dbPTM

AKAP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKAP2_HUMAN
UniProt AC	Q9Y2D5
Protein Name	A-kinase anchor protein 2
Gene Name	AKAP2
Organism	Homo sapiens (Human).
Sequence Length	859
Subcellular Localization
Protein Description	Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity)..
Protein Sequence	MEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEANCCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSPSSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLMENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNALQENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGPEATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMEDYETHKSKRRERMDDSSVLEATRVNRRKSALALRWEAGIYANQEEEDNE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	VSVAECKSVPGITST EEEECCCCCCCCCCC	45.24	29449344
16 (in isoform 5)	Phosphorylation	-	1.94	28985074
16 (in isoform 7)	Phosphorylation	-	1.94	28985074
17	Phosphorylation	CKSVPGITSTPHPMD CCCCCCCCCCCCCCC	32.25	27251275
18	Phosphorylation	KSVPGITSTPHPMDH CCCCCCCCCCCCCCC	37.71	27251275
19	Phosphorylation	SVPGITSTPHPMDHP CCCCCCCCCCCCCCC	19.57	27251275
22 (in isoform 5)	Phosphorylation	-	30.97	28985074
22 (in isoform 7)	Phosphorylation	-	30.97	28985074
27	Phosphorylation	PHPMDHPSAFYSPPH CCCCCCCHHHCCCCC	27.82	16219699
30	Phosphorylation	MDHPSAFYSPPHNGL CCCCHHHCCCCCCCC	21.71	28796482
31	Phosphorylation	DHPSAFYSPPHNGLL CCCHHHCCCCCCCCC	26.04	28796482
39	Phosphorylation	PPHNGLLTDHHESLD CCCCCCCCCCHHHCC	38.03	26074081
44	Phosphorylation	LLTDHHESLDNDVAR CCCCCHHHCCHHHHH	36.34	9378273
58 (in isoform 5)	Phosphorylation	-	46.54	27251275
58 (in isoform 7)	Phosphorylation	-	46.54	27251275
66 (in isoform 5)	Phosphorylation	-	41.66	28176443
66 (in isoform 7)	Phosphorylation	-	41.66	28176443
67	Phosphorylation	LEANCCDSAVDGTYN HHHCCCCCCCCCCCC	19.10	26074081
71 (in isoform 5)	Phosphorylation	-	24.41	28796482
71 (in isoform 7)	Phosphorylation	-	24.41	28796482
72	Phosphorylation	CDSAVDGTYNGTSSP CCCCCCCCCCCCCCC	14.89	26074081
72 (in isoform 5)	Phosphorylation	-	14.89	28176443
72 (in isoform 7)	Phosphorylation	-	14.89	28176443
73	Phosphorylation	DSAVDGTYNGTSSPE CCCCCCCCCCCCCCC	19.68	26074081
74 (in isoform 5)	Phosphorylation	-	47.29	28176443
74 (in isoform 7)	Phosphorylation	-	47.29	28176443
76	Phosphorylation	VDGTYNGTSSPEPGA CCCCCCCCCCCCCCE	23.53	26074081
77	Phosphorylation	DGTYNGTSSPEPGAV CCCCCCCCCCCCCEE	45.34	26074081
78	Phosphorylation	GTYNGTSSPEPGAVV CCCCCCCCCCCCEEE	32.87	26074081
81 (in isoform 5)	Phosphorylation	-	39.15	30266825
81 (in isoform 7)	Phosphorylation	-	39.15	30266825
82 (in isoform 5)	Phosphorylation	-	29.37	30266825
82 (in isoform 7)	Phosphorylation	-	29.37	30266825
84 (in isoform 5)	Phosphorylation	-	4.19	30266825
84 (in isoform 7)	Phosphorylation	-	4.19	30266825
