NDUC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUC2_HUMAN
• UniProt AC: O95298
• Protein Name: NADH dehydrogenase [ubiquinone] 1 subunit C2
• Gene Name: NDUFC2
• Organism: Homo sapiens (Human).
• Sequence Length: 119
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MIARRNPEPLRFLPDEARSLPPPKLTDPRLLYIGFLGYCSGLIDNLIRRRPIATAGLHRQLLYITAFFFAGYYLVKREDYLYAVRDREMFGYMKLHPEDFPEEDKKTYGEIFEKFHPIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	FLPDEARSLPPPKLT CCCHHHHCCCCCCCC	52.88	24888630
54	Phosphorylation	IRRRPIATAGLHRQL HHHCCCCHHHHHHHH	23.21	-
80	Phosphorylation	YLVKREDYLYAVRDR HECCHHHHEEEEECH	9.25	-
91	Ubiquitination	VRDREMFGYMKLHPE EECHHHHCCCCCCHH	21.95	19608861
91	Acetylation	VRDREMFGYMKLHPE EECHHHHCCCCCCHH	21.95	19608861
92	Phosphorylation	RDREMFGYMKLHPED ECHHHHCCCCCCHHH	4.64	29496907
94	Ubiquitination	REMFGYMKLHPEDFP HHHHCCCCCCHHHCC	34.85	21890473
105	Ubiquitination	EDFPEEDKKTYGEIF HHCCHHHHHCHHHHH	50.74	21890473
105	2-Hydroxyisobutyrylation	EDFPEEDKKTYGEIF HHCCHHHHHCHHHHH	50.74	-
106	Ubiquitination	DFPEEDKKTYGEIFE HCCHHHHHCHHHHHH	60.34	21890473
106	Ubiquitination	DFPEEDKKTYGEIFE HCCHHHHHCHHHHHH	60.34	21890473
107	Phosphorylation	FPEEDKKTYGEIFEK CCHHHHHCHHHHHHH	42.36	29496907
108	Phosphorylation	PEEDKKTYGEIFEKF CHHHHHCHHHHHHHH	22.95	29496907
114	2-Hydroxyisobutyrylation	TYGEIFEKFHPIR-- CHHHHHHHHCCCC--	37.92	-
114	Malonylation	TYGEIFEKFHPIR-- CHHHHHHHHCCCC--	37.92	26320211
114	Sumoylation	TYGEIFEKFHPIR-- CHHHHHHHHCCCC--	37.92	19608861
114	Ubiquitination	TYGEIFEKFHPIR-- CHHHHHHHHCCCC--	37.92	21890473
114	Acetylation	TYGEIFEKFHPIR-- CHHHHHHHHCCCC--	37.92	25825284
114	Ubiquitination	TYGEIFEKFHPIR-- CHHHHHHHHCCCC--	37.92	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUC2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01136: Carvedilol

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-114, AND MASS SPECTROMETRY.
PubMed: 19608861