VQKLKAESISEEADS HHHHHHHHCCHHHCC	35.95	30379171
1786	Phosphorylation	VQKLKAESISEEADS HHHHHHHHCCHHHCC	35.95	25159151
1786 (in isoform 2)	Phosphorylation	-	35.95	18669648
1788	Phosphorylation	KLKAESISEEADSEP HHHHHHCCHHHCCCC	38.37	29255136
1788 (in isoform 2)	Phosphorylation	-	38.37	18669648
1793	Phosphorylation	SISEEADSEPGRSGG HCCHHHCCCCCCCCC	53.38	29255136
1793 (in isoform 2)	Phosphorylation	-	53.38	18669648
1798	Phosphorylation	ADSEPGRSGGRKYNT HCCCCCCCCCCCCCC	52.06	21712546
1811	Phosphorylation	NTFHKNASFFKKTKI CCCCCCHHHHHCCEE	40.38	21712546
1820	Phosphorylation	FKKTKILSDSEDSES HHCCEECCCCCCCCC	42.43	25849741
1822	Phosphorylation	KTKILSDSEDSESEE CCEECCCCCCCCCHH	39.67	25849741
1825	Phosphorylation	ILSDSEDSESEEQDR ECCCCCCCCCHHHHC	38.68	25849741
1827	Phosphorylation	SDSEDSESEEQDRED CCCCCCCCHHHHCCC	50.84	25849741
1867	Phosphorylation	SSDHGCETDLDSDDD CCCCCCCCCCCCCCC	46.03	-
1871	Phosphorylation	GCETDLDSDDDKIEK CCCCCCCCCCCCCCC	50.68	-
1888	Phosphorylation	NFMKDSASQDNGLSR CCCCCCCCCCCCCCH	41.86	28674419
1904	Phosphorylation	ISRKRVCSSDSDSSL HCCCCCCCCCCCCCH	34.03	25159151
1904 (in isoform 2)	Phosphorylation	-	34.03	18669648
1905	Phosphorylation	SRKRVCSSDSDSSLQ CCCCCCCCCCCCCHH	35.69	25159151
1905 (in isoform 2)	Phosphorylation	-	35.69	18669648
1907	Phosphorylation	KRVCSSDSDSSLQVV CCCCCCCCCCCHHHH	41.14	26503892
1907 (in isoform 2)	Phosphorylation	-	41.14	18669648
1909	Phosphorylation	VCSSDSDSSLQVVKK CCCCCCCCCHHHHHH	36.58	26503892
1909 (in isoform 2)	Phosphorylation	-	36.58	18669648
1910	Phosphorylation	CSSDSDSSLQVVKKS CCCCCCCCHHHHHHC	28.01	26503892
1910 (in isoform 2)	Phosphorylation	-	28.01	18669648
1922	Phosphorylation	KKSSKARTGLLRITR HHCCCCCCHHHHHHH	36.72	20873877
1943	Phosphorylation	ANKIKLMSDVEDVSL HHHCCCCCCCCCCCH	49.28	30266825
1949	Phosphorylation	MSDVEDVSLENVHTR CCCCCCCCHHHCCCC	42.14	23312004
1955	Phosphorylation	VSLENVHTRSKNGRK CCHHHCCCCCCCCCC	32.15	-
1962	Acetylation	TRSKNGRKKPLHLAC CCCCCCCCCCCEEEE	61.21	30593429
1973	Acetylation	HLACTTAKKKLSDCE EEEEECCCHHHHCCC	48.63	30593435
1977	Phosphorylation	TTAKKKLSDCEGSVH ECCCHHHHCCCCCEE	49.44	23898821
1982	Phosphorylation	KLSDCEGSVHCEVPS HHHCCCCCEECCCCH	6.08	29449344
1989	Phosphorylation	SVHCEVPSEQYACEG CEECCCCHHHEECCC	42.37	25841592
1992	Phosphorylation	CEVPSEQYACEGKPP CCCCHHHEECCCCCC	14.79	25841592
2003	Phosphorylation	GKPPDPDSEGSTKVL CCCCCCCCCCCHHHH	49.60	23663014
2006	Phosphorylation	PDPDSEGSTKVLSQA CCCCCCCCHHHHHHH	22.47	23663014
2007	Phosphorylation	DPDSEGSTKVLSQAL CCCCCCCHHHHHHHH	35.71	23663014
2011	Phosphorylation	EGSTKVLSQALNGDS CCCHHHHHHHHCCCC	19.18	23403867
2018	Phosphorylation	SQALNGDSDSEDMLN HHHHCCCCCCHHHCC	44.42	30278072
2018 (in isoform 2)	Phosphorylation	-	44.42	18669648
2020	Phosphorylation	ALNGDSDSEDMLNSE HHCCCCCCHHHCCCH	39.17	30278072
2020 (in isoform 2)	Phosphorylation	-	39.17	18669648
2026	Phosphorylation	DSEDMLNSEHKHRHT CCHHHCCCHHHCCCC	36.80	23403867
2045	Acetylation	IDAPSKRKSSSVTSS CCCCCCCCCCCCCCC	59.43	7693251
2046	Phosphorylation	DAPSKRKSSSVTSSG CCCCCCCCCCCCCCC	31.70	-
2047	Phosphorylation	APSKRKSSSVTSSGE CCCCCCCCCCCCCCC	31.68	-
2050	Phosphorylation	KRKSSSVTSSGEDSK CCCCCCCCCCCCCHH	21.08	28985074
