| UniProt ID | MIA40_HUMAN | |
|---|---|---|
| UniProt AC | Q8N4Q1 | |
| Protein Name | Mitochondrial intermembrane space import and assembly protein 40 | |
| Gene Name | CHCHD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 142 | |
| Subcellular Localization | Mitochondrion intermembrane space . Mitochondrion . | |
| Protein Description | Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1. [PubMed: 16185709] | |
| Protein Sequence | MSYCRQEGKDRIIFVTKEDHETPSSAELVADDPNDPYEEHGLILPNGNINWNCPCLGGMASGPCGEQFKSAFSCFHYSTEEIKGSDCVDQFRAMQECMQKYPDLYPQEDEDEEEEREKKPAEQAEETAPIEATATKEEEGSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSYCRQEGK ------CCCCCCCCC | 32.70 | 28509920 | |
| 3 | Phosphorylation | -----MSYCRQEGKD -----CCCCCCCCCC | 7.14 | 28509920 | |
| 4 (in isoform 2) | Phosphorylation | - | 2.58 | 25072903 | |
| 5 (in isoform 2) | Phosphorylation | - | 29.38 | 25072903 | |
| 6 (in isoform 2) | Phosphorylation | - | 61.30 | 25072903 | |
| 7 (in isoform 2) | Phosphorylation | - | 49.19 | 25072903 | |
| 9 (in isoform 2) | Phosphorylation | - | 42.98 | 25072903 | |
| 10 (in isoform 2) | Phosphorylation | - | 58.84 | 25072903 | |
| 90 | Phosphorylation | KGSDCVDQFRAMQEC CCCCHHHHHHHHHHH | 14.88 | 27642862 | |
| 100 | Ubiquitination | AMQECMQKYPDLYPQ HHHHHHHHCCCCCCC | 31.69 | - | |
| 101 | Phosphorylation | MQECMQKYPDLYPQE HHHHHHHCCCCCCCC | 5.77 | 18452278 | |
| 133 | Phosphorylation | ETAPIEATATKEEEG HHCCCCCEEECCCCC | 23.28 | 30108239 | |
| 135 | Phosphorylation | APIEATATKEEEGSS CCCCCEEECCCCCCC | 34.33 | 30108239 | |
| 136 | Acetylation | PIEATATKEEEGSS- CCCCEEECCCCCCC- | 61.74 | 26051181 | |
| 141 | Phosphorylation | ATKEEEGSS------ EECCCCCCC------ | 35.83 | 30108239 | |
| 142 | Phosphorylation | TKEEEGSS------- ECCCCCCC------- | 55.91 | 30108239 | |
| 154 | Phosphorylation | ------------------- ------------------- | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIA40_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIA40_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIA40_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CPIN1_HUMAN | CIAPIN1 | physical | 21700214 | |
| SURF1_HUMAN | SURF1 | physical | 22939629 | |
| TIM10_HUMAN | TIMM10 | physical | 22939629 | |
| SON_HUMAN | SON | physical | 22939629 | |
| MIRO2_HUMAN | RHOT2 | physical | 22939629 | |
| PEX3_HUMAN | PEX3 | physical | 22939629 | |
| RL10L_HUMAN | RPL10L | physical | 22939629 | |
| NDUF4_HUMAN | NDUFAF4 | physical | 22939629 | |
| RAB5B_HUMAN | RAB5B | physical | 22939629 | |
| RHBD2_HUMAN | RHBDD2 | physical | 22939629 | |
| SENP3_HUMAN | SENP3 | physical | 22939629 | |
| STX7_HUMAN | STX7 | physical | 22939629 | |
| ECHB_HUMAN | HADHB | physical | 21988832 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