91	Phosphorylation	VVLVGGLSPPVHEAT EEEECCCCCCCCCCC	30.36	26074081
118	Phosphorylation	APPHIELSNSSPDPM CCCCEECCCCCCCHH	23.13	30266825
120	Phosphorylation	PHIELSNSSPDPMAE CCEECCCCCCCHHHH	39.61	30266825
121	Phosphorylation	HIELSNSSPDPMAEA CEECCCCCCCHHHHH	37.26	23401153
124 (in isoform 4)	Acetylation	-	27.54	-
131	Phosphorylation	PMAEAERTNGHSPSQ HHHHHHHHCCCCCCC	36.74	30266825
135	Phosphorylation	AERTNGHSPSQPRDA HHHHCCCCCCCCCCC	27.87	30266825
137	Phosphorylation	RTNGHSPSQPRDALG HHCCCCCCCCCCCCC	56.69	30266825
146	Phosphorylation	PRDALGDSLQVPVSP CCCCCCCCCEECCCC	20.92	22167270
152	Phosphorylation	DSLQVPVSPSSTTSS CCCEECCCCCCCCCC	17.00	19664994
154	Phosphorylation	LQVPVSPSSTTSSRC CEECCCCCCCCCCCC	32.58	29255136
155	Phosphorylation	QVPVSPSSTTSSRCS EECCCCCCCCCCCCC	38.80	22167270
156	Phosphorylation	VPVSPSSTTSSRCSS ECCCCCCCCCCCCCC	34.73	30266825
157	Phosphorylation	PVSPSSTTSSRCSSR CCCCCCCCCCCCCCC	27.01	30266825
158	Phosphorylation	VSPSSTTSSRCSSRD CCCCCCCCCCCCCCC	18.84	30266825
159	Phosphorylation	SPSSTTSSRCSSRDG CCCCCCCCCCCCCCC	34.90	29209046
162	Phosphorylation	STTSSRCSSRDGEFT CCCCCCCCCCCCCEE	27.57	26074081
163	Phosphorylation	TTSSRCSSRDGEFTL CCCCCCCCCCCCEEE	37.71	26074081
169	Phosphorylation	SSRDGEFTLTTLKKE CCCCCCEEEEECCHH	20.92	29255136
171	Phosphorylation	RDGEFTLTTLKKEAK CCCCEEEEECCHHHH	27.33	29255136
172	Phosphorylation	DGEFTLTTLKKEAKF CCCEEEEECCHHHHH	39.43	29255136
174	Sumoylation	EFTLTTLKKEAKFEL CEEEEECCHHHHHEH	46.61	25114211
200 (in isoform 4)	Phosphorylation	-	57.13	27251275
200 (in isoform 6)	Phosphorylation	-	57.13	27251275
201	Acetylation	FEDDEHEKEQYCIRK CCCCHHHHHHHHHHH	52.61	26051181
204	Phosphorylation	DEHEKEQYCIRKVRP CHHHHHHHHHHHCCC	7.31	28796482
208	Ubiquitination	KEQYCIRKVRPSEEM HHHHHHHHCCCCHHH	23.76	29967540
208 (in isoform 4)	Phosphorylation	-	23.76	28176443
208 (in isoform 6)	Phosphorylation	-	23.76	28176443
212	Phosphorylation	CIRKVRPSEEMLELE HHHHCCCCHHHHHHH	35.31	46161359
213 (in isoform 4)	Phosphorylation	-	50.54	28796482
213 (in isoform 6)	Phosphorylation	-	50.54	28796482
214 (in isoform 4)	Phosphorylation	-	54.10	28176443
214 (in isoform 6)	Phosphorylation	-	54.10	28176443
215	Sulfoxidation	KVRPSEEMLELEKER HCCCCHHHHHHHHHH	2.86	21406390
216 (in isoform 4)	Phosphorylation	-	8.43	28176443
216 (in isoform 6)	Phosphorylation	-	8.43	28176443
220	Ubiquitination	EEMLELEKERRELIR HHHHHHHHHHHHHHH	69.97	29967540
223	Phosphorylation	LELEKERRELIRSQA HHHHHHHHHHHHHHH	44.13	17081983
223 (in isoform 4)	Phosphorylation	-	44.13	30266825
223 (in isoform 6)	Phosphorylation	-	44.13	30266825
224 (in isoform 4)	Phosphorylation	-	55.56	30266825
224 (in isoform 6)	Phosphorylation	-	55.56	30266825
226	Phosphorylation	EKERRELIRSQAVKK HHHHHHHHHHHHHHH	3.22	17081983
226 (in isoform 4)	Phosphorylation	-	3.22	30266825