2052	Phosphorylation	KSSSVTSSGEDSKSH CCCCCCCCCCCHHHC	36.51	-
2056	Phosphorylation	VTSSGEDSKSHIPGS CCCCCCCHHHCCCCC	31.58	-
2058	Phosphorylation	SSGEDSKSHIPGSET CCCCCHHHCCCCCCC	30.51	30576142
2063	Phosphorylation	SKSHIPGSETDRTFS HHHCCCCCCCCCCCC	31.78	25627689
2068	Phosphorylation	PGSETDRTFSSESTL CCCCCCCCCCCHHHH	30.58	30576142
2070	Phosphorylation	SETDRTFSSESTLAQ CCCCCCCCCHHHHHH	32.36	30576142
2118	Phosphorylation	KTKVIHDSQETAEKE CCEEEECCHHHHHHH	18.76	25849741
2121	Phosphorylation	VIHDSQETAEKEVKR EEECCHHHHHHHHHH	32.26	26074081
2131	Phosphorylation	KEVKRKRSHPELENV HHHHHHHCCHHHHCC	46.56	25159151
2139	Ubiquitination	HPELENVKISETTGN CHHHHCCEEEECCCC	52.69	29967540
2141	Phosphorylation	ELENVKISETTGNSK HHHCCEEEECCCCCC	24.15	26074081
2143	Phosphorylation	ENVKISETTGNSKFR HCCEEEECCCCCCCC	32.96	26074081
2144	Phosphorylation	NVKISETTGNSKFRP CCEEEECCCCCCCCC	30.25	26074081
2147	Phosphorylation	ISETTGNSKFRPDTS EEECCCCCCCCCCCC	34.22	26074081
2153	Phosphorylation	NSKFRPDTSSKSSDL CCCCCCCCCCCCCCC	37.27	26074081
2154	Phosphorylation	SKFRPDTSSKSSDLG CCCCCCCCCCCCCCC	43.05	26074081
2155	Phosphorylation	KFRPDTSSKSSDLGS CCCCCCCCCCCCCCC	38.35	26074081
2157	Phosphorylation	RPDTSSKSSDLGSVT CCCCCCCCCCCCCCC	30.91	26074081
2158	Phosphorylation	PDTSSKSSDLGSVTE CCCCCCCCCCCCCCH	40.36	26074081
2162	Phosphorylation	SKSSDLGSVTESDID CCCCCCCCCCHHHCC	32.91	28985074
2164	Phosphorylation	SSDLGSVTESDIDCT CCCCCCCCHHHCCCC	31.31	25159151
2166	Phosphorylation	DLGSVTESDIDCTDN CCCCCCHHHCCCCCC	30.42	25849741
2184	Acetylation	KRRKTKGKAKVVRKE CCCCCCCCEEEEECH	46.74	130401
2214 (in isoform 2)	Phosphorylation	-	7.80	28450419
2218	O-linked_Glycosylation	KDAVQMPSETLKAKM CCCCCCCHHHHHHHC	37.56	30379171
2218	Phosphorylation	KDAVQMPSETLKAKM CCCCCCCHHHHHHHC	37.56	24719451
2227	Ubiquitination	TLKAKMVPEKVPRRC HHHHHCCCCCCCCCH	31.99	29967540
2246	Phosphorylation	ANKIKIMSNLKETIS HHHHHHHHCCCHHCC	42.35	30140170
2249 (in isoform 2)	Phosphorylation	-	58.00	20068231
2257 (in isoform 2)	Phosphorylation	-	37.24	25849741
2284	Phosphorylation	KKKLLNVYKEDDTTI HHHHHHHHCCCCCCC	13.95	25219547
2289	Phosphorylation	NVYKEDDTTINSESE HHHCCCCCCCCCCCH	41.73	25219547
2290	Phosphorylation	VYKEDDTTINSESEK HHCCCCCCCCCCCHH	25.75	25219547
2293	Phosphorylation	EDDTTINSESEKELE CCCCCCCCCCHHHHH	38.35	20886841
2295	Phosphorylation	DTTINSESEKELEDI CCCCCCCCHHHHHHH	54.51	25219547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BRWD1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BRWD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BRWD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SMCA4_HUMAN	SMARCA4	physical	12889071
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRWD1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1475; SER-1605;SER-1607; SER-2018 AND SER-2020, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696; SER-701; THR-1275;SER-1289; SER-1605; SER-1607; SER-1786; SER-1788; SER-1793; SER-1904;SER-1905; SER-1907; SER-1910; SER-2018 AND SER-2020, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-418 AND SER-791, ANDMASS SPECTROMETRY.	19007248 [Abstract]