dbPTM

PIPNB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIPNB_HUMAN
UniProt AC	P48739
Protein Name	Phosphatidylinositol transfer protein beta isoform
Gene Name	PITPNB
Organism	Homo sapiens (Human).
Sequence Length	271
Subcellular Localization	Cytoplasm. Golgi apparatus.
Protein Description	Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes..
Protein Sequence	MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MVLIKEFRVVLP ---CCEEEEEEEEEE	46.79	19608861
5	Ubiquitination	---MVLIKEFRVVLP ---CCEEEEEEEEEE	46.79	23000965
5 (in isoform 2)	Ubiquitination	-	46.79	-
13	Glutathionylation	EFRVVLPCSVQEYQV EEEEEEEECCEEEEC	5.64	22555962
18	Phosphorylation	LPCSVQEYQVGQLYS EEECCEEEECCCEEE	7.45	-
31	Ubiquitination	YSVAEASKNETGGGE EEHHHHHCCCCCCCC	66.89	32015554
33	Ubiquitination	VAEASKNETGGGEGI HHHHHCCCCCCCCCE	53.19	32015554
44	Ubiquitination	GEGIEVLKNEPYEKD CCCEEEECCCCCCCC	65.52	21906983
44	Acetylation	GEGIEVLKNEPYEKD CCCEEEECCCCCCCC	65.52	23236377
44 (in isoform 1)	Ubiquitination	-	65.52	21890473
46	Ubiquitination	GIEVLKNEPYEKDGE CEEEECCCCCCCCCC	47.90	29967540
46 (in isoform 2)	Ubiquitination	-	47.90	21890473
50	Ubiquitination	LKNEPYEKDGEKGQY ECCCCCCCCCCCCCC	66.25	22817900
50	Acetylation	LKNEPYEKDGEKGQY ECCCCCCCCCCCCCC	66.25	22424773
52	Ubiquitination	NEPYEKDGEKGQYTH CCCCCCCCCCCCCEE	49.97	22817900
54	Ubiquitination	PYEKDGEKGQYTHKI CCCCCCCCCCCEEEE	57.77	22817900
56	Ubiquitination	EKDGEKGQYTHKIYH CCCCCCCCCEEEEEE	51.52	22817900
57	Phosphorylation	KDGEKGQYTHKIYHL CCCCCCCCEEEEEEH	21.34	22817900
58	Phosphorylation	DGEKGQYTHKIYHLK CCCCCCCEEEEEEHH	14.59	22817900
60	Ubiquitination	EKGQYTHKIYHLKSK CCCCCEEEEEEHHHC	36.84	29967540
62	Ubiquitination	GQYTHKIYHLKSKVP CCCEEEEEEHHHCCC	13.10	29967540
65	Ubiquitination	THKIYHLKSKVPAFV EEEEEEHHHCCCEEE	34.61	29967540
67	Ubiquitination	KIYHLKSKVPAFVRM EEEEHHHCCCEEEEE	51.13	32142685
67 (in isoform 2)	Ubiquitination	-	51.13	-
69	Ubiquitination	YHLKSKVPAFVRMIA EEHHHCCCEEEEEEC	24.58	32142685
74	Sulfoxidation	KVPAFVRMIAPEGSL CCCEEEEEECCCCCE	2.29	21406390
80	Phosphorylation	RMIAPEGSLVFHEKA EEECCCCCEEEECCC	21.50	23532336
86	Ubiquitination	GSLVFHEKAWNAYPY CCEEEECCCHHHCCC	50.56	23000965
86 (in isoform 2)	Ubiquitination	-	50.56	-
86	Acetylation	GSLVFHEKAWNAYPY CCEEEECCCHHHCCC	50.56	26051181
86 (in isoform 1)	Ubiquitination	-	50.56	21890473
88	Ubiquitination	LVFHEKAWNAYPYCR EEEECCCHHHCCCEE	10.89	23000965
88	Ubiquitination	LVFHEKAWNAYPYCR EEEECCCHHHCCCEE	10.89	21890473
88 (in isoform 2)	Ubiquitination	-	10.89	21890473
91	Phosphorylation	HEKAWNAYPYCRTIV ECCCHHHCCCEEEEE	7.48	28152594
93	Phosphorylation	KAWNAYPYCRTIVTN CCHHHCCCEEEEECC	5.06	20090780
