N4BP3_HUMAN - dbPTM
N4BP3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID N4BP3_HUMAN
UniProt AC O15049
Protein Name NEDD4-binding protein 3
Gene Name N4BP3
Organism Homo sapiens (Human).
Sequence Length 544
Subcellular Localization Cytoplasmic vesicle . Cell projection, axon . Cell projection, dendrite . In developing neurons, accumulates in early growth cones and at branching points of axons and dendrites.
Protein Description Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage..
Protein Sequence MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDGLLRKGLGQREFLSYLHLPKKDSKSTKNTKRAPRNEPADYATLYYREHSRAGDFSKTSLPERGRFDKCRIRPSVFKPTAGNGKGFLSMQSLASHKGQKLWRSNGSLHTLACHPPLSPGPRASQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHLNHLGGSLDRASQGPKEAGPPAVLSCLPEPPPPYEFSCSSAEEMGAVLPETCEELKRGLGDEDGSNPFTQVLEERQRLWLAELKRLYVERLHEVTQKAERSERNLQLQLFMAQQEQRRLRKELRAQQGLAPEPRAPGTLPEADPSARPEEEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRAQAQAQDAELVRLREAVRSLQEQAPREEAPGSCETDDCKSRGLLGEAGGSEARDSAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQGGYMDMYRRNQALEQELRALREPPTPWSPRLESSKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationLLERQDFSPEELRAA
HHHCCCCCHHHHHHH		39.4328674419
39PhosphorylationALAGSRGSRQPDGLL
HHHCCCCCCCCCCCH		26.9922617229
58PhosphorylationGQREFLSYLHLPKKD
CCHHHHHHHCCCCCC		10.5727251275
66PhosphorylationLHLPKKDSKSTKNTK
HCCCCCCCCCCCCCC		37.0724719451
83PhosphorylationPRNEPADYATLYYRE
CCCCCCCHHHHHHHC		12.0028152594
85PhosphorylationNEPADYATLYYREHS
CCCCCHHHHHHHCCC		14.7428152594
87PhosphorylationPADYATLYYREHSRA
CCCHHHHHHHCCCCC		8.9828152594
88PhosphorylationADYATLYYREHSRAG
CCHHHHHHHCCCCCC		16.7928152594
92PhosphorylationTLYYREHSRAGDFSK
HHHHHCCCCCCCCCC		21.0527642862
98PhosphorylationHSRAGDFSKTSLPER
CCCCCCCCCCCCCCC		39.5030183078
99UbiquitinationSRAGDFSKTSLPERG
CCCCCCCCCCCCCCC		41.9729967540
100PhosphorylationRAGDFSKTSLPERGR
CCCCCCCCCCCCCCC		34.0125849741
101PhosphorylationAGDFSKTSLPERGRF
CCCCCCCCCCCCCCC		45.7425849741
130PhosphorylationGNGKGFLSMQSLASH
CCCCCCCCHHHHHHC		16.7125849741
133PhosphorylationKGFLSMQSLASHKGQ
CCCCCHHHHHHCCCC		19.7723312004
145PhosphorylationKGQKLWRSNGSLHTL
CCCCHHHCCCCEEEE		33.6825849741
148PhosphorylationKLWRSNGSLHTLACH
CHHHCCCCEEEEEEC		22.6423879269
151PhosphorylationRSNGSLHTLACHPPL
HCCCCEEEEEECCCC		22.7326330541
159PhosphorylationLACHPPLSPGPRASQ
EEECCCCCCCCCHHH		33.3225849741
176PhosphorylationAQLLHALSLDEGGPE
HHHHHHHCCCCCCCC		34.2630175587
187PhosphorylationGGPEPEPSLSDSSSG
CCCCCCCCCCCCCCC		38.5529978859
189PhosphorylationPEPEPSLSDSSSGGS
CCCCCCCCCCCCCCC		39.5227732954
191PhosphorylationPEPSLSDSSSGGSFG
CCCCCCCCCCCCCCC		24.0327732954
200PhosphorylationSGGSFGRSPGTGPSP
CCCCCCCCCCCCCCC		28.2327732954
203PhosphorylationSFGRSPGTGPSPFSS
CCCCCCCCCCCCCCH		49.6727732954
206PhosphorylationRSPGTGPSPFSSSLG
CCCCCCCCCCCHHHH		39.6627732954
209PhosphorylationGTGPSPFSSSLGHLN
CCCCCCCCHHHHCHH		23.5427732954
210PhosphorylationTGPSPFSSSLGHLNH
CCCCCCCHHHHCHHH		29.9328857561
211PhosphorylationGPSPFSSSLGHLNHL
CCCCCCHHHHCHHHH		36.8525849741
221PhosphorylationHLNHLGGSLDRASQG
CHHHHCCCHHHHHCC		25.8725849741
270UbiquitinationPETCEELKRGLGDED
HHHHHHHHHCCCCCC		47.9321963094
279PhosphorylationGLGDEDGSNPFTQVL
CCCCCCCCCCHHHHH		54.36-
283PhosphorylationEDGSNPFTQVLEERQ
CCCCCCHHHHHHHHH		21.01-
311UbiquitinationRLHEVTQKAERSERN
HHHHHHHHHHHHHHH		42.7329967540
378PhosphorylationCQKTAEISLLKQQLR
HHHHHHHHHHHHHHH		21.1024719451
381UbiquitinationTAEISLLKQQLREAQ
HHHHHHHHHHHHHHH		41.0929967540
459PhosphorylationLLGEAGGSEARDSAE
CCCCCCCHHHHHHHH		27.45-
503PhosphorylationEKERVLRYQREIQGG
HHHHHHHHHHHHHCC		14.04-
511PhosphorylationQREIQGGYMDMYRRN
HHHHHCCHHHHHHHH		9.21-
515PhosphorylationQGGYMDMYRRNQALE
HCCHHHHHHHHHHHH		11.36-
533PhosphorylationRALREPPTPWSPRLE
HHHHCCCCCCCCCCC		48.3723312004
536PhosphorylationREPPTPWSPRLESSK
HCCCCCCCCCCCCCC		11.0123312004
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of N4BP3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of N4BP3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of N4BP3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEDD4_HUMANNEDD4physical
11717310
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of N4BP3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, AND MASSSPECTROMETRY.

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