BCS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BCS1_HUMAN
• UniProt AC: Q9Y276
• Protein Name: Mitochondrial chaperone BCS1
• Gene Name: BCS1L
• Organism: Homo sapiens (Human).
• Sequence Length: 419
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex..
• Protein Sequence: MPLSDFILALKDNPYFGAGFGLVGVGTALALARKGVQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFVPSPGNHFIWYRGKWIRVERSREMQMIDLQTGTPWESVTFTALGTDRKVFFNILEEARELALQQEEGKTVMYTAVGSEWRPFGYPRRRRPLNSVVLQQGLADRIVRDVQEFIDNPKWYTDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHVDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLRATNQISPAQVQGYFMLYKNDPVGAIHNAESLRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPLSDFILALK ----CCHHHHHHHHC	25.30	-
145	Ubiquitination	TALGTDRKVFFNILE EEECCCHHHHHHHHH	46.32	21890473
169	Phosphorylation	EEGKTVMYTAVGSEW HCCCEEEEEEECCCC	6.29	28152594
170	Phosphorylation	EGKTVMYTAVGSEWR CCCEEEEEEECCCCC	9.21	28152594
174	Phosphorylation	VMYTAVGSEWRPFGY EEEEEECCCCCCCCC	27.64	28152594
181	Phosphorylation	SEWRPFGYPRRRRPL CCCCCCCCCCCCCCC	8.24	12910490
213	Ubiquitination	QEFIDNPKWYTDRGI HHHHHCCCCCCCCCC	60.12	21890473
241	Phosphorylation	CGKSSFITALAGELE CCHHHHHHHHHHHHC	17.38	22210691
262	Phosphorylation	SLTDSSLSDDRLNHL ECCCCCCCHHHHHHH	39.14	22210691
271	Phosphorylation	DRLNHLLSVAPQQSL HHHHHHHHHCCCCEE	23.69	24719451
277	Phosphorylation	LSVAPQQSLVLLEDV HHHCCCCEEEEEECC	18.39	24719451
290	Phosphorylation	DVDAAFLSRDLAVEN CCCHHHHCCCCCCCC	19.79	24719451
300	Ubiquitination	LAVENPVKYQGLGRL CCCCCCCCCCCCCCC	32.87	21890473
330	Phosphorylation	EARIVFMTTNHVDRL CEEEEEEECCCHHCC	17.00	20068231
331	Phosphorylation	ARIVFMTTNHVDRLD EEEEEEECCCHHCCC	16.13	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BCS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BCS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BCS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJA1_HUMAN	DNAJA1	physical	21900206
UCRI_HUMAN	UQCRFS1	physical	22939629
RM10_HUMAN	MRPL10	physical	22939629
AIFM1_HUMAN	AIFM1	physical	26344197
VAPA_HUMAN	VAPA	physical	26344197

Drug and Disease Associations

• Kegg Disease
• H00473: Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
• H00820: Bjornstad syndrome
• OMIM Disease
• 603358: GRACILE syndrome (GRACILE)
• 124000: Mitochondrial complex III deficiency, nuclear 1 (MC3DN1)
• 262000: Bjoernstad syndrome (BJS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-181, AND MASSSPECTROMETRY.
PubMed: 19534553