dbPTM

QCR7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	QCR7_HUMAN
UniProt AC	P14927
Protein Name	Cytochrome b-c1 complex subunit 7
Gene Name	UQCRB
Organism	Homo sapiens (Human).
Sequence Length	111
Subcellular Localization	Mitochondrion inner membrane.
Protein Description	This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping..
Protein Sequence	MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGKQAVSA ------CCCCHHHCC	33.61	-
4	Acetylation	----MAGKQAVSASG ----CCCCHHHCCCC	26.08	20167786
4	Ubiquitination	----MAGKQAVSASG ----CCCCHHHCCCC	26.08	33845483
8	Phosphorylation	MAGKQAVSASGKWLD CCCCHHHCCCCCHHH	21.52	21712546
10	Phosphorylation	GKQAVSASGKWLDGI CCHHHCCCCCHHHHH	33.14	21712546
12	Acetylation	QAVSASGKWLDGIRK HHHCCCCCHHHHHHH	41.93	23236377
12	Succinylation	QAVSASGKWLDGIRK HHHCCCCCHHHHHHH	41.93	-
12	Ubiquitination	QAVSASGKWLDGIRK HHHCCCCCHHHHHHH	41.93	21890473
12	Ubiquitination	QAVSASGKWLDGIRK HHHCCCCCHHHHHHH	41.93	21890473
12	Succinylation	QAVSASGKWLDGIRK HHHCCCCCHHHHHHH	41.93	21890473
13	Ubiquitination	AVSASGKWLDGIRKW HHCCCCCHHHHHHHH	11.83	22817900
19	Acetylation	KWLDGIRKWYYNAAG CHHHHHHHHHHCCCC	37.31	25825284
19	Succinylation	KWLDGIRKWYYNAAG CHHHHHHHHHHCCCC	37.31	23954790
19	Malonylation	KWLDGIRKWYYNAAG CHHHHHHHHHHCCCC	37.31	26320211
21	Phosphorylation	LDGIRKWYYNAAGFN HHHHHHHHHCCCCCH	7.00	-
29	Ubiquitination	YNAAGFNKLGLMRDD HCCCCCHHCCCCCCC	41.49	21890473
29	Ubiquitination	YNAAGFNKLGLMRDD HCCCCCHHCCCCCCC	41.49	21906983
37	Phosphorylation	LGLMRDDTIYEDEDV CCCCCCCCCCCCHHH	29.73	-
39	Phosphorylation	LMRDDTIYEDEDVKE CCCCCCCCCCHHHHH	21.30	27642862
40	Ubiquitination	MRDDTIYEDEDVKEA CCCCCCCCCHHHHHH	51.58	23503661
45	Acetylation	IYEDEDVKEAIRRLP CCCCHHHHHHHHHCC	54.47	26822725
45	Ubiquitination	IYEDEDVKEAIRRLP CCCCHHHHHHHHHCC	54.47	21906983
45	2-Hydroxyisobutyrylation	IYEDEDVKEAIRRLP CCCCHHHHHHHHHCC	54.47	-
46	Acetylation	YEDEDVKEAIRRLPE CCCHHHHHHHHHCCH	49.53	19608861
46	Ubiquitination	YEDEDVKEAIRRLPE CCCHHHHHHHHHCCH	49.53	23503661
51	Ubiquitination	VKEAIRRLPENLYND HHHHHHHCCHHHHCC	4.48	23503661
56	Phosphorylation	RRLPENLYNDRMFRI HHCCHHHHCCHHHHH	26.97	-
59	Methylation	PENLYNDRMFRIKRA CHHHHCCHHHHHHHH	23.62	115919541
64	Ubiquitination	NDRMFRIKRALDLNL CCHHHHHHHHHCCCC	27.62	23503661
72	Ubiquitination	RALDLNLKHQILPKE HHHCCCCCCCCCCHH	32.18	23503661
72	Acetylation	RALDLNLKHQILPKE HHHCCCCCCCCCCHH	32.18	25825284
78	Acetylation	LKHQILPKEQWTKYE CCCCCCCHHHHCCHH	60.12	23954790
78	Succinylation	LKHQILPKEQWTKYE CCCCCCCHHHHCCHH	60.12	-
78	Succinylation	LKHQILPKEQWTKYE CCCCCCCHHHHCCHH	60.12	23954790
78	Ubiquitination	LKHQILPKEQWTKYE CCCCCCCHHHHCCHH	60.12	19608861
83	Ubiquitination	LPKEQWTKYEEENFY CCHHHHCCHHHHCCC	47.94	23503661