226 (in isoform 6)	Phosphorylation	-	3.22	30266825
240	Acetylation	KNPGIAAKWWNPPQE HCCCCCCCCCCCCCC	43.66	25953088
241	Phosphorylation	NPGIAAKWWNPPQEK CCCCCCCCCCCCCCC	8.71	32142685
247	Phosphorylation	KWWNPPQEKTIEEQL CCCCCCCCCCHHHHC	58.92	32142685
261	Phosphorylation	LDEEHLESHKKYKER CCHHHHHHHHHHHHH	47.14	28555341
263	Malonylation	EEHLESHKKYKERKE HHHHHHHHHHHHHHH	68.05	26320211
297	Ubiquitination	QPPSQLCTAPASSHE CCHHHHCCCCCCHHH	44.24	29967540
309	Ubiquitination	SHERASMIDKAKEDI HHHHHHHHHHHHHHH	4.56	29967540
324	Phosphorylation	VTEQIDFSAARKQFQ HHHCCCHHHHHHHHH	19.78	28318491
336	Phosphorylation	QFQLMENSRQAVAKG HHHHHHHHHHHHHCC	16.68	-
345	Phosphorylation	QAVAKGQSTPRLFSI HHHHCCCCCCCCEEE	49.39	29514088
346	Phosphorylation	AVAKGQSTPRLFSIK HHHCCCCCCCCEEEC	12.44	29514088
351	Phosphorylation	QSTPRLFSIKPFYRP CCCCCCEEECCCCCC	34.00	29514088
352	Phosphorylation	STPRLFSIKPFYRPL CCCCCEEECCCCCCC	5.28	20068231
356	Phosphorylation	LFSIKPFYRPLGSVN CEEECCCCCCCCCCC	21.61	20560235
361	Phosphorylation	PFYRPLGSVNSDKPL CCCCCCCCCCCCCCC	26.30	29507054
364	Phosphorylation	RPLGSVNSDKPLTNP CCCCCCCCCCCCCCC	44.87	29507054
366	Phosphorylation	LGSVNSDKPLTNPRP CCCCCCCCCCCCCCC	41.57	19651622
368	Phosphorylation	SVNSDKPLTNPRPPS CCCCCCCCCCCCCCC	9.96	19651622
369	Phosphorylation	VNSDKPLTNPRPPSV CCCCCCCCCCCCCCC	52.26	26074081
375	Phosphorylation	LTNPRPPSVGGPPED CCCCCCCCCCCCCCC	35.76	29255136
383	Phosphorylation	VGGPPEDSGASAAKG CCCCCCCCCCCCCCC	34.30	19664994
385	Phosphorylation	GPPEDSGASAAKGQK CCCCCCCCCCCCCCC	10.43	17081983
386	Phosphorylation	PPEDSGASAAKGQKS CCCCCCCCCCCCCCC	32.08	20068231
387	Phosphorylation	PEDSGASAAKGQKSP CCCCCCCCCCCCCCC	16.80	18669648
389	Phosphorylation	DSGASAAKGQKSPGA CCCCCCCCCCCCCCC	62.68	32142685
393	Phosphorylation	SAAKGQKSPGALETP CCCCCCCCCCCCCCC	22.22	29255136
399	Phosphorylation	KSPGALETPSAAGSQ CCCCCCCCCCCCCCC	24.32	30266825
401	Phosphorylation	PGALETPSAAGSQGN CCCCCCCCCCCCCCC	37.86	30266825
405	Phosphorylation	ETPSAAGSQGNTASQ CCCCCCCCCCCCCCC	30.13	23927012
409	Phosphorylation	AAGSQGNTASQGKEG CCCCCCCCCCCCCCC	34.21	11026235
411	Phosphorylation	GSQGNTASQGKEGPY CCCCCCCCCCCCCCC	37.11	7932365
418	Phosphorylation	SQGKEGPYSEPSKRG CCCCCCCCCCCCCCC	36.20	28796482
419	Phosphorylation	QGKEGPYSEPSKRGP CCCCCCCCCCCCCCC	46.28	23401153
422	Phosphorylation	EGPYSEPSKRGPLSK CCCCCCCCCCCCCHH	30.82	26356563
428	Phosphorylation	PSKRGPLSKLWAEDG CCCCCCCHHHCCCCC	28.92	28122231
429	Ubiquitination	SKRGPLSKLWAEDGE CCCCCCHHHCCCCCC	56.59	-
439	Ubiquitination	AEDGEFTSARAVLTV CCCCCCCEEEEEEEE	22.52	29967540
448	Ubiquitination	RAVLTVVKDDDHGIL EEEEEEEECCCCCHH	51.62	33845483
451	Ubiquitination	LTVVKDDDHGILDQF EEEEECCCCCHHHHH	52.63	29967540
461	Phosphorylation	ILDQFSRSVNVSLTQ HHHHHHCEECCCCCH	19.49	19664994
465	Phosphorylation	FSRSVNVSLTQEELD HHCEECCCCCHHHHH	22.09	30266825
