T126B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T126B_HUMAN
• UniProt AC: Q8IUX1
• Protein Name: Complex I assembly factor TMEM126B, mitochondrial
• Gene Name: TMEM126B
• Organism: Homo sapiens (Human).
• Sequence Length: 230
• Subcellular Localization: Mitochondrion membrane ; Multi-pass membrane protein .
• Protein Description: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I..
• Protein Sequence: MVVFGYEAGTKPRDSGVVPVGTEEAPKVFKMAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	FGYEAGTKPRDSGVV ECCCCCCCCCCCCCC	36.82	-
15	Phosphorylation	AGTKPRDSGVVPVGT CCCCCCCCCCCCCCC	34.46	-
22	Phosphorylation	SGVVPVGTEEAPKVF CCCCCCCCCCHHHHH	30.77	-
27	Ubiquitination	VGTEEAPKVFKMAAS CCCCCHHHHHHHHHH	68.31	21890473
27 (in isoform 1)	Ubiquitination	-	68.31	21890473
27 (in isoform 4)	Ubiquitination	-	68.31	21890473
34	Phosphorylation	KVFKMAASMHGQPSP HHHHHHHHHCCCCCC	11.19	14702039
40	Phosphorylation	ASMHGQPSPSLEDAK HHHCCCCCCCHHHHH	21.16	24043423
42	Phosphorylation	MHGQPSPSLEDAKLR HCCCCCCCHHHHHHC	49.05	24043423
106	Phosphorylation	VKHDALKTYASLATL CCHHHHHHHHHHHHH	25.77	25072903
107	Phosphorylation	KHDALKTYASLATLP CHHHHHHHHHHHHHH	7.81	25072903
109	Phosphorylation	DALKTYASLATLPFL HHHHHHHHHHHHHHH	14.23	25072903
112	Phosphorylation	KTYASLATLPFLSTV HHHHHHHHHHHHHHC	40.01	25072903
117	Phosphorylation	LATLPFLSTVVTDKL HHHHHHHHHCCCCCE	21.38	25072903
118	Phosphorylation	ATLPFLSTVVTDKLF HHHHHHHHCCCCCEE	22.57	25072903
121	Phosphorylation	PFLSTVVTDKLFVID HHHHHCCCCCEEHHH	24.07	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T126B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T126B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T126B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MR1L1_HUMAN	MRFAP1L1	physical	25416956
CIA30_HUMAN	NDUFAF1	physical	26186194
NDUC2_HUMAN	NDUFC2	physical	26186194
NDUC2_HUMAN	NDUFC2	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.