SURF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SURF4_HUMAN
• UniProt AC: O15260
• Protein Name: Surfeit locus protein 4
• Gene Name: SURF4
• Organism: Homo sapiens (Human).
• Sequence Length: 269
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cycles between the endoplasmic retic
• Protein Description: May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi..
• Protein Sequence: MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Sulfoxidation	-MGQNDLMGTAEDFA -CCCCCCCCCHHHHH	5.10	21406390
9	Phosphorylation	GQNDLMGTAEDFADQ CCCCCCCCHHHHHHH	16.95	18491316
22	Ubiquitination	DQFLRVTKQYLPHVA HHHHHHHHHHHHHHH	33.80	-
22 (in isoform 1)	Ubiquitination	-	33.80	21890473
22	Malonylation	DQFLRVTKQYLPHVA HHHHHHHHHHHHHHH	33.80	26320211
22	Ubiquitination	DQFLRVTKQYLPHVA HHHHHHHHHHHHHHH	33.80	21906983
22 (in isoform 2)	Ubiquitination	-	33.80	21890473
32	S-palmitoylation	LPHVARLCLISTFLE HHHHHHHHHHHHHHH	2.36	29575903
32	S-nitrosylation	LPHVARLCLISTFLE HHHHHHHHHHHHHHH	2.36	25040305
35	Phosphorylation	VARLCLISTFLEDGI HHHHHHHHHHHHHHC	10.52	20860994
36	Phosphorylation	ARLCLISTFLEDGIR HHHHHHHHHHHHHCH	25.83	20860994
44	Sulfoxidation	FLEDGIRMWFQWSEQ HHHHHCHHHHHCHHC	3.87	28465586
86	Phosphorylation	TGCVLVLSRNFVQYA HHHHHHHCCCHHHHH	20.07	24719451
136	Phosphorylation	LLLAESRSEGKSMFA HHHHHHHHCCCCCCC	61.04	20068231
139 (in isoform 2)	Ubiquitination	-	34.39	21890473
139	2-Hydroxyisobutyrylation	AESRSEGKSMFAGVP HHHHHCCCCCCCCCC	34.39	-
139	Malonylation	AESRSEGKSMFAGVP HHHHHCCCCCCCCCC	34.39	26320211
139	Ubiquitination	AESRSEGKSMFAGVP HHHHHCCCCCCCCCC	34.39	21890473
139	Acetylation	AESRSEGKSMFAGVP HHHHHCCCCCCCCCC	34.39	27452117
139 (in isoform 1)	Ubiquitination	-	34.39	21890473
140	Phosphorylation	ESRSEGKSMFAGVPT HHHHCCCCCCCCCCC	29.95	20068231
141	Sulfoxidation	SRSEGKSMFAGVPTM HHHCCCCCCCCCCCC	2.80	28465586
147	Phosphorylation	SMFAGVPTMRESSPK CCCCCCCCCCCCCHH	26.84	20068231
148	Sulfoxidation	MFAGVPTMRESSPKQ CCCCCCCCCCCCHHH	3.51	28465586
154	Ubiquitination	TMRESSPKQYMQLGG CCCCCCHHHHHHHHH	56.88	2190698
154 (in isoform 1)	Ubiquitination	-	56.88	21890473
154 (in isoform 2)	Ubiquitination	-	56.88	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SURF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SURF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SURF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPO_HUMAN	ATP5O	physical	26344197
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.