467	Phosphorylation	RSVNVSLTQEELDSG CEECCCCCHHHHHCC	26.82	30266825
473	Phosphorylation	LTQEELDSGLDELSV CCHHHHHCCCCEEHH	54.61	26055452
479	Phosphorylation	DSGLDELSVRSQDTT HCCCCEEHHHCCCCC	17.28	29396449
482	Phosphorylation	LDELSVRSQDTTVLE CCEEHHHCCCCCHHH	30.19	20166139
490	Phosphorylation	QDTTVLETLSNDFSM CCCCHHHHHCCCCCC	31.18	24275569
496	Phosphorylation	ETLSNDFSMDNISDS HHHCCCCCCCCCCCC	28.26	24275569
501	Phosphorylation	DFSMDNISDSGASNE CCCCCCCCCCCCCHH	31.79	69004705
517	Phosphorylation	TNALQENSLADFSLP HHHHHHCCCCCCCCC	24.96	26074081
522	Phosphorylation	ENSLADFSLPQTPQT HCCCCCCCCCCCCCC	39.42	26074081
526	Phosphorylation	ADFSLPQTPQTDNPS CCCCCCCCCCCCCCC	18.54	26657352
529	Phosphorylation	SLPQTPQTDNPSEGR CCCCCCCCCCCCCCC	38.66	26074081
533	Phosphorylation	TPQTDNPSEGRGEGV CCCCCCCCCCCCCCC	59.96	26074081
537	Ubiquitination	DNPSEGRGEGVSKSF CCCCCCCCCCCCCHH	47.03	33845483
541	Phosphorylation	EGRGEGVSKSFSDHG CCCCCCCCCHHCCCC	33.18	26074081
543	Phosphorylation	RGEGVSKSFSDHGFY CCCCCCCHHCCCCCC	23.60	26074081
545	Phosphorylation	EGVSKSFSDHGFYSP CCCCCHHCCCCCCCC	35.47	26074081
550	Phosphorylation	SFSDHGFYSPSSTLG HHCCCCCCCCCCCCC	25.02	26074081
559	Phosphorylation	PSSTLGDSPLVDDPL CCCCCCCCCCCCCHH	20.52	26074081
568	Phosphorylation	LVDDPLEYQAGLLVQ CCCCHHHHHHHHHHH	16.02	28464451
606	Phosphorylation	EQQGPEATVEEAEAA HHHCCCCCHHHHHHH	27.13	24732914
617	Phosphorylation	AEAAAFGSEKPQSMF HHHHHHCCCCCHHHC	35.67	23663014
622	Phosphorylation	FGSEKPQSMFEPPQV HCCCCCHHHCCCCCC	33.69	69007199
624	Phosphorylation	SEKPQSMFEPPQVSS CCCCHHHCCCCCCCC	18.05	20166139
630	Phosphorylation	MFEPPQVSSPVQEKR HCCCCCCCCCHHHCC	24.55	29255136
631	Phosphorylation	FEPPQVSSPVQEKRD CCCCCCCCCHHHCCC	30.18	29255136
636	Phosphorylation	VSSPVQEKRDVLPKI CCCCHHHCCCCHHHH	36.49	18077418
642	Phosphorylation	EKRDVLPKILPAEDR HCCCCHHHHCCHHHH	53.35	19413330
654	Ubiquitination	EDRALRERGPPQPLP HHHHHHHHCCCCCCC	57.39	23503661
660	Ubiquitination	ERGPPQPLPAVQPSG HHCCCCCCCCCCCCC	3.42	22817900
660 (in isoform 4)	Ubiquitination	-	3.42	-
666	Phosphorylation	PLPAVQPSGPINMEE CCCCCCCCCCCCCCC	39.86	20068231
674	Phosphorylation	GPINMEETRPEGSYF CCCCCCCCCCCCCCC	37.91	20068231
679	Phosphorylation	EETRPEGSYFSKYSE CCCCCCCCCCCCHHH	22.73	20068231
679	Ubiquitination	EETRPEGSYFSKYSE CCCCCCCCCCCCHHH	22.73	33845483
679 (in isoform 4)	Ubiquitination	-	22.73	-
680	Phosphorylation	ETRPEGSYFSKYSEA CCCCCCCCCCCHHHH	23.80	20068231
682	Phosphorylation	RPEGSYFSKYSEAAE CCCCCCCCCHHHHHH	23.58	24719451
683	Ubiquitination	PEGSYFSKYSEAAEL CCCCCCCCHHHHHHH	42.78	29967540
684	Phosphorylation	EGSYFSKYSEAAELR CCCCCCCHHHHHHHH	15.56	28796482
685	Phosphorylation	GSYFSKYSEAAELRS CCCCCCHHHHHHHHH	25.21	28796482
692	Phosphorylation	SEAAELRSTASLLAT HHHHHHHHHHHHHHC	40.73	19664994
