SYMM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYMM_HUMAN
• UniProt AC: Q96GW9
• Protein Name: Methionine--tRNA ligase, mitochondrial
• Gene Name: MARS2
• Organism: Homo sapiens (Human).
• Sequence Length: 593
• Subcellular Localization: Mitochondrion matrix .
• Protein Sequence: MLRTSVLRLLGRTGASRLSLLEDFGPRYYSSGSLSAGDDACDVRAYFTTPIFYVNAAPHIGHLYSALLADALCRHRRLRGPSTAATRFSTGTDEHGLKIQQAAATAGLAPTELCDRVSEQFQQLFQEAGISCTDFIRTTEARHRVAVQHFWGVLKSRGLLYKGVYEGWYCASDECFLPEAKVTQQPGPSGDSFPVSLESGHPVSWTKEENYIFRLSQFRKPLQRWLRGNPQAITPEPFHHVVLQWLDEELPDLSVSRRSSHLHWGIPVPGDDSQTIYVWLDALVNYLTVIGYPNAEFKSWWPATSHIIGKDILKFHAIYWPAFLLGAGMSPPQRICVHSHWTVCGQKMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADALGGLLNRCTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAEDYALVSAVATLPKQVADHYDNFRIYKALEAVSSCVRQTNGFVQRHAPWKLNWESPVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSASERSLGELYFLPRFYGHPCPFEGRRLGPETGLLFPRLDQSRTWLVKAHRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLRTSVLRLLG ----CCHHHHHHHHC	21.16	28060719
5	Phosphorylation	---MLRTSVLRLLGR ---CCHHHHHHHHCC	16.84	23909892
16	Phosphorylation	LLGRTGASRLSLLED HHCCCCHHHHHHHHH	34.79	24719451
83	Phosphorylation	RRLRGPSTAATRFST HHCCCCCCHHHCCCC	24.36	17929957
86	Phosphorylation	RGPSTAATRFSTGTD CCCCCHHHCCCCCCC	29.77	17929957
89	Phosphorylation	STAATRFSTGTDEHG CCHHHCCCCCCCCCC	23.72	17929957
90	Phosphorylation	TAATRFSTGTDEHGL CHHHCCCCCCCCCCH	41.19	17929957
92	Phosphorylation	ATRFSTGTDEHGLKI HHCCCCCCCCCCHHH	38.00	17929957
131	O-linked_Glycosylation	LFQEAGISCTDFIRT HHHHHCCCHHHHHHH	15.28	29351928
139	Phosphorylation	CTDFIRTTEARHRVA HHHHHHHHHHHHHHH	20.14	27251275
234	Phosphorylation	RGNPQAITPEPFHHV CCCCCCCCCCCCHHH	25.31	-
254	Phosphorylation	DEELPDLSVSRRSSH CHHCCCCCEECCCCC	25.98	24719451
339	Phosphorylation	PQRICVHSHWTVCGQ CCEEEEECCCEECCH	10.58	22468782
342	Phosphorylation	ICVHSHWTVCGQKMS EEEECCCEECCHHHH	10.65	22468782
390	Acetylation	DCDYYDEKVVKLLNS CCCCCCHHHHHHHCH	49.80	25953088
447	Phosphorylation	VRAQAEDYALVSAVA HHHHHHHHHHHHHHH	8.04	-
471	Malonylation	YDNFRIYKALEAVSS CCHHHHHHHHHHHHH	44.09	32601280
478	Phosphorylation	KALEAVSSCVRQTNG HHHHHHHHHHHHCCC	15.27	-
542	Phosphorylation	LLSRLGVSASERSLG HHHHHCCCHHHCCHH	25.03	22210691
544	Phosphorylation	SRLGVSASERSLGEL HHHCCCHHHCCHHHH	26.49	22210691
552	Phosphorylation	ERSLGELYFLPRFYG HCCHHHHEECHHHCC	9.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYMM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYMM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYMM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.