CX6B1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CX6B1_HUMAN
• UniProt AC: P14854
• Protein Name: Cytochrome c oxidase subunit 6B1
• Gene Name: COX6B1
• Organism: Homo sapiens (Human).
• Sequence Length: 86
• Subcellular Localization: Mitochondrion intermembrane space.
• Protein Description: Connects the two COX monomers into the physiological dimeric form..
• Protein Sequence: MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRVYQSLCPTSWVTDWDEQRAEGTFPGKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEDMETKI ------CCCHHHHHH	22.84	22814378
7	Phosphorylation	-MAEDMETKIKNYKT -CCCHHHHHHHHCCC	31.28	23532336
8	Ubiquitination	MAEDMETKIKNYKTA CCCHHHHHHHHCCCC	38.07	23000965
8	Acetylation	MAEDMETKIKNYKTA CCCHHHHHHHHCCCC	38.07	25953088
8	Sumoylation	MAEDMETKIKNYKTA CCCHHHHHHHHCCCC	38.07	-
10	Ubiquitination	EDMETKIKNYKTAPF CHHHHHHHHCCCCCC	56.64	23000965
13	Ubiquitination	ETKIKNYKTAPFDSR HHHHHHCCCCCCCCC	47.83	23000965
13	Acetylation	ETKIKNYKTAPFDSR HHHHHHCCCCCCCCC	47.83	25953088
13	2-Hydroxyisobutyrylation	ETKIKNYKTAPFDSR HHHHHHCCCCCCCCC	47.83	-
30	Glutathionylation	NQNQTRNCWQNYLDF CCHHCCCHHHHHHHH	3.40	22555962
34	Phosphorylation	TRNCWQNYLDFHRCQ CCCHHHHHHHHHHHH	7.79	28152594
42	Ubiquitination	LDFHRCQKAMTAKGG HHHHHHHHHHHHCCC	43.69	22817900
45	Phosphorylation	HRCQKAMTAKGGDIS HHHHHHHHHCCCCCC	30.03	29759185
47	Ubiquitination	CQKAMTAKGGDISVC HHHHHHHCCCCCCHH	55.02	21906983
52	Phosphorylation	TAKGGDISVCEWYQR HHCCCCCCHHHHHHH	26.00	29759185
54	S-nitrosocysteine	KGGDISVCEWYQRVY CCCCCCHHHHHHHHH	2.13	-
54	Glutathionylation	KGGDISVCEWYQRVY CCCCCCHHHHHHHHH	2.13	22555962
54	S-nitrosylation	KGGDISVCEWYQRVY CCCCCCHHHHHHHHH	2.13	22178444
57	Phosphorylation	DISVCEWYQRVYQSL CCCHHHHHHHHHHHH	2.41	28152594
61	Phosphorylation	CEWYQRVYQSLCPTS HHHHHHHHHHHCCCC	8.45	27642862
65	Glutathionylation	QRVYQSLCPTSWVTD HHHHHHHCCCCCCCC	4.12	22555962
67	Phosphorylation	VYQSLCPTSWVTDWD HHHHHCCCCCCCCHH	33.94	19060867
68	Phosphorylation	YQSLCPTSWVTDWDE HHHHCCCCCCCCHHH	12.51	19060867
81	Phosphorylation	DEQRAEGTFPGKI-- HHHHHCCCCCCCC--	20.40	21406692
85	Ubiquitination	AEGTFPGKI------ HCCCCCCCC------	45.54	27667366
85	2-Hydroxyisobutyrylation	AEGTFPGKI------ HCCCCCCCC------	45.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CX6B1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CX6B1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CX6B1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COX5A_HUMAN	COX5A	physical	26344197
CX6B1_HUMAN	COX6B1	physical	27499296
CX6A1_HUMAN	COX6A1	physical	27499296
COX7R_HUMAN	COX7A2L	physical	27499296
COX6C_HUMAN	COX6C	physical	27499296
NDUS6_HUMAN	NDUFS6	physical	27499296
NDUC2_HUMAN	NDUFC2	physical	27499296
NDUA9_HUMAN	NDUFA9	physical	27499296
NDUA6_HUMAN	NDUFA6	physical	27499296
CX7A2_HUMAN	COX7A2	physical	27499296
NDUAA_HUMAN	NDUFA10	physical	27499296
NDUV1_HUMAN	NDUFV1	physical	27499296
MIA40_HUMAN	CHCHD4	physical	27499296
SNP29_HUMAN	SNAP29	physical	27499296
UCRI_HUMAN	UQCRFS1	physical	27499296
NDUS1_HUMAN	NDUFS1	physical	27499296
NDUA7_HUMAN	NDUFA7	physical	27499296
NDUS4_HUMAN	NDUFS4	physical	27499296
QCR7_HUMAN	UQCRB	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
QCR7_HUMAN	UQCRB	physical	28514442
SUOX_HUMAN	SUOX	physical	28514442
SRC_HUMAN	SRC	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 220110: Mitochondrial complex IV deficiency (MT-C4D)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.