MMSA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMSA_HUMAN
• UniProt AC: Q02252
• Protein Name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
• Gene Name: ALDH6A1
• Organism: Homo sapiens (Human).
• Sequence Length: 535
• Subcellular Localization: Mitochondrion.
• Protein Description: Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA..
• Protein Sequence: MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	RARILQVSSKVKSSP HHHHHHHHHCCCCCC	16.10	29496963
19	Phosphorylation	ARILQVSSKVKSSPT HHHHHHHHCCCCCCC	42.48	46162107
47	Malonylation	VKLFIGGKFVESKSD EEEEECCEEEECCCC	40.81	26320211
47	Acetylation	VKLFIGGKFVESKSD EEEEECCEEEECCCC	40.81	25953088
47	Succinylation	VKLFIGGKFVESKSD EEEEECCEEEECCCC	40.81	-
47	Succinylation	VKLFIGGKFVESKSD EEEEECCEEEECCCC	40.81	-
52	Succinylation	GGKFVESKSDKWIDI CCEEEECCCCCEEEE	49.52	23954790
52	Succinylation	GGKFVESKSDKWIDI CCEEEECCCCCEEEE	49.52	-
52	Acetylation	GGKFVESKSDKWIDI CCEEEECCCCCEEEE	49.52	27178108
55	Succinylation	FVESKSDKWIDIHNP EEECCCCCEEEECCC	53.81	-
55	Succinylation	FVESKSDKWIDIHNP EEECCCCCEEEECCC	53.81	-
55	Acetylation	FVESKSDKWIDIHNP EEECCCCCEEEECCC	53.81	27178108
55	Malonylation	FVESKSDKWIDIHNP EEECCCCCEEEECCC	53.81	26320211
55	2-Hydroxyisobutyrylation	FVESKSDKWIDIHNP EEECCCCCEEEECCC	53.81	-
76	Succinylation	GRVPQATKAEMDAAI CCCCCCCHHHHHHHH	45.42	-
76	Succinylation	GRVPQATKAEMDAAI CCCCCCCHHHHHHHH	45.42	-
76	Acetylation	GRVPQATKAEMDAAI CCCCCCCHHHHHHHH	45.42	-
87	Acetylation	DAAIASCKRAFPAWA HHHHHHCHHHCCCCC	44.24	155509
96	Phosphorylation	AFPAWADTSVLSRQQ HCCCCCCCHHHCHHH	17.00	28857561
97	Phosphorylation	FPAWADTSVLSRQQV CCCCCCCHHHCHHHH	22.93	28857561
100	Phosphorylation	WADTSVLSRQQVLLR CCCCHHHCHHHHHHH	26.36	28857561
113	Acetylation	LRYQQLIKENLKEIA HHHHHHHHHHHHHHH	49.49	27178108
116	Acetylation	QQLIKENLKEIAKLI HHHHHHHHHHHHHHH	5.74	-
117	Succinylation	QLIKENLKEIAKLIT HHHHHHHHHHHHHHH	59.67	-
117	Succinylation	QLIKENLKEIAKLIT HHHHHHHHHHHHHHH	59.67	23954790
117	Acetylation	QLIKENLKEIAKLIT HHHHHHHHHHHHHHH	59.67	25953088
117	Malonylation	QLIKENLKEIAKLIT HHHHHHHHHHHHHHH	59.67	26320211
121	Acetylation	ENLKEIAKLITLEQG HHHHHHHHHHHHHCC	46.19	27178108
129	Succinylation	LITLEQGKTLADAEG HHHHHCCCCHHHCCC	39.81	-
129	Succinylation	LITLEQGKTLADAEG HHHHHCCCCHHHCCC	39.81	-
129	Acetylation	LITLEQGKTLADAEG HHHHHCCCCHHHCCC	39.81	23236377
170	Phosphorylation	ITKDMDLYSYRLPLG CCCCCCHHHCCCCCC	10.21	21406692
171	Phosphorylation	TKDMDLYSYRLPLGV CCCCCHHHCCCCCCC	15.86	24719451
172	Phosphorylation	KDMDLYSYRLPLGVC CCCCHHHCCCCCCCC	11.56	21406692
