RHBD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHBD2_HUMAN
• UniProt AC: Q6NTF9
• Protein Name: Rhomboid domain-containing protein 2
• Gene Name: RHBDD2
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Subcellular Localization: Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein.
• Protein Sequence: MAASGPGCRSWCLCPEVPSATFFTALLSLLVSGPRLFLLQQPLAPSGLTLKSEALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSSLSKLGEVEDARGFTPVAFAMLGVTTVRSRMRRALVFGMVVPSVLVPWLLLGASWLIPQTSFLSNVCGLSIGLAYGLTYCYSIDLSERVALKLDQTFPFSLMRRISVFKYVSGSSAERRAAQSRKLNPVPGSYPTQSCHPHLSPSHPVSQTQHASGQKLASWPSCTPGHMPTLPPYQPASGLCYVQNHFGPNPTSSSVYPASAGTSLGIQPPTPVNSPGTVYSGALGTPGAAGSKESSRVPMP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	S-palmitoylation	MAASGPGCRSWCLCP CCCCCCCCCHHCCCC	3.33	29575903
21	Phosphorylation	CPEVPSATFFTALLS CCCCCHHHHHHHHHH	24.50	-
51	Ubiquitination	APSGLTLKSEALRNW CCCCCCCCHHHHHHC	40.80	21963094
72	Ubiquitination	TYIFVYENPISLLCG EEEEECCCHHHHHHH	22.86	23503661
77	Ubiquitination	YENPISLLCGAIIIW CCCHHHHHHHHHHHH	1.70	23503661
82	Ubiquitination	SLLCGAIIIWRFAGN HHHHHHHHHHHHCCC	2.15	23000965
89	Ubiquitination	IIWRFAGNFERTVGT HHHHHCCCHHHHHHH	31.98	23000965
94	Ubiquitination	AGNFERTVGTVRHCF CCCHHHHHHHHHHHH	8.29	23000965
96	Ubiquitination	NFERTVGTVRHCFFT CHHHHHHHHHHHHHH	15.27	21890473
98	Ubiquitination	ERTVGTVRHCFFTVI HHHHHHHHHHHHHHH	22.24	29967540
105	Ubiquitination	RHCFFTVIFAIFSAI HHHHHHHHHHHHHHH	1.43	29967540
110	Ubiquitination	TVIFAIFSAIIFLSF HHHHHHHHHHHHHHH	16.67	29967540
213	Ubiquitination	LSERVALKLDQTFPF CHHHHHHCCCCCCCH	40.04	23503661
227	Phosphorylation	FSLMRRISVFKYVSG HHHHHHHEEHHHHCC	21.49	24719451
230	Ubiquitination	MRRISVFKYVSGSSA HHHHEEHHHHCCCHH	42.46	23000965
231	Phosphorylation	RRISVFKYVSGSSAE HHHEEHHHHCCCHHH	6.59	23403867
233	Phosphorylation	ISVFKYVSGSSAERR HEEHHHHCCCHHHHH	29.84	23403867
235	Phosphorylation	VFKYVSGSSAERRAA EHHHHCCCHHHHHHH	20.90	23403867
236	Phosphorylation	FKYVSGSSAERRAAQ HHHHCCCHHHHHHHH	37.36	23403867
246	Ubiquitination	RRAAQSRKLNPVPGS HHHHHHCCCCCCCCC	58.84	29967540
253	Phosphorylation	KLNPVPGSYPTQSCH CCCCCCCCCCCCCCC	23.13	20068231
254	Phosphorylation	LNPVPGSYPTQSCHP CCCCCCCCCCCCCCC	19.06	20068231
256	Phosphorylation	PVPGSYPTQSCHPHL CCCCCCCCCCCCCCC	25.53	28152594
258	Phosphorylation	PGSYPTQSCHPHLSP CCCCCCCCCCCCCCC	19.51	28152594
264	Phosphorylation	QSCHPHLSPSHPVSQ CCCCCCCCCCCCCCC	22.71	28152594
266	Phosphorylation	CHPHLSPSHPVSQTQ CCCCCCCCCCCCCCC	36.73	28152594
270	Phosphorylation	LSPSHPVSQTQHASG CCCCCCCCCCCCCCC	31.77	27174698
272	Phosphorylation	PSHPVSQTQHASGQK CCCCCCCCCCCCCCC	18.15	27174698
276	Phosphorylation	VSQTQHASGQKLASW CCCCCCCCCCCCCCC	39.36	20068231
343	Phosphorylation	VNSPGTVYSGALGTP CCCCCCEEECCCCCC	10.96	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHBD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHBD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHBD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IFT27_HUMAN	IFT27	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.