dbPTM

NDUS7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NDUS7_HUMAN
UniProt AC	O75251
Protein Name	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Gene Name	NDUFS7
Organism	Homo sapiens (Human).
Sequence Length	213
Subcellular Localization	Mitochondrion .
Protein Description	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
Protein Sequence	MAVLSAPGLRGFRILGLRSSVGPAVQARGVHQSVATDGPSSTQPALPKARAVAPKPSSRGEYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVMIVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYIPGCPPTAEALLYGILQLQRKIKRERRLQIWYRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAVLSAPGLRGF ---CCCCCCCCCCCE	26.31	24043423
19	Phosphorylation	FRILGLRSSVGPAVQ EEEEECCCCCCHHHH	34.12	22468782
20	Phosphorylation	RILGLRSSVGPAVQA EEEECCCCCCHHHHH	25.34	22468782
48	Ubiquitination	STQPALPKARAVAPK CCCCCCCCCEEECCC	51.89	-
48	Ubiquitination	STQPALPKARAVAPK CCCCCCCCCEEECCC	51.89	21906983
55	Ubiquitination	KARAVAPKPSSRGEY CCEEECCCCCCCCCE	48.04	-
57	Phosphorylation	RAVAPKPSSRGEYVV EEECCCCCCCCCEEE	38.50	28348404
58	Phosphorylation	AVAPKPSSRGEYVVA EECCCCCCCCCEEEE	53.48	26437602
66	Ubiquitination	RGEYVVAKLDDLVNW CCCEEEEEHHHHHHH	40.62	-
66	Ubiquitination	RGEYVVAKLDDLVNW CCCEEEEEHHHHHHH	40.62	-
75	Methylation	DDLVNWARRSSLWPM HHHHHHHHHCCCCHH	30.54	115484751
111	Hydroxylation	DRFGVVFRASPRQSD HHCEEEEECCCCCCC	23.65	-
113	Phosphorylation	FGVVFRASPRQSDVM CEEEEECCCCCCCEE	19.16	21406692
117	Phosphorylation	FRASPRQSDVMIVAG EECCCCCCCEEEEEE	33.19	21406692
120	Sulfoxidation	SPRQSDVMIVAGTLT CCCCCCEEEEEEECC	2.15	21406390
125	Phosphorylation	DVMIVAGTLTNKMAP CEEEEEEECCCCHHH	22.22	21406692
127	Phosphorylation	MIVAGTLTNKMAPAL EEEEEECCCCHHHHH	32.41	21406692
129	Ubiquitination	VAGTLTNKMAPALRK EEEECCCCHHHHHHH	31.07	21906983
129	Ubiquitination	VAGTLTNKMAPALRK EEEECCCCHHHHHHH	31.07	2190698
133	Ubiquitination	LTNKMAPALRKVYDQ CCCCHHHHHHHHHHC	15.51	21906983
136	Ubiquitination	KMAPALRKVYDQMPE CHHHHHHHHHHCCCC	46.10	-
136	Ubiquitination	KMAPALRKVYDQMPE CHHHHHHHHHHCCCC	46.10	-
149	Phosphorylation	PEPRYVVSMGSCANG CCCCEEEEECCCCCC	13.84	22210691
160	Phosphorylation	CANGGGYYHYSYSVV CCCCCCCCCEEEEEE	9.50	22210691
165	Phosphorylation	GYYHYSYSVVRGCDR CCCCEEEEEECCCCE	14.27	22210691
214	Ubiquitination	LQIWYRR-------- HHHEECC--------		21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NDUS7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
111	R	Hydroxylation		27226634
Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NDUS7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUS8_HUMAN	NDUFS8	physical	22939629
NDUV2_HUMAN	NDUFV2	physical	22939629
NDUV1_HUMAN	NDUFV1	physical	22939629
SCO1_HUMAN	SCO1	physical	24344204
NDUF5_HUMAN	NDUFAF5	physical	24344204
MMSA_HUMAN	ALDH6A1	physical	24344204
NDUF4_HUMAN	NDUFAF4	physical	24344204
ETHE1_HUMAN	ETHE1	physical	24344204
NDUF3_HUMAN	NDUFAF3	physical	24344204
ACAD9_HUMAN	ACAD9	physical	24344204
NDUS7_HUMAN	NDUFS7	physical	24344204
LONM_HUMAN	LONP1	physical	24344204
NQO1_HUMAN	NQO1	physical	24344204
NDUS2_HUMAN	NDUFS2	physical	24344204
NDUS3_HUMAN	NDUFS3	physical	24344204
NDUA9_HUMAN	NDUFA9	physical	24344204
NDUA5_HUMAN	NDUFA5	physical	24344204
NDUS1_HUMAN	NDUFS1	physical	24344204
NDUS8_HUMAN	NDUFS8	physical	24344204
ALKB7_HUMAN	ALKBH7	physical	28514442
HEMK1_HUMAN	HEMK1	physical	28514442
PDP2_HUMAN	PDP2	physical	28514442
NDUB7_HUMAN	NDUFB7	physical	28514442
NDUF5_HUMAN	NDUFAF5	physical	28514442
SYVM_HUMAN	VARS2	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
ACS2L_HUMAN	ACSS1	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
CHDH_HUMAN	CHDH	physical	28514442
MMAD_HUMAN	MMADHC	physical	28514442
RRF2M_HUMAN	GFM2	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
SYNM_HUMAN	NARS2	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
TRM2_HUMAN	TRMT2B	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
ACSF3_HUMAN	ACSF3	physical	28514442
SYMM_HUMAN	MARS2	physical	28514442
DPOG1_HUMAN	POLG	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
PDK1_HUMAN	PDK1	physical	28514442
NDUV3_HUMAN	NDUFV3	physical	28514442
BCS1_HUMAN	BCS1L	physical	28514442
NDUA7_HUMAN	NDUFA7	physical	28514442
SIR3_HUMAN	SIRT3	physical	28514442
SYHM_HUMAN	HARS2	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
SYLM_HUMAN	LARS2	physical	28514442
PDPR_HUMAN	PDPR	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
CPSM_HUMAN	CPS1	physical	28514442
SYAM_HUMAN	AARS2	physical	28514442
NDUF7_HUMAN	NDUFAF7	physical	28514442
PDK3_HUMAN	PDK3	physical	28514442
NDUS3_HUMAN	NDUFS3	physical	28514442
INT1_HUMAN	INTS1	physical	28514442
MCCA_HUMAN	MCCC1	physical	28514442
NNTM_HUMAN	NNT	physical	28514442
ACOT9_HUMAN	ACOT9	physical	28514442
NDUV1_HUMAN	NDUFV1	physical	28514442
EFGM_HUMAN	GFM1	physical	28514442
SYIM_HUMAN	IARS2	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442
MRRP3_HUMAN	KIAA0391	physical	28514442
ATPF1_HUMAN	ATPAF1	physical	28514442
NDUF4_HUMAN	NDUFAF4	physical	28514442
NDUA8_HUMAN	NDUFA8	physical	28514442
PPOX_HUMAN	PPOX	physical	28514442
IPO13_HUMAN	IPO13	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
256000	Leigh syndrome (LS)
252010	Mitochondrial complex I deficiency (MT-C1D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00997	Doxorubicin

Regulatory Network of NDUS7_HUMAN

Related Literatures of Post-Translational Modification

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