693	Phosphorylation	EAAELRSTASLLATQ HHHHHHHHHHHHHCC	17.52	21406692
695	Phosphorylation	AELRSTASLLATQES HHHHHHHHHHHCCCC	24.81	20068231
699	Phosphorylation	STASLLATQESDVMV HHHHHHHCCCCCCCC	32.60	20068231
702	Phosphorylation	SLLATQESDVMVGPF HHHHCCCCCCCCCCC	26.20	20068231
710	Ubiquitination	DVMVGPFKLRSRKQR CCCCCCCCCCCCCHH	46.23	-
713	Phosphorylation	VGPFKLRSRKQRTLS CCCCCCCCCCHHHHH	55.02	22210691
718	Phosphorylation	LRSRKQRTLSMIEEE CCCCCHHHHHHHHHH	22.23	30266825
720	Phosphorylation	SRKQRTLSMIEEEIR CCCHHHHHHHHHHHH	19.66	19664994
721	Sulfoxidation	RKQRTLSMIEEEIRA CCHHHHHHHHHHHHH	5.13	21406390
745	Phosphorylation	RQRQVLQSTQSPRTK HHHHHHHHCCCCCCC	25.01	23927012
746	Phosphorylation	QRQVLQSTQSPRTKN HHHHHHHCCCCCCCC	21.80	22167270
748	Phosphorylation	QVLQSTQSPRTKNAP HHHHHCCCCCCCCCC	19.21	29255136
751	Phosphorylation	QSTQSPRTKNAPSLP HHCCCCCCCCCCCCC	31.84	24732914
756	Phosphorylation	PRTKNAPSLPSRTCY CCCCCCCCCCCCCEE	50.96	26074081
763	Phosphorylation	SLPSRTCYKTAPGKI CCCCCCEEECCCCCE	15.68	45553661
765	Phosphorylation	PSRTCYKTAPGKIEK CCCCEEECCCCCEEE	16.17	26074081
772	Ubiquitination	TAPGKIEKVKPPPSP CCCCCEEECCCCCCC	60.06	29967540
778	Phosphorylation	EKVKPPPSPTTEGPS EECCCCCCCCCCCCC	40.42	29255136
780	Phosphorylation	VKPPPSPTTEGPSLQ CCCCCCCCCCCCCCC	41.64	29255136
781	Phosphorylation	KPPPSPTTEGPSLQP CCCCCCCCCCCCCCC	42.18	29255136
785	Phosphorylation	SPTTEGPSLQPDLAP CCCCCCCCCCCCCCH	50.96	29255136
798	Phosphorylation	APEEAAGTQRPKNLM CHHHHCCCCCCHHHH	19.37	23927012
807	Phosphorylation	RPKNLMQTLMEDYET CCHHHHHHHHHHHHH	17.69	28796482
809	Phosphorylation	KNLMQTLMEDYETHK HHHHHHHHHHHHHHH	4.12	32142685
812	Phosphorylation	MQTLMEDYETHKSKR HHHHHHHHHHHHHHH	14.93	28796482
814	Phosphorylation	TLMEDYETHKSKRRE HHHHHHHHHHHHHHH	28.51	28796482
817	Phosphorylation	EDYETHKSKRRERMD HHHHHHHHHHHHHCC	24.64	82900455
826	Phosphorylation	RRERMDDSSVLEATR HHHHCCCCHHHHHHH	20.34	28857561
827	Phosphorylation	RERMDDSSVLEATRV HHHCCCCHHHHHHHH	37.40	28857561
839	Phosphorylation	TRVNRRKSALALRWE HHHHHHHHHHHHHHH	27.06	23403867
850	Phosphorylation	LRWEAGIYANQEEED HHHHHCCCCCCCCCC	9.89	18083107
853	Phosphorylation	EAGIYANQEEEDNE- HHCCCCCCCCCCCC-	51.83	17081983
861	Phosphorylation	EEEDNE--------- CCCCCC---------		18669648
862	Phosphorylation	EEDNE---------- CCCCC----------		19413330
867	Phosphorylation	--------------- ---------------		32142685
897	Phosphorylation	--------------------------------------------- ---------------------------------------------		20068231
905	Phosphorylation	----------------------------------------------------- -----------------------------------------------------		20068231
914	Ubiquitination	-------------------------------------------------------------- --------------------------------------------------------------		29967540
915 (in isoform 7)	Phosphorylation	-		-
