SYLM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYLM_HUMAN
• UniProt AC: Q15031
• Protein Name: Probable leucine--tRNA ligase, mitochondrial
• Gene Name: LARS2
• Organism: Homo sapiens (Human).
• Sequence Length: 903
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	QRLGFYASLLKRQLN HHHHHHHHHHHHHHC	23.90	24719451
39	Phosphorylation	VIPGCTRSIYSATGK CCCCCCCCHHHHCCC	14.02	-
41	Phosphorylation	PGCTRSIYSATGKWT CCCCCCHHHHCCCCE	8.10	-
42	Phosphorylation	GCTRSIYSATGKWTK CCCCCHHHHCCCCEE	20.06	-
44	Phosphorylation	TRSIYSATGKWTKEY CCCHHHHCCCCEEEE	33.10	24719451
52	Phosphorylation	GKWTKEYTLQTRKDV CCCEEEEEECCHHHH	17.30	24719451
68	Acetylation	KWWHQRIKEQASKIS HHHHHHHHHHHHHHC	46.06	-
85	Phosphorylation	DKSKPKFYVLSMFPY HHCCCCEEEEEECCC	13.45	20058876
88	Phosphorylation	KPKFYVLSMFPYPSG CCCEEEEEECCCCCC	14.34	20058876
108	Phosphorylation	HVRVYTISDTIARFQ EEEEEEEHHHHHHHH	22.39	-
110	Phosphorylation	RVYTISDTIARFQKM EEEEEHHHHHHHHHH	15.11	-
155	Acetylation	SWTQSNIKHMRKQLD CCCHHHHHHHHHHHH	35.28	25953088
155	Succinylation	SWTQSNIKHMRKQLD CCCHHHHHHHHHHHH	35.28	23954790
155	Malonylation	SWTQSNIKHMRKQLD CCCHHHHHHHHHHHH	35.28	26320211
199	Phosphorylation	LYEAGLAYQKEALVN HHHHCCCHHHHHHCC	25.76	25159151
232	Ubiquitination	CSWRSGAKVEQKYLR CCCCCCCCHHHHHHH	50.24	24816145
236	Acetylation	SGAKVEQKYLRQWFI CCCCHHHHHHHHHHH	32.52	19608861
315	Phosphorylation	GTSHVAISPSHRLLH CCCCEEECCCHHHHC	15.60	-
328	Acetylation	LHGHSSLKEALRMAL HCCCCCHHHHHHHHH	42.78	23236377
343	Phosphorylation	VPGKDCLTPVMAVNM CCCCCCCCHHHHHHC	21.84	-
352	Phosphorylation	VMAVNMLTQQEVPVV HHHHHCCCCCCCCEE	19.89	-
369	Phosphorylation	AKADLEGSLDSKIGI EECCCCCCCCCCCCC	21.45	21406692
372	Phosphorylation	DLEGSLDSKIGIPST CCCCCCCCCCCCCCC	31.31	21406692
409	Phosphorylation	PDGTERLSSSAEFTG CCCCCCCCCCCCCCC	28.59	22210691
410	Phosphorylation	DGTERLSSSAEFTGM CCCCCCCCCCCCCCC	37.85	26852163
411	Phosphorylation	GTERLSSSAEFTGMT CCCCCCCCCCCCCCC	28.57	26852163
415	Phosphorylation	LSSSAEFTGMTRQDA CCCCCCCCCCCHHHH	19.97	26852163
418	Phosphorylation	SAEFTGMTRQDAFLA CCCCCCCCHHHHHHH	26.90	26852163
427	Phosphorylation	QDAFLALTQKARGKR HHHHHHHHHHHCCCC	23.55	22210691
429	Ubiquitination	AFLALTQKARGKRVG HHHHHHHHHCCCCCC	34.51	30230243
445	Ubiquitination	DVTSDKLKDWLISRQ CCCHHHHHHHHHHCC	53.23	-
450	Phosphorylation	KLKDWLISRQRYWGT HHHHHHHHCCCCCCC	21.86	23898821
517	Phosphorylation	KGAAKRETDTMDTFV CCCCCCCCCCHHHHH	40.58	25907765
519	Phosphorylation	AAKRETDTMDTFVDS CCCCCCCCHHHHHHH	25.11	25907765
522	Phosphorylation	RETDTMDTFVDSAWY CCCCCHHHHHHHCHH	18.09	25907765
526	Phosphorylation	TMDTFVDSAWYYFRY CHHHHHHHCHHHCCC	18.52	25907765
529	Phosphorylation	TFVDSAWYYFRYTDP HHHHHCHHHCCCCCC	7.76	25907765
530	Phosphorylation	FVDSAWYYFRYTDPH HHHHCHHHCCCCCCC	3.20	25907765
600	Ubiquitination	LLAQGLIKGQTFRLP HHHHCCCCCCEEECC	50.43	-
600	Malonylation	LLAQGLIKGQTFRLP HHHHCCCCCCEEECC	50.43	26320211
608	Phosphorylation	GQTFRLPSGQYLQRE CCEEECCCCCEEEEE	43.02	20068231
611	Phosphorylation	FRLPSGQYLQREEVD EECCCCCEEEEEEEE	14.34	20068231
628	Ubiquitination	GSVPVHAKTKEKLEV CCCCCCCCCHHHEEE	45.30	29967540
636	Phosphorylation	TKEKLEVTWEKMSKS CHHHEEECHHHHCCC	20.66	21406692
643	Phosphorylation	TWEKMSKSKHNGVDP CHHHHCCCCCCCCCH	31.66	27259358
657	Phosphorylation	PEEVVEQYGIDTIRL HHHHHHHHCCCCEEE	11.53	27259358
681	Ubiquitination	KDILWDVKTDALPGV CCCCEEECCCCCCHH	37.91	-
708	Phosphorylation	RFIEARASGKSPQPQ HHHHHHHCCCCCCCH	41.00	23186163
710	Ubiquitination	IEARASGKSPQPQLL HHHHHCCCCCCCHHH	57.37	27667366
711	Phosphorylation	EARASGKSPQPQLLS HHHHCCCCCCCHHHC	32.09	26537577
718	Phosphorylation	SPQPQLLSNKEKAEA CCCCHHHCCHHHHHH	55.22	23186163
720	Ubiquitination	QPQLLSNKEKAEARK CCHHHCCHHHHHHHH	58.16	24816145
720	Malonylation	QPQLLSNKEKAEARK CCHHHCCHHHHHHHH	58.16	30639696
852	Malonylation	INNKACGKIPVPQQV ECCCCCCCCCCCHHH	43.66	26320211
873	Phosphorylation	VHEFVLQSELGVRLL HHHHHHHHHHHHHHH	30.54	-
891	Phosphorylation	SIKKSFLSPRTALIN CCCHHHCCCHHHHHH	15.43	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYLM_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYLM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYLM_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SYLM_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615300: Perrault syndrome 4 (PRLTS4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00149: L-Leucine

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-236, AND MASS SPECTROMETRY.
PubMed: 19608861