83	Acetylation	LPKEQWTKYEEENFY CCHHHHCCHHHHCCC	47.94	25038526
90	Phosphorylation	KYEEENFYLEPYLKE CHHHHCCCHHHHHHH	23.03	27642862
94	Phosphorylation	ENFYLEPYLKEVIRE HCCCHHHHHHHHHHH	22.49	-
96	Ubiquitination	FYLEPYLKEVIRERK CCHHHHHHHHHHHHH	44.05	23503661
96	Acetylation	FYLEPYLKEVIRERK CCHHHHHHHHHHHHH	44.05	23236377
96	Succinylation	FYLEPYLKEVIRERK CCHHHHHHHHHHHHH	44.05	23954790
110	Acetylation	KEREEWAKK------ HHHHHHHHC------	61.15	6572095
110	Succinylation	KEREEWAKK------ HHHHHHHHC------	61.15	23954790
111	Acetylation	EREEWAKK------- HHHHHHHC-------	58.80	5643605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of QCR7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of QCR7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of QCR7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UCRI_HUMAN	UQCRFS1	physical	22939629
RS10_HUMAN	RPS10	physical	22939629
RL9_HUMAN	RPL9	physical	22939629
RL23_HUMAN	RPL23	physical	22939629
RL11_HUMAN	RPL11	physical	22939629
TIM10_HUMAN	TIMM10	physical	22939629
RL14_HUMAN	RPL14	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
THIL_HUMAN	ACAT1	physical	22939629
RS16_HUMAN	RPS16	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
1A1L1_HUMAN	ACCS	physical	25416956
QCR2_HUMAN	UQCRC2	physical	26186194
COX7R_HUMAN	COX7A2L	physical	26186194
MY18A_HUMAN	MYO18A	physical	26186194
UHRF1_HUMAN	UHRF1	physical	26186194
S10AA_HUMAN	S100A10	physical	26186194
KPCA_HUMAN	PRKCA	physical	26186194
QCR1_HUMAN	UQCRC1	physical	26186194
CYB_HUMAN	CYTB	physical	26186194
RABL6_HUMAN	RABL6	physical	26186194
QCR9_HUMAN	UQCR10	physical	26186194
QCR6_HUMAN	UQCRH	physical	26186194
COX1_HUMAN	COX1	physical	26186194
CX6B1_HUMAN	COX6B1	physical	26186194
QCR8_HUMAN	UQCRQ	physical	26186194
COX5A_HUMAN	COX5A	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
NDUAC_HUMAN	NDUFA12	physical	26344197
NDUA8_HUMAN	NDUFA8	physical	26344197
NDUS4_HUMAN	NDUFS4	physical	26344197
NDUV1_HUMAN	NDUFV1	physical	26344197
VDAC1_HUMAN	VDAC1	physical	26344197
CYB_HUMAN	CYTB	physical	28514442
COX7R_HUMAN	COX7A2L	physical	28514442
MY18A_HUMAN	MYO18A	physical	28514442
QCR1_HUMAN	UQCRC1	physical	28514442
UHRF1_HUMAN	UHRF1	physical	28514442
QCR2_HUMAN	UQCRC2	physical	28514442
S10AA_HUMAN	S100A10	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
COX1_HUMAN	COX1	physical	28514442
ZO1_HUMAN	TJP1	physical	28514442
ACTB_HUMAN	ACTB	physical	28514442

Drug and Disease Associations

Kegg Disease
H00473	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
OMIM Disease
615158	Mitochondrial complex III deficiency, nuclear 3 (MC3DN3)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of QCR7_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-78, AND MASS SPECTROMETRY.	19608861 [Abstract]