916 (in isoform 7)	Phosphorylation	-		-
930	Phosphorylation	------------------------------------------------------------------------------ ------------------------------------------------------------------------------		20068231
933	Phosphorylation	--------------------------------------------------------------------------------- ---------------------------------------------------------------------------------		20068231
941	Ubiquitination	----------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------		22817900
946	Ubiquitination	---------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------		22817900
951	Phosphorylation	--------------------------------------------------------------------------------------------------- ---------------------------------------------------------------------------------------------------		19664994
968	Ubiquitination	-------------------------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------------------------		24816145
976	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------		17081983
977	Phosphorylation	----------------------------------------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------------------------------------		17081983
979	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------		20068231
1009	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------		17081983
1012	Phosphorylation	---------------------------------------------------------------------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------------------------------------------------------------------		17081983
1057 (in isoform 4)	Phosphorylation	-		-
1058 (in isoform 4)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AKAP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKAP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKAP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAP2_HUMAN	PRKAR2A	physical	9497389
BABA1_HUMAN	BABAM1	physical	22863883
BABA2_HUMAN	BRE	physical	22863883
CSTF2_HUMAN	CSTF2	physical	22863883
WASC5_HUMAN	KIAA0196	physical	22863883
KINH_HUMAN	KIF5B	physical	22863883
PIHD1_HUMAN	PIH1D1	physical	22863883
RPP38_HUMAN	RPP38	physical	22863883
SART3_HUMAN	SART3	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKAP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-324; SER-393;SER-461; SER-479; SER-720 AND SER-748, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152; SER-411 ANDSER-631, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-121; SER-152; SER-393;SER-631; SER-720 AND SER-748, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393 AND SER-720, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-748, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152 AND SER-720, ANDMASS SPECTROMETRY.	17081983 [Abstract]