218	Phosphorylation	SERVPGATMLLAKLL HHCCCCHHHHHHHHH	17.80	28857561
219	Sulfoxidation	ERVPGATMLLAKLLQ HCCCCHHHHHHHHHH	2.60	21406390
262	Phosphorylation	KAISFVGSNKAGEYI EEEEEECCCCCCCCC	29.83	24275569
264	Acetylation	ISFVGSNKAGEYIFE EEEECCCCCCCCCCC	60.51	23954790
264	Malonylation	ISFVGSNKAGEYIFE EEEECCCCCCCCCCC	60.51	26320211
268	Phosphorylation	GSNKAGEYIFERGSR CCCCCCCCCCCCCCC	15.25	7105073
298	Acetylation	VVMPDANKENTLNQL EECCCCCCCCHHHHH	54.80	23954790
330	Acetylation	AVLVGEAKKWLPELV HHHHHHHHHHHHHHH	39.93	2402835
331	Acetylation	VLVGEAKKWLPELVE HHHHHHHHHHHHHHH	62.10	-
341	Acetylation	PELVEHAKNLRVNAG HHHHHHHHHCCCCCC	59.42	25953088
360	Phosphorylation	ADLGPLITPQAKERV CCCCCCCCHHHHHHH	19.61	110748477
364	Succinylation	PLITPQAKERVCNLI CCCCHHHHHHHHHHH	40.58	-
364	Succinylation	PLITPQAKERVCNLI CCCCHHHHHHHHHHH	40.58	-
364	Ubiquitination	PLITPQAKERVCNLI CCCCHHHHHHHHHHH	40.58	-
364	Acetylation	PLITPQAKERVCNLI CCCCHHHHHHHHHHH	40.58	23236377
373	Phosphorylation	RVCNLIDSGTKEGAS HHHHHHHCCCCCCCE	41.17	37817221
375	Phosphorylation	CNLIDSGTKEGASIL HHHHHCCCCCCCEEE	29.85	21406692
376	Acetylation	NLIDSGTKEGASILL HHHHCCCCCCCEEEE	58.64	-
376	Succinylation	NLIDSGTKEGASILL HHHHCCCCCCCEEEE	58.64	-
376	Succinylation	NLIDSGTKEGASILL HHHHCCCCCCCEEEE	58.64	-
380	Phosphorylation	SGTKEGASILLDGRK CCCCCCCEEEECCCE	25.32	27499020
391	Succinylation	DGRKIKVKGYENGNF CCCEEEEEEEECCCE	51.26	-
391	Succinylation	DGRKIKVKGYENGNF CCCEEEEEEEECCCE	51.26	-
487	Phosphorylation	PMFSFTGSRSSFRGD CCEEEECCCCCCCCC	26.40	46162113
490	Phosphorylation	SFTGSRSSFRGDTNF EEECCCCCCCCCCCC	20.18	17081983
492	Methylation	TGSRSSFRGDTNFYG ECCCCCCCCCCCCCC	43.98	-
498	Phosphorylation	FRGDTNFYGKQGIQF CCCCCCCCCCCCHHH	26.03	20561487
500	Acetylation	GDTNFYGKQGIQFYT CCCCCCCCCCHHHEE	33.69	-
517	Succinylation	KTITSQWKEEDATLS HHHHHHHHHHCCCCC	43.52	-
517	Succinylation	KTITSQWKEEDATLS HHHHHHHHHHCCCCC	43.52	-
525	Phosphorylation	EEDATLSSPAVVMPT HHCCCCCCCCEECCC	21.71	110748485

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMSA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMSA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMSA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBTN2_HUMAN	LMO2	physical	21988832
AL4A1_HUMAN	ALDH4A1	physical	26344197
FAXC_HUMAN	FAXC	physical	26344197
GSTK1_HUMAN	GSTK1	physical	26344197
GLYG2_HUMAN	GYG2	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
PIPNB_HUMAN	PITPNB	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614105: Methylmalonate semialdehyde dehydrogenase deficiency (MMSDHD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.