THAP5_HUMAN - dbPTM
THAP5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID THAP5_HUMAN
UniProt AC Q7Z6K1
Protein Name THAP domain-containing protein 5
Gene Name THAP5
Organism Homo sapiens (Human).
Sequence Length 395
Subcellular Localization Nucleus .
Protein Description Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). [PubMed: 21110952 May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase]
Protein Sequence MPRYCAAICCKNRRGRNNKDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKSQKKNLEDEKEVCPKAKSEESFVLNETKKNIVNTDVPHQHPELLHSSSLVKPPAPKTGSIQNNMLTLNLVKQHTGKPESTLETSVNQDTGRGGFHTCFENLNSTTITLTTSNSESIHQSLETQEVLEVTTSHLANPNFTSNSMEIKSAQENPFLFSTINQTVEELNTNKESVIAIFVPAENSKPSVNSFISAQKETTEMEDTDIEDSLYKDVDYGTEVLQIEHSYCRQDINKEHLWQKVSKLHSKITLLELKEQQTLGRLKSLEALIRQLKQENWLSEENVKIIENHFTTYEVTMI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51UbiquitinationKRDSWVPSKYQFLCS
CCCCCCCCCHHHHHC		34.0829967540
74UbiquitinationDIRWGIRYLKQTAVP
CHHHHHHHHHHCCCC		19.1429967540
85UbiquitinationTAVPTIFSLPEDNQG
CCCCEEECCCCCCCC		38.8829967540
93UbiquitinationLPEDNQGKDPSKKKS
CCCCCCCCCCCHHHH		57.6229967540
103UbiquitinationSKKKSQKKNLEDEKE
CHHHHHCCCHHHHHC		60.16-
108UbiquitinationQKKNLEDEKEVCPKA
HCCCHHHHHCCCCCC		41.5629967540
109SumoylationKKNLEDEKEVCPKAK
CCCHHHHHCCCCCCC		68.70-
109SumoylationKKNLEDEKEVCPKAK
CCCHHHHHCCCCCCC		68.70-
109UbiquitinationKKNLEDEKEVCPKAK
CCCHHHHHCCCCCCC		68.70-
116UbiquitinationKEVCPKAKSEESFVL
HCCCCCCCCHHHCCC		65.6129967540
127SumoylationSFVLNETKKNIVNTD
HCCCCHHHHCCCCCC		37.33-
127UbiquitinationSFVLNETKKNIVNTD
HCCCCHHHHCCCCCC		37.3329967540
127SumoylationSFVLNETKKNIVNTD
HCCCCHHHHCCCCCC		37.33-
133UbiquitinationTKKNIVNTDVPHQHP
HHHCCCCCCCCCCCH		27.7229967540
150UbiquitinationLHSSSLVKPPAPKTG
HHCCCCCCCCCCCCC		51.0529967540
156PhosphorylationVKPPAPKTGSIQNNM
CCCCCCCCCCCCCCE		34.79-
158PhosphorylationPPAPKTGSIQNNMLT
CCCCCCCCCCCCEEH		26.66-
169UbiquitinationNMLTLNLVKQHTGKP
CEEHHHHHHHHCCCC		5.6629967540
175UbiquitinationLVKQHTGKPESTLET
HHHHHCCCCCCCEEE		46.9332015554
183PhosphorylationPESTLETSVNQDTGR
CCCCEEEEECCCCCC		15.0828555341
189UbiquitinationTSVNQDTGRGGFHTC
EEECCCCCCCCHHHC		34.2329967540
198UbiquitinationGGFHTCFENLNSTTI
CCHHHCCCCCCCCEE		64.0629967540
208UbiquitinationNSTTITLTTSNSESI
CCCEEEEEECCCHHH		21.3829967540
284PhosphorylationPAENSKPSVNSFISA
ECCCCCCCHHHHHHC		37.3525003641
289UbiquitinationKPSVNSFISAQKETT
CCCHHHHHHCCCCCC		3.1529967540
295UbiquitinationFISAQKETTEMEDTD
HHHCCCCCCCCCCCC		34.7829967540
309 (in isoform 2)Ubiquitination-57.4821906983
309UbiquitinationDIEDSLYKDVDYGTE
CCHHHHHCCCCCCCE		57.4829967540
318UbiquitinationVDYGTEVLQIEHSYC
CCCCCEEEEEEEEHH		3.2729967540
328UbiquitinationEHSYCRQDINKEHLW
EEEHHCCCCCHHHHH		27.3829967540
331UbiquitinationYCRQDINKEHLWQKV
HHCCCCCHHHHHHHH		47.0129967540
337UbiquitinationNKEHLWQKVSKLHSK
CHHHHHHHHHHHHHC		36.5729967540
346PhosphorylationSKLHSKITLLELKEQ
HHHHHCEEHHHHHHH		29.0924719451
351 (in isoform 1)Ubiquitination-44.0721906983
351UbiquitinationKITLLELKEQQTLGR
CEEHHHHHHHHHHHH		44.072190698
360UbiquitinationQQTLGRLKSLEALIR
HHHHHHHHHHHHHHH		52.1929967540
370UbiquitinationEALIRQLKQENWLSE
HHHHHHHHHCCCCCH		47.4229967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of THAP5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of THAP5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of THAP5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of THAP5_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of THAP5_HUMAN

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Related Literatures of Post-Translational Modification

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