NDUBB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUBB_HUMAN
• UniProt AC: Q9NX14
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
• Gene Name: NDUFB11
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAAGLFGLSARRLLAAAATRGLPAARVRWESSFSRTVVAPSAVAGKRPPEPTTPWQEDPEPEDENLYEKNPDSHGYDKDPVLDVWNMRLVFFFGVSIILVLGSTFVAYLPDYRMKEWSRREAERLVKYREANGLPIMESNCFDPSKIQLPEDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	O-linked_Glycosylation	AAGLFGLSARRLLAA CCCHHHHHHHHHHHH	21.80	30379171
12	Dimethylation	LFGLSARRLLAAAAT HHHHHHHHHHHHHHH	33.50	-
12	Methylation	LFGLSARRLLAAAAT HHHHHHHHHHHHHHH	33.50	24377053
36	O-linked_Glycosylation	WESSFSRTVVAPSAV ECCCCCCEEECCHHH	20.38	OGP
36	Phosphorylation	WESSFSRTVVAPSAV ECCCCCCEEECCHHH	20.38	26437602
41	O-linked_Glycosylation	SRTVVAPSAVAGKRP CCEEECCHHHCCCCC	26.15	OGP
41	Phosphorylation	SRTVVAPSAVAGKRP CCEEECCHHHCCCCC	26.15	26437602
46	Ubiquitination	APSAVAGKRPPEPTT CCHHHCCCCCCCCCC	52.58	22817900
46 (in isoform 2)	Ubiquitination	-	52.58	21890473
51 (in isoform 1)	Ubiquitination	-	47.55	21890473
52	Phosphorylation	GKRPPEPTTPWQEDP CCCCCCCCCCCCCCC	43.77	-
53	Phosphorylation	KRPPEPTTPWQEDPE CCCCCCCCCCCCCCC	32.99	-
115	Ubiquitination	YLPDYRMKEWSRREA HCCCHHCHHHHHHHH	47.21	-
125 (in isoform 2)	Ubiquitination	-	2.68	-
128	Phosphorylation	EAERLVKYREANGLP HHHHHHHHHHHCCCC	13.25	24927040
139	Phosphorylation	NGLPIMESNCFDPSK CCCCCEECCCCCHHH	22.86	20833797
145	Phosphorylation	ESNCFDPSKIQLPED ECCCCCHHHCCCCCC	44.21	29759185
146	Acetylation	SNCFDPSKIQLPEDE CCCCCHHHCCCCCCC	39.60	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUBB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUBB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUBB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	21900206
CXCL7_HUMAN	PPBP	physical	21900206
QCR7_HUMAN	UQCRB	physical	22939629
SURF4_HUMAN	SURF4	physical	22939629
NDUF3_HUMAN	NDUFAF3	physical	22939629
TMX1_HUMAN	TMX1	physical	22939629
TXND5_HUMAN	TXNDC5	physical	22939629
FATE1_HUMAN	FATE1	physical	25416956
NDUB7_HUMAN	NDUFB7	physical	28514442
NDUV3_HUMAN	NDUFV3	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
NDUA7_HUMAN	NDUFA7	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
NDUB5_HUMAN	NDUFB5	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
DJC30_HUMAN	DNAJC30	physical	28514442
NDUV2_HUMAN	NDUFV2	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442
NDUV1_HUMAN	NDUFV1	physical	28514442
NDUS6_HUMAN	NDUFS6	physical	28514442
NDUBA_HUMAN	NDUFB10	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NDUA9_HUMAN	NDUFA9	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUS1_HUMAN	NDUFS1	physical	28514442
NDUAA_HUMAN	NDUFA10	physical	28514442
NDUA3_HUMAN	NDUFA3	physical	28514442
NDUA2_HUMAN	NDUFA2	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442
NDUB4_HUMAN	NDUFB4	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
NDUS5_HUMAN	NDUFS5	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
NDUS7_HUMAN	NDUFS7	physical	28514442
NDUA6_HUMAN	NDUFA6	physical	28514442
NDUS3_HUMAN	NDUFS3	physical	28514442
NDUS2_HUMAN	NDUFS2	physical	28514442
T126B_HUMAN	TMEM126B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300952: Linear skin defects with multiple congenital anomalies 3 (LSDMCA3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.