NDUS8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUS8_HUMAN
• UniProt AC: O00217
• Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
• Gene Name: NDUFS8
• Organism: Homo sapiens (Human).
• Sequence Length: 210
• Subcellular Localization: Mitochondrion .
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone..
• Protein Sequence: MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAANIQADYLYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRCLTTPMLLRA ---CCCCCHHHHHHH	32.26	24043423
6	Phosphorylation	--MRCLTTPMLLRAL --CCCCCHHHHHHHH	8.18	24043423
38	Phosphorylation	AVAATYKYVNMQDPE HHHHHHEECCCCCCC	6.14	-
49	Ubiquitination	QDPEMDMKSVTDRAA CCCCCCHHHHHHHHH	37.19	21906983
49	Methylation	QDPEMDMKSVTDRAA CCCCCCHHHHHHHHH	37.19	23748837
49	2-Hydroxyisobutyrylation	QDPEMDMKSVTDRAA CCCCCCHHHHHHHHH	37.19	-
52	Phosphorylation	EMDMKSVTDRAARTL CCCHHHHHHHHHHHH	27.19	-
71	Phosphorylation	LFRGLGMTLSYLFRE HHHHHCCHHHHHHCC	15.68	20068231
73	Phosphorylation	RGLGMTLSYLFREPA HHHCCHHHHHHCCCC	15.60	20068231
74	Phosphorylation	GLGMTLSYLFREPAT HHCCHHHHHHCCCCE	16.99	20068231
88	Ubiquitination	TINYPFEKGPLSPRF EECCCCCCCCCCCCC	67.23	22817900
92	Phosphorylation	PFEKGPLSPRFRGEH CCCCCCCCCCCCCHH	19.70	24719451
96	Methylation	GPLSPRFRGEHALRR CCCCCCCCCHHHHHH	51.36	115919197
106	Phosphorylation	HALRRYPSGEERCIA HHHHHCCCCCCCHHH	50.32	26471730
121	Glutathionylation	CKLCEAICPAQAITI HHHHHHHCCCCCEEE	2.70	22555962
133	Dimethylation	ITIEAEPRADGSRRT EEEEEECCCCCCCCC	36.49	-
133	Methylation	ITIEAEPRADGSRRT EEEEEECCCCCCCCC	36.49	24377269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUS8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUS8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUS8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUV1_HUMAN	NDUFV1	physical	22939629
NDUV2_HUMAN	NDUFV2	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
SAM50_HUMAN	SAMM50	physical	22939629
PYRD_HUMAN	DHODH	physical	22939629
OPA1_HUMAN	OPA1	physical	22939629
RLA0_HUMAN	RPLP0	physical	22939629
PSN1_HUMAN	PSEN1	physical	22939629
RAB5B_HUMAN	RAB5B	physical	22939629
AFG32_HUMAN	AFG3L2	physical	26344197
CY1_HUMAN	CYC1	physical	26344197
NDUAC_HUMAN	NDUFA12	physical	26344197
NDUS3_HUMAN	NDUFS3	physical	26344197
PHB2_HUMAN	PHB2	physical	26344197
RAB1A_HUMAN	RAB1A	physical	26344197
RAB1B_HUMAN	RAB1B	physical	26344197
SDHB_HUMAN	SDHB	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
QCR8_HUMAN	UQCRQ	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 256000: Leigh syndrome (LS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.