T161A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T161A_HUMAN
• UniProt AC: Q9NX61
• Protein Name: Transmembrane protein 161A
• Gene Name: TMEM161A
• Organism: Homo sapiens (Human).
• Sequence Length: 479
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis..
• Protein Sequence: MAVLGVQLVVTLLTATLMHRLAPHCSFARWLLCNGSLFRYKHPSEEELRALAGKPRPRGRKERWANGLSEEKPLSVPRDAPFQLETCPLTTVDALVLRFFLEYQWFVDFAVYSGGVYLFTEAYYYMLGPAKETNIAVFWCLLTVTFSIKMFLTVTRLYFSAEEGGERSVCLTFAFLFLLLAMLVQVVREETLELGLEPGLASMTQNLEPLLKKQGWDWALPVAKLAIRVGLAVVGSVLGAFLTFPGLRLAQTHRDALTMSEDRPMLQFLLHTSFLSPLFILWLWTKPIARDFLHQPPFGETRFSLLSDSAFDSGRLWLLVVLCLLRLAVTRPHLQAYLCLAKARVEQLRREAGRIEAREIQQRVVRVYCYVTVVSLQYLTPLILTLNCTLLLKTLGGYSWGLGPAPLLSPDPSSASAAPIGSGEDEVQQTAARIAGALGGLLTPLFLRGVLAYLIWWTAACQLLASLFGLYFHQHLAGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	LGVQLVVTLLTATLM HHHHHHHHHHHHHHH	14.47	24043423
14	Phosphorylation	QLVVTLLTATLMHRL HHHHHHHHHHHHHHH	22.25	24043423
16	Phosphorylation	VVTLLTATLMHRLAP HHHHHHHHHHHHHHC	21.27	24043423
26	Phosphorylation	HRLAPHCSFARWLLC HHHHCCCHHHHHHHH	20.93	24043423
34	N-linked_Glycosylation	FARWLLCNGSLFRYK HHHHHHHCCCCEECC	42.95	UniProtKB CARBOHYD
41	Ubiquitination	NGSLFRYKHPSEEEL CCCCEECCCCCHHHH	44.79	21906983
44	Phosphorylation	LFRYKHPSEEELRAL CEECCCCCHHHHHHH	58.31	30624053
54	Ubiquitination	ELRALAGKPRPRGRK HHHHHCCCCCCCCCH	32.04	-
69	Phosphorylation	ERWANGLSEEKPLSV HHHCCCCCCCCCCCC	45.14	25159151
72	Ubiquitination	ANGLSEEKPLSVPRD CCCCCCCCCCCCCCC	47.40	21890473
72	Ubiquitination	ANGLSEEKPLSVPRD CCCCCCCCCCCCCCC	47.40	21890473
75	Phosphorylation	LSEEKPLSVPRDAPF CCCCCCCCCCCCCCC	38.31	30624053
191	Phosphorylation	VQVVREETLELGLEP HHHHHHHHHHHCCCC	22.30	-
204	Phosphorylation	EPGLASMTQNLEPLL CCCHHHHHHCHHHHH	16.29	-
213	Ubiquitination	NLEPLLKKQGWDWAL CHHHHHHHCCCCCHH	54.75	21890473
413	O-linked_Glycosylation	PLLSPDPSSASAAPI CCCCCCCCCCCCCCC	46.01	OGP
416	O-linked_Glycosylation	SPDPSSASAAPIGSG CCCCCCCCCCCCCCC	27.23	OGP
443	Phosphorylation	GALGGLLTPLFLRGV HHHHHHHHHHHHHHH	24.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T161A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T161A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T161A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.