NDUB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUB8_HUMAN
• UniProt AC: O95169
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
• Gene Name: NDUFB8
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAVARAGVLGVQWLQRASRNVMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLNWGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVGPKQYPYNNLYLERGGDPSKEPERVVHYEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	VQWLQRASRNVMPLG HHHHHHHHCCCCCCC	26.95	24043423
22	Ubiquitination	QRASRNVMPLGARTA HHHHCCCCCCCCCHH	2.30	24816145
28	O-linked_Glycosylation	VMPLGARTASHMTKD CCCCCCCHHHHCCCC	31.79	30379171
34	Ubiquitination	RTASHMTKDMFPGPY CHHHHCCCCCCCCCC	39.35	21906983
34	Ubiquitination	RTASHMTKDMFPGPY CHHHHCCCCCCCCCC	39.35	21890473
41	Phosphorylation	KDMFPGPYPRTPEER CCCCCCCCCCCHHHH	15.97	-
44	Phosphorylation	FPGPYPRTPEERAAA CCCCCCCCHHHHHHH	30.46	29214152
46	Ubiquitination	GPYPRTPEERAAAAK CCCCCCHHHHHHHHH	60.55	21906983
46	Ubiquitination	GPYPRTPEERAAAAK CCCCCCHHHHHHHHH	60.55	22817900
53	Ubiquitination	EERAAAAKKYNMRVE HHHHHHHHHHCCCCC	51.57	24816145
70	Sulfoxidation	EPYPDDGMGYGDYPK CCCCCCCCCCCCCCC	4.87	28465586
77	Ubiquitination	MGYGDYPKLPDRSQH CCCCCCCCCCCCCCC	67.43	27667366
90	Phosphorylation	QHERDPWYSWDQPGL CCCCCCCCCCCCCCC	12.79	-
153	Phosphorylation	VGDVYPVYQPVGPKQ HHCCCCCCCCCCCCC	11.55	-
161	Phosphorylation	QPVGPKQYPYNNLYL CCCCCCCCCCCCEEE	17.51	-
163	Phosphorylation	VGPKQYPYNNLYLER CCCCCCCCCCEEECC	16.26	-
167	Phosphorylation	QYPYNNLYLERGGDP CCCCCCEEECCCCCC	14.51	-
170	Methylation	YNNLYLERGGDPSKE CCCEEECCCCCCCCC	52.37	115484735
175	Phosphorylation	LERGGDPSKEPERVV ECCCCCCCCCCCCEE	55.16	22210691
184	Phosphorylation	EPERVVHYEI----- CCCCEEEEEC-----	12.05	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUB8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUB8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EI2BG_HUMAN	EIF2B3	physical	16169070
PIM2_HUMAN	PIM2	physical	16169070
PROF2_HUMAN	PFN2	physical	16169070
NDUBB_HUMAN	NDUFB11	physical	22939629
QCR7_HUMAN	UQCRB	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
ZAP70_HUMAN	ZAP70	physical	21988832
NDUV1_HUMAN	NDUFV1	physical	26344197
ADT3_HUMAN	SLC25A6	physical	26344197
SSRA_HUMAN	SSR1	physical	26344197
UCRI_HUMAN	UQCRFS1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.