FAXC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAXC_HUMAN
• UniProt AC: Q5TGI0
• Protein Name: Failed axon connections homolog
• Gene Name: FAXC
• Organism: Homo sapiens (Human).
• Sequence Length: 409
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: May play a role in axonal development..
• Protein Sequence: MHWGVGFASSRPCVVDLSWNQSISFFGWWAGSEEPFSFYGDIIAFPLQDYGGIMAGLGSDPWWKKTLYLTGGALLAAAAYLLHELLVIRKQQEIDSKDAIILHQFARPNNGVPSLSPFCLKMETYLRMADLPYQNYFGGKLSAQGKMPWIEYNHEKVSGTEFIIDFLEEKLGVNLNKNLGPHERAISRAVTKMVEEHFYWTLAYCQWVDNLNETRKMLSLSGGGPFSNLLRWVVCHITKGIVKREMHGHGIGRFSEEEIYMLMEKDMRSLAGLLGDKKYIMGPKLSTLDATVFGHLAQAMWTLPGTRPERLIKGELINLAMYCERIRRKFWPEWHHDDDNTIYESEESSEGSKTHTPLLDFSFYSRTETFEDEGAENSFSRTPDTDFTGHSLFDSDVDMDDYTDHEQCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	RKQQEIDSKDAIILH HHHCCCCCCCEEEEE	37.79	-
114	Phosphorylation	RPNNGVPSLSPFCLK CCCCCCCCCCHHHHH	38.79	-
116	Phosphorylation	NNGVPSLSPFCLKME CCCCCCCCHHHHHHH	21.92	-
142	Phosphorylation	NYFGGKLSAQGKMPW CCCCCCCCCCCCCCE	23.25	24260401
152	Phosphorylation	GKMPWIEYNHEKVSG CCCCEEEECCCCCCC	16.82	22817900
219	Phosphorylation	NETRKMLSLSGGGPF HHHHHHHHHCCCCHH	19.59	25278378
221	Phosphorylation	TRKMLSLSGGGPFSN HHHHHHHCCCCHHHH	31.83	25278378
227	Phosphorylation	LSGGGPFSNLLRWVV HCCCCHHHHHHHHHH	29.69	25278378
354	Phosphorylation	ESSEGSKTHTPLLDF CCCCCCCCCCCCCCE	32.45	30576142
356	Phosphorylation	SEGSKTHTPLLDFSF CCCCCCCCCCCCEEE	22.36	22468782
362	Phosphorylation	HTPLLDFSFYSRTET CCCCCCEEEEECCCC	23.96	30576142
364	Phosphorylation	PLLDFSFYSRTETFE CCCCEEEEECCCCCC	8.95	22468782
365	Phosphorylation	LLDFSFYSRTETFED CCCEEEEECCCCCCC	30.62	22468782
395	Phosphorylation	TGHSLFDSDVDMDDY CCCCCCCCCCCCCCC	32.00	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAXC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAXC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAXC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAXC_HUMAN	FAXC	physical	25416956
ACADM_HUMAN	ACADM	physical	26344197
TCPQ_HUMAN	CCT8	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.