MIRO2_HUMAN - dbPTM
MIRO2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MIRO2_HUMAN
UniProt AC Q8IXI1
Protein Name Mitochondrial Rho GTPase 2
Gene Name RHOT2
Organism Homo sapiens (Human).
Sequence Length 618
Subcellular Localization Mitochondrion outer membrane
Single-pass type IV membrane protein . Colocalizes with MGARP and RHOT2 at the mitochondria.
Protein Description Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity)..
Protein Sequence MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPPRAEEITIPADVTPEKVPTHIVDYSEAEQTDEELREEIHKANVVCVVYDVSEEATIEKIRTKWIPLVNGGTTQGPRVPIILVGNKSDLRSGSSMEAVLPIMSQFPEIETCVECSAKNLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDLDQALSDEELNAFQKSCFGHPLAPQALEDVKTVVCRNVAGGVREDRLTLDGFLFLNTLFIQRGRHETTWTILRRFGYSDALELTADYLSPLIHVPPGCSTELNHLGYQFVQRVFEKHDQDRDGALSPVELQSLFSVFPAAPWGPELPRTVRTEAGRLPLHGYLCQWTLVTYLDVRSCLGHLGYLGYPTLCEQDQAHAITVTREKRLDQEKGQTQRSVLLCKVVGARGVGKSAFLQAFLGRGLGHQDTREQPPGYAIDTVQVNGQEKYLILCEVGTDGLLATSLDATCDVACLMFDGSDPKSFAHCASVYKHHYMDGQTPCLFVSSKADLPEGVAVSGPSPAEFCRKHRLPAPVPFSCAGPAEPSTTIFTQLATMAAFPHLVHAELHPSSFWLRGLLGVVGAAVAAVLSFSLYRVLVKSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
37UbiquitinationPEEVPPRAEEITIPA
CCCCCCCHHHEEECC		25.2523503661
50UbiquitinationPADVTPEKVPTHIVD
CCCCCCCCCCCCEEC		55.5129967540
52UbiquitinationDVTPEKVPTHIVDYS
CCCCCCCCCCEECHH		29.3521890473
52 (in isoform 2)Ubiquitination-29.3521890473
57UbiquitinationKVPTHIVDYSEAEQT
CCCCCEECHHHHHHC		40.4123503661
58PhosphorylationVPTHIVDYSEAEQTD
CCCCEECHHHHHHCC		9.49-
59PhosphorylationPTHIVDYSEAEQTDE
CCCEECHHHHHHCCH		26.35-
64PhosphorylationDYSEAEQTDEELREE
CHHHHHHCCHHHHHH		36.56-
71UbiquitinationTDEELREEIHKANVV
CCHHHHHHHHHCCEE		43.9129901268
72UbiquitinationDEELREEIHKANVVC
CHHHHHHHHHCCEEE		3.2821890473
78UbiquitinationEIHKANVVCVVYDVS
HHHHCCEEEEEEECC		1.7421890473
87UbiquitinationVVYDVSEEATIEKIR
EEEECCCHHHHHHHH		43.5421963094
90UbiquitinationDVSEEATIEKIRTKW
ECCCHHHHHHHHHCE		7.0021963094
91UbiquitinationVSEEATIEKIRTKWI
CCCHHHHHHHHHCEE		37.7729901268
92UbiquitinationSEEATIEKIRTKWIP
CCHHHHHHHHHCEEE		33.3722053931
96UbiquitinationTIEKIRTKWIPLVNG
HHHHHHHCEEEEECC		33.0221890473
101UbiquitinationRTKWIPLVNGGTTQG
HHCEEEEECCCCCCC		5.4022817900
103UbiquitinationKWIPLVNGGTTQGPR
CEEEEECCCCCCCCC		27.6121963094
107UbiquitinationLVNGGTTQGPRVPII
EECCCCCCCCCCCEE		60.7821963094
119UbiquitinationPIILVGNKSDLRSGS
CEEEECCHHHCCCCC		39.1422817900
119 (in isoform 1)Ubiquitination-39.1421890473
123UbiquitinationVGNKSDLRSGSSMEA
ECCHHHCCCCCCHHH		43.9221963094
124UbiquitinationGNKSDLRSGSSMEAV
CCHHHCCCCCCHHHH		50.7721963094
146UbiquitinationPEIETCVECSAKNLR
CCCHHHHHHCHHCCC		25.5423503661
156PhosphorylationAKNLRNISELFYYAQ
HHCCCCHHHHHHHHH		31.6222396657
160PhosphorylationRNISELFYYAQKAVL
CCHHHHHHHHHHHHC		15.54-
161UbiquitinationNISELFYYAQKAVLH
CHHHHHHHHHHHHCC		8.6721890473
164UbiquitinationELFYYAQKAVLHPTA
HHHHHHHHHHCCCCC		32.0823503661
174PhosphorylationLHPTAPLYDPEAKQL
CCCCCCCCCHHHHHH		28.5227642862