96	Phosphorylation	NAYPYCRTIVTNEYM HHCCCEEEEECCCHH	19.08	-
104	Methylation	IVTNEYMKDDFFIKI EECCCHHCCCEEEEE	53.92	44498999
104	Ubiquitination	IVTNEYMKDDFFIKI EECCCHHCCCEEEEE	53.92	23000965
104 (in isoform 2)	Ubiquitination	-	53.92	-
104 (in isoform 1)	Ubiquitination	-	53.92	21890473
106	Ubiquitination	TNEYMKDDFFIKIET CCCHHCCCEEEEEEE	34.53	21890473
106	Ubiquitination	TNEYMKDDFFIKIET CCCHHCCCEEEEEEE	34.53	21890473
106 (in isoform 2)	Ubiquitination	-	34.53	21890473
110	Ubiquitination	MKDDFFIKIETWHKP HCCCEEEEEEEECCC	29.36	23000965
110 (in isoform 1)	Ubiquitination	-	29.36	21890473
112	Ubiquitination	DDFFIKIETWHKPDL CCEEEEEEEECCCCC	40.62	23000965
112	Ubiquitination	DDFFIKIETWHKPDL CCEEEEEEEECCCCC	40.62	21890473
112 (in isoform 2)	Ubiquitination	-	40.62	21890473
116	Ubiquitination	IKIETWHKPDLGTLE EEEEEECCCCCCCEE	31.61	29967540
116	Acetylation	IKIETWHKPDLGTLE EEEEEECCCCCCCEE	31.61	26051181
118	Ubiquitination	IETWHKPDLGTLENV EEEECCCCCCCEECC	63.63	29967540
146	Methylation	VHIDIADRSQVEPAD EEEECCCHHHCCCCC	21.70	115487603
154	Phosphorylation	SQVEPADYKADEDPA HHCCCCCCCCCCCHH	15.35	-
155	Ubiquitination	QVEPADYKADEDPAL HCCCCCCCCCCCHHH	50.32	21906983
155 (in isoform 2)	Ubiquitination	-	50.32	-
155 (in isoform 1)	Ubiquitination	-	50.32	21890473
157	Ubiquitination	EPADYKADEDPALFQ CCCCCCCCCCHHHHH	57.59	21963094
157	Ubiquitination	EPADYKADEDPALFQ CCCCCCCCCCHHHHH	57.59	21890473
157 (in isoform 2)	Ubiquitination	-	57.59	21890473
167	Ubiquitination	PALFQSVKTKRGPLG HHHHHHHCCCCCCCC	54.28	21906983
167 (in isoform 1)	Ubiquitination	-	54.28	21890473
169	Ubiquitination	LFQSVKTKRGPLGPN HHHHHCCCCCCCCCC	50.03	24816145
169 (in isoform 2)	Ubiquitination	-	50.03	21890473
169	Ubiquitination	LFQSVKTKRGPLGPN HHHHHCCCCCCCCCC	50.03	21890473
178	Ubiquitination	GPLGPNWKKELANSP CCCCCCHHHHHCCCC	42.90	23000965
179	Ubiquitination	PLGPNWKKELANSPD CCCCCHHHHHCCCCC	49.96	23000965
179 (in isoform 2)	Ubiquitination	-	49.96	-
179 (in isoform 1)	Ubiquitination	-	49.96	21890473
180	Ubiquitination	LGPNWKKELANSPDC CCCCHHHHHCCCCCC	49.76	23000965
181	Ubiquitination	GPNWKKELANSPDCP CCCHHHHHCCCCCCH	8.20	23000965
181	Ubiquitination	GPNWKKELANSPDCP CCCHHHHHCCCCCCH	8.20	21890473
181 (in isoform 2)	Ubiquitination	-	8.20	21890473
184	Phosphorylation	WKKELANSPDCPQMC HHHHHCCCCCCHHHH	19.26	25159151
193	Phosphorylation	DCPQMCAYKLVTIKF CCHHHHHHHEEEEEH	10.42	18083107
194	Acetylation	CPQMCAYKLVTIKFK CHHHHHHHEEEEEHH	20.25	26051181
199	Ubiquitination	AYKLVTIKFKWWGLQ HHHEEEEEHHHHCCH	31.37	23000965
199	Acetylation	AYKLVTIKFKWWGLQ HHHEEEEEHHHHCCH	31.37	25953088
201	Ubiquitination	KLVTIKFKWWGLQSK HEEEEEHHHHCCHHH	36.71	23000965
201 (in isoform 2)	Ubiquitination	-	36.71	-
