SAM50_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAM50_HUMAN
• UniProt AC: Q9Y512
• Protein Name: Sorting and assembly machinery component 50 homolog
• Gene Name: SAMM50
• Organism: Homo sapiens (Human).
• Sequence Length: 469
• Subcellular Localization: Mitochondrion outer membrane ; Multi-pass membrane protein. Cytoplasm . Mitochondrion .
• Protein Description: Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. [PubMed: 22252321]
• Protein Sequence: MGTVHARSLEPLPSSGPDFGGLGEEAEFVEVEPEAKQEILENKDVVVQHVHFDGLGRTKDDIIICEIGDVFKAKNLIEVMRKSHEAREKLLRLGIFRQVDVLIDTCQGDDALPNGLDVTFEVTELRRLTGSYNTMVGNNEGSMVLGLKLPNLLGRAEKVTFQFSYGTKETSYGLSFFKPRPGNFERNFSVNLYKVTGQFPWSSLRETDRGMSAEYSFPIWKTSHTVKWEGVWRELGCLSRTASFAVRKESGHSLKSSLSHAMVIDSRNSSILPRRGALLKVNQELAGYTGGDVSFIKEDFELQLNKQLIFDSVFSASFWGGMLVPIGDKPSSIADRFYLGGPTSIRGFSMHSIGPQSEGDYLGGEAYWAGGLHLYTPLPFRPGQGGFGELFRTHFFLNAGNLCNLNYGEGPKAHIRKLAECIRWSYGAGIVLRLGNIARLELNYCVPMGVQTGDRICDGVQFGAGIRFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Ubiquitination	VEVEPEAKQEILENK EEECHHHHHHHHHCC	46.96	2190698
43	Acetylation	KQEILENKDVVVQHV HHHHHHCCCEEEEEE	42.39	26051181
43	Ubiquitination	KQEILENKDVVVQHV HHHHHHCCCEEEEEE	42.39	29967540
59	2-Hydroxyisobutyrylation	FDGLGRTKDDIIICE CCCCCCCCCCEEEEE	52.63	-
59	Ubiquitination	FDGLGRTKDDIIICE CCCCCCCCCCEEEEE	52.63	21963094
65	Glutathionylation	TKDDIIICEIGDVFK CCCCEEEEEECHHHH	1.88	22555962
72	Ubiquitination	CEIGDVFKAKNLIEV EEECHHHHHHHHHHH	59.30	21963094
72	Acetylation	CEIGDVFKAKNLIEV EEECHHHHHHHHHHH	59.30	26051181
74	Ubiquitination	IGDVFKAKNLIEVMR ECHHHHHHHHHHHHH	53.53	29967540
82	Ubiquitination	NLIEVMRKSHEAREK HHHHHHHHCHHHHHH	37.76	17623298
129	Phosphorylation	VTELRRLTGSYNTMV EEHHHHHHCCCCEEE	23.44	26437602
131	Phosphorylation	ELRRLTGSYNTMVGN HHHHHHCCCCEEECC	15.24	26437602
142	Phosphorylation	MVGNNEGSMVLGLKL EECCCCCCEEEEEEC	10.27	29507054
148	Ubiquitination	GSMVLGLKLPNLLGR CCEEEEEECCCHHCC	61.16	21963094
178	Acetylation	SYGLSFFKPRPGNFE EEEEEEECCCCCCCC	37.80	25825284
178	Ubiquitination	SYGLSFFKPRPGNFE EEEEEEECCCCCCCC	37.80	27667366
189	Phosphorylation	GNFERNFSVNLYKVT CCCCCCEEEEEEEEE	17.40	30576142
194	Ubiquitination	NFSVNLYKVTGQFPW CEEEEEEEEECCCCH	36.16	17623298
215	Phosphorylation	DRGMSAEYSFPIWKT CCCCCEEEECCEECC	18.48	-
216	Phosphorylation	RGMSAEYSFPIWKTS CCCCEEEECCEECCC	18.95	-
221	Ubiquitination	EYSFPIWKTSHTVKW EEECCEECCCCEEEE	40.65	29967540
227	Acetylation	WKTSHTVKWEGVWRE ECCCCEEEECCHHHH	40.46	25825284
227	Ubiquitination	WKTSHTVKWEGVWRE ECCCCEEEECCHHHH	40.46	-
239	Phosphorylation	WRELGCLSRTASFAV HHHHHCEEEEEEEEE	31.49	26437602
241	Phosphorylation	ELGCLSRTASFAVRK HHHCEEEEEEEEEEH	24.23	26437602
243	Phosphorylation	GCLSRTASFAVRKES HCEEEEEEEEEEHHH	17.08	30266825
248	2-Hydroxyisobutyrylation	TASFAVRKESGHSLK EEEEEEEHHHCCCCC	50.02	-
250	Phosphorylation	SFAVRKESGHSLKSS EEEEEHHHCCCCCHH	44.86	26437602
255	Methylation	KESGHSLKSSLSHAM HHHCCCCCHHCCEEE	40.80	24129315
255	Ubiquitination	KESGHSLKSSLSHAM HHHCCCCCHHCCEEE	40.80	17623298
256	Phosphorylation	ESGHSLKSSLSHAMV HHCCCCCHHCCEEEE	41.63	26437602
257	Phosphorylation	SGHSLKSSLSHAMVI HCCCCCHHCCEEEEE	32.10	28122231
259	Phosphorylation	HSLKSSLSHAMVIDS CCCCHHCCEEEEEEC	15.91	28857561
269	Phosphorylation	MVIDSRNSSILPRRG EEEECCCCCCCCCCC	20.04	20068231
270	Phosphorylation	VIDSRNSSILPRRGA EEECCCCCCCCCCCE	31.52	20068231
294	Phosphorylation	GYTGGDVSFIKEDFE CCCCCCCEEECHHHH	26.45	24719451
297	Acetylation	GGDVSFIKEDFELQL CCCCEEECHHHHHHH	49.58	7431301
297	Ubiquitination	GGDVSFIKEDFELQL CCCCEEECHHHHHHH	49.58	-
412	Ubiquitination	LNYGEGPKAHIRKLA CCCCCCCHHHHHHHH	64.55	-
417	Ubiquitination	GPKAHIRKLAECIRW CCHHHHHHHHHHHHH	51.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAM50_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAM50_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAM50_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM22_HUMAN	TOMM22	physical	22939629
SSBP_HUMAN	SSBP1	physical	22939629
SURF1_HUMAN	SURF1	physical	22939629
TOM40_HUMAN	TOMM40	physical	22939629
SQOR_HUMAN	SQRDL	physical	22939629
SERC1_HUMAN	SERINC1	physical	22939629
MIC19_HUMAN	CHCHD3	physical	25416956
RAB8A_HUMAN	RAB8A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.