179UbiquitinationPLYDPEAKQLRPACA
CCCCHHHHHHHHHHH		48.4821963094
179 (in isoform 1)Ubiquitination-48.4821890473
182UbiquitinationDPEAKQLRPACAQAL
CHHHHHHHHHHHHHH		17.8023503661
188UbiquitinationLRPACAQALTRIFRL
HHHHHHHHHHHHHHC		7.7432142685
196PhosphorylationLTRIFRLSDQDLDQA
HHHHHHCCCCCHHHH		29.0327067055
196UbiquitinationLTRIFRLSDQDLDQA
HHHHHHCCCCCHHHH		29.0321963094
197UbiquitinationTRIFRLSDQDLDQAL
HHHHHCCCCCHHHHC		51.0821963094
199UbiquitinationIFRLSDQDLDQALSD
HHHCCCCCHHHHCCH		58.1523000965
205PhosphorylationQDLDQALSDEELNAF
CCHHHHCCHHHHHHH		46.0927499020
208UbiquitinationDQALSDEELNAFQKS
HHHCCHHHHHHHHHH		52.9221890473
212UbiquitinationSDEELNAFQKSCFGH
CHHHHHHHHHHHHCC		10.2621963094
213UbiquitinationDEELNAFQKSCFGHP
HHHHHHHHHHHHCCC		34.0521963094
214UbiquitinationEELNAFQKSCFGHPL
HHHHHHHHHHHCCCC		42.6221963094
2302-HydroxyisobutyrylationPQALEDVKTVVCRNV
HHHHHHCCEEEEECC		48.18-
230UbiquitinationPQALEDVKTVVCRNV
HHHHHHCCEEEEECC		48.1821963094
231UbiquitinationQALEDVKTVVCRNVA
HHHHHCCEEEEECCC		20.3021963094
250UbiquitinationEDRLTLDGFLFLNTL
CCCEEECCEEEEEEE		25.0332142685
261UbiquitinationLNTLFIQRGRHETTW
EEEEHHHCCCCCHHH		39.0232015554
263UbiquitinationTLFIQRGRHETTWTI
EEHHHCCCCCHHHHH		27.0223503661
269UbiquitinationGRHETTWTILRRFGY
CCCCHHHHHHHHHCC		14.1932142685
270UbiquitinationRHETTWTILRRFGYS
CCCHHHHHHHHHCCC		1.8132142685
276UbiquitinationTILRRFGYSDALELT
HHHHHHCCCHHHHHH		10.7223503661
280UbiquitinationRFGYSDALELTADYL
HHCCCHHHHHHHHHH		7.1323000965
281UbiquitinationFGYSDALELTADYLS
HCCCHHHHHHHHHHH		45.8832015554
282UbiquitinationGYSDALELTADYLSP
CCCHHHHHHHHHHHC		5.0732142685
289UbiquitinationLTADYLSPLIHVPPG
HHHHHHHCCCCCCCC		32.5121890473
290UbiquitinationTADYLSPLIHVPPGC
HHHHHHCCCCCCCCC		3.6730230243
293UbiquitinationYLSPLIHVPPGCSTE
HHHCCCCCCCCCCCH		4.9223000965
296UbiquitinationPLIHVPPGCSTELNH
CCCCCCCCCCCHHHH		16.3723503661
297UbiquitinationLIHVPPGCSTELNHL
CCCCCCCCCCHHHHH		5.8423503661
302UbiquitinationPGCSTELNHLGYQFV
CCCCCHHHHHHHHHH		23.3132142685
303UbiquitinationGCSTELNHLGYQFVQ
CCCCHHHHHHHHHHH		33.0032142685
313UbiquitinationYQFVQRVFEKHDQDR
HHHHHHHHHHCCCCC		12.9423000965
314UbiquitinationQFVQRVFEKHDQDRD
HHHHHHHHHCCCCCC		46.7723000965
322UbiquitinationKHDQDRDGALSPVEL
HCCCCCCCCCCHHHH		29.3421890473
323UbiquitinationHDQDRDGALSPVELQ
CCCCCCCCCCHHHHH		14.7921890473
325PhosphorylationQDRDGALSPVELQSL
CCCCCCCCHHHHHHH		26.7727499020
331PhosphorylationLSPVELQSLFSVFPA
CCHHHHHHHHHHCCC		43.9628450419
334PhosphorylationVELQSLFSVFPAAPW
HHHHHHHHHCCCCCC		28.3028450419
352UbiquitinationLPRTVRTEAGRLPLH
CCCCCCCCCCCCCCC		38.2623503661
358UbiquitinationTEAGRLPLHGYLCQW
CCCCCCCCCCCCCCE		6.0732142685
369UbiquitinationLCQWTLVTYLDVRSC
CCCEEEEEHHHHHHH		22.8323000965
370UbiquitinationCQWTLVTYLDVRSCL
CCEEEEEHHHHHHHH		8.0723503661
376UbiquitinationTYLDVRSCLGHLGYL
EHHHHHHHHHHCCCC		3.5532142685
378UbiquitinationLDVRSCLGHLGYLGY
HHHHHHHHHCCCCCC		20.5021890473
385UbiquitinationGHLGYLGYPTLCEQD
HHCCCCCCCCCCCHH		7.1723503661
