ABRX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABRX2_HUMAN
• UniProt AC: Q15018
• Protein Name: BRISC complex subunit Abraxas 2 {ECO:0000312|HGNC:HGNC:28975}
• Gene Name: ABRAXAS2 {ECO:0000312|HGNC:HGNC:28975}
• Organism: Homo sapiens (Human).
• Sequence Length: 415
• Subcellular Localization: Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton . A minor proportion is detected in the nucleus (PubMed:21282113, PubMed:22974638). Translocates into the nucleus in response to DNA damage (PubMed:25283148). Direc
• Protein Description: Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. [PubMed: 19214193]
• Protein Sequence: MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQQQMSYREQVLHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAVLSRQMPSESLDPAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPNNQESTLSHSRMERSVFMPRPQAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDDSDYENLIDPTEPSNSEYSHSKDSRPMAHPDEDPRNTQTSQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	ASISGYTFSAVCFHS CCCCCEEEEEEEEEC		22817900
70	Ubiquitination	SKLFSFYDYASKVNE HHHHHHHHHHHHCCH		21963094
74	Ubiquitination	SFYDYASKVNEESLD HHHHHHHHCCHHHHH		21906983
79	Phosphorylation	ASKVNEESLDRILKD HHHCCHHHHHHHHHH		25159151
83	Ubiquitination	NEESLDRILKDRRKK CHHHHHHHHHHHHHH		21890473
86	Ubiquitination	SLDRILKDRRKKVIG HHHHHHHHHHHHHHH		22817900
95	Ubiquitination	RKKVIGWYRFRRNTQ HHHHHHHHHCCCCCH		22817900
100	Ubiquitination	GWYRFRRNTQQQMSY HHHHCCCCCHHHHHH		22817900
101	Phosphorylation	WYRFRRNTQQQMSYR HHHCCCCCHHHHHHH		-
114	Acetylation	YREQVLHKQLTRILG HHHHHHHHHHHHHHC		26051181
114	Ubiquitination	YREQVLHKQLTRILG HHHHHHHHHHHHHHC		21906983
115	Ubiquitination	REQVLHKQLTRILGV HHHHHHHHHHHHHCC		21963094
139	Ubiquitination	FISTANNSTHALEYV HHHCCCCCCHHHHEE		24816145
159	Phosphorylation	RRYNQRISLAIPNLG CCCCCCEEEEECCCC		27050516
168	Phosphorylation	AIPNLGNTSQQEYKV EECCCCCCCCCEEEC		20068231
169	Phosphorylation	IPNLGNTSQQEYKVS ECCCCCCCCCEEECC		20068231
173	Phosphorylation	GNTSQQEYKVSSVPN CCCCCCEEECCCCCC		20068231
174	Ubiquitination	NTSQQEYKVSSVPNT CCCCCEEECCCCCCC		21906983
187	Ubiquitination	NTSQSYAKVIKEHGT CCCHHHHHHHHHHCC		21906983
190	Ubiquitination	QSYAKVIKEHGTDFF HHHHHHHHHHCCCCC		22817900
199	Ubiquitination	HGTDFFDKDGVMKDI HCCCCCCCCCHHHHH		21906983
204	Ubiquitination	FDKDGVMKDIRAIYQ CCCCCHHHHHHHHHH		22817900
210	Phosphorylation	MKDIRAIYQVYNALQ HHHHHHHHHHHHHHH		28152594
213	Phosphorylation	IRAIYQVYNALQEKV HHHHHHHHHHHHHHH		18785766
219	Ubiquitination	VYNALQEKVQAVCAD HHHHHHHHHHHHHCC		21963094
229	Acetylation	AVCADVEKSERVVES HHHCCCHHHHHHHHH		26051181
229	Ubiquitination	AVCADVEKSERVVES HHHCCCHHHHHHHHH		32015554
230	Phosphorylation	VCADVEKSERVVESC HHCCCHHHHHHHHHH		27732954
243	Ubiquitination	SCQAEVNKLRRQITQ HHHHHHHHHHHHHHH		24816145
249	Phosphorylation	NKLRRQITQRKNEKE HHHHHHHHHHHCHHH		-
255	Acetylation	ITQRKNEKEQERRLQ HHHHHCHHHHHHHHH		19823645
272	Phosphorylation	VLSRQMPSESLDPAF HHHCCCCHHHCCCCC		23403867
274	Phosphorylation	SRQMPSESLDPAFSP HCCCCHHHCCCCCCC		29255136
280	Phosphorylation	ESLDPAFSPRMPSSG HHCCCCCCCCCCCCC		23401153
285	Phosphorylation	AFSPRMPSSGFAAEG CCCCCCCCCCCCCCC		28857561
286	Phosphorylation	FSPRMPSSGFAAEGR CCCCCCCCCCCCCCC		28348404
294	Phosphorylation	GFAAEGRSTLGDAEA CCCCCCCCCCCCCCC		24248375
