| UniProt ID | BABA2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NXR7 | |
| Protein Name | BRISC and BRCA1-A complex member 2 {ECO:0000312|HGNC:HGNC:1106} | |
| Gene Name | BABAM2 {ECO:0000312|HGNC:HGNC:1106} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 383 | |
| Subcellular Localization | Cytoplasm . Nucleus . Localizes at sites of DNA damage at double-strand breaks (DSBs). | |
| Protein Description | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. [PubMed: 17525341] | |
| Protein Sequence | MSPEVALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALQNLASWNPSNPECLLLVVKELVQQYHQFQCSRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MSPEVALN -------CCHHHHHH | 22223895 | ||
| 2 | Phosphorylation | ------MSPEVALNR ------CCHHHHHHH | 23401153 | ||
| 11 | Phosphorylation | EVALNRISPMLSPFI HHHHHHHHHHHHHHH | 28348404 | ||
| 15 | Phosphorylation | NRISPMLSPFISSVV HHHHHHHHHHHHHHH | 21815630 | ||
| 19 | Phosphorylation | PMLSPFISSVVRNGK HHHHHHHHHHHHCCC | 26270265 | ||
| 20 | Phosphorylation | MLSPFISSVVRNGKV HHHHHHHHHHHCCCC | 28857561 | ||
| 26 | Acetylation | SSVVRNGKVGLDATN HHHHHCCCCCCCCCC | 25953088 | ||
| 26 | Ubiquitination | SSVVRNGKVGLDATN HHHHHCCCCCCCCCC | 29967540 | ||
| 41 | Ubiquitination | CLRITDLKSGCTSLT CEEEEECCCCCCCCC | 21963094 | ||
| 42 | Phosphorylation | LRITDLKSGCTSLTP EEEEECCCCCCCCCC | 23312004 | ||
| 45 | Phosphorylation | TDLKSGCTSLTPGPN EECCCCCCCCCCCCC | 23312004 | ||
| 46 | Phosphorylation | DLKSGCTSLTPGPNC ECCCCCCCCCCCCCC | 23312004 | ||
| 48 | Phosphorylation | KSGCTSLTPGPNCDR CCCCCCCCCCCCCCC | 21815630 | ||
| 57 | Ubiquitination | GPNCDRFKLHIPYAG CCCCCCEEEECCCCC | 29967540 | ||
| 135 | Phosphorylation | QCSRLRESSRLMFEY HHHHHHHHHHHHHHH | 27273156 | ||
| 161 | Ubiquitination | NMEIYAGKKNNWTGE CEEEEEECCCCCCCE | - | ||
| 162 (in isoform 4) | Ubiquitination | - | 21890473 | ||
| 162 (in isoform 3) | Ubiquitination | - | 21890473 | ||
| 162 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 162 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 162 | Ubiquitination | MEIYAGKKNNWTGEF EEEEEECCCCCCCEE | 21890473 | ||
| 176 | Ubiquitination | FSARFLLKLPVDFSN EEEEEEECCCCCHHH | - | ||
| 263 | Phosphorylation | LLTNKVQYVIQGYHK HHHCHHHHHHCCHHH | 27174698 | ||
| 270 | Acetylation | YVIQGYHKRREYIAA HHHCCHHHHHHHHHH | 19608861 | ||
| 347 | Phosphorylation | YSQAQKNYPYSPRWD HCHHHHHCCCCCCCC | 20068231 | ||
| 349 | Phosphorylation | QAQKNYPYSPRWDGN HHHHHCCCCCCCCHH | 20068231 | ||
| 350 | Phosphorylation | AQKNYPYSPRWDGNE HHHHCCCCCCCCHHH | 20068231 | ||
| 360 | Ubiquitination | WDGNEMAKRAKAYFK CCHHHHHHHHHHHHH | - | ||
| 366 (in isoform 4) | Phosphorylation | - | - | ||
| 367 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 367 | Ubiquitination | KRAKAYFKTFVPQFQ HHHHHHHHHHHHHHH | 21890473 | ||
| 373 (in isoform 4) | Phosphorylation | - | - | ||
| 374 (in isoform 3) | Phosphorylation | - | - | ||
| 374 (in isoform 4) | Phosphorylation | - | - | ||
| 375 (in isoform 4) | Phosphorylation | - | - | ||
| 382 | Acetylation | EAAFANGKL------ HHHHHCCCC------ | 24431675 | ||
| 382 | Ubiquitination | EAAFANGKL------ HHHHHCCCC------ | 21906983 | ||
| 382 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 389 | Ubiquitination | KL------------- CC------------- | 29967540 | ||
| 424 | Ubiquitination | ------------------------------------------------ ------------------------------------------------ | 21890473 | ||
| 439 | Ubiquitination | --------------------------------------------------------------- --------------------------------------------------------------- | 27667366 | ||
| 446 | Ubiquitination | ---------------------------------------------------------------------- ---------------------------------------------------------------------- | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BABA2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BABA2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BABA2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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