386UbiquitinationHLGYLGYPTLCEQDQ
HCCCCCCCCCCCHHH		19.6623503661
387UbiquitinationLGYLGYPTLCEQDQA
CCCCCCCCCCCHHHC		35.2423000965
391UbiquitinationGYPTLCEQDQAHAIT
CCCCCCCHHHCEEEE		47.3132142685
392UbiquitinationYPTLCEQDQAHAITV
CCCCCCHHHCEEEEE		25.9132142685
396UbiquitinationCEQDQAHAITVTREK
CCHHHCEEEEEEHHH		11.3621890473
402UbiquitinationHAITVTREKRLDQEK
EEEEEEHHHHCHHCC		32.9123000965
403UbiquitinationAITVTREKRLDQEKG
EEEEEHHHHCHHCCC		55.7823000965
404UbiquitinationITVTREKRLDQEKGQ
EEEEHHHHCHHCCCC		38.4523503661
409UbiquitinationEKRLDQEKGQTQRSV
HHHCHHCCCCCHHHH		51.1632142685
410UbiquitinationKRLDQEKGQTQRSVL
HHCHHCCCCCHHHHH		34.7132142685
411UbiquitinationRLDQEKGQTQRSVLL
HCHHCCCCCHHHHHH		45.5921890473
412UbiquitinationLDQEKGQTQRSVLLC
CHHCCCCCHHHHHHH		34.3221890473
420UbiquitinationQRSVLLCKVVGARGV
HHHHHHHHHHCCCCC		39.6723000965
420 (in isoform 1)Ubiquitination-39.6721890473
421UbiquitinationRSVLLCKVVGARGVG
HHHHHHHHHCCCCCC		4.7223000965
429UbiquitinationVGARGVGKSAFLQAF
HCCCCCCHHHHHHHH		35.8821963094
429 (in isoform 1)Ubiquitination-35.8821890473
430UbiquitinationGARGVGKSAFLQAFL
CCCCCCHHHHHHHHH		20.5121890473
506PhosphorylationKSFAHCASVYKHHYM
HHHHHHHHHHHHHCC		31.2330108239
508PhosphorylationFAHCASVYKHHYMDG
HHHHHHHHHHHCCCC		11.3429083192
509AcetylationAHCASVYKHHYMDGQ
HHHHHHHHHHCCCCC		23.0425953088
509MalonylationAHCASVYKHHYMDGQ
HHHHHHHHHHCCCCC		23.0426320211
509UbiquitinationAHCASVYKHHYMDGQ
HHHHHHHHHHCCCCC		23.0429967540
517PhosphorylationHHYMDGQTPCLFVSS
HHCCCCCCCEEEEEC		22.84-
524PhosphorylationTPCLFVSSKADLPEG
CCEEEEECCCCCCCC		26.93-
525UbiquitinationPCLFVSSKADLPEGV
CEEEEECCCCCCCCC		38.1129967540
535PhosphorylationLPEGVAVSGPSPAEF
CCCCCEECCCCHHHH		34.9428348404
538PhosphorylationGVAVSGPSPAEFCRK
CCEECCCCHHHHHHH		40.0226471730
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligasePRKNO60260
PMID:22078885
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MIRO2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MIRO2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TECR_HUMANTECRphysical
22939629
RAB5A_HUMANRAB5Aphysical
22939629
RS26_HUMANRPS26physical
22939629
OXA1L_HUMANOXA1Lphysical
22939629
NDUS7_HUMANNDUFS7physical
22939629
SRSF5_HUMANSRSF5physical
22939629
RS2_HUMANRPS2physical
22939629
RL9_HUMANRPL9physical
22939629
NDUS8_HUMANNDUFS8physical
22939629
NDUS1_HUMANNDUFS1physical
22939629
SAM50_HUMANSAMM50physical
22939629
PINK1_HUMANPINK1physical
19152501
UBC_HUMANUBCphysical
28514442
RM20_HUMANMRPL20physical
28514442
MIRO1_HUMANRHOT1physical
28514442
SARM1_HUMANSARM1physical
28514442
XPR1_HUMANXPR1physical
28514442
FKRP_HUMANFKRPphysical
28514442
MYO19_HUMANMYO19physical
28514442
BTAF1_HUMANBTAF1physical
28514442
SGPP1_HUMANSGPP1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MIRO2_HUMAN

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Related Literatures of Post-Translational Modification

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