295	Phosphorylation	FAAEGRSTLGDAEAS CCCCCCCCCCCCCCC		24248375
302	Phosphorylation	TLGDAEASDPPPPYS CCCCCCCCCCCCCCC		25394399
308	Phosphorylation	ASDPPPPYSDFHPNN CCCCCCCCCCCCCCC		28796482
309	Phosphorylation	SDPPPPYSDFHPNNQ CCCCCCCCCCCCCCC		28796482
318	Phosphorylation	FHPNNQESTLSHSRM CCCCCCCCCCCCCHH		28796482
319	Phosphorylation	HPNNQESTLSHSRME CCCCCCCCCCCCHHC		28796482
321	Phosphorylation	NNQESTLSHSRMERS CCCCCCCCCCHHCCC		28796482
323	Phosphorylation	QESTLSHSRMERSVF CCCCCCCCHHCCCEE		28796482
328	Phosphorylation	SHSRMERSVFMPRPQ CCCHHCCCEEECCCC		21945579
339	Phosphorylation	PRPQAVGSSNYASTS CCCCCCCCCCCCCCC		21945579
340	Phosphorylation	RPQAVGSSNYASTSA CCCCCCCCCCCCCCC		21945579
342	Phosphorylation	QAVGSSNYASTSAGL CCCCCCCCCCCCCCC		21945579
344	Phosphorylation	VGSSNYASTSAGLKY CCCCCCCCCCCCCCC		21945579
345	Phosphorylation	GSSNYASTSAGLKYP CCCCCCCCCCCCCCC		21945579
346	Phosphorylation	SSNYASTSAGLKYPG CCCCCCCCCCCCCCC		21945579
354	Phosphorylation	AGLKYPGSGADLPPP CCCCCCCCCCCCCCC		25159151
368	Phosphorylation	PQRAAGDSGEDSDDS CCCCCCCCCCCCCCC		26055452
372	Phosphorylation	AGDSGEDSDDSDYEN CCCCCCCCCCCCCCC		26055452
375	Phosphorylation	SGEDSDDSDYENLID CCCCCCCCCCCCCCC		26055452
377	Phosphorylation	EDSDDSDYENLIDPT CCCCCCCCCCCCCCC		22617229
384	Phosphorylation	YENLIDPTEPSNSEY CCCCCCCCCCCCCCC		28796482
387	Phosphorylation	LIDPTEPSNSEYSHS CCCCCCCCCCCCCCC		28796482
389	Phosphorylation	DPTEPSNSEYSHSKD CCCCCCCCCCCCCCC		28796482
391	Phosphorylation	TEPSNSEYSHSKDSR CCCCCCCCCCCCCCC		28796482
392	Phosphorylation	EPSNSEYSHSKDSRP CCCCCCCCCCCCCCC		28796482
394	Phosphorylation	SNSEYSHSKDSRPMA CCCCCCCCCCCCCCC		28796482
410	Phosphorylation	PDEDPRNTQTSQI-- CCCCCCCCCCCCC--		29214152
412	Phosphorylation	EDPRNTQTSQI---- CCCCCCCCCCC----		23312004
413	Phosphorylation	DPRNTQTSQI----- CCCCCCCCCC-----		20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABRX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABRX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABRX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THAP5_HUMAN	THAP5	physical	21195082
BRCC3_HUMAN	BRCC3	physical	21282113
BABA2_HUMAN	BRE	physical	21282113
BABA1_HUMAN	BABAM1	physical	21282113
BRCC3_HUMAN	BRCC3	physical	20656690
BABA2_HUMAN	BRE	physical	22863883
JIP4_HUMAN	SPAG9	physical	22863883
ROA2_HUMAN	HNRNPA2B1	physical	22863883
UBP7_HUMAN	USP7	physical	25283148
P53_HUMAN	TP53	physical	25283148
BABA1_HUMAN	BABAM1	physical	25283148
BABA2_HUMAN	BRE	physical	25283148
BRCC3_HUMAN	BRCC3	physical	25283148
LAMC1_HUMAN	LAMC1	physical	26186194
THA11_HUMAN	THAP11	physical	26186194
TRAF7_HUMAN	TRAF7	physical	26186194
BRCC3_HUMAN	BRCC3	physical	26186194
BIRC6_HUMAN	BIRC6	physical	26186194
NUMA1_HUMAN	NUMA1	physical	26195665
BRCC3_HUMAN	BRCC3	physical	26195665
BABA1_HUMAN	BABAM1	physical	26195665
BABA2_HUMAN	BRE	physical	26195665
GLYM_HUMAN	SHMT2	physical	28514442
BRCC3_HUMAN	BRCC3	physical	28514442
THA11_HUMAN	THAP11	physical	28514442
LAMC1_HUMAN	LAMC1	physical	28514442
PRS8_HUMAN	PSMC5	physical	28514442
TRAF7_HUMAN	TRAF7	physical	28514442
BRCC3_HUMAN	BRCC3	physical	24075985
BABA1_HUMAN	BABAM1	physical	24075985
BABA2_HUMAN	BRE	physical	24075985
GLYM_HUMAN	SHMT2	physical	24075985
GLYC_HUMAN	SHMT1	physical	24075985
INAR1_HUMAN	IFNAR1	physical	24075985

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.