1A1L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 1A1L1_HUMAN
• UniProt AC: Q96QU6
• Protein Name: 1-aminocyclopropane-1-carboxylate synthase-like protein 1
• Gene Name: ACCS
• Organism: Homo sapiens (Human).
• Sequence Length: 501
• Protein Description: Does not catalyze the synthesis of 1-aminocyclopropane-1-carboxylate but is capable of catalyzing the deamination of L-vinylglycine..
• Protein Sequence: MFTLPQKDFRAPTTCLGPTCMQDLGSSHGEDLEGECSRKLDQKLPELRGVGDPAMISSDTSYLSSRGRMIKWFWDSAEEGYRTYHMDEYDEDKNPSGIINLGTSENKLCFDLLSWRLSQRDMQRVEPSLLQYADWRGHLFLREEVAKFLSFYCKSPVPLRPENVVVLNGGASLFSALATVLCEAGEAFLIPTPYYGAITQHVCLYGNIRLAYVYLDSEVTGLDTRPFQLTVEKLEMALREAHSEGVKVKGLILISPQNPLGDVYSPEELQEYLVFAKRHRLHVIVDEVYMLSVFEKSVGYRSVLSLERLPDPQRTHVMWATSKDFGMSGLRFGTLYTENQDVATAVASLCRYHGLSGLVQYQMAQLLRDRDWINQVYLPENHARLKAAHTYVSEELRALGIPFLSRGAGFFIWVDLRKYLPKGTFEEEMLLWRRFLDNKVLLSFGKAFECKEPGWFRFVFSDQVHRLCLGMQRVQQVLAGKSQVAEDPRPSQSQEPSDQRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	TCMQDLGSSHGEDLE CHHHHHCCCCCCCCC	26.85	46157499
37	Phosphorylation	EDLEGECSRKLDQKL CCCCCHHHHHHHHCC	28.31	46157503
43	Methylation	CSRKLDQKLPELRGV HHHHHHHCCHHHCCC	66.72	-
43	Methylation	CSRKLDQKLPELRGV HHHHHHHCCHHHCCC	66.72	23644510
114	Phosphorylation	KLCFDLLSWRLSQRD CHHHHHHHHHHCHHH	19.90	24719451
315	Phosphorylation	RLPDPQRTHVMWATS CCCCCCCCEEEEEEC	17.36	68736209
321	Phosphorylation	RTHVMWATSKDFGMS CCEEEEEECCCCCCC	22.31	68736215
322	Phosphorylation	THVMWATSKDFGMSG CEEEEEECCCCCCCC	23.60	68736221
323	N6-(pyridoxal phosphate)lysine	HVMWATSKDFGMSGL EEEEEECCCCCCCCC	53.36	-
323	Other	HVMWATSKDFGMSGL EEEEEECCCCCCCCC	53.36	-
439	Acetylation	WRRFLDNKVLLSFGK HHHHHCCEEEEEECC	33.65	11688525

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 1A1L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 1A1L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 1A1L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1A1L1_HUMAN	ACCS	physical	16189514
FBF1_HUMAN	FBF1	physical	16189514
1A1L1_HUMAN	ACCS	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.