201	Acetylation	KLVTIKFKWWGLQSK HEEEEEHHHHCCHHH	36.71	25953088
201 (in isoform 1)	Ubiquitination	-	36.71	21890473
203	Ubiquitination	VTIKFKWWGLQSKVE EEEEHHHHCCHHHHH	9.75	23000965
203	Ubiquitination	VTIKFKWWGLQSKVE EEEEHHHHCCHHHHH	9.75	21890473
203 (in isoform 2)	Ubiquitination	-	9.75	21890473
208	Ubiquitination	KWWGLQSKVENFIQK HHHCCHHHHHHHHHH	40.38	23000965
208 (in isoform 2)	Ubiquitination	-	40.38	-
208 (in isoform 1)	Ubiquitination	-	40.38	21890473
210	Ubiquitination	WGLQSKVENFIQKQE HCCHHHHHHHHHHHH	50.59	23000965
210	Ubiquitination	WGLQSKVENFIQKQE HCCHHHHHHHHHHHH	50.59	21890473
210 (in isoform 2)	Ubiquitination	-	50.59	21890473
215	Acetylation	KVENFIQKQEKRIFT HHHHHHHHHHHHHHH	56.46	19608861
215	Ubiquitination	KVENFIQKQEKRIFT HHHHHHHHHHHHHHH	56.46	23000965
215 (in isoform 2)	Ubiquitination	-	56.46	-
215 (in isoform 1)	Ubiquitination	-	56.46	21890473
217	Ubiquitination	ENFIQKQEKRIFTNF HHHHHHHHHHHHHHH	51.87	23000965
217	Ubiquitination	ENFIQKQEKRIFTNF HHHHHHHHHHHHHHH	51.87	21890473
217	Acetylation	ENFIQKQEKRIFTNF HHHHHHHHHHHHHHH	51.87	19608861
217 (in isoform 2)	Ubiquitination	-	51.87	21890473
218	Ubiquitination	NFIQKQEKRIFTNFH HHHHHHHHHHHHHHH	48.58	23000965
218 (in isoform 2)	Ubiquitination	-	48.58	-
220	Ubiquitination	IQKQEKRIFTNFHRQ HHHHHHHHHHHHHHH	8.06	23000965
220	Ubiquitination	IQKQEKRIFTNFHRQ HHHHHHHHHHHHHHH	8.06	-
240	Sulfoxidation	DKWIDLTMEDIRRME HHHHCCCHHHHHHCC	5.91	30846556
244	Methylation	DLTMEDIRRMEDETQ CCCHHHHHHCCHHHH	44.19	115487611
250	Phosphorylation	IRRMEDETQKELETM HHHCCHHHHHHHHHH	58.21	20068231
252	Ubiquitination	RMEDETQKELETMRK HCCHHHHHHHHHHHH	72.23	29967540
252 (in isoform 1)	Ubiquitination	-	72.23	21890473
254	Ubiquitination	EDETQKELETMRKRG CHHHHHHHHHHHHHC	9.52	21890473
254	Ubiquitination	EDETQKELETMRKRG CHHHHHHHHHHHHHC	9.52	21890473
254 (in isoform 2)	Ubiquitination	-	9.52	21890473
256	Phosphorylation	ETQKELETMRKRGSV HHHHHHHHHHHHCCC	34.59	20068231
262	Phosphorylation	ETMRKRGSVRGTSAA HHHHHHCCCCCCCCC	16.81	28355574
266	Phosphorylation	KRGSVRGTSAADV-- HHCCCCCCCCCCC--	12.48	25159151
267	Phosphorylation	RGSVRGTSAADV--- HCCCCCCCCCCC---	25.04	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIPNB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
262	S	Phosphorylation		-
Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIPNB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PIPNB_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIPNB_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-5 AND LYS-215, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-57, AND MASSSPECTROMETRY.	18083107